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Lactobacillus salivarius UCC118 (lsal0)
Gene : nei
DDBJ      :nei          Formamidopyrimidine-DNA glycosylase
Swiss-Prot:FPG_LACS1    RecName: Full=Formamidopyrimidine-DNA glycosylase;         Short=Fapy-DNA glycosylase;         EC=3.2.2.23;AltName: Full=DNA-(apurinic or apyrimidinic site) lyase mutM;         Short=AP lyase mutM;         EC=4.2.99.18;

Homologs  Archaea  0/68 : Bacteria  726/915 : Eukaryota  76/199 : Viruses  0/175   --->[See Alignment]
a.156.1b.113.1g.39.1
:276 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   2->272 1pm5A PDBj 3e-68 48.3 %
:RPS:PDB   2->272 1ee8A PDBj 1e-80 41.2 %
:RPS:SCOP  2->133 1k82A2  b.113.1.1 * 7e-37 35.9 %
:RPS:SCOP  134->221 1ee8A1  a.156.1.2 * 5e-28 44.3 %
:RPS:SCOP  222->272 1ee8A3  g.39.1.8 * 2e-22 51.0 %
:HMM:SCOP  2->142 1nnjA2 b.113.1.1 * 5.1e-43 45.8 %
:HMM:SCOP  132->223 1tdhA1 a.156.1.2 * 1.4e-30 51.1 %
:HMM:SCOP  221->272 1ee8A3 g.39.1.8 * 4e-17 50.0 %
:RPS:PFM   2->116 PF01149 * Fapy_DNA_glyco 1e-22 43.5 %
:RPS:PFM   133->221 PF06831 * H2TH 7e-19 49.4 %
:RPS:PFM   245->272 PF06827 * zf-FPG_IleRS 8e-09 60.7 %
:HMM:PFM   2->117 PF01149 * Fapy_DNA_glyco 1.2e-38 41.7 115/116  
:HMM:PFM   133->223 PF06831 * H2TH 2.5e-30 46.2 91/93  
:HMM:PFM   245->272 PF06827 * zf-FPG_IleRS 3e-14 46.4 28/30  
:BLT:SWISS 1->276 FPG_LACS1 e-159 100.0 %
:PROS 248->272|PS01242|ZF_FPG_1

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID ABD99298.1 GT:GENE nei GT:PRODUCT Formamidopyrimidine-DNA glycosylase GT:DATABASE GIB00337CH01 GT:ORG lsal0 GB:ACCESSION GIB00337CH01 GB:LOCATION 539236..540066 GB:FROM 539236 GB:TO 540066 GB:DIRECTION + GB:GENE nei GB:PRODUCT Formamidopyrimidine-DNA glycosylase GB:NOTE COG0266 [L] Formamidopyrimidine-DNA glycosylase GB:PROTEIN_ID ABD99298.1 GB:DB_XREF GI:90820659 GB:GENE:GENE nei LENGTH 276 SQ:AASEQ MPELPEVETVRRGLEKLVLNKKIKDIRVLYSKTIVNEESEFIEKLTNKTIKKIDRRGKYLLFRFSSDLTMISHLRMEGKYFVEPSTKEVEKHTHVVFDFTDGTSLRYNDVRKFGRMQLVKTGMEIQTAGLAKLGPEPKEKTFIVEDFSKNLKRRKKAIKNALLDQTIVAGLGNIYADEVLWMSKIHPETPANKLTEEEVKVLRDNIIKELALATEAGGTTIRSYTDAFRHSGGFQFSLHAYQRTGDPCERCGTPIQRIVVGQRGTHFCPKCQVVKS GT:EXON 1|1-276:0| SW:ID FPG_LACS1 SW:DE RecName: Full=Formamidopyrimidine-DNA glycosylase; Short=Fapy-DNA glycosylase; EC=3.2.2.23;AltName: Full=DNA-(apurinic or apyrimidinic site) lyase mutM; Short=AP lyase mutM; EC=4.2.99.18; SW:GN Name=mutM; Synonyms=fpg; OrderedLocusNames=LSL_0489; SW:KW Complete proteome; DNA damage; DNA repair; DNA-binding; Glycosidase;Hydrolase; Lyase; Metal-binding; Multifunctional enzyme; Zinc;Zinc-finger. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->276|FPG_LACS1|e-159|100.0|276/276| GO:SWS:NREP 9 GO:SWS GO:0006974|"GO:response to DNA damage stimulus"|DNA damage| GO:SWS GO:0006281|"GO:DNA repair"|DNA repair| GO:SWS GO:0003677|"GO:DNA binding"|DNA-binding| GO:SWS GO:0016798|"GO:hydrolase activity, acting on glycosyl bonds"|Glycosidase| GO:SWS GO:0008152|"GO:metabolic process"|Glycosidase| GO:SWS GO:0016787|"GO:hydrolase activity"|Hydrolase| GO:SWS GO:0016829|"GO:lyase activity"|Lyase| GO:SWS GO:0046872|"GO:metal ion binding"|Metal-binding| GO:SWS GO:0003824|"GO:catalytic activity"|Multifunctional enzyme| PROS 248->272|PS01242|ZF_FPG_1|PDOC00956| BL:PDB:NREP 1 BL:PDB:REP 2->272|1pm5A|3e-68|48.3|269/271| RP:PDB:NREP 1 RP:PDB:REP 2->272|1ee8A|1e-80|41.2|260/266| RP:PFM:NREP 3 RP:PFM:REP 2->116|PF01149|1e-22|43.5|115/118|Fapy_DNA_glyco| RP:PFM:REP 