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Desulfotomaculum reducens MI-1 (dred0)
Gene : ABO50276.1
DDBJ      :             methionine synthase (B12-independent)
Swiss-Prot:METE_DESRM   RecName: Full=5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase;         EC=2.1.1.14;AltName: Full=Methionine synthase, vitamin-B12 independent isozyme;AltName: Full=Cobalamin-independent methionine synthase;

Homologs  Archaea  38/68 : Bacteria  501/915 : Eukaryota  116/199 : Viruses  0/175   --->[See Alignment]
c.1.22
:764 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   7->755 1u1hA PDBj e-164 48.1 %
:RPS:PDB   6->755 3bq6B PDBj e-129 44.1 %
:RPS:SCOP  7->362 1u1hA1  c.1.22.2 * 2e-77 41.7 %
:RPS:SCOP  398->755 1u1hA2  c.1.22.2 * 7e-89 56.2 %
:HMM:SCOP  7->395 1u1jA1 c.1.22.2 * 2.3e-98 37.8 %
:HMM:SCOP  396->756 1u1jA2 c.1.22.2 * 6.8e-112 31.6 %
:RPS:PFM   7->311 PF08267 * Meth_synt_1 1e-73 47.8 %
:RPS:PFM   308->406 PF07964 * Red1 2e-04 33.7 %
:RPS:PFM   435->752 PF01717 * Meth_synt_2 6e-97 52.8 %
:HMM:PFM   430->752 PF01717 * Meth_synt_2 2.2e-138 53.3 323/324  
:HMM:PFM   7->313 PF08267 * Meth_synt_1 2.7e-110 49.0 304/311  
:BLT:SWISS 1->764 METE_DESRM 0.0 100.0 %
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID ABO50276.1 GT:GENE ABO50276.1 GT:PRODUCT methionine synthase (B12-independent) GT:DATABASE GIB00494CH01 GT:ORG dred0 GB:ACCESSION GIB00494CH01 GB:LOCATION complement(1914246..1916540) GB:FROM 1914246 GB:TO 1916540 GB:DIRECTION - GB:PRODUCT methionine synthase (B12-independent) GB:NOTE KEGG: tdn:Tmden_0899 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase TIGRFAM: 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase PFAM: Methionine synthase, vitamin-B12 independent; Cobalamin-independent synthase MetE, N-terminal domain protein GB:PROTEIN_ID ABO50276.1 GB:DB_XREF GI:134052305 InterPro:IPR002629 InterPro:IPR006276 InterPro:IPR013215 LENGTH 764 SQ:AASEQ MYTGATTYVVGFPRIGEQRELKKVLERYWDQKTSFSEIDEIAKNLRRRHWLYQKEAGISFISSNDFSLYDNMLDTAIMLNAVPERFSNIHDKQELYFAMARGTNNTVAMEMTKWFNTNYHYIVPELSDTMNFSLCADKIINEYREAKEYGLRTKINLIGPITFLSLSKPVDGNQDTLELLPKILPCYVSLLKKIADLDDEVYIQFDEPIVVKDIDRRTLNLFYLCYKELSNVSNRLRLIVMTYFDHAVEAVKILSDIPIYGIGLDFVYGQENLKVLDSLNGKKLIAGVIDGRNIWKNNYHNTLTLLKDIEKNVKKEDIILSTTCSLLHVPYSLKHENHLDKDIKSWMSFAREKLDELSDLAKLFFVENNSEDILTILENNQRIFREKQQSSKVIDPIVRERVGNIKRRERDGSFNDRNEAQRKKLDLPLLPTTTIGSFPQTEEIRKLRRDFKNNVISQIEYDTGIKNYIDSCIQFQEDIGLDVLVHGEPERNDMVEYFGERLSGFVFTQNGWVQSYGSRCVKPTVIFGDVSRPKPMTIDTILYAKSKTNKIVKGMLTGPVTILNWSYCRSDMERSAVCEQIALAIRDEINDLQKAGIKIIQVDEAAFKEGYPLRKEKVAYYENWAVKSFKLAVSSAAIETQIHTHMCYSDFNDIIHTIEKMDADVITIETSRSGNKLLTVFATRGYKNEIGPGIYDIHSPRVPSVEELEEKIRNLMLVLPPSKLWINPDCGLKTRKWDEIRWSLSNMVKAAQHIRLGLQRVMFV