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Lactobacillus salivarius UCC118 (lsal0)
Gene : topA.1
DDBJ      :topA         DNA topoisomerase I
Swiss-Prot:             

Homologs  Archaea  66/68 : Bacteria  902/915 : Eukaryota  186/199 : Viruses  1/175   --->[See Alignment]
e.10.1g.41.3g.54.1
:703 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   20->573 1cy7A PDBj e-132 46.4 %
:RPS:PDB   20->582 1eclA PDBj e-169 45.6 %
:RPS:PDB   616->699 3a43A PDBj 3e-15 25.3 %
:RPS:SCOP  20->566 1cy0A  e.10.1.1 * e-160 46.6 %
:RPS:SCOP  575->633 1yuaA1  g.41.3.3 * 6e-17 25.4 %
:RPS:SCOP  628->682 1nltA3  g.54.1.1 * 5e-10 14.5 %
:RPS:SCOP  669->703 1i3qI1  g.41.3.1 * 3e-08 25.7 %
:HMM:SCOP  17->601 1mw9X_ e.10.1.1 * 2.2e-198 45.4 %
:RPS:PFM   20->106 PF01751 * Toprim 8e-12 47.0 %
:RPS:PFM   143->554 PF01131 * Topoisom_bac 5e-98 48.5 %
:RPS:PFM   587->624 PF01396 * zf-C4_Topoisom 1e-08 44.7 %
:RPS:PFM   627->660 PF01396 * zf-C4_Topoisom 5e-04 44.1 %
:HMM:PFM   143->558 PF01131 * Topoisom_bac 2.2e-131 41.1 389/404  
:HMM:PFM   588->624 PF01396 * zf-C4_Topoisom 1.1e-16 43.2 37/39  
:HMM:PFM   628->666 PF01396 * zf-C4_Topoisom 1.2e-15 43.2 37/39  
:HMM:PFM   669->703 PF01396 * zf-C4_Topoisom 1.5e-07 45.7 35/39  
:HMM:PFM   18->125 PF01751 * Toprim 3.7e-30 47.4 95/96  
:BLT:SWISS 19->701 TOP1_LACLA 0.0 67.6 %
:PROS 295->318|PS00396|TOPOISOMERASE_I_PROK
:REPEAT 2|607->645|649->685
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID ABD99530.1 GT:GENE topA.1 GT:PRODUCT DNA topoisomerase I GT:DATABASE GIB00337CH01 GT:ORG lsal0 GB:ACCESSION GIB00337CH01 GB:LOCATION 765005..767116 GB:FROM 765005 GB:TO 767116 GB:DIRECTION + GB:GENE topA GB:PRODUCT DNA topoisomerase I GB:NOTE COG0550 [L] Topoisomerase IA GB:PROTEIN_ID ABD99530.1 GB:DB_XREF GI:90820891 GB:GENE:GENE topA LENGTH 703 SQ:AASEQ MPTTQKPKKKTTKRTRKKNLVIVESPSKAKTIEKYLGSNYKVMASLGHIRDLPKSKMGIDVENGYEPHYISIRGKGDVIKELRKEAKKASHVYLAADPDREGEAIAWHLSYLLGLNPEDKNRVVFNEITKDAVKNAFKSPRSIDMNLVDAQQARRVLDRLVGYSISPLLWSKIKKGLSAGRVQSIALNLIIQREKEIRDFKPEEYWTIDAKFKKGRTKFEADFWGVDNKKKKLSNEKDVKEVIEKIDKDKPFNVINIEQKERKRMPPLPFTTSAMQQTANNNLKFRTQKTMMVAQQLYEGINIGRGGAVGLITYMRTDSTRISSVAKHEAAVFLHENYGEEYAASKPRQGKLSENAQDAHEAIRPSSVERTPEKMAKYLDKDQLKLYTLIWSRFVASQMTPAVFDTMRVDIEQNGVQYRANGSKMKFPGFIKVYKAATSKDNLLPELKVGDEVDMVQNQPNQHFTLPPARYSEATLIRTLEENGVGRPSTYAPTLSTIQKRYYVKLVSRKFEPTELGEIVNSMIEECFPDILNVDFTAHLEDQLDDVEEGKEEWVRIIDEFYQPFSKEVDNAQVKMDKIKIKDEPAGIDCEICGAPMVIKLGRYGKFYACSRFPDCRNTKAIVKEIGVVCPKCHKGQIIERKSKKNRVFYGCSLYPDCDFVSWDKPIGRDCPKCSHYLVEKKTKKGMQVKCSNCDYEEAIQNN GT:EXON 1|1-703:0| BL:SWS:NREP 1 BL:SWS:REP 19->701|TOP1_LACLA|0.0|67.6|680/710| PROS 295->318|PS00396|TOPOISOMERASE_I_PROK|PDOC00333| NREPEAT 1 REPEAT 2|607->645|649->685| SEG 2->18|pttqkpkkkttkrtrkk| BL:PDB:NREP 1 BL:PDB:REP 20->573|1cy7A|e-132|46.4|535/563| RP:PDB:NREP 2 RP:PDB:REP 20->582|1eclA|e-169|45.6|540/552| RP:PDB:REP 616->699|3a43A|3e-15|25.3|79/138| RP:PFM:NREP 4 RP:PFM:REP 20->106|PF01751|8e-12|47.0|83/110|Toprim| RP:PFM:REP 143->554|PF01131|5e-98|48.5|398/407|Topoisom_bac| RP:PFM:REP 587->624|PF01396|1e-08|44.7|38/39|zf-C4_Topoisom| RP:PFM:REP 627->660|PF01396|5e-04|44.1|32/39|zf-C4_Topoisom| HM:PFM:NREP 5 HM:PFM:REP 143->558|PF01131|2.2e-131|41.1|389/404|Topoisom_bac| HM:PFM:REP 588->624|PF01396|1.1e-16|43.2|37/39|zf-C4_Topoisom| HM:PFM:REP 628->666|PF01396|1.2e-15|43.2|37/39|zf-C4_Topoisom| HM:PFM:REP 669->703|PF01396|1.5e-07|45.7|35/39|zf-C4_Topoisom| HM:PFM:REP 18->125|PF01751|3.7e-30|47.4|95/96|Toprim| GO:PFM:NREP 12 GO:PFM GO:0003677|"GO:DNA binding"|PF01131|IPR013497| GO:PFM GO:0003916|"GO:DNA topoisomerase activity"|PF01131|IPR013497| GO:PFM GO:0005694|"GO:chromosome"|PF01131|IPR013497| GO:PFM GO:0006265|"GO:DNA topological change"|PF01131|IPR013497| GO:PFM GO:0003677|"GO:DNA binding"|PF01396|IPR013498| GO:PFM GO:0003916|"GO:DNA topoisomerase activity"|PF01396|IPR013498| GO:PFM GO:0005694|"GO:chromosome"|PF01396|IPR013498| GO:PFM GO:0006265|"GO:DNA topological change"|PF01396|IPR013498| GO:PFM GO:0003677|"GO:DNA binding"|PF01396|IPR013498| GO:PFM GO:0003916|"GO:DNA topoisomerase activity"|PF01396|IPR013498| GO:PFM GO:0005694|"GO:chromosome"|PF01396|IPR013498| GO:PFM GO:0006265|"GO:DNA topological change"|PF01396|IPR013498| RP:SCP:NREP 4 RP:SCP:REP 20->566|1cy0A|e-160|46.6|528/534|e.10.1.1| RP:SCP:REP 575->633|1yuaA1|6e-17|25.4|59/65|g.41.3.3| RP:SCP:REP 628->682|1nltA3|5e-10|14.5|55/74|g.54.1.1| RP:SCP:REP 669->703|1i3qI1|3e-08|25.7|35/49|g.41.3.1| HM:SCP:REP 17->601|1mw9X_|2.2e-198|45.4|559/0|e.10.1.1|1/1|Prokaryotic type I DNA topoisomerase| OP:NHOMO 2023 OP:NHOMOORG 1155 OP:PATTERN 333333323333333322222222111111111112211111111111122223222222211123-- 