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Francisella tularensis subsp. mediasiatica FSC147 (ftul2)
Gene : ligA
DDBJ      :ligA         DNA ligase, NAD-dependent
Swiss-Prot:DNLJ_FRATW   RecName: Full=DNA ligase;         EC=6.5.1.2;AltName: Full=Polydeoxyribonucleotide synthase [NAD+];

Homologs  Archaea  6/68 : Bacteria  899/915 : Eukaryota  23/199 : Viruses  1/175   --->[See Alignment]
a.60.2b.40.4c.15.1d.142.2
:678 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   19->591 2owoA PDBj e-138 43.4 %
:BLT:PDB   605->666 1l7bA PDBj 4e-11 52.5 %
:RPS:PDB   14->678 1dgtB PDBj e-168 38.3 %
:RPS:SCOP  25->328 1b04A  d.142.2.2 * 9e-73 41.8 %
:RPS:SCOP  327->377 1dgsA2  b.40.4.6 * 1e-07 52.9 %
:RPS:SCOP  414->594 1dgsA1  a.60.2.2 * 3e-35 38.8 %
:RPS:SCOP  603->678 1l7bA  c.15.1.2 * 1e-16 48.0 %
:HMM:SCOP  13->326 1ta8A_ d.142.2.2 * 3e-100 48.2 %
:HMM:SCOP  327->412 1dgsA2 b.40.4.6 * 3.8e-29 53.5 %
:HMM:SCOP  413->596 1dgsA1 a.60.2.2 * 7.6e-60 45.3 %
:HMM:SCOP  600->680 1l7bA_ c.15.1.2 * 1.7e-18 46.2 %
:RPS:PFM   20->328 PF01653 * DNA_ligase_aden 3e-79 46.9 %
:RPS:PFM   331->409 PF03120 * DNA_ligase_OB 5e-15 45.6 %
:RPS:PFM   417->444 PF03119 * DNA_ligase_ZBD 9e-05 42.9 %
:RPS:PFM   607->672 PF00533 * BRCT 9e-10 44.6 %
:HMM:PFM   19->328 PF01653 * DNA_ligase_aden 1.3e-104 43.3 307/315  
:HMM:PFM   331->410 PF03120 * DNA_ligase_OB 6.8e-34 55.0 80/82  
:HMM:PFM   607->678 PF00533 * BRCT 3e-15 36.6 71/78  
:HMM:PFM   417->444 PF03119 * DNA_ligase_ZBD 3.9e-12 39.3 28/28  
:HMM:PFM   544->573 PF00633 * HHH 1.8e-05 36.7 30/30  
:BLT:SWISS 1->678 DNLJ_FRATW 0.0 100.0 %
:PROS 341->356|PS01056|DNA_LIGASE_N2
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID ACD30624.1 GT:GENE ligA GT:PRODUCT DNA ligase, NAD-dependent GT:DATABASE GIB00719CH01 GT:ORG ftul2 GB:ACCESSION GIB00719CH01 GB:LOCATION 698831..700867 GB:FROM 698831 GB:TO 700867 GB:DIRECTION + GB:GENE ligA GB:PRODUCT DNA ligase, NAD-dependent GB:PROTEIN_ID ACD30624.1 GB:DB_XREF GI:187712327 GB:GENE:GENE ligA LENGTH 678 SQ:AASEQ MTPNEFFSIKYHILAKAELKAYIDKLADYLSQQSYLYHTLDKPIISDSDYDKLFRLLQDLVNDNPQFKPINSVLDRVGGEVLAGFETIKHKKKMTSLANVFSLEELRDFYDKIEYDIELECEPKMDGLAISIFYKNGKFDYAVTRGDGIQGEKVSENVKTIRNVPLKLNTSNPPEELEVRGEIILDKQSFLSLNEYMQTHENKTFANPRNAAAGSIRMLDSKVVAKRPLKLYSYGIGYFSKDFVYPETQFELMQLLQSFGFTISDNMFLAKNFSEVEEYHHKMSHQRADLAYDIDGLVFKVNNIKLQDTIGYTARGPKWAIAYKFPAEEVESEVLNVEFQVGRTGAITPVARLKPVAVGGVIVSNATLHNINEIKRKDIRVGDRVIVRRAGDVIPEVVKSLPQYRKSDAQMVEMPTNCPVCDSKIENVNDQAIYRCTGGWHCQAQTTERLKHFVSRKAMDIDKLGAKLIEQLVAANLIKYPADIYKLNFEQLTGLERMAAKSSQNVLDSITKSKEPSLARFIFAIGIKDIGEVSSDALANHFGSLESFRDAKFEELIEINDIGEIMANNIVSFWHDSLNIKIVEEFLAIGIKIQNPVKVEHAYNESFTGKTVVITGSFENYGRTELTQLLKSIGAKVTSSVSKKTDMVICGDNAGSKLTKAQELGVEVILEDNLKDLL GT:EXON 1|1-678:0| SW:ID DNLJ_FRATW SW:DE RecName: Full=DNA ligase; EC=6.5.1.2;AltName: Full=Polydeoxyribonucleotide synthase [NAD+]; SW:GN Name=ligA; OrderedLocusNames=FTW_0501; SW:KW Complete proteome; DNA damage; DNA repair; DNA replication; Ligase;Magnesium; Manganese; Metal-binding; NAD; Zinc. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->678|DNLJ_FRATW|0.0|100.0|678/678| GO:SWS:NREP 5 GO:SWS GO:0006974|"GO:response to DNA damage stimulus"|DNA damage| GO:SWS GO:0006281|"GO:DNA repair"|DNA repair| GO:SWS GO:0006260|"GO:DNA replication"|DNA replication| GO:SWS GO:0016874|"GO:ligase activity"|Ligase| GO:SWS GO:0046872|"GO:metal ion binding"|Metal-binding| PROS 341->356|PS01056|DNA_LIGASE_N2|PDOC00809| SEG 378->394|dirvgdrvivrragdvi| BL:PDB:NREP 2 BL:PDB:REP 19->591|2owoA|e-138|43.4|572/586| BL:PDB:REP 605->666|1l7bA|4e-11|52.5|61/92| RP:PDB:NREP 1 RP:PDB:REP 14->678|1dgtB|e-168|38.3|652/660| RP:PFM:NREP 4 RP:PFM:REP 20->328|PF01653|3e-79|46.9|307/314|DNA_ligase_aden| RP:PFM:REP 331->409|PF03120|5e-15|45.6|79/82|DNA_ligase_OB| RP:PFM:REP 417->444|PF03119|9e-05|42.9|28/28|DNA_ligase_ZBD| RP:PFM:REP 607->672|PF00533|9e-10|44.6|65/76|BRCT| HM:PFM:NREP 5 HM:PFM:REP 19->328|PF01653|1.3e-104|43.3|307/315|DNA_ligase_aden| HM:PFM:REP 331->410|PF03120|6.8e-34|55.0|80/82|DNA_ligase_OB| HM:PFM:REP 607->678|PF00533|3e-15|36.6|71/78|BRCT| HM:PFM:REP 417->444|PF03119|3.9e-12|39.3|28/28|DNA_ligase_ZBD| HM:PFM:REP 544->573|PF00633|1.8e-05|36.7|30/30|HHH| GO:PFM:NREP 8 GO:PFM GO:0003911|"GO:DNA ligase (NAD+) activity"|PF01653|IPR013839| GO:PFM GO:0003911|"GO:DNA ligase (NAD+) activity"|PF03120|IPR004150| GO:PFM GO:0006260|"GO:DNA replication"|PF03120|IPR004150| GO:PFM GO:0006281|"GO:DNA repair"|PF03120|IPR004150| GO:PFM GO:0003911|"GO:DNA ligase (NAD+) activity"|PF03119|IPR004149| GO:PFM GO:0006260|"GO:DNA replication"|PF03119|IPR004149| GO:PFM GO:0006281|"GO:DNA repair"|PF03119|IPR004149| GO:PFM GO:0005622|"GO:intracellular"|PF00533|IPR001357| RP:SCP:NREP 4 RP:SCP:REP 25->328|1b04A|9e-73|41.8|297/310|d.142.2.2| RP:SCP:REP 327->377|1dgsA2|1e-07|52.9|51/86|b.40.4.6| RP:SCP:REP 414->594|1dgsA1|3e-35|38.8|178/181|a.60.2.2| RP:SCP:REP 603->678|1l7bA|1e-16|48.0|75/92|c.15.1.2| HM:SCP:REP 13->326|1ta8A_|3e-100|48.2|309/0|d.142.2.2|1/1|DNA ligase/mRNA capping enzyme, catalytic domain| HM:SCP:REP 327->412|1dgsA2|3.8e-29|53.5|86/86|b.40.4.6|1/1|Nucleic acid-binding proteins| HM:SCP:REP 413->596|1dgsA1|7.6e-60|45.3|181/181|a.60.2.2|1/1|RuvA domain 2-like| HM:SCP:REP 600->680|1l7bA_|1.7e-18|46.2|80/92|c.15.1.2|1/1|BRCT domain| OP:NHOMO 1035 