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Lactobacillus salivarius UCC118 (lsal0)
Gene : fhs
DDBJ      :fhs          Formate--tetrahydrofolate ligase
Swiss-Prot:FTHS_LACS1   RecName: Full=Formate--tetrahydrofolate ligase;         EC=6.3.4.3;AltName: Full=Formyltetrahydrofolate synthetase;         Short=FHS;         Short=FTHFS;

Homologs  Archaea  7/68 : Bacteria  350/915 : Eukaryota  187/199 : Viruses  0/175   --->[See Alignment]
c.37.1
:552 amino acids
:SECSTR
:PSIPRED
:BLT:PDB   3->550 1fp7A PDBj e-176 58.1 %
:RPS:PDB   14->551 3do6A PDBj 6e-77 47.2 %
:RPS:SCOP  3->550 1eg7A  c.37.1.10 * 2e-69 55.9 %
:HMM:SCOP  3->550 1eg7A_ c.37.1.10 * 1.5e-248 64.7 %
:RPS:PFM   3->552 PF01268 * FTHFS 0.0 61.6 %
:HMM:PFM   2->551 PF01268 * FTHFS 7.4e-269 62.2 550/555  
:BLT:SWISS 1->552 FTHS_LACS1 0.0 100.0 %
:PROS 100->110|PS00721|FTHFS_1
:PROS 325->336|PS00722|FTHFS_2
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID ABD99652.1 GT:GENE fhs GT:PRODUCT Formate--tetrahydrofolate ligase GT:DATABASE GIB00337CH01 GT:ORG lsal0 GB:ACCESSION GIB00337CH01 GB:LOCATION 859086..860744 GB:FROM 859086 GB:TO 860744 GB:DIRECTION + GB:GENE fhs GB:PRODUCT Formate--tetrahydrofolate ligase GB:NOTE COG2759 [F] Formyltetrahydrofolate synthetase GB:PROTEIN_ID ABD99652.1 GB:DB_XREF GI:90821013 GB:GENE:GENE fhs LENGTH 552 SQ:AASEQ MKDIEIAQKSEMLPITEVAQKVGLTADEIEQYGKYKAKISLPLSAREQTKRKLVLVTAINPTPAGEGKSTVTVGLGDAFSLLNKKVMIALREPSLGPVMGMKGGATGGGYSQVVPMEDINLHFTGDMHALTTANNTLAALIDNHIYQGNKLNIDQRRVIWKRVLDINDRALRHVVIGLGGATQGIPREDGFDITVASELMAILCLSKDISDLKKRIGQIVIGYNFDKEPVTVDQLGVTGAITLLLKDACKPNLVQTLAHTPAIVHGGPFANIAHGCNSVLATQTALNLADYTITEAGFGADLGAEKFLDIKTPVLGKTPDTIVIVATARALKMNGGVAKDNLDEENVAAVEQGFANLKKHIQSMKRYNVPVVVAINKFTQDTDAELAKIVELCEQDDTKAIVADVWAKGGEGATELAKAVIESCDNDQEFTRLYNSDDSVEEKINKIVTEIYGGDGVEFSAKAKRQLRQFEKLGWNHLPVCMAKTQYSLSDNAKVLGAPKGFKIHVREFVPKLGAQFLVALTGNILTMPGLPKVPAADGMDVDENGKISGLY GT:EXON 1|1-552:0| SW:ID FTHS_LACS1 SW:DE RecName: Full=Formate--tetrahydrofolate ligase; EC=6.3.4.3;AltName: Full=Formyltetrahydrofolate synthetase; Short=FHS; Short=FTHFS; SW:GN Name=fhs; OrderedLocusNames=LSL_0842; SW:KW ATP-binding; Complete proteome; Ligase; Nucleotide-binding;One-carbon metabolism. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->552|FTHS_LACS1|0.0|100.0|552/552| GO:SWS:NREP 4 GO:SWS GO:0005524|"GO:ATP binding"|ATP-binding| GO:SWS GO:0016874|"GO:ligase activity"|Ligase| GO:SWS GO:0000166|"GO:nucleotide binding"|Nucleotide-binding| GO:SWS GO:0006730|"GO:one-carbon metabolic process"|One-carbon metabolism| PROS 100->110|PS00721|FTHFS_1|PDOC00595| PROS 325->336|PS00722|FTHFS_2|PDOC00595| SEG 96->109|gpvmgmkggatggg| SEG 129->140|alttanntlaal| BL:PDB:NREP 1 BL:PDB:REP 3->550|1fp7A|e-176|58.1|546/549| RP:PDB:NREP 1 RP:PDB:REP 14->551|3do6A|6e-77|47.2|525/530| RP:PFM:NREP 1 RP:PFM:REP 3->552|PF01268|0.0|61.6|550/553|FTHFS| HM:PFM:NREP 1 HM:PFM:REP 