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Desulfotomaculum reducens MI-1 (dred0)
Gene : ABO50722.1
DDBJ      :             methionine synthase (B12-dependent)
Swiss-Prot:             

Homologs  Archaea  20/68 : Bacteria  643/915 : Eukaryota  116/199 : Viruses  0/175   --->[See Alignment]
a.46.1c.1.21c.1.26c.23.6
:800 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   5->560 1q7zA PDBj 3e-95 36.9 %
:BLT:PDB   599->800 1bmtA PDBj 2e-30 37.6 %
:RPS:PDB   2->565 3bolB PDBj 7e-70 36.0 %
:RPS:PDB   574->799 3bicB PDBj 2e-28 15.5 %
:RPS:SCOP  3->291 1q7mA2  c.1.26.1 * 3e-55 39.3 %
:RPS:SCOP  320->571 1f6yA  c.1.21.2 * 8e-37 35.2 %
:RPS:SCOP  599->674 1bmtA1  a.46.1.1 * 1e-18 26.3 %
:RPS:SCOP  677->800 1bmtA2  c.23.6.1 * 1e-07 38.7 %
:HMM:SCOP  1->360 1umyA_ c.1.26.1 * 4e-124 46.6 %
:HMM:SCOP  317->577 1f6yA_ c.1.21.2 * 1.4e-84 47.7 %
:HMM:SCOP  587->676 1bmtA1 a.46.1.1 * 1.2e-20 32.2 %
:HMM:SCOP  661->800 1xrsB1 c.23.6.1 * 5e-43 53.2 %
:RPS:PFM   11->282 PF02574 * S-methyl_trans 3e-53 42.8 %
:RPS:PFM   348->477 PF00809 * Pterin_bind 6e-08 30.7 %
:RPS:PFM   599->674 PF02607 * B12-binding_2 3e-12 39.5 %
:RPS:PFM   684->772 PF02310 * B12-binding 7e-19 48.3 %
:HMM:PFM   11->288 PF02574 * S-methyl_trans 1.7e-68 42.0 276/305  
:HMM:PFM   682->791 PF02310 * B12-binding 2.5e-28 41.8 110/121  
:HMM:PFM   320->518 PF00809 * Pterin_bind 5.7e-27 25.0 188/210  
:HMM:PFM   597->675 PF02607 * B12-binding_2 8.9e-27 40.5 79/84  
:BLT:SWISS 9->800 METH_MYCLE e-100 32.1 %
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID ABO50722.1 GT:GENE ABO50722.1 GT:PRODUCT methionine synthase (B12-dependent) GT:DATABASE GIB00494CH01 GT:ORG dred0 GB:ACCESSION GIB00494CH01 GB:LOCATION complement(2414799..2417201) GB:FROM 2414799 GB:TO 2417201 GB:DIRECTION - GB:PRODUCT methionine synthase (B12-dependent) GB:NOTE PFAM: dihydropteroate synthase, DHPS; homocysteine S-methyltransferase; Methionine synthase, B12-binding module, cap domain protein; cobalamin B12-binding domain protein KEGG: pca:Pcar_2722 5-methyltetrahydrofolate-homocysteine methyltransferase, truncation GB:PROTEIN_ID ABO50722.1 GB:DB_XREF GI:134052751 InterPro:IPR000489 InterPro:IPR003726 InterPro:IPR003759 InterPro:IPR006158 LENGTH 800 SQ:AASEQ MSFRKRVKKEVLIIDGAMGTLLQQRGLPGGWCPEEWNLSHPEAVKEIHKLYLEAGADIITTNTFGAIQLKLADYHLGDQVKEINQAAVKLAKEVAQPYGAMVAGSVGPLGKFLQPLGTMTFEEAYQQFYEQCAAMVEAGVDLILFETFGDIGEMRAALIAAADAGDVPVVASFTFDETGRTFTGTDPETAAVVAERLGIAAIGVNCSVGPRQLEGVVRKLTESTNLPVLVSPNAGMPEIIGGKTVFRETPEIMAEYAQRFVDYGASILGGCCGTTPKHIQAIYQQVKKLKPKCRNKRFGLRVASRVKTVTIQPSGVPVAIGERLNPTGKKALQAEIREGKTEITRRDALTQVQAGAEILDVNVGVGGVDQVAAMERAVQAVQVLVEAPLCIDSTDPTVIEHALKLYHGKALINSVNGEENSIETILPLAKRYGAALIGLTLDDEGIPPTAAGRLAVARRLVERTEAMGIPRDDLMMDCLVLTVSAQPEGVPETLEAIRLVKQKLQITTSLGVSNVSFGLPNRVLINAAFFAMALNAGLDAAILNPQDQRMMETLRASAVLTGRDVRAEKYIAIEQQTHNGSKMETTGEQMKASTPLDILYQAVLSGDKDNIVSYINEALKTGLSPMELLDKALIPGIEEVGRRYGAGIYFLPQLMMAGETMTKSFERLRPELAKGPAKKAGTVVLATVKGDIHDIGKNIVSVMLANHGFEVIDLGKNVANEEILRVAAEQKANIIGLSALMTTTMVHMQEIIKLVKEQGLNCKVMVGGAAVTEHYAREIGADGYAIDAVEAVNVAKKLAS