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Francisella tularensis subsp. mediasiatica FSC147 (ftul2)
Gene : hemC
DDBJ      :hemC         hydroxymethylbilane synthase (porphobilinogen deaminase)
Swiss-Prot:HEM3_FRATM   RecName: Full=Porphobilinogen deaminase;         Short=PBG;         EC=2.5.1.61;AltName: Full=Hydroxymethylbilane synthase;         Short=HMBS;AltName: Full=Pre-uroporphyrinogen synthase;

Homologs  Archaea  56/68 : Bacteria  751/915 : Eukaryota  185/199 : Viruses  0/175   --->[See Alignment]
c.94.1d.50.2
:300 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   4->298 1ypnA PDBj 2e-76 54.7 %
:RPS:PDB   2->299 3ecrB PDBj 3e-94 38.4 %
:RPS:SCOP  2->216 1ah5A1  c.94.1.1 * 1e-77 58.6 %
:RPS:SCOP  217->299 1ah5A2  d.50.2.1 * 8e-21 43.4 %
:HMM:SCOP  1->216 1pdaA1 c.94.1.1 * 1.6e-82 56.5 %
:HMM:SCOP  217->300 1gtkA2 d.50.2.1 * 2.4e-20 42.9 %
:RPS:PFM   4->211 PF01379 * Porphobil_deam 9e-62 59.6 %
:RPS:PFM   226->293 PF03900 * Porphobil_deamC 5e-12 50.0 %
:HMM:PFM   4->211 PF01379 * Porphobil_deam 5.4e-87 59.6 208/214  
:HMM:PFM   225->292 PF03900 * Porphobil_deamC 1.9e-22 47.1 68/76  
:BLT:SWISS 1->300 HEM3_FRATM e-168 100.0 %
:PROS 228->244|PS00533|PORPHOBILINOGEN_DEAM

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID ACD31398.1 GT:GENE hemC GT:PRODUCT hydroxymethylbilane synthase (porphobilinogen deaminase) GT:DATABASE GIB00719CH01 GT:ORG ftul2 GB:ACCESSION GIB00719CH01 GB:LOCATION 1694314..1695216 GB:FROM 1694314 GB:TO 1695216 GB:DIRECTION + GB:GENE hemC GB:PRODUCT hydroxymethylbilane synthase (porphobilinogen deaminase) GB:PROTEIN_ID ACD31398.1 GB:DB_XREF GI:187713101 GB:GENE:GENE hemC LENGTH 300 SQ:AASEQ MKQITIASRESKLALWQTNFVKNRIQSELNIPCEISTMKTQGDIILDQPLNKIGGKALFMKELEVAMLSNKADIAVHSLKDVPYQLPQGFCLAGFMPREDPRDAFVSNKYNSIDDLPKGAVVGTSSLRRKAQLLHYRDDLEIRDLRGNIQTRLSKLDNGDYDAIILASAGLIRLELVERITQFIPVEISLPAVGQGIVVIEALERDNDLLEKIQKLNCRESSRVATAERAFNQELKGGCHVAIGAYAELDNNQITLMAMVASSDGKKILKRKMIGDDPTKLGKLLAQEMIALGAYKILES GT:EXON 1|1-300:0| SW:ID HEM3_FRATM SW:DE RecName: Full=Porphobilinogen deaminase; Short=PBG; EC=2.5.1.61;AltName: Full=Hydroxymethylbilane synthase; Short=HMBS;AltName: Full=Pre-uroporphyrinogen synthase; SW:GN Name=hemC; OrderedLocusNames=FTM_1581; SW:KW Complete proteome; Porphyrin biosynthesis; Transferase. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->300|HEM3_FRATM|e-168|100.0|300/300| GO:SWS:NREP 2 GO:SWS GO:0006779|"GO:porphyrin biosynthetic process"|Porphyrin biosynthesis| GO:SWS GO:0016740|"GO:transferase activity"|Transferase| PROS 228->244|PS00533|PORPHOBILINOGEN_DEAM|PDOC00461| BL:PDB:NREP 1 BL:PDB:REP 4->298|1ypnA|2e-76|54.7|285/294| RP:PDB:NREP 1 RP:PDB:REP 2->299|3ecrB|3e-94|38.4|284/310| RP:PFM:NREP 