2->551|PF01268|7.4e-269|62.2|550/555|FTHFS| GO:PFM:NREP 3 GO:PFM GO:0004329|"GO:formate-tetrahydrofolate ligase activity"|PF01268|IPR000559| GO:PFM GO:0005524|"GO:ATP binding"|PF01268|IPR000559| GO:PFM GO:0009396|"GO:folic acid and derivative biosynthetic process"|PF01268|IPR000559| RP:SCP:NREP 1 RP:SCP:REP 3->550|1eg7A|2e-69|55.9|546/549|c.37.1.10| HM:SCP:REP 3->550|1eg7A_|1.5e-248|64.7|546/0|c.37.1.10|1/1|P-loop containing nucleoside triphosphate hydrolases| OP:NHOMO 753 OP:NHOMOORG 544 OP:PATTERN ------------------------1---1-1--------------1---------------111---- 1----11----111--------------------------------11----111--1----11--1----111111111123-----1111-111----1-----------------------------------1111111211----------------------------------------1-111-1-111111111111111--111-111---2-111111111-1111111111111111111212111111121111111111111111111211121111111111111222222222222221111111111211111111111111111111111111111122211111111111111111------1--111-----------------------1111111111--1--11111111111-111121111112--------1---1--------------------------------1----1---------------------------------------1-------------1-1-11111111-------1111-1-1-----1-------------1-11-11------------------------11---------11111--111111111111-----------------1---------------------------------------1--------------------------1------------------------1----111---1-----------------1-----------------------------11111111111121-----------------1--------------1-1------------------1---1111111111111111 ----111-21--1111111111111111111111111111-111111111111111111111222222122121222-3222222122-12111111111111212-12223334332222222552825Q2-4242222322322222232242223313311153411332111111H1111111521211112113 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 551 STR:RPRED 99.8 SQ:SECSTR #EcccTTcccccccHHHHHHHTTccGGGEEEETTTEEEEcTTHHTTTccccEEEEEEEccccTTcccHHHHHHHHHHHHHHTTccEEEEEccccHHHHHHccccTTEETTEEEEcHHHHHTTTTcHHHHHHHHHHHHHHHHHHHHHTTcTTcEEEEEEcccEEEEcccGGGccEEEccccGGGcccEEEcEEEGGGcHHHHHHHcccccHHHHHHHHTcEEEEETTccEEEHHHHTcHHHHHHHTTTTTccEEEEETTccEEEEccccccccccccccHHHHHHHHHHccEEEEEccccTTTHHHHHHHTHHHHHTccccEEEEEEcHHHHHHHTTccGGGTTcccHHHHHHHHHHHHHHHHHHHHTTccEEEEEEccTTccHHHHHHHHHHHHTTTcEEEEEcHHHHGGGGcHHHHHHHHHHcHccccccccccTTccHHHHHHHHHHHTccccEEEEcHHHHHHHHHHHHTTcTTccEEEEcccccccccTTccccccccEEEEcEEEEETTTTEEEEEccccccccccccccGGGTGEEcTTccEEccc PSIPRED ccHHHHHHHcccccHHHHHHHccccHHHHHHccccEEEEcHHHHHcccccccEEEEEEccccccccccHHHHHHHHHHHHHcccEEEEEEcccccccccccccccccccEEEEEcHHHcccccccccccccccccHHHHHHHHHHHccccccccccEEEEEEEHHcccHHHcEEEEcccccccccEEEcccEEEHHHHHHHHHHHHccHHHHHHHHHcEEEEEEcccccEEEEEcccHHHHHHHHHHHccccEEEEEcccEEEEEccccHHHHccccHHHHHHHHHHHccEEEEcccccccccccEEEEEEcccccccccEEEEEcccccHHHcccccHHHcccccHHHHHHHHHHHHHHHHHHHHccccEEEEEEccccccHHHHHHHHHHHHHccccEEEEHHHHHccHHHHHHHHHHHHHHccccccEEcccccccHHHHHHHHHHHHcccccEEEcHHHHHHHHHHHHcccccccEEEEEccccccccHHHcccccccEEEEEEEEEEccccEEEEEEcccccccccccccHHHcccccccccEEEcc //