GT:EXON 1|1-800:0| BL:SWS:NREP 1 BL:SWS:REP 9->800|METH_MYCLE|e-100|32.1|787/1206| SEG 156->171|aaliaaadagdvpvva| SEG 363->368|vgvggv| SEG 450->463|aagrlavarrlver| BL:PDB:NREP 2 BL:PDB:REP 5->560|1q7zA|3e-95|36.9|545/559| BL:PDB:REP 599->800|1bmtA|2e-30|37.6|202/246| RP:PDB:NREP 2 RP:PDB:REP 2->565|3bolB|7e-70|36.0|542/549| RP:PDB:REP 574->799|3bicB|2e-28|15.5|220/715| RP:PFM:NREP 4 RP:PFM:REP 11->282|PF02574|3e-53|42.8|271/296|S-methyl_trans| RP:PFM:REP 348->477|PF00809|6e-08|30.7|127/208|Pterin_bind| RP:PFM:REP 599->674|PF02607|3e-12|39.5|76/84|B12-binding_2| RP:PFM:REP 684->772|PF02310|7e-19|48.3|89/117|B12-binding| HM:PFM:NREP 4 HM:PFM:REP 11->288|PF02574|1.7e-68|42.0|276/305|S-methyl_trans| HM:PFM:REP 682->791|PF02310|2.5e-28|41.8|110/121|B12-binding| HM:PFM:REP 320->518|PF00809|5.7e-27|25.0|188/210|Pterin_bind| HM:PFM:REP 597->675|PF02607|8.9e-27|40.5|79/84|B12-binding_2| GO:PFM:NREP 8 GO:PFM GO:0008898|"GO:homocysteine S-methyltransferase activity"|PF02574|IPR003726| GO:PFM GO:0042558|"GO:pteridine and derivative metabolic process"|PF00809|IPR000489| GO:PFM GO:0008705|"GO:methionine synthase activity"|PF02607|IPR003759| GO:PFM GO:0009086|"GO:methionine biosynthetic process"|PF02607|IPR003759| GO:PFM GO:0031419|"GO:cobalamin binding"|PF02607|IPR003759| GO:PFM GO:0046872|"GO:metal ion binding"|PF02607|IPR003759| GO:PFM GO:0031419|"GO:cobalamin binding"|PF02310|IPR006158| GO:PFM GO:0046872|"GO:metal ion binding"|PF02310|IPR006158| RP:SCP:NREP 4 RP:SCP:REP 3->291|1q7mA2|3e-55|39.3|285/300|c.1.26.1| RP:SCP:REP 320->571|1f6yA|8e-37|35.2|247/258|c.1.21.2| RP:SCP:REP 599->674|1bmtA1|1e-18|26.3|76/90|a.46.1.1| RP:SCP:REP 677->800|1bmtA2|1e-07|38.7|124/156|c.23.6.1| HM:SCP:REP 1->360|1umyA_|4e-124|46.6|352/0|c.1.26.1|1/1|Homocysteine S-methyltransferase| HM:SCP:REP 317->577|1f6yA_|1.4e-84|47.7|260/0|c.1.21.2|1/1|Dihydropteroate synthetase-like| HM:SCP:REP 587->676|1bmtA1|1.2e-20|32.2|90/90|a.46.1.1|1/1|Methionine synthase domain| HM:SCP:REP 661->800|1xrsB1|5e-43|53.2|139/0|c.23.6.1|1/1|Cobalamin (vitamin B12)-binding domain| OP:NHOMO 1420 OP:NHOMOORG 779 OP:PATTERN ----1-----------2------2--------141--12111-11----8FBC-----------1-22 