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Pyrobaculum aerophilum str. IM2 (paer1)
Gene : AAL64596.1
DDBJ      :             DNA topoisomerase (topA)
Swiss-Prot:             

Homologs  Archaea  66/68 : Bacteria  879/915 : Eukaryota  193/199 : Viruses  1/175   --->[See Alignment]
e.10.1
:602 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   3->583 1cy6A PDBj 8e-38 29.7 %
:RPS:PDB   2->593 1cy7A PDBj e-110 26.0 %
:RPS:SCOP  1->579 1d6mA  e.10.1.1 * e-103 23.3 %
:HMM:SCOP  1->578 1mw9X_ e.10.1.1 * 6.2e-142 35.7 %
:RPS:PFM   2->116 PF01751 * Toprim 3e-06 46.4 %
:RPS:PFM   155->555 PF01131 * Topoisom_bac 2e-42 36.3 %
:HMM:PFM   156->563 PF01131 * Topoisom_bac 4.4e-106 35.9 390/404  
:HMM:PFM   2->137 PF01751 * Toprim 2.7e-20 39.4 94/96  
:BLT:SWISS 3->587 TOP1_ARCFU 2e-83 35.5 %
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID AAL64596.1 GT:GENE AAL64596.1 GT:PRODUCT DNA topoisomerase (topA) GT:DATABASE GIB00076CH01 GT:ORG paer1 GB:ACCESSION GIB00076CH01 GB:LOCATION 1781522..1783330 GB:FROM 1781522 GB:TO 1783330 GB:DIRECTION + GB:PRODUCT DNA topoisomerase (topA) GB:NOTE DNA metabolism; DNA replication, recombination, and repair GB:PROTEIN_ID AAL64596.1 GB:DB_XREF GI:18161303 LENGTH 602 SQ:AASEQ MKLIVAEKRSVAQSIAKFLGRSYKSQKLYGVSVYRFNYGGGEAVAIGLSGHIMDFDFAARQNVWTWLPPEELFNATPILVLRGETLKYVKALKSLATKADEVYLALDADVEGEAIAYETALVVKMVNPRARLYRVRFNAVTYKEIVSAFQKPTYIDLKKVEKVFTRMQVDLTLGAVFTRFLTLTVRNSLNKGQFLSYGPCQTPVLGIVVTRELQRRNFKPEKYYVIKAVVEIGSSKVEMSADAKFKTKGEAEAIAATIKRGVVKIAVYKPHYVEPPEPLETVELERRASRWLGINSKKTLDIAEELYRAGYISYPRTETTIYPPTLDLKEVLEELTAGEHGPYALELLRKGFKPTRGDSDDGAHPPIYPTKGATRAEIFKVFGKAGGHAWAVYDLVVRHFLATLSPPALVEKQKIVVSFGKIELSAEGQRTIDEGYWRIYPWERQPEKPLPRVAPGEPARAVEIRVVERETEPPPQMTESELLALMKKYGIGTDATMQDHIYTNIKRGYVKLVKGKCIPTALGISLATSLFQYAPELIEPTVRAKIEKSLNSIVKDGVSPAKLIAEIKLEFSKYYQNLKAKREEIKKALETALYSIQQQSRG GT:EXON 1|1-602:0| BL:SWS:NREP 1 BL:SWS:REP 3->587|TOP1_ARCFU|2e-83|35.5|564/663| SEG 273->285|veppepletvele| BL:PDB:NREP 1 BL:PDB:REP 3->583|1cy6A|8e-38|29.7|529/562| RP:PDB:NREP 1 RP:PDB:REP 2->593|1cy7A|e-110|26.0|549/563| RP:PFM:NREP 2 RP:PFM:REP 2->116|PF01751|3e-06|46.4|84/110|Toprim| RP:PFM:REP 155->555|PF01131|2e-42|36.3|383/407|Topoisom_bac| HM:PFM:NREP 2 HM:PFM:REP 156->563|PF01131|4.4e-106|35.9|390/404|Topoisom_bac| HM:PFM:REP 2->137|PF01751|2.7e-20|39.4|94/96|Toprim| GO:PFM:NREP 4 GO:PFM GO:0003677|"GO:DNA binding"|PF01131|IPR013497| GO:PFM GO:0003916|"GO:DNA topoisomerase activity"|PF01131|IPR013497| GO:PFM GO:0005694|"GO:chromosome"|PF01131|IPR013497| GO:PFM GO:0006265|"GO:DNA topological change"|PF01131|IPR013497| RP:SCP:NREP 1 RP:SCP:REP 1->579|1d6mA|e-103|23.3|554/603|e.10.1.1| HM:SCP:REP 1->578|1mw9X_|6.2e-142|35.7|538/0|e.10.1.1|1/1|Prokaryotic