2 RP:PFM:REP 4->211|PF01379|9e-62|59.6|208/214|Porphobil_deam| RP:PFM:REP 226->293|PF03900|5e-12|50.0|68/75|Porphobil_deamC| HM:PFM:NREP 2 HM:PFM:REP 4->211|PF01379|5.4e-87|59.6|208/214|Porphobil_deam| HM:PFM:REP 225->292|PF03900|1.9e-22|47.1|68/76|Porphobil_deamC| GO:PFM:NREP 4 GO:PFM GO:0004418|"GO:hydroxymethylbilane synthase activity"|PF01379|IPR000860| GO:PFM GO:0033014|"GO:tetrapyrrole biosynthetic process"|PF01379|IPR000860| GO:PFM GO:0004418|"GO:hydroxymethylbilane synthase activity"|PF03900|IPR000860| GO:PFM GO:0033014|"GO:tetrapyrrole biosynthetic process"|PF03900|IPR000860| RP:SCP:NREP 2 RP:SCP:REP 2->216|1ah5A1|1e-77|58.6|203/205|c.94.1.1| RP:SCP:REP 217->299|1ah5A2|8e-21|43.4|83/94|d.50.2.1| HM:SCP:REP 1->216|1pdaA1|1.6e-82|56.5|216/217|c.94.1.1|1/1|Periplasmic binding protein-like II| HM:SCP:REP 217->300|1gtkA2|2.4e-20|42.9|84/0|d.50.2.1|1/1|Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain| OP:NHOMO 1078 OP:NHOMOORG 992 OP:PATTERN 11-1-11111111111-1111111111111111111111111111111111111-------111--11 1111111111111111111-111111111111111111111111111111111111111111111112211--------111111111----1------111111111111111111111----11111111111111111---11111111111111111111111111111111111111111111---11111111111111111111111111111111111111111111111111111111111111-------------11---------------------------------------------1---------11111111111111111111111211---1111111111-11111-1-111111111-----1-1111111111111111111111-11111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111-11111---11111111111111111111-11111111111111111111111111111111111111111111111111111111111111111111111111111111111111111-----11111111111111111111111111111111111111111111112111111111111111111111111111-111111---------------------------------------11-----111 11--111-1---1111211123232321111113211111111111112211211111111111111111111111111111111111-12121121-11111231-11-21112411121111121413F2-11111111111111212111111112211121-11111--111221G1111131221111111142 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 299 STR:RPRED 99.7 SQ:SECSTR cccEEEEEcccHHHHHHHHHHHHHHHHcTTcEEEEEEcHHcTTccEEEEEccTTccHHHHHHHHHHHHTTcccEEEEEGGGccccccTTEEEEEEcccccccEEEEEcGTccTTTccTTcEEEcccHHHHHHHHHHcTTcEEEcccccHHHHHHHHHcccccEEEEEHHHHHHTTcGGGccEEccTTTccccTTTTcEEEEEETTcHHHHHHHGGGccHHHHHHHHHHHHHHHHHHHcccccEEEEEEEETTEEEEEEEEEcTTcccEEEEEEEEHHHHHHHHHHHHHHHHTTHHHHHH# DISOP:02AL 300-301| PSIPRED ccEEEEEccccHHHHHHHHHHHHHHHHcccccEEEEEEEEEccccccccHHHHccEEEEHHHHHHHHHcccccEEEEcccccccccccccEEEEEcccccccEEEEEcccccHHHcccccEEEccHHHHHHHHHHHccccEEEEccccHHHHHHHHHcccccHHHHHHHHHHHccccccEEEEccHHHccccccccEEEEEEEcccHHHHHHHHHcccHHHHHHHHHHHHHHHHcccccccEEEEEEEEEccEEEEEEEEEcccccEEEEEEEccccHHHHHHHHHHHHHHHHHHHHHHc //