33511-11111-1-11111-111111111111111111111111----1---121-----211-1221111----------31--11-332211-----2-2-2122111---------------1111111111122211---2111111111111111111111111121111111111111111122-1222222222222222222233222232222-1-1111113211111111111111111112-------1---22-----1-1-----212-----22------------------------111111111-47134222222212143331111112-112132Pc3212311D11141112112222-----111111111111211111111111121111111142-41111141114411222332555565411111111111121-1------------------------------22222111112222222-222222222222222222222222232222222222111111111-------111111-9C72431111111-232133223112113211-------------------11-11--1112111-1221111111111111111111---1111------22111212111211111-112111111111111111122221--1111111111111111121-11111--111111111111---1---------11112----11---------11111-21111111111121111211222---------1111111111211112232222222-----111111111------------------------------------1-11111111131 ----111-31----1111---11----------------------------------------1---11--1-1-322231111-1------1----------221-131K4633431221231522415G3-3563311411221232242142322457A27612---A-183-111H1113122451311121211 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 797 STR:RPRED 99.6 SQ:SECSTR #HHHHHHHHccEEcccccHHHHGGGTcccTccGGGHHHHcHHHHHHHHHHHHHHTccEEEcccTTccHHHHGGGTcGGGHHHHHHHHHHHHHHHHTTTTcEEEEEEcccccccTTTccccHHHHHHHHHHHHHHHHHHTcccEEEEEEccHHHHHHHHHHHHHcccccEEEEEcccTTcccTTcccHHHHHHHHHTccccEEEEEccccHHHHHHHHHHHHTTcccEEEEEccccccEEETTEEEccccHHHHHTTHHHHHTTTccEEcccTTccHHHHHHHHHHHccccccccccccccEEEcEEccccEEEccccEEEEEEEccTTcHHHHHHHHTTccHHHHHHHHHHHHTTccEEEEEcccGGGccHHHHHHHHHHHHHHTcccEEEEcccHHHHHHHHHHcccccEEEEEEccHHHHHHHHHHHHHHccEEEEEEcccccccccHHHHHHHHHHHHHHHHHTTcTGTcEEEEcccccGGGTccHHHHHHHHHHHHHHHTTccccccGGGTTcTcccHHHHHHHHHHHHHHTTccEEEEcTTcHHHHHHHHHHHHHTTcccccTTHH##HHHHHHHHHHHHHccHHHHHHHHHHHHHHHHHccccHHHHHHHHHHHHHHHHTTccHHHHHHHHHHHHccccccccccccHHHHHHcccHHHHHHHHHHHHHTTccccEEEEEEcccccccHHHHHHHHHHHHTTcEEEEccTTccHHHHHHHHHHHTccEEEEEEcccGGGTHHHHHHHHHHHTTcTTcEEEEEEcccGGGHHHHTccEEEcTTccHHHHHHHHHH DISOP:02AL 1-1,576-594,670-682| PSIPRED ccHHHHHHcccEEEEcHHHHHHHHcccccccccHHHHcccHHHHHHHHHHHHHHHHHEEEcccccccHHHHHHccHHHHHHHHHHHHHHHHHHHccccccEEEEEcccccccccccccccHHHHHHHHHHHHHHHHcccccEEEEEccccHHHHHHHHHHHHHccccEEEEEEEEcccccccccccHHHHHHHHHHccccEEEEcccccHHHHHHHHHHHHHcccccEEEEEcccccccccccEEEcccHHHHHHHHHHHHHccccEEEEcccccHHHHHHHHHHHHHccccccccccccccccccccccccccccEEEEEEHccccHHHHHHHccccccHHHHHHHHHHHHHccccEEcccccccccccHHHHHHHHHHHHHHccccEEEEcccHHHHHHHHHHccccEEEEEcccccccHHHHHHHHHHccccEEEEEEccccccccHHHHHHHHHHHHHHHHHccccHHHEEEEcccccccccHHHHHHHHHHHHHHHHHccccEEEEEcccccccHHHHHHHHHHHHHHHHHHHHHHcccHHHHHHHccccHHHHHcccccccHHHHHHHHHHHccccccccHHHHccccHHHHHHHHHHHccHHHHHHHHHHHHHccccHHHHHHHHHHHHHHHHHHHHHcccccHHHHHHHHHHHHHHHHHHHHHHHccccccccEEEEEEccccHHHHHHHHHHHHHHHcccEEEEccccccHHHHHHHHHHccccEEEEEccccccHHHHHHHHHHHHHccccccEEEEcccccHHHHHHHcccEEEccHHHHHHHHHHHHc //