OP:NHOMOORG 929 OP:PATTERN ------------------------1--11111------------------------------------ 1111111111111111-11-11111111111111112111111111111111121111111111211122111111111111111111111111111--111111111111111111111111111111112111111111111111111111111111111111111111-111--11111-21111--111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111121111112112111111111111111111111111111111111111111111111111111111111111111111111111-11112111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111112111111111111111111111111111111111111111111111211112111111112111111111111111111-11111-1111122221222222222222-222222222222322222111122221222222222221212211-1222211222222222222111111111111111121111111111111111111111111121111121222222222121111111111111111111111111111111111111111111111111111111111111111-11111111111111211111111111111121 -1--11-------------------------------------------------1--------------1---------------------------------------1----------------------------------------------------1----111--1--2114111--212----11----- ----------------------------------------------------------------------------------------------------------------------------------------------------------------1-------------- STR:NPRED 678 STR:RPRED 100.0 SQ:SECSTR cHHHHHHHHHHHHccGGGHHHHHHHHHHHHHHHHHHHHTTccccccTTHHHHHHHHHHHHHHHcGGGccTTcGGGccTTcccccccEEEcccccccccEEccHHHHHHHHHTTcccccccEEEEcccEEEEEEEETTEEEEEEEcccccEEEccHHHHTTcTTccccccccccccEEEEEEEEEccHHHHHHHHHHHHTTTccccccHHHHHHHHHccccTHHHHccccEEEEEEEccccccccccccHHHHHHHHHHHTccccccEEEEEHHHHHHHHHHHHHHTGGGccccccEEEEEEccGGGTTTccccccccccEEEEEccccEEEEEccEEEEEEcTTccEEEEEEEEEEEccccEEEEEEccccTTTTTTTccTTcEEEEEcTTccccEEEEEcTTcccccccccccccccTTTccccHHccccccccccccTTcTTcHHHHHHHHccTTccccTTccHHHHHHHHTTTccccTTTTcccccHHHHTTcccccHHHHHHHHHHHTGGGccHHHHHHHHTcTTccTTHHHHHHHHHccHHHHHTccHHHHcccccccHHHHHHHHHHHHcHHHHHHHHHHHTTTccccHHHHcccccccTTcccccccccTcccccTTHHHHcccccccccccccccccccccccTTTcccccccTTTccccccccccTTTT DISOP:02AL 678-679| PSIPRED cccccccccccccccHHHHHHHHHHHHHHHHHHHHHHHHcccccccHHHHHHHHHHHHHHHHHccccccccccHHcccccccccccccccccccccHHHcccHHHHHHHHHHccccccEEEEEEccEEEEEEEEEccEEEEEEEcccccccccHHHHHHHHHHHHHHccccccccEEEEEEEEEEEHHHHHHHHHHHHHHcccccccHHHHHHHHHHHccHHHHHHccccEEEEEcccccccccccccHHHHHHHHHHccccccccEEEEccHHHHHHHHHHHHHHHccccccccEEEEEEccHHHHHHcccccccccEEEEEEccccEEEEEEEEEEEEEccccEEEEEEEEEEEEEccEEEEEEEcccHHHHHHcccccccEEEEEEccccccEEccEEccccccccccEEccccccccccEEccccccEEEEcccccccHHHHHHHHHHHHcccccccccccHHHHHHHHHccccccHHHHHcccHHHHHcccccccHHHHHHHHHHHHHHcccHHHHHHHcccccccHHHHHHHHHHcccHHHHHHccHHHHHccccccHHHHHHHHHHHccHHHHHHHHHHHHccccccccccccccccccccccEEEEEEEcccccHHHHHHHHHHcccEEEEcccccccEEEEccccccHHHHHHHcccEEEcHHHHHHHc //