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Clostridium perfringens str. 13 (cper0)
Gene : mtrA
DDBJ      :mtrA         GTP cyclohydrolase
Swiss-Prot:GCH1_CLOPE   RecName: Full=GTP cyclohydrolase 1;         EC=3.5.4.16;AltName: Full=GTP cyclohydrolase I;         Short=GTP-CH-I;

Homologs  Archaea  22/68 : Bacteria  714/915 : Eukaryota  186/199 : Viruses  2/175   --->[See Alignment]
d.96.1
:185 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   14->183 1is7A PDBj 3e-43 49.4 %
:RPS:PDB   2->183 1a9cA PDBj 3e-53 35.2 %
:RPS:SCOP  2->183 1a8rA  d.96.1.1 * 1e-62 34.6 %
:HMM:SCOP  2->185 1fb1A_ d.96.1.1 * 1.3e-74 52.7 %
:RPS:PFM   82->167 PF01227 * GTP_cyclohydroI 6e-29 61.6 %
:HMM:PFM   82->167 PF01227 * GTP_cyclohydroI 1.8e-41 66.3 86/86  
:BLT:SWISS 1->185 GCH1_CLOPE e-105 100.0 %
:PROS 63->79|PS00859|GTP_CYCLOHYDROL_1_1
:PROS 111->121|PS00860|GTP_CYCLOHYDROL_1_2

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID BAB80725.1 GT:GENE mtrA GT:PRODUCT GTP cyclohydrolase GT:DATABASE GIB00075CH01 GT:ORG cper0 GB:ACCESSION GIB00075CH01 GB:LOCATION 1222555..1223112 GB:FROM 1222555 GB:TO 1223112 GB:DIRECTION + GB:GENE mtrA GB:PRODUCT GTP cyclohydrolase GB:NOTE 185 aa, similar to sp:GCH1_STRPN GTP CYCLOHYDROLASE I (EC 3.5.4.16) (GTP-CH-I) from Streptococcus pneumoniae (184 aa); 61.4% identity in 184 aa overlap CPE1019 GB:PROTEIN_ID BAB80725.1 LENGTH 185 SQ:AASEQ MIDKEKIKEGMKLILEAIGEDVNREGLIETPDRIARMYEEIFSGIGMNAKEHLSKTFEVHSNDLVLEKDITFYSMCEHHLVPFYGKVHIAYIPNGRVVGLSKLARCVEVYSKKPQLQERLTKEIADSIMEYLDAQGVMVVVEGEHMCMTMRGVRKPGAKTVTTTYRGKFLEDESLKNDVFRMISM GT:EXON 1|1-185:0| SW:ID GCH1_CLOPE SW:DE RecName: Full=GTP cyclohydrolase 1; EC=3.5.4.16;AltName: Full=GTP cyclohydrolase I; Short=GTP-CH-I; SW:GN Name=folE; Synonyms=mtrA; OrderedLocusNames=CPE1019; SW:KW Complete proteome; GTP-binding; Hydrolase; Metal-binding;Nucleotide-binding; One-carbon metabolism; Zinc. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->185|GCH1_CLOPE|e-105|100.0|185/185| GO:SWS:NREP 5 GO:SWS GO:0005525|"GO:GTP binding"|GTP-binding| GO:SWS GO:0016787|"GO:hydrolase activity"|Hydrolase| GO:SWS GO:0046872|"GO:metal ion binding"|Metal-binding| GO:SWS GO:0000166|"GO:nucleotide binding"|Nucleotide-binding| GO:SWS GO:0006730|"GO:one-carbon metabolic process"|One-carbon metabolism| PROS 63->79|PS00859|GTP_CYCLOHYDROL_1_1|PDOC00672| PROS 111->121|PS00860|GTP_CYCLOHYDROL_1_2|PDOC00672| BL:PDB:NREP 1 BL:PDB:REP 14->183|1is7A|3e-43|49.4|170/194| RP:PDB:NREP 1 RP:PDB:REP 2->183|1a9cA|3e-53|35.2|182/221| RP:PFM:NREP 1 RP:PFM:REP 82->167|PF01227|6e-29|61.6|86/86|GTP_cyclohydroI| HM:PFM:NREP 1 HM:PFM:REP 82->167|PF01227|1.8e-41|66.3|86/86|GTP_cyclohydroI| RP:SCP:NREP 1 RP:SCP:REP 2->183|1a8rA|1e-62|34.6|182/221|d.96.1.1| HM:SCP:REP 2->185|1fb1A_|1.3e-74|52.7|184/196|d.96.1.1|1/1|Tetrahydrobiopterin biosynthesis enzymes-like| OP:NHOMO 1098 OP:NHOMOORG 924 OP:PATTERN ---1-11111111111-111111-1--1--------------------------------------11 1111211111111111111-1111211111121111213322211111111111111111113111211111---111111211111111111111---11122413111--------------1111111111111111111111322122211111111112111221211211111111111111--12111111111111111111111111111111---11111111--------------------1--1--11-1-1111--1--1--111111111111111111111111111111111111111111-1111-1-111111111-1-111111111-1-111-11221111--11111--11111211311111121221121111211111111111111111311111111111112111111111----------11111111111112121121111111--1111111111111----1131111----1111212323322113333-11211111-1--1111111111111112---2----------111-1-----------------------111111--1111111111111111111111111--1111113-11-11111121111111121111--11-11-----11111111111111111-1111111111111111111111111211111111111111111111111111111111111111111111111111111-11111111111111-11111111111111122222322221222222111111111-1111111111121111111111111111----111111-----------------------------------------------1- 11--11--1---111221112112122111111111211111111-2111122211221111111111111111111-1111111111-11121111111111111-1113143411111111111131494-312111111111111111111111222211111-321511211111F1111121221211121111 -------------------1-----------------------------------------------------------------------------------------------------1----------------------------------------------------- STR:NPRED 182 STR:RPRED 98.4 SQ:SECSTR #HHHHHHHHHHHHHHHHTTccTTcTTGGGHHHHHHHHHHTTTGGGcGGGcccccEEEcTTccccEEEEEEEEEEEETTTccEEEEEEEEEEccccEEEcHHHHHHHHHHHHccEEcHHHHHHHHHHHHHHHHTcccEEEEEEEEEHHHHccTTccccccEEEEEEcTHHHHcHHHHHHHHHHc## DISOP:02AL 1-2| PSIPRED cccHHHHHHHHHHHHHHHcccccccHHHHHHHHHHHHHHHHHHHHcccHHHHHccccccccccEEEEEccEEEEEcccccccEEEEEEEEEEcccEEEEHHHHHHHHHHHHccccHHHHHHHHHHHHHHHHHccccEEEEEEEEEEEEEEEcEEccccEEEEEEEEEEEEccHHHHHHHHHHHcc //