GT:EXON 1|1-764:0| SW:ID METE_DESRM SW:DE RecName: Full=5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; EC=2.1.1.14;AltName: Full=Methionine synthase, vitamin-B12 independent isozyme;AltName: Full=Cobalamin-independent methionine synthase; SW:GN Name=metE; OrderedLocusNames=Dred_1751; SW:KW Amino-acid biosynthesis; Complete proteome; Metal-binding;Methionine biosynthesis; Methyltransferase; Repeat; Transferase; Zinc. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->764|METE_DESRM|0.0|100.0|764/764| GO:SWS:NREP 5 GO:SWS GO:0008652|"GO:cellular amino acid biosynthetic process"|Amino-acid biosynthesis| GO:SWS GO:0046872|"GO:metal ion binding"|Metal-binding| GO:SWS GO:0009086|"GO:methionine biosynthetic process"|Methionine biosynthesis| GO:SWS GO:0008168|"GO:methyltransferase activity"|Methyltransferase| GO:SWS GO:0016740|"GO:transferase activity"|Transferase| SEG 427->434|lpllpttt| BL:PDB:NREP 1 BL:PDB:REP 7->755|1u1hA|e-164|48.1|715/728| RP:PDB:NREP 1 RP:PDB:REP 6->755|3bq6B|e-129|44.1|705/718| RP:PFM:NREP 3 RP:PFM:REP 7->311|PF08267|1e-73|47.8|301/309|Meth_synt_1| RP:PFM:REP 308->406|PF07964|2e-04|33.7|95/686|Red1| RP:PFM:REP 435->752|PF01717|6e-97|52.8|318/323|Meth_synt_2| HM:PFM:NREP 2 HM:PFM:REP 430->752|PF01717|2.2e-138|53.3|323/324|Meth_synt_2| HM:PFM:REP 7->313|PF08267|2.7e-110|49.0|304/311|Meth_synt_1| GO:PFM:NREP 7 GO:PFM GO:0003871|"GO:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"|PF08267|IPR013215| GO:PFM GO:0008270|"GO:zinc ion binding"|PF08267|IPR013215| GO:PFM GO:0008652|"GO:cellular amino acid biosynthetic process"|PF08267|IPR013215| GO:PFM GO:0007059|"GO:chromosome segregation"|PF07964|IPR012491| GO:PFM GO:0007131|"GO:reciprocal meiotic recombination"|PF07964|IPR012491| GO:PFM GO:0003871|"GO:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"|PF01717|IPR002629| GO:PFM GO:0009086|"GO:methionine biosynthetic process"|PF01717|IPR002629| RP:SCP:NREP 2 RP:SCP:REP 7->362|1u1hA1|2e-77|41.7|355/394|c.1.22.2| RP:SCP:REP 398->755|1u1hA2|7e-89|56.2|345/352|c.1.22.2| HM:SCP:REP 7->395|1u1jA1|2.3e-98|37.8|384/0|c.1.22.2|1/2|UROD/MetE-like| HM:SCP:REP 396->756|1u1jA2|6.8e-112|31.6|361/0|c.1.22.2|2/2|UROD/MetE-like| OP:NHOMO 736 OP:NHOMOORG 655 OP:PATTERN 11-1-11111111111--------1--121111-11111111-1-11-------111-1--11----- 