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Clostridium perfringens str. 13 (cper0)
Gene : murE
DDBJ      :murE         UDP-N-acetylmuramoylalanyl-D-glutamate-2, 6-diaminopimelate ligase
Swiss-Prot:MURE_CLOPE   RecName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase;         EC=6.3.2.13;AltName: Full=UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase;AltName: Full=Meso-diaminopimelate-adding enzyme;AltName: Full=Meso-A2pm-adding enzyme;AltName: Full=UDP-N-acetylmuramyl-tripeptide synthetase;AltName: Full=UDP-MurNAc-tripeptide synthetase;

Homologs  Archaea  0/68 : Bacteria  868/915 : Eukaryota  15/199 : Viruses  0/175   --->[See Alignment]
c.59.1c.72.2c.98.1
:484 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   29->481 1e8cB PDBj 2e-48 33.3 %
:RPS:PDB   17->484 1e8cA PDBj 4e-79 28.0 %
:RPS:SCOP  1->95 1gg4A3  c.98.1.1 * 2e-19 28.6 %
:RPS:SCOP  117->326 1e8cA3  c.72.2.1 * 2e-44 25.2 %
:RPS:SCOP  328->484 1e8cA2  c.59.1.1 * 1e-33 41.3 %
:HMM:SCOP  1->98 1e8cA1 c.98.1.1 * 4.3e-23 35.1 %
:HMM:SCOP  99->330 1e8cA3 c.72.2.1 * 7.2e-67 38.6 %
:HMM:SCOP  328->484 1e8cA2 c.59.1.1 * 2.1e-42 40.0 %
:RPS:PFM   29->95 PF01225 * Mur_ligase 5e-07 35.8 %
:RPS:PFM   120->306 PF08245 * Mur_ligase_M 1e-12 31.0 %
:RPS:PFM   328->405 PF02875 * Mur_ligase_C 6e-13 40.8 %
:HMM:PFM   108->308 PF08245 * Mur_ligase_M 5.4e-49 33.1 181/188  
:HMM:PFM   328->415 PF02875 * Mur_ligase_C 3.8e-21 32.6 86/91  
:HMM:PFM   23->94 PF01225 * Mur_ligase 2.3e-17 33.3 72/76  
:HMM:PFM   73->137 PF07755 * DUF1611 0.00015 20.0 65/301  
:BLT:SWISS 1->484 MURE_CLOPE 0.0 100.0 %
:PROS 106->129|PS01011|FOLYLPOLYGLU_SYNT_1
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID BAB81568.1 GT:GENE murE GT:PRODUCT UDP-N-acetylmuramoylalanyl-D-glutamate-2, 6-diaminopimelate ligase GT:DATABASE GIB00075CH01 GT:ORG cper0 GB:ACCESSION GIB00075CH01 GB:LOCATION complement(2130930..2132384) GB:FROM 2130930 GB:TO 2132384 GB:DIRECTION - GB:GENE murE GB:PRODUCT UDP-N-acetylmuramoylalanyl-D-glutamate-2, 6-diaminopimelate ligase GB:NOTE 484 aa, similar to gpu:AP001515_305 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate ligase (EC 6.3.2.13) from Bacillus halodurans (486 aa); 40.4% identity in 480 aa overlap CPE1862 GB:PROTEIN_ID BAB81568.1 LENGTH 484 SQ:AASEQ MILKSLLKGLDYEVIKGNEESKVQNIRYDNRKIEQGDAFVCVKGFKVDGHSFIGDAIKKGAKTLIVQEDVSVQEDITIIKVRDTRKALAIMSSNYFGNPKDKLKIIGITGTNGKTTSAFIIKSILEKAGFMTGLIGTIANYIGNKKVDAVRTTPESYELHELFKNMVDAGVEYCVMEVSSHSLELDRVYGIQFEEGIFTNLTRDHLDFHKTFENYYNAKFKLFERSNHSIINLDDPYGANIVKDIEERGVKTKVSTFSIEKESDFKAFEIKSHSNGSEFKVNLEGIEEFSINIPGEYNIYNSLGCIICAYNLNIPMDKIKEGLSDVVIPGRCELVAKEKNLPYSIIIDYAHTPDGLENILSTVKAFTKNRMISVFGCGGDRDKVKRPQMGKIGCELSDIAIITSDNPRSEEPMDIINDIVKPLNYDNFVIEVNRKEAIRKAMNMALEGDVIVIAGKGHETYQILKDETIHFDEREVVYDILEGK