type I DNA topoisomerase| OP:NHOMO 1799 OP:NHOMOORG 1139 OP:PATTERN 223333323333333221222222111111111112211111111111122222222222211122-- 1111111111111111111-1111111111111111111111111-111111111-11111111111-1111---1211121231322444412131--113111222121------1111111111111111111111111111132321111111111111111222211111111111111111122112234345333333334331222243413422221222223332222221232222222221311111211111211112211121111141122111111111111111111111121111111111111123333333333323226223322132221222133341211121112112111111111111111111112111111111111111-1121211211211111-11111111111111111111111111111111111-1111111111-1111111111-11111111111111111115111112211111111111111142121211111132412111-1211111211121111111121111211122111222111111-111111111111111211211211121111111221331211322123112121121111111111111-111121--11122223222222222222-3222222222222222222223322133222322232332322423222222-122222222322--111111111111112222223222121233221121111112112222233122222223111111111112112222221111112142211141121121111111111-111111111111-111-111---111111111211112112211- 1122112-632111111111111111122111122111112111111111111111111111111111111111111-2111111111-1211111111111121211215232221222222273131EL2-322222222222-222222-42322234C23222212422222123L3432242131233221112 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------1---- STR:NPRED 595 STR:RPRED 98.8 SQ:SECSTR cEEEEEccHHHHHHHHTTccTTEEEEEcccEcccccEEETTTEEEEEcccccEEccccccHHHHHHHTEETTTTTEEccEEcTTTHHHHHHHHHHHHTccEEEEcccccHHHHHHHHHHHHHHcccGGGHGEEEcccccccHHHHHHHHHccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHTcTHHHHcTTccccTTHHHHHHHHHHHHHHHHHccccEEEEEEEEEEcccccEEEEEEEEETcHHHHHHHHHHHTTccEEEcccEEEEEcccccccHHHHHHHHHHHHcccHHHHHHHHHHHHHTTcccccccccccccHHHHHHHHHHHHHHHHHHHTcGGGccccGcccccccccccccccccccTTccGGGccccccccHHHHHHHHHHHHHHHHHTcccEEEEEEEEEEEETTEEEEEEEEEEEEcGGGGGcccccccccccccccTTcEEEEEEEEEEEEEccccccccHHHHHHHHHHTTcccTTTHHHHHHHTTTTTcEEEETTEEEEcHHHHHHHHHHHHHcHHHHcHHHHHHHHHHHHHHHTTcccHHHHHHHHHHHHHHHHHHHHccGGGTcccccccccc####### DISOP:02AL 270-272, 349-361, 586-587, 592-602| PSIPRED cEEEEEEcHHHHHHHHHHccccEEEccccccccEEEEEccccEEEEEccHHHcccccccccccccccccccccccccEEEEcccHHHHHHHHHHHHHHccEEEEEccccccHHHHHHHHHHHHHHcccccEEEEEEEEcccHHHHHHHHHccccccHHHHHHHHHHHHHHHHHHHHccHHHHHHHHHcccccccEEEcccHHHHHHHHHHHHHHHHccccccEEEEEEEEEcccEEEEEEcccccccHHHHHHHHHHHcccEEEEEEEEEEEEcccccccHHHHHHHHHHHHcccHHHHHHHHHHHHHcccEEEcccccccccccHHHHHHHHHHHcccccHHHHHHHcccccccccccccccccccccccccccHHHHHHHHcccHHHHHHHHHHHHHHHHHHccccEEEEEEEEEEEccEEEEEEEEEEEcccHHHcccccccccccccccccccEEEEEEEEEEccEEcccccccHHHHHHHHHHcccccccccHHHHHHHHccccEEEEccEEEEcHHHHHHHHHHHHHccccccHHHHHHHHHHHHHHHHccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccccccccc //