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Nocardia farcinica IFM 10152 (nfar0)
Gene : guaA
DDBJ      :guaA         putative GMP synthase
Swiss-Prot:GUAA_NOCFA   RecName: Full=GMP synthase [glutamine-hydrolyzing];         EC=6.3.5.2;AltName: Full=Glutamine amidotransferase;AltName: Full=GMP synthetase;

Homologs  Archaea  64/68 : Bacteria  850/915 : Eukaryota  190/199 : Viruses  0/175   --->[See Alignment]
c.23.16c.26.2d.52.2
:524 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   8->524 1gpmA PDBj e-121 49.4 %
:RPS:PDB   8->201 2a9vB PDBj 1e-39 24.9 %
:RPS:PDB   206->524 2dplA PDBj 2e-53 53.2 %
:RPS:SCOP  8->192 1gpmA2  c.23.16.1 * 2e-37 38.9 %
:RPS:SCOP  202->444 1xngA1  c.26.2.1 * 4e-33 23.8 %
:HMM:SCOP  6->226 1l9xA_ c.23.16.1 * 2.2e-54 38.8 %
:HMM:SCOP  182->445 2nsyA_ c.26.2.1 * 6.7e-56 39.2 %
:HMM:SCOP  403->524 1gpmA3 d.52.2.1 * 1e-45 66.9 %
:RPS:PFM   10->186 PF00117 * GATase 3e-16 31.6 %
:RPS:PFM   220->400 PF02540 * NAD_synthase 1e-12 37.9 %
:RPS:PFM   431->523 PF00958 * GMP_synt_C 2e-28 64.1 %
:HMM:PFM   9->189 PF00117 * GATase 1.8e-41 35.0 180/192  
:HMM:PFM   431->523 PF00958 * GMP_synt_C 4.8e-40 62.0 92/93  
:HMM:PFM   202->243 PF02540 * NAD_synthase 2.2e-08 46.3 41/242  
:HMM:PFM   371->400 PF02540 * NAD_synthase 0.00043 30.0 30/242  
:BLT:SWISS 1->524 GUAA_NOCFA 0.0 100.0 %
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID BAD55742.1 GT:GENE guaA GT:PRODUCT putative GMP synthase GT:DATABASE GIB00210CH01 GT:ORG nfar0 GB:ACCESSION GIB00210CH01 GB:LOCATION 999226..1000800 GB:FROM 999226 GB:TO 1000800 GB:DIRECTION + GB:GENE guaA GB:PRODUCT putative GMP synthase GB:PROTEIN_ID BAD55742.1 LENGTH 524 SQ:AASEQ MAETQRPVLVVDFGAQYAQLIARRVREASVYSEVVPHTATVEEIAAKKPLAVILSGGPASVYAEGAPQLDPRLFDLNLPVFGICYGFQAMAQALGGTVAHTGTREYGRTELNIDGGVLHGGLPTIQPVWMSHGDAVTDAPEGFEVTGTTAGAPVAAFEDRARRLAGVQYHPEVLHSPHGQQVLSRFLHELAGIPASWTPSNIADVLVEQVRAQVGDGHAICGLSGGVDSAVAAALVQRAIGDRLTCVFVDHGLLRAGEREQVQQDFVASTGAKLVTVDAVDKFLGELKGVTDPEEKRKIIGREFIRSFEDAVRQIVDEQGAAEGKQPEVEFLVQGTLYPDVVESGGGTGTANIKSHHNVGGLPEDLEFELVEPLRLLFKDEVRAVGRELGLPEEIVARQPFPGPGLAIRIIGEVTADRLATLRQADAIAREELTAAGLDRQIWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWTRLPYEVLERISTRITNEVAEVNRVVLDVTSKPPGTIEWE GT:EXON 1|1-524:0| SW:ID GUAA_NOCFA SW:DE RecName: Full=GMP synthase [glutamine-hydrolyzing]; EC=6.3.5.2;AltName: Full=Glutamine amidotransferase;AltName: Full=GMP synthetase; SW:GN Name=guaA; OrderedLocusNames=NFA_8970; SW:KW ATP-binding; Complete proteome; Glutamine amidotransferase;GMP biosynthesis; Ligase; Nucleotide-binding; Purine biosynthesis. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->524|GUAA_NOCFA|0.0|100.0|524/524| GO:SWS:NREP 6 GO:SWS GO:0005524|"GO:ATP binding"|ATP-binding| GO:SWS GO:0006541|"GO:glutamine metabolic process"|Glutamine amidotransferase| GO:SWS GO:0006177|"GO:GMP biosynthetic process"|GMP biosynthesis| GO:SWS GO:0016874|"GO:ligase activity"|Ligase| GO:SWS GO:0000166|"GO:nucleotide binding"|Nucleotide-binding| GO:SWS GO:0006164|"GO:purine nucleotide biosynthetic process"|Purine biosynthesis| SEG 145->156|vtgttagapvaa| BL:PDB:NREP 1 BL:PDB:REP 8->524|1gpmA|e-121|49.4|484/501| RP:PDB:NREP 2 RP:PDB:REP 8->201|2a9vB|1e-39|24.9|193/195| RP:PDB:REP 206->524|2dplA|2e-53|53.2|278/287| RP:PFM:NREP 3 RP:PFM:REP 10->186|PF00117|3e-16|31.6|177/185|GATase| RP:PFM:REP 220->400|PF02540|1e-12|37.9|153/208|NAD_synthase| RP:PFM:REP 431->523|PF00958|2e-28|64.1|92/93|GMP_synt_C| HM:PFM:NREP 4 HM:PFM:REP 9->189|PF00117|1.8e-41|35.0|180/192|GATase| HM:PFM:REP 431->523|PF00958|4.8e-40|62.0|92/93|GMP_synt_C| HM:PFM:REP 