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Lactobacillus salivarius UCC118 (lsal0)
Gene : guaA.3
DDBJ      :guaA         GMP synthase
Swiss-Prot:GUAA_LACS1   RecName: Full=GMP synthase [glutamine-hydrolyzing];         EC=6.3.5.2;AltName: Full=Glutamine amidotransferase;AltName: Full=GMP synthetase;

Homologs  Archaea  64/68 : Bacteria  851/915 : Eukaryota  190/199 : Viruses  0/175   --->[See Alignment]
c.23.16c.26.2d.52.2
:518 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   11->518 1gpmA PDBj e-137 49.6 %
:RPS:PDB   11->123 1aa7B PDBj 2e-20 7.1 %
:RPS:PDB   99->518 3dlaB PDBj 1e-51 11.1 %
:RPS:SCOP  5->202 1gpmA2  c.23.16.1 * 3e-40 44.9 %
:RPS:SCOP  204->397 1gpmA1  c.26.2.1 * 8e-25 48.6 %
:RPS:SCOP  398->518 1gpmA3  d.52.2.1 * 4e-31 55.4 %
:HMM:SCOP  10->233 1l9xA_ c.23.16.1 * 3.1e-60 40.3 %
:HMM:SCOP  193->411 1jgtA1 c.26.2.1 * 5.5e-62 40.6 %
:HMM:SCOP  398->518 1gpmA3 d.52.2.1 * 3.1e-50 65.3 %
:RPS:PFM   14->193 PF00117 * GATase 4e-23 36.5 %
:RPS:PFM   244->395 PF02540 * NAD_synthase 1e-05 30.4 %
:RPS:PFM   426->517 PF00958 * GMP_synt_C 2e-29 63.0 %
:HMM:PFM   14->195 PF00117 * GATase 2.9e-43 34.3 181/192  
:HMM:PFM   426->517 PF00958 * GMP_synt_C 1e-42 65.2 92/93  
:HMM:PFM   216->290 PF02540 * NAD_synthase 2e-10 32.4 74/242  
:HMM:PFM   366->395 PF02540 * NAD_synthase 0.00018 33.3 30/242  
:BLT:SWISS 1->518 GUAA_LACS1 0.0 100.0 %
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID ABE00341.1 GT:GENE guaA.3 GT:PRODUCT GMP synthase GT:DATABASE GIB00337CH01 GT:ORG lsal0 GB:ACCESSION GIB00337CH01 GB:LOCATION complement(1613487..1615043) GB:FROM 1613487 GB:TO 1615043 GB:DIRECTION - GB:GENE guaA GB:PRODUCT GMP synthase GB:NOTE COG0519 [F] GMP synthase, PP-ATPase domain/subunit glutamine-hydrolyzing GB:PROTEIN_ID ABE00341.1 GB:DB_XREF GI:90821702 GB:GENE:GENE guaA LENGTH 518 SQ:AASEQ MANVDMQTFDKIIVLDFGSQYNQLITRRIREFGVYSELLSHKLTAAQIKEMNPKGIIFSGGPNSVYDDGAFQIDPEIFELGIPILGICYGMQLMAHNLSGGKVESADNKEYGKAIITVKNQENVMFKDLPETQTVWMSHGDLVTQVPEGFEVTATSDNCPISAMANDAKKFYGLQFHTEVRNTEYGNDILRHFAFDVCQARSNWSMDDFIDMQIQKIRETVGDKKVLLGLSGGVDSSVVGVLLHKAIGNQLTSIFVDHGLLRKGEAEQVMDSLGGKFGLNIIKVDAKERFLNKLAGVSDPEKKRKIIGNEFIRVFDDESAKLEGIEFLAQGTLYTDIIESGTDTAQTIKSHHNVGGLPEDVQFKLIEPLNTLFKDEVRELGEKLGMPHELVWRQPFPGPGLGIRVIGEITEEKLEIVRDSDLILREEIAKHGLDKEIWQYFTVLPGIRSVGVMGDGRTYDYTVGIRAVTSIDGMTADFAQIPWDVLQEISVRIVNEVDHVNRVVYDITSKPPATIEWE GT:EXON 1|1-518:0| SW:ID GUAA_LACS1 SW:DE RecName: Full=GMP synthase [glutamine-hydrolyzing]; EC=6.3.5.2;AltName: Full=Glutamine amidotransferase;AltName: Full=GMP synthetase; SW:GN Name=guaA; OrderedLocusNames=LSL_1537; SW:KW ATP-binding; Complete proteome; Glutamine amidotransferase;GMP biosynthesis; Ligase; Nucleotide-binding; Purine biosynthesis. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->518|GUAA_LACS1|0.0|100.0|518/518| GO:SWS:NREP 6 GO:SWS GO:0005524|"GO:ATP binding"|ATP-binding| GO:SWS GO:0006541|"GO:glutamine metabolic process"|Glutamine amidotransferase| GO:SWS GO:0006177|"GO:GMP biosynthetic process"|GMP biosynthesis| GO:SWS GO:0016874|"GO:ligase activity"|Ligase| GO:SWS GO:0000166|"GO:nucleotide binding"|Nucleotide-binding| GO:SWS GO:0006164|"GO:purine nucleotide biosynthetic process"|Purine biosynthesis| SEG 221->243|vgdkkvllglsggvdssvvgvll| BL:PDB:NREP 1 BL:PDB:REP 11->518|1gpmA|e-137|49.6|488/501| RP:PDB:NREP 2 RP:PDB:REP 11->123|1aa7B|2e-20|7.1|112/157| RP:PDB:REP 99->518|3dlaB|1e-51|11.1|398/649| RP:PFM:NREP 3 RP:PFM:REP 14->193|PF00117|4e-23|36.5|178/185|GATase| RP:PFM:REP 244->395|PF02540|1e-05|30.4|135/208|NAD_synthase| RP:PFM:REP 426->517|PF00958|2e-29|63.0|92/93|GMP_synt_C| HM:PFM:NREP 4 HM:PFM:REP 14->195|PF00117|2.9e-43|34.3|181/192|GATase| HM:PFM:REP 426->517|PF00958|1e-42|65.2|92/93|GMP_synt_C| HM:PFM:REP 216->290|PF02540|2e-10|32.4|74/242|NAD_synthase| HM:PFM:REP 366->395|PF02540|0.00018|33.3|30/242|NAD_synthase| GO:PFM:NREP 8 GO:PFM GO:0003824|"GO:catalytic activity"|PF00117|IPR000991| GO:PFM GO:0003952|"GO:NAD+ synthase (glutamine-hydrolyzing) activity"|PF02540|IPR003694| GO:PFM GO:0005524|"GO:ATP binding"|PF02540|IPR003694| GO:PFM GO:0009435|"GO:NAD biosynthetic process"|PF02540|IPR003694| GO:PFM GO:0003922|"GO:GMP synthase (glutamine-hydrolyzing) activity"|PF00958|IPR001674| GO:PFM GO:0005524|"GO:ATP binding"|PF00958|IPR001674| GO:PFM GO:0006164|"GO:purine nucleotide biosynthetic process"|PF00958|IPR001674| GO:PFM GO:0006177|"GO:GMP biosynthetic process"|PF00958|IPR001674| RP:SCP:NREP 3 RP:SCP:REP 5->202|1gpmA2|3e-40|44.9|196/205|c.23.16.1| RP:SCP:REP 204->397|1gpmA1|8e-25|48.6|175/175|c.26.2.1| RP:SCP:REP 398->518|1gpmA3|4e-31|55.4|121/121|d.52.2.1| HM:SCP:REP 10->233|1l9xA_|3.1e-60|40.3|221/0|c.23.16.1|1/1|Class I glutamine amidotransferase-like| HM:SCP:REP 193->411|1jgtA1|5.5e-62|40.6|219/299|c.26.2.1|1/1|Adenine nucleotide alpha hydrolases-like| HM:SCP:REP 398->518|1gpmA3|3.1e-50|65.3|121/0|d.52.2.1|1/1|GMP synthetase C-terminal dimerisation domain| OP:NHOMO 1826 OP:NHOMOORG 1105 OP:PATTERN 2212--3222222223-222222332223322333333333332112322223233223222221-22 1111212122211111111-1111111111111111112211111111111211111122111111111111111111112212122211222211---111121121221-------111111-222222222211112122212222211211112212122132342222122222222221211111222333333332333333222222333222232233333322122222222222222322121111111-1112211111111-13331112111222222222222222222222222222211222111123123111111111112432222212112122211421111323322122111122211111122111112111111111111111-22222121112111111111111112222112111221111111111111112121111111111---------------111112211222222111111133332222333333212222222222222222222322222222222222222212222131321111111111213122112111122232222233333212122222222222221122211222133333333333333333331-21111------21121112222222222-222222222222222222212122221222222222222222212222222111111111111111213221221222222131111111111112211111121222121111211211121111122233333212333111112221211111111111111112133222211111-1-1------1------1------1------1121121222221 1111112-311-11111111111111111111111111211121111112112111111111111212121112112-1221121122-11111131111111222-1312111111112111112-11251-11211111-1111111-1111111112641111111123322122191112233351821143221 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 512 STR:RPRED 98.8 SQ:SECSTR ######cccccEEEEEccccTTcHHHHHHHHTTccccEEETTccGGGGTTccEEEEccccccGGGTGGGHHHHHHHHHHccccEEEEEEccHHHHHHHcccTTcccccccccccEEEEETTEEEEEcccccccccEEEEEEEEHHHHHHHHHHcHHHHHHHHHTHHHHHccEEEEEccccccccccccccccccTTccHHHHHHHHHHHHHHHHHHHHHHHHHTTccEEEEEccccHHHHHHHHHHHHHHTTccGGGEEEEEccccHHHHHHHHHHHTcEEEEcccHHHHHHHTTcccHHHHHHHHHHHHHHHHHHHHTEHHHTccEEEEEcccHHHHHHTcccHHHTcccccccTccccTTcccEEccTTccHHHHHHHHHHHHHHcTTHHHHHHHHHHHHHHHcccTTcccHHHHHHHHHHHHHcccHHHHHHHHHHHHccTTcccccccccGGGcccccHHHHHHHHHHHHHHTTcHHHHHTccHccccccTTccccTTTTcccccccccHHHHH DISOP:02AL 1-6| PSIPRED ccccccccccEEEEEEccccHHHHHHHHHHHcccEEEEEcccccHHHHHHccccEEEEccccccccccccHHHHHHHHHccccEEEEcHHHHHHHHHHcccEEEEccccEEEEEEEEEEcccccccccccccEEEEEEEcccccccccccEEEEEEccccEEEEEEccccEEEEEccccccccccHHHHHHHHHHHHHHHccccccccHHHHHHHHHHHHHcccEEEEEEcccccHHHHHHHHHHHHcccEEEEEEccccHHcccHHHHHHHHHHHcccEEEEEcHHHHHHHHHcccccHHHHHHHHHHHHHHHHHHHHHHcccccEEEEccccHHHHHccccccccEEEcccccccHHHcccEEEcHHHHHHHHHHHHHHHHccccHHHHcccccccccccEEEcccccHHHHHHHHHHHHHHHHHHHHccccHHHHHcEEEEccccEEEEEccccccccEEEEEEEEcccccccccccccHHHHHHHHHHHHcccccccEEEEEcccccccccccc //