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Pyrobaculum aerophilum str. IM2 (paer1)
Gene : AAL63861.1
DDBJ      :             3-isopropylmalate dehydratase large subunit (leuC)
Swiss-Prot:LEUC_PYRAE   RecName: Full=3-isopropylmalate dehydratase large subunit;         EC=4.2.1.33;AltName: Full=Isopropylmalate isomerase;AltName: Full=Alpha-IPM isomerase;         Short=IPMI;

Homologs  Archaea  58/68 : Bacteria  745/915 : Eukaryota  176/199 : Viruses  0/175   --->[See Alignment]
c.83.1
:415 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   92->381 1c97A PDBj 3e-27 33.1 %
:RPS:PDB   4->383 1c96A PDBj 2e-87 26.5 %
:RPS:SCOP  18->387 2b3xA2  c.83.1.1 * 3e-75 24.1 %
:HMM:SCOP  3->413 1acoA2 c.83.1.1 * 3.7e-119 40.2 %
:RPS:PFM   20->383 PF00330 * Aconitase 8e-35 33.2 %
:HMM:PFM   19->237 PF00330 * Aconitase 2.9e-40 30.7 218/465  
:HMM:PFM   281->404 PF00330 * Aconitase 1.1e-26 33.1 124/465  
:BLT:SWISS 1->415 LEUC_PYRAE 0.0 100.0 %
:PROS 287->303|PS00450|ACONITASE_1
:PROS 345->358|PS01244|ACONITASE_2
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID AAL63861.1 GT:GENE AAL63861.1 GT:PRODUCT 3-isopropylmalate dehydratase large subunit (leuC) GT:DATABASE GIB00076CH01 GT:ORG paer1 GB:ACCESSION GIB00076CH01 GB:LOCATION 1165919..1167166 GB:FROM 1165919 GB:TO 1167166 GB:DIRECTION + GB:PRODUCT 3-isopropylmalate dehydratase large subunit (leuC) GB:NOTE Amino acid biosynthesis; Pyruvate family GB:PROTEIN_ID AAL63861.1 GB:DB_XREF GI:18160513 LENGTH 415 SQ:AASEQ MPTWTEYILYKKLGKTPSPGDVVEIVPDLVGFHDLTGYHVLEVLESMGKVEVFDRERVVVAFDHLSPPPNQRAAEIMVYIRRHVKALGLPNFYDVGGGILHQIILEKYALPGQVIFAADSHTNTAGAVGAFAHGMGATDIAAALKLGKTWIVVPAPFRIDVVGEFPIGVMGKDVALHLLGQFGAEGFNGYSVEVFVETPKAFPMDDRATVANMSTEMGADALMFIPDVITAEYLKTERGVDYTPPRIEPGNYADKYTVELPRLEPLVAAPYSVDNIKSVREVEGVEVDQVFIGSCTNGRLSDIAVAAKILKGRRVKSRCIAIPASYEVFRRAMKLGYIDVLTEAGCVVTYGTCGPCLGGHFGVAGPGEVVVTTSNRNFRGRVGHPDAKIYLANPAVAAATAAEGKIADPRPYLRG GT:EXON 1|1-415:0| SW:ID LEUC_PYRAE SW:DE RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33;AltName: Full=Isopropylmalate isomerase;AltName: Full=Alpha-IPM isomerase; Short=IPMI; SW:GN Name=leuC; OrderedLocusNames=PAE1984; SW:KW 4Fe-4S; Amino-acid biosynthesis;Branched-chain amino acid biosynthesis; Complete proteome; Iron;Iron-sulfur; Leucine biosynthesis; Lyase; Metal-binding. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->415|LEUC_PYRAE|0.0|100.0|415/415| GO:SWS:NREP 7 GO:SWS GO:0051539|"GO:4 iron, 4 sulfur cluster binding"|4Fe-4S| GO:SWS GO:0008652|"GO:cellular amino acid biosynthetic process"|Amino-acid biosynthesis| GO:SWS GO:0009082|"GO:branched chain family amino acid biosynthetic process"|Branched-chain amino acid biosynthesis| GO:SWS GO:0051536|"GO:iron-sulfur cluster binding"|Iron-sulfur| GO:SWS GO:0009098|"GO:leucine biosynthetic process"|Leucine biosynthesis| GO:SWS GO:0016829|"GO:lyase activity"|Lyase| GO:SWS GO:0046872|"GO:metal ion binding"|Metal-binding| PROS 287->303|PS00450|ACONITASE_1|PDOC00423| PROS 345->358|PS01244|ACONITASE_2|PDOC00423| SEG 390->408|ylanpavaaataaegkiad| BL:PDB:NREP 1 BL:PDB:REP 92->381|1c97A|3e-27|33.1|287/753| RP:PDB:NREP 1 RP:PDB:REP 4->383|1c96A|2e-87|26.5|377/753| RP:PFM:NREP 1 RP:PFM:REP 20->383|PF00330|8e-35|33.2|361/434|Aconitase| HM:PFM:NREP 2 HM:PFM:REP 19->237|PF00330|2.9e-40|30.7|218/465|Aconitase| HM:PFM:REP 281->404|PF00330|1.1e-26|33.1|124/465|Aconitase| GO:PFM:NREP 1 GO:PFM GO:0008152|"GO:metabolic process"|PF00330|IPR001030| RP:SCP:NREP 1 RP:SCP:REP 18->387|2b3xA2|3e-75|24.1|370/629|c.83.1.1| HM:SCP:REP 3->413|1acoA2|3.7e-119|40.2|408/527|c.83.1.1|1/1|Aconitase iron-sulfur domain| OP:NHOMO 2132 OP:NHOMOORG 979 OP:PATTERN 11-2--2222222222-2111112211222322222222222222222322222221-1--3--2-33 1212211222222112211-11111411111111111133211122211221212212--221-13311211222111-111322222222212---1111213322232---------------12121111123222322222222222221122212122222222322222222222222222222112122222222222222211221122221211-121121111-1111111111111111111-------1------------111212-------111------------------------111111-11-24-22111111121232221---2-21-1322211222221222222--2-223221-----312211111111111111111111-113114211121111211111111215322222222123111111111222132111111111-----------------1111211212486353334333222233532222-243565762255322222222234223222243222333311132222222222222222-232233222222213231111111111-11111111-1111122221222323232222222222222222222-1-4311-11--132323243333333333-3323333333333223325232222223232323332323223232233332-22222222222211-311111----23211111113-11112222333333344432222223433334324441-1-11-1-221121111132233333232233322221121332222-------------------------------------12--2-222112 ----113-1---2246533655568754434444444444444444334655865455444444444434454454413444444444-46454455554444656-32322511111---11-12-113I1-114--111-111-111-1-11-111212312111412513112222R1111212354122133332 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 389 STR:RPRED 93.7 SQ:SECSTR HHHHHTTcccTTTccccTTTcEEEEcccEEEEETTTHHHHHHHHHHHTcccccccEEEEcEcccccccccHHTHHHHHHHHHHHHHHTcEEEEcTTcccHHHHHHHHTccTTcEEEEccTTGGGGGGGTcEEEEccHHHHHHHHHTccEEEEccEEEEEEEEccccTTccHHHHHHHHHHHHTTTTTTTEEEEEEcGGGGGccHHHHHHHHHHGGGGTccEEEccccHHHHHHHHHTTcHHHGccccTTccccEEEEEEGGGcccEEEccccTTcEEEHHHHccccEEEEEEcTTTcccHHHHHHHHHHHHTTTcccEEEEccccHHHHHHHHHTTHHHHHHHTTEEEcccccGGGGTcccccccTTcEEEEccccccTTTTTTTccEE########################## DISOP:02AL 414-416| PSIPRED cccHHHHHHHHHcccccccccEEEEEEEEEEEEccccHHHHHHHHHcccccccccccEEEEEccccccccHHHHHHHHHHHHHHHHHccccEEcccccEEEEEEcccccccccEEEEcccccccccccccEEEcccHHHHHHHHHcccEEEccccEEEEEEEEEccccccHHHHHHHHHHHHccccccEEEEEEEccHHHcccHHHHHHHHHHHHHHccEEEEEccHHHHHHHHHHccccccHHcccccccccEEEEEEHHHccEEEEccccHHHcEEcHHcccccEEEEEEEcccccccHHHHHHHHHHccccccccEEEEcccHHHHHHHHHcccHHHHHHcccEEEcccHHHcccccccccccccEEEEEccccccccccccccEEEEccHHHHHHHHHHcccccHHHHHcc //