1121111111111111111-11111111111111111111111111111111111111111111111111111111221111231322444412341--1131112221211111111111111111111111111111111111132321111111111111111222211111111111111111222112234346343334434332222253413422221222223332222221232222223222311111211111211112211121111141122111111111111111111111121111111111111123333333333333326333333132232232133341211121122112111111111111111111112111111111111111-11112112112111111111111111111111111111111111111111111111111111111111111111111111111111111111116111112211111111111111162121211111132512111112111112111211111121411112111221122221111111111111121111111211311111232121111221333432323234334343333333333333331-111121--11133344333333333333-4333333333333333333334433454333443343443433533333223-333333333633--1111111111111123332333443333443211211111121122222331223322331111111111343333333433331121422111422311211111111111111111111111-111-1111111111111112112121222121 1122112-733111111111111111122111111111-121111111111111111-1111111111111-11111--111111111-121111111111-121211215232121211222-6313-8I2-322121121221-211122-42322234C24221212322321233N3232343241333121111 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------1---- STR:NPRED 681 STR:RPRED 96.9 SQ:SECSTR ##################EEEEEccHHHHHHHHTTccTTEEEEEcccccEEcccHHHcEETTTTTEEccEEcTTTHHHHHHHHHHHHHccEEEEcccccHHHHHHHHHHHHHHcccGGGEEEcccccccHHHHHHHHHccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHTcTTccccTTHHHHHHHHHHHHHHHHTccccEEEEEEEEEcTTccEEEEEEEEETTEEcccccHHHHHHHHHHHcHHccEEEEEEEEEEEEEcccccccHHHHHHHHHHHHcccHHHHHHHHHHHHHTTcTTcGGTcTcccccccccccccHHHHHHHHHHHHHHTcGGGcccccccccccccccccccccccccTTccGGGccccccHHHHHHHHHHHHHHHHHTcccEEEEEEEEEEEETTEEEEEEEEEEEEcGGGGTcccccccccccccccTTcEEEEEEEEEEEEEccccccccHHHHHHHHHHTTcccTTTHHHHHHHHHHTTcEEEETTEEEEcHHHHHHHHHHHHHcHHHHcHHHHHHHHHHHHHHHTTcccHHHHHHHHHHHHHHHHHHHTccGGGTcccccccccccGGGTcccEEEEEEEEEcccTTTcccccccEEEEEEEEEEEEcccEEcHHHHHTTcccEEEEccHHHHHHHHHHHHHHHHHHHHcTcTTTTccTTccHHEEEEEEEcccc#### DISOP:02AL 1-15,348-355,462-462,697-704| PSIPRED cccccccHHHHHHHHccccEEEEEcHHHHHHHHHHHccccEEEEEEccHHccccHHHcccHHHccccccEEcccHHHHHHHHHHHHHcccEEEEccccccHHHHHHHHHHHHHccccccEEEEEEEcccHHHHHHHHHccccccHHHHHHHHHHHHHHHHHHHHHcHHHHHHHccccEEccccHHHHHHHHHHHHHHHccccccEEEEEEEEEcccEEEEEEEEcccccccccccHHHHHHHHHHHHccccEEEEEEEEEEEEccccccccHHHHHHHHHHHccccHHHHHHHHHHHHHcccccccccEEEEEccccccccccHHHHHHHHHHHHHHHHHHHHHHccccccccccccccccccccccccccHHHHHHHccHHHHHHHHHHHHHHHHHHcccEEEEEEEEEEEEccEEEEEEEEEEEEccHHHHccccccccccccccccccEEEEEEEEEEEEEccccccccHHHHHHHHHHccccccccHHHHHHHHHHcccEEEEccEEEEcHHHHHHHHHHHHHccccccHHHHHHHHHHHHHHHcccccHHHHHHHHHHHHHHHHHHHHHHHHccccccccccccccccccccEEEEcccccEEEcccccccccccccccccccccccccccEEEEccccccccEEEEccccccccccccccccccccccccccEEEEcccccEEEccccccEEEcccc //