1----1-111111111111-1-1111111111----12231--1111-1---11111111----1-2111-1111111----111111------------12---11111-------------------------1--------1111-----21----------1----1-----------------22-1-1111111111111111111111111---2---11111111-1111111111111111111----111--1-11--11----1-111111----11111111111111-------------111111111-1----------------11--------1-1--1---1-1-------1--1-1--11--------12211211-11--------------------111--11----------------1-------1111111111111--1--------------------------------1-1211111111112111111111111112111112--111---11----1112-1111111111111111----------1--1111--------1---------1111-11111--1-------11111111111111-1111222211-1112111121111-11-211111121221221111111111-1111111111111-11111222221111111111111111111211111111-11111111111111--11111----11111111-1---1111221111111111111111122111222111-1---------1-1111111122222111111111111111--------------------------------------------------1-1111-- ----11--211-221-11111111111111111111111111111111111111-1111111111111111111111-1111111111-11111121111111122-1-12----------------------------------------------------1---------2-11------1142951411-3121- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 758 STR:RPRED 99.2 SQ:SECSTR #####EEcccccccccTTcHHHHHHHHHHTTcccHHHHHHHHHHHHHHHHHHHHHTTccccEEcccccccHHHHHHHHTTcccGGGccccTcHHHHHHHHHcTcTTTccEEEEcTTcccEEEEccccccccccccccHHHHHHHHHHTTTcccEEEEEcHHHHHHTcEETTEEcccHHHHHHHHHHHHHHHHHHHHTTccccEEEEcGGGGccccHHHHHHHHHHHHTTTTccTTcEEEEEEccccccccHHHHHTccccEEEEEcccccHHHHHHHHcTTcEEEEEEEcccccccccHHHHHHHHHHHTcHHHHTccEEEEcccGGGcccccTTcccccTTcGGGcccHHHHHHHHHHHHHHHHHTTcccccHHHHTTccHHHHccccccccccHHHHHHHHTccGGcccccHHHHHHHHHHHHccccccccccccccccHHHHHHHHHHHTTcccHHHHHHHHHHHHHHHHHHHHHHTccccccccTTcccTTHHHHTTcEEEEccccccEEEETTEEEcccEEEEEEEccccccHHHHHHHHTTccccccEEEEcHHHHHHTcEEcccccHHHHHHHHHHHHHHHHHHHHHTTccEEEEEcTHHHHTccccGGGHHHHHHHHHHHHHHHTTcccTTcEEEEEccccccTTTHHHHTTccccEEEEccTTTTTGGGHHHTcTTcccEEEEEcccTTccccccHHHHHHHHHHHTTTccGGGEEEEcccccTTccHHHHHHHHHHHHHHHHHHHcccTTcHH# DISOP:02AL 1-2,387-387,390-393,404-421| PSIPRED ccccEEEEEEEcccccccHHHHHHHHHHHcccccHHHHHHHHHHHHHHHHHHHHHccccEEEccccHHHHHHHHHHHHHccccHHHccccccHHHHHHHHcccccccccccccccccccEEEEEEEccccccccccccHHHHHHHHHHccccEEEEEccHHHHHHHHHcccccccHHHHHHHHHHHHHHHHHHHHHccccEEEEEccccHHccccHHHHHHHHHHHHHHHHccccccEEEEEccccHHHHHHHHHHccccEEEEEEEccHHHHHHHccccccEEEEEEEcccccccccHHHHHHHHHHHHHHHcccEEEEEccccccEEEEcccccccccHHHHHHHHHHHHHHHHHHHHHHHHcccccHHHHHHHHHHHHHHHHHHHHcccccHHHHHHHHHcccHHHcccccHHHHHHHccccccccccccccccccccHHHHHHHHHHHcccccHHHHHHHHHHHHHHHHHHHHHccccEEEccccccccHHHHHHHccccEEEcccccEEEEcccEEcccEEEEcccccccccHHHHHHHHHHccccEEEEEccHHHHHHHHcccccccHHHHHHHHHHHHHHHHHHHHHccccEEEEEcccccccccccHHHHHHHHHHHHHHHHHHHcccccccEEEEEEEcccHHHHHHHHHHccccEEEEEccccccHHHHHHHHccccccEEEEEEEccccccccHHHHHHHHHHHHHHccHHHEEEccccccccccHHHHHHHHHHHHHHHHHHHHHHHHHHcc //