GT:EXON 1|1-484:0| SW:ID MURE_CLOPE SW:DE RecName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase; EC=6.3.2.13;AltName: Full=UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase;AltName: Full=Meso-diaminopimelate-adding enzyme;AltName: Full=Meso-A2pm-adding enzyme;AltName: Full=UDP-N-acetylmuramyl-tripeptide synthetase;AltName: Full=UDP-MurNAc-tripeptide synthetase; SW:GN Name=murE; OrderedLocusNames=CPE1862; SW:KW ATP-binding; Cell cycle; Cell division; Cell shape;Cell wall biogenesis/degradation; Complete proteome; Cytoplasm;Ligase; Nucleotide-binding; Peptidoglycan synthesis. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->484|MURE_CLOPE|0.0|100.0|484/484| GO:SWS:NREP 9 GO:SWS GO:0005524|"GO:ATP binding"|ATP-binding| GO:SWS GO:0007049|"GO:cell cycle"|Cell cycle| GO:SWS GO:0051301|"GO:cell division"|Cell division| GO:SWS GO:0008360|"GO:regulation of cell shape"|Cell shape| GO:SWS GO:0007047|"GO:cellular cell wall organization"|Cell wall biogenesis/degradation| GO:SWS GO:0005737|"GO:cytoplasm"|Cytoplasm| GO:SWS GO:0016874|"GO:ligase activity"|Ligase| GO:SWS GO:0000166|"GO:nucleotide binding"|Nucleotide-binding| GO:SWS GO:0009252|"GO:peptidoglycan biosynthetic process"|Peptidoglycan synthesis| PROS 106->129|PS01011|FOLYLPOLYGLU_SYNT_1|PDOC00773| SEG 102->116|klkiigitgtngktt| BL:PDB:NREP 1 BL:PDB:REP 29->481|1e8cB|2e-48|33.3|439/484| RP:PDB:NREP 1 RP:PDB:REP 17->484|1e8cA|4e-79|28.0|460/482| RP:PFM:NREP 3 RP:PFM:REP 29->95|PF01225|5e-07|35.8|67/76|Mur_ligase| RP:PFM:REP 120->306|PF08245|1e-12|31.0|168/187|Mur_ligase_M| RP:PFM:REP 328->405|PF02875|6e-13|40.8|76/84|Mur_ligase_C| HM:PFM:NREP 4 HM:PFM:REP 108->308|PF08245|5.4e-49|33.1|181/188|Mur_ligase_M| HM:PFM:REP 328->415|PF02875|3.8e-21|32.6|86/91|Mur_ligase_C| HM:PFM:REP 23->94|PF01225|2.3e-17|33.3|72/76|Mur_ligase| HM:PFM:REP 73->137|PF07755|0.00015|20.0|65/301|DUF1611| GO:PFM:NREP 7 GO:PFM GO:0005524|"GO:ATP binding"|PF01225|IPR000713| GO:PFM GO:0009058|"GO:biosynthetic process"|PF01225|IPR000713| GO:PFM GO:0005524|"GO:ATP binding"|PF08245|IPR013221| GO:PFM GO:0009058|"GO:biosynthetic process"|PF08245|IPR013221| GO:PFM GO:0005524|"GO:ATP binding"|PF02875|IPR004101| GO:PFM GO:0009058|"GO:biosynthetic process"|PF02875|IPR004101| GO:PFM GO:0016874|"GO:ligase activity"|PF02875|IPR004101| RP:SCP:NREP 3 RP:SCP:REP 1->95|1gg4A3|2e-19|28.6|91/98|c.98.1.1| RP:SCP:REP 