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Nocardia farcinica IFM 10152 (nfar0)
Gene : leuA
DDBJ      :leuA         putative 2-isopropylmalate synthase
Swiss-Prot:             

Homologs  Archaea  52/68 : Bacteria  697/915 : Eukaryota  116/199 : Viruses  0/175   --->[See Alignment]
a.5.7c.1.10d.270.1
:597 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   14->596 3figA PDBj 0.0 80.5 %
:RPS:PDB   4->594 3bg9A PDBj 5e-77 11.8 %
:RPS:SCOP  56->365 1sr9A2  c.1.10.5 * 1e-83 84.5 %
:RPS:SCOP  432->483 1sr9A1  a.5.7.1 * 1e-18 84.8 %
:RPS:SCOP  484->596 1sr9A3  d.270.1.1 * 6e-22 67.3 %
:HMM:SCOP  56->365 1sr9A2 c.1.10.5 * 3.2e-100 39.7 %
:HMM:SCOP  432->483 1sr9A1 a.5.7.1 * 1.9e-16 53.8 %
:HMM:SCOP  484->597 1sr9A3 d.270.1.1 * 4e-38 47.4 %
:RPS:PFM   75->319 PF00682 * HMGL-like 1e-26 37.2 %
:RPS:PFM   467->595 PF08502 * LeuA_dimer 3e-18 39.4 %
:HMM:PFM   75->327 PF00682 * HMGL-like 4.8e-68 35.9 234/237  
:HMM:PFM   466->596 PF08502 * LeuA_dimer 3e-35 35.4 130/133  
:BLT:SWISS 3->596 LEU1_MYCLE 0.0 79.3 %
:PROS 74->90|PS00815|AIPM_HOMOCIT_SYNTH_1
:PROS 277->290|PS00816|AIPM_HOMOCIT_SYNTH_2
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID BAD55150.1 GT:GENE leuA GT:PRODUCT putative 2-isopropylmalate synthase GT:DATABASE GIB00210CH01 GT:ORG nfar0 GB:ACCESSION GIB00210CH01 GB:LOCATION complement(322994..324787) GB:FROM 322994 GB:TO 324787 GB:DIRECTION - GB:GENE leuA GB:PRODUCT putative 2-isopropylmalate synthase GB:PROTEIN_ID BAD55150.1 LENGTH 597 SQ:AASEQ MSPADAYVSGSRHITAPSKPAPADQPAWNAQKNSSMPAYRYRPFAEEVEPVTLPDRTWPDKVIDRAPGWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDYDFVREIIEDNAIPDDVTIQVLTQCRPELIERTFEACAGAANVIVHFYNSTSILQRRVVFRADREQVKKIATDAAKLCLEVEKRYPDTNWRYEYSPESYTGTELEYAREVCDAVSEIIAPTPEKPLIINLPATVEMATPNVYADSIEWMSRNLARRESIVLSLHPHNDRGTAVAAAELGYQAGADRIEGCLFGNGERTGNVCLVTLGMNMFSRGIDPQIDFSDIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDAMKAAADAQNADVSDIVWEVPYLPIDPKDVGRTYEAVIRVNSQSGKGGVAYIMKTDHGLVLPRRLQIEFSQVVQKITDGEGGEVTPKEMWDVFHEEYLAPIRPLERIRQKVTAAETDGGVDSITAVVKVDGVEQEITGQGNGPLAAFVDAIATVGYDVRVLDYSEHAMSAGDDAQAAAYVECAIGDKVVWGVGIATSITTASLRAVVSAVNRAH GT:EXON 1|1-597:0| BL:SWS:NREP 1 BL:SWS:REP 3->596|LEU1_MYCLE|0.0|79.3|593/607| PROS 74->90|PS00815|AIPM_HOMOCIT_SYNTH_1|PDOC00643| PROS 277->290|PS00816|AIPM_HOMOCIT_SYNTH_2|PDOC00643| SEG 383->398|damkaaadaqnadvsd| SEG 550->561|amsagddaqaaa| BL:PDB:NREP 1 BL:PDB:REP 14->596|3figA|0.0|80.5|570/574| RP:PDB:NREP 1 RP:PDB:REP 4->594|3bg9A|5e-77|11.8|552/601| RP:PFM:NREP 2 RP:PFM:REP 75->319|PF00682|1e-26|37.2|226/237|HMGL-like| RP:PFM:REP 467->595|PF08502|3e-18|39.4|127/132|LeuA_dimer| HM:PFM:NREP 2 HM:PFM:REP 75->327|PF00682|4.8e-68|35.9|234/237|HMGL-like| HM:PFM:REP 466->596|PF08502|3e-35|35.4|130/133|LeuA_dimer| GO:PFM:NREP 3 GO:PFM GO:0003824|"GO:catalytic activity"|PF00682|IPR000891| GO:PFM GO:0003852|"GO:2-isopropylmalate synthase activity"|PF08502|IPR013709| GO:PFM GO:0009098|"GO:leucine biosynthetic process"|PF08502|IPR013709| RP:SCP:NREP 3 