202->243|PF02540|2.2e-08|46.3|41/242|NAD_synthase| HM:PFM:REP 371->400|PF02540|0.00043|30.0|30/242|NAD_synthase| GO:PFM:NREP 8 GO:PFM GO:0003824|"GO:catalytic activity"|PF00117|IPR000991| GO:PFM GO:0003952|"GO:NAD+ synthase (glutamine-hydrolyzing) activity"|PF02540|IPR003694| GO:PFM GO:0005524|"GO:ATP binding"|PF02540|IPR003694| GO:PFM GO:0009435|"GO:NAD biosynthetic process"|PF02540|IPR003694| GO:PFM GO:0003922|"GO:GMP synthase (glutamine-hydrolyzing) activity"|PF00958|IPR001674| GO:PFM GO:0005524|"GO:ATP binding"|PF00958|IPR001674| GO:PFM GO:0006164|"GO:purine nucleotide biosynthetic process"|PF00958|IPR001674| GO:PFM GO:0006177|"GO:GMP biosynthetic process"|PF00958|IPR001674| RP:SCP:NREP 2 RP:SCP:REP 8->192|1gpmA2|2e-37|38.9|185/205|c.23.16.1| RP:SCP:REP 202->444|1xngA1|4e-33|23.8|214/255|c.26.2.1| HM:SCP:REP 6->226|1l9xA_|2.2e-54|38.8|219/0|c.23.16.1|1/1|Class I glutamine amidotransferase-like| HM:SCP:REP 182->445|2nsyA_|6.7e-56|39.2|237/271|c.26.2.1|1/1|Adenine nucleotide alpha hydrolases-like| HM:SCP:REP 403->524|1gpmA3|1e-45|66.9|121/0|d.52.2.1|1/1|GMP synthetase C-terminal dimerisation domain| OP:NHOMO 1750 OP:NHOMOORG 1104 OP:PATTERN 1112--2222222222-222111222222323222223222223212223222232222222221-21 2111221111111111111-1111211111121111114311111111111233211311111111112211111111112211111111221211---111111111111-------111111-221212121212222111112111111111113122122121111111111111111111211111212222222222222222222221222222223211111122111111111111111111111111111-1111111111111-11112221111111222212222222222221212222111111111112111111111111121211111212113221211312121221111111111222211111222111113222222222222222-33333332232111111111111123333222132222122222222122121221111111111---------------111113312322222222222322222222222222222222222221222222111122221111222222222222222111321111111111222222222222231222121211111112111111111112222221111111131111211222211122211-11112------33221323333333333-333333333333333333333322221333233333333333333333333112212222122221112111112211122111111111111111111111111221111111111311111112121111211111111222221111122212122222222111111111111111-1-1------1------1------1------1-11121222121 1111111-311-11222221222132222111212211322232222122223222122222211211112111112-2221111122-11121131111111222-1212111111112111112-11251-11211111-1111111-1111111112651111111133322111191112132232221132111 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 524 STR:RPRED 100.0 SQ:SECSTR ccTTGccEEEEEccccTTcHHHHHHHHTTccccEEETTccGGGGTTccEEEEccccccGGGTGGGHHHHHHHHHHccccEEEEEEcHHEEEEEcccTTcccccccccccEEEEETEEEEEccccccccEEEEEEEEHHHHHHHHHHcHHHHHHHHHTHHHHHccEEEEEccccccccccccccccccTTccccHHHHHHHHHHHHHHHHHHHHHTTccEEEEccccHHHHHHHHHHHHHHGGGEEEEEEEcccccTTHHHHHHHHHTTTTccEEEEEEcHHHHHHHTTTcccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTccEEEcccccccHHHcccHHHHHHTcccHTcccccccTccEEEcTTTTccHHHHHHHHHHTTccHHHHTcccccTTGGGGGccccccHHHHHHHHHHHHHHHHHHHHTTccccEEEEEEcccTcccEEEEccccEEEEEEEEEEEEEcccccccEEccccHHHHHHHHHHHHHHcTTEEEEEEcccccTTcccccc DISOP:02AL 1-4, 204-205| PSIPRED ccccccEEEEEEcccHHHHHHHHHHHHcccEEEEEEccccHHHHHHHcccEEEEccccccccccccHHHHHHHHHccccEEEEEHHHHHHHHHcccEEEEccccEEccEEEEEcccHHHccccccEEEEEEccEEEEEcccccEEEEEEccccEEEEEEccccEEEEEccccccccHHHHHHHHHHHHHHHcccccccccHHHHHHHHHHHHHHcccEEEEEEcccHHHHHHHHHHHHHHcccEEEEEEEcccccccHHHHHHHHHHHHccccEEEEcHHHHHHHHHcccccHHHHHHHHHHHHHHHHHHHHHHHHHHHcccccccccEEEEEEcccccEEEEccccccccccEEEEccccccccccEEEEccHHHccHHHHHHHHHHccccHHHHcccccccccccEEEEEcccHHHHHHHHHHHHHHHHHHHHHccccccEEEEEEEcccccEEEEcccccccccEEEEEEEEcccccccccccccHHHHHHHHHHHHHHccccEEEEEccccccccccccc //