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Pyrobaculum aerophilum str. IM2 (paer1)
Gene : AAL63182.1
DDBJ      :             phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA)
Swiss-Prot:HIS4_PYRAE   RecName: Full=1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase;         EC=5.3.1.16;AltName: Full=Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase;

Homologs  Archaea  45/68 : Bacteria  421/915 : Eukaryota  1/199 : Viruses  0/175   --->[See Alignment]
c.1.2
:229 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   1->222 1qo2A PDBj 8e-10 27.4 %
:RPS:PDB   2->222 2a0nA PDBj 1e-06 11.0 %
:RPS:SCOP  1->222 1qo2A  c.1.2.1 * 1e-29 27.0 %
:HMM:SCOP  1->223 1qo2A_ c.1.2.1 * 4.4e-40 40.7 %
:RPS:PFM   2->222 PF00977 * His_biosynth 2e-13 28.7 %
:HMM:PFM   1->222 PF00977 * His_biosynth 4.5e-52 34.4 221/228  
:BLT:SWISS 1->229 HIS4_PYRAE e-109 100.0 %
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID AAL63182.1 GT:GENE AAL63182.1 GT:PRODUCT phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA) GT:DATABASE GIB00076CH01 GT:ORG paer1 GB:ACCESSION GIB00076CH01 GB:LOCATION 580134..580823 GB:FROM 580134 GB:TO 580823 GB:DIRECTION + GB:PRODUCT phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA) GB:NOTE Amino acid biosynthesis; Histidine family GB:PROTEIN_ID AAL63182.1 GB:DB_XREF GI:18159781 LENGTH 229 SQ:AASEQ MIIPSIDIEGGRAVKRIRGQRGNYIFQGDPLELAARFRKAPLVHVVDLDGAEAGGLVNISVISKIAEILEGRCELGGGLRSLEAVERALSLCQYAVVGSLPFKNWPLFRRAAELYRDRLAVSLDYRGGEVLVGGWREKAASIAEAVRRLEEAGPYAAVIVTSVEVEGTGGGVKADIDVKSLKRIARRVFYAGGVRDCNDVERAYALGFDGVIVGYALYAGDLKKCANWY GT:EXON 1|1-229:0| SW:ID HIS4_PYRAE SW:DE RecName: Full=1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; EC=5.3.1.16;AltName: Full=Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; SW:GN Name=hisA; OrderedLocusNames=PAE0991; SW:KW Amino-acid biosynthesis; Complete proteome; Cytoplasm;Histidine biosynthesis; Isomerase. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->229|HIS4_PYRAE|e-109|100.0|229/229| GO:SWS:NREP 4 GO:SWS GO:0008652|"GO:cellular amino acid biosynthetic process"|Amino-acid biosynthesis| GO:SWS GO:0005737|"GO:cytoplasm"|Cytoplasm| GO:SWS GO:0000105|"GO:histidine biosynthetic process"|Histidine biosynthesis| GO:SWS GO:0016853|"GO:isomerase activity"|Isomerase| SEG 67->83|eilegrcelggglrsle| SEG 160->172|vtsvevegtgggv| BL:PDB:NREP 1 BL:PDB:REP 1->222|1qo2A|8e-10|27.4|219/238| RP:PDB:NREP 1 RP:PDB:REP 2->222|2a0nA|1e-06|11.0|218/251| RP:PFM:NREP 1 RP:PFM:REP 2->222|PF00977|2e-13|28.7|216/229|His_biosynth| HM:PFM:NREP 1 HM:PFM:REP 1->222|PF00977|4.5e-52|34.4|221/228|His_biosynth| GO:PFM:NREP 1 GO:PFM GO:0000105|"GO:histidine biosynthetic process"|PF00977|IPR006062| RP:SCP:NREP 1 RP:SCP:REP 1->222|1qo2A|1e-29|27.0|215/241|c.1.2.1| HM:SCP:REP 1->223|1qo2A_|4.4e-40|40.7|216/0|c.1.2.1|1/1|Ribulose-phoshate binding barrel| OP:NHOMO 470 OP:NHOMOORG 467 OP:PATTERN ---1--1111111111-111111--111-111-11-11111111----111111-1-111------11 ----1------111-1111-11--111111111111111111-1111-1111111111--1-11111---1---------1--11111----11-----1-11111-11----------------11111111111111111111-111111-1111---1--11111111---1111-111-11111----11111111111111111111111111111-1111111111-------------------------1--1-------------1-111--------11-----------------------------1----11-11---1-----111111---1-1-----1111111-11111111--111-1111-----111111111111111111111111-11-11-11111-1111111111111111--11-1--1121111111111111111-----------------------------1111111111111111111111111111111111111111111111111111111--11111111111111111-1--1-1-1111-1111-1111111111111--1111111-------1-------1111111----11---------------------------1-11--------------------------------------------------------------------------------------------------1111-111-----------------------1111111111111111111111--------------------------------------1111--------------------------------------------1--------1- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------1------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 228 STR:RPRED 99.6 SQ:SECSTR EEEEEEEEETTEETTccccTTcccTEcTcHHHHHHHHHHccEEEEEEcccHHHHHHHHHHHHHHHHHHccccEEEEcccccHHHHHHHHHHTccEEEEcHHHHHcTHHHHcGGGEEEEEEEEEETTEEEEEETTTTEEEEEEHHHHHHHHHHTTccEEEEEETTTTTccccccHHHHHHHHGGGccccEEEEccccHHHHHHHHHTTccEEEEcHHHHTTccHHHHEc# DISOP:02AL 229-230| PSIPRED cEEEEEEEEccEEEEEEccccccEEEcccHHHHHHHHccccEEEEEEcHHHHccccccHHHHHHHHHHccccEEEEcccccHHHHHHHHHHccEEEEcHHHHccHHHHHHHHHHccccEEEEEEEcccEEEEccccccccccHHHHHHHHHcccccEEEEcccccccccccccHHHHHHHHHHccccEEEEcccccHHHHHHHHHccccEEEEEHHHHcccHHHHHHcc //