117->326|1e8cA3|2e-44|25.2|210/234|c.72.2.1| RP:SCP:REP 328->484|1e8cA2|1e-33|41.3|155/160|c.59.1.1| HM:SCP:REP 1->98|1e8cA1|4.3e-23|35.1|94/101|c.98.1.1|1/1|MurE/MurF N-terminal domain| HM:SCP:REP 99->330|1e8cA3|7.2e-67|38.6|228/0|c.72.2.1|1/1|MurD-like peptide ligases, catalytic domain| HM:SCP:REP 328->484|1e8cA2|2.1e-42|40.0|155/0|c.59.1.1|1/1|MurD-like peptide ligases, peptide-binding domain| OP:NHOMO 1208 OP:NHOMOORG 883 OP:PATTERN -------------------------------------------------------------------- 1112111122211111111-11111111111111111122111121111112111111111111111112111111111111132332222222111--323231211221111111111111111111112111111111---2111111111211111111112222112111232121231111133221122424223123322121112132111133323222322311111111111111121111122211222221111111121111111111111111111111111111111111111111111111111134735333344334422333444134342222333323145216653-3312-111121122111111111111211111111111-111111111112122311111111111111111111111111111111111111111--------222322222223222122211111111111111111111111111111111111111111111111111111111111311211111111111111122131111112211121222213111111221111111111111111111111111111111111111111111111222112111111-11111-2-11111111111111111111-11111111111111111111111111111111111111111111111111111111111111111111111111111111111111111211112112222222211111111121111222111111233223322111111111111111111111111111132121111111111111111--------------------------2423211111211 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------1119111112121-11------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 482 STR:RPRED 99.6 SQ:SECSTR ##HHHHHTTccccTTcTTccccccccEccGGGccTTcEEEEcccccccGGGGHHHHHHTTccEEEEEcTcEEETTEEEEEETTHHHHHHHHHHHHTTcGGGccEEEEEEccccHHHHHHHHHHHHHHTTEccEEEETTEEEETTcccccccccccHHHHHHHHHHHTHHTTccEEEEccHHHHHTTTTTTccccEEEEcccccccHHHHccHHHHHHHHHHHTccccEEEEETTcHHHHHHHTTcTTcEEEEcccccTTTccEEEEEEEEEEccccEEEEEEETTccEEEEEcccHHHHHHHHHHHHHHHHTTccHHHHHHHGGGcccTTcEEEccTTccEEcEEEEEccccHHHHHHHHHHHHHTccccEEEEEccccccccTHHHHHHHHHHHHccEEEEccccccTccHHHHHHHHHTTccEGGGcEEccHHHHHHHHHHHccTTcEEEEEccTTccEEEETTEEEEccHHHHHHHHHTcc DISOP:02AL 484-485| PSIPRED ccHHHHHHHccccEEccccccEEEEEEEcccccccccEEEEEccccccHHHHHHHHHHcccEEEEEccccccccccEEEEEcHHHHHHHHHHHHHHccHHHcccEEEEEccccHHHHHHHHHHHHHHccccEEEEccccccccccccccccccccHHHHHHHHHHHHccccEEEEEEccccccHHHHHccccccEEEEccccHHHHHHcccHHHHHHHHHHHcccccEEEEEcccHHHHHHHHHHHHcccccEEEEEEccccccEEEEEEEEccccEEEEEEcccccEEEcccccHHHHHHHHHHHHHHHHccccHHHHHHHHHHccccccEEEEEEcccccEEEEEcccccHHHHHHHHHHHHHcccccEEEEEEccccccHHHHHHHHHHHHHcccEEEEcccccccccHHHHHHHHHHHcccccEEEEccHHHHHHHHHHHcccccEEEEEccccccHHHHccEEEcccHHHHHHHHHccc //