RP:SCP:REP 56->365|1sr9A2|1e-83|84.5|310/310|c.1.10.5| RP:SCP:REP 432->483|1sr9A1|1e-18|84.8|46/46|a.5.7.1| RP:SCP:REP 484->596|1sr9A3|6e-22|67.3|113/115|d.270.1.1| HM:SCP:REP 56->365|1sr9A2|3.2e-100|39.7|310/0|c.1.10.5|1/1|Aldolase| HM:SCP:REP 432->483|1sr9A1|1.9e-16|53.8|52/0|a.5.7.1|1/1|post-HMGL domain-like| HM:SCP:REP 484->597|1sr9A3|4e-38|47.4|114/152|d.270.1.1|1/1|2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain| OP:NHOMO 1127 OP:NHOMOORG 865 OP:PATTERN ---1--2212222222-31121-22--11221213223333333222211111322-----1-11-11 1131211111111111111-111111111111111122221111112-2111111111--112111211111111111-12-111211111111---11--1-1111111---------------22123333313111111121111122211111111111111111211111111111111121112-11111111111111111111112111111121--11111122-1111111111111111111--------------------111-1--------111------------------------111111111-21-22-------1-13122----2-2--111122231112-112212--1-111111-----111111112111111111111111-11111111111-2111111111111111111121111111111111111111212-----------------------------21111122221233342312222232222222322222211222212223121212221212111111111111122-1312121111111-111122221221212112111111111--1-------11111222211221-2121111111111111111111-1-1111-11--111211211111111111-11-1111111111111111222121111111111111111111211111111-11111111111111-1---------22222111111-111-11111111111111211121121121111311111---11-1211111111111111111111111111111121222222--------------------------------------2--1-111211 --------------12211111112111111111111111111111111211111122111112222112212122222222222211-13221111111111111--2----------------------------------------------------------------2-1-2181111121211411121112 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 593 STR:RPRED 99.3 SQ:SECSTR ###HHHHHHcccccccccccccccccccccccccccccccHHHHHHTTccEHHHHHHHHHHHHHHccccEEEETTHHHHHHcTTccHHHHHHTHHHHHHHcccEEEEEEccHHHHHHHTccccHHHHHHcccccEEEEEcccHHHHHHHHHHHHHHTccEEEEEcccccHHHHHHHHHHHHHHTcEEEEEEEHHHHHHHHHTTcEccccTTcccccTTcHHHHHHHHHHHHHccccEEEEccEEEEEcTTccccHHHHHHHHHHHHHHcTTccHHHEEEEccTTcccTHHHHHHHHHTTccEEEEccGGGccTTccccHHHHHHHHTTcTTcccccHHHHHHHHHHHHHHHHHGGGGcGGGcTcccccTTHHHHcccHHHHHHHHHHHHHHHHTTTcHHHHHHHHHHHHHHHHHTTcccccHHHHHHHHHHHHHHHHTTccHHHHHHGGGcccccHHHHHHHTTcccccTTcccHHHHHHHHcccccccTTTTcccccHHHHHHHHHTTTccccHHHHHHHHHcHHHHHHHHHHHHHHccTTcccEEHHHHHHcccTTcEEEcccTTTcccEEEccccccTTTTccEEEEEccTHT# DISOP:02AL 1-4, 8-9, 13-48| PSIPRED cccccccccccccccccccccccccccccccccccccHHHHcccccccccccccHHccccccccccEEEEEcccccHHHcccccccHHHHHHHHHHHHHccccEEEEEEccccHHHHHHHHHHHHccccccccEEEEEEcccHHHHHHHHHHHHHccEEEEEEEcccHHHHHHHHHcccHHHHHHHHHHHHHHHHHHHHHHcccEEEEEEEEcccccccHHHHHHHHHHHHHHHHHcccccEEEEEccccccccHHHHHHHHHHHHHHcccccccEEEEEEcccHHHHHHHHHHHHHHcccEEEHHccccccccccccHHHHHHHHHHccccccccHHHHHHHHHHHHHHHccccccccccccccHHHHccccHHHHHHccHHHHHHHHHHHHccccccccccccccccHHHHcccEEEEEEEcHHHHHHHHHHHHHHHccccccHHHHHHHHHHHHHHHHHHcccccHHHHHHHHHHHHHcccccEEEEEEEEEEEEccccEEEEEEEEEEccEEEEEEEEcccHHHHHHHHHHHccccEEEEEEEEEEccccccEEEEEEEEEEEccEEEEEEEccHHHHHHHHHHHHHHHHHcc //