133->221|PF06831|7e-19|49.4|89/92|H2TH| RP:PFM:REP 245->272|PF06827|8e-09|60.7|28/30|zf-FPG_IleRS| HM:PFM:NREP 3 HM:PFM:REP 2->117|PF01149|1.2e-38|41.7|115/116|Fapy_DNA_glyco| HM:PFM:REP 133->223|PF06831|2.5e-30|46.2|91/93|H2TH| HM:PFM:REP 245->272|PF06827|3e-14|46.4|28/30|zf-FPG_IleRS| GO:PFM:NREP 11 GO:PFM GO:0003684|"GO:damaged DNA binding"|PF01149|IPR012319| GO:PFM GO:0003906|"GO:DNA-(apurinic or apyrimidinic site) lyase activity"|PF01149|IPR012319| GO:PFM GO:0006284|"GO:base-excision repair"|PF01149|IPR012319| GO:PFM GO:0008270|"GO:zinc ion binding"|PF01149|IPR012319| GO:PFM GO:0016799|"GO:hydrolase activity, hydrolyzing N-glycosyl compounds"|PF01149|IPR012319| GO:PFM GO:0003684|"GO:damaged DNA binding"|PF06831|IPR015886| GO:PFM GO:0003906|"GO:DNA-(apurinic or apyrimidinic site) lyase activity"|PF06831|IPR015886| GO:PFM GO:0006289|"GO:nucleotide-excision repair"|PF06831|IPR015886| GO:PFM GO:0008270|"GO:zinc ion binding"|PF06831|IPR015886| GO:PFM GO:0016799|"GO:hydrolase activity, hydrolyzing N-glycosyl compounds"|PF06831|IPR015886| GO:PFM GO:0003824|"GO:catalytic activity"|PF06827|IPR010663| RP:SCP:NREP 3 RP:SCP:REP 2->133|1k82A2|7e-37|35.9|128/128|b.113.1.1| RP:SCP:REP 134->221|1ee8A1|5e-28|44.3|88/89|a.156.1.2| RP:SCP:REP 222->272|1ee8A3|2e-22|51.0|51/56|g.39.1.8| HM:SCP:REP 2->142|1nnjA2|5.1e-43|45.8|131/131|b.113.1.1|1/1|N-terminal domain of MutM-like DNA repair proteins| HM:SCP:REP 132->223|1tdhA1|1.4e-30|51.1|92/115|a.156.1.2|1/1|S13-like H2TH domain| HM:SCP:REP 221->272|1ee8A3|4e-17|50.0|52/56|g.39.1.8|1/1|Glucocorticoid receptor-like (DNA-binding domain)| OP:NHOMO 1044 OP:NHOMOORG 802 OP:PATTERN -------------------------------------------------------------------- 2331322333311244433-32114233333434443444131253132324444213--32423253332-----------3-------1--1---------1-1--11--------------1-----------11-1111111211111111111111111111111111121111121111111---111111111111111111211111111111111111111122111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111----------------------------1--112211111111-------3-21111111111111121111111111111111-1-1111111111111111111111111111111111111111111111111111111111-1111----1-1111111-11-1111111111111111111111111111111111111111111111111111111111111111111111111111111111---111111111112221111112222211--------------------------111111111111111111111111111111111-11111------22112222222222222-1222222222222222221222221112222222222222222222222221-111111111111---1-----111111211111111111111111-111111111111111111111111111111111111112111111111111121111111112222111-----------------111111-1111111111111111111-----------2- ------1-------1111111111111111111111-111111-1111111111111-1111------------1--------------111111-2---1--1-1-14------------------------------------------------------1------------221E111124221121------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 271 STR:RPRED 98.2 SQ:SECSTR #ccHHHHHHHHHHHHHHHTTcEEEEEEcccTTTHccTTEEcGGGGTTEEEEEEEEETTEEEEEETTTEEEEEEcTTTcEEEccccTccccTTEEEEEEEcccEEEEEEcTTcccEEEEEETTccTTcTHHHHccccTTcTTccHHHHHHHHHTccccHHHHHHHccccTTccHHHHHHHHHHTTccccccGGGccHHHHHHHHHHHHHHHHHHHHTTcccccccccTTccccccGGGcccTTcTTcccTTTccccEEEEccccEEEEcTTTT#### DISOP:02AL 275-277| PSIPRED cccccHHHHHHHHHHHHHcccEEEEEEEEcccccccccHHHHHHHHccEEEEEEEEcEEEEEEEccccEEEEEccccEEEEEEccccccccccEEEEEEcccEEEEEEcccccEEEEEEEcccccccHHHHHcccccccccccHHHHHHHHccccccHHHHHHccccccccHHHHHHHHHHHHccccccccccccHHHHHHHHHHHHHHHHHHHHHcccEEccccccccccccEEEEEEEEccccccccccccEEEEEEEccccEEEccccEEccc //