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Pyrobaculum aerophilum str. IM2 (paer1)
Gene : AAL64871.1
DDBJ      :             GMP synthetase (glutamine-hydrolysing)
Swiss-Prot:GUAA_PYRAE   RecName: Full=GMP synthase [glutamine-hydrolyzing];         EC=6.3.5.2;AltName: Full=Glutamine amidotransferase;AltName: Full=GMP synthetase;

Homologs  Archaea  64/68 : Bacteria  851/915 : Eukaryota  190/199 : Viruses  0/175   --->[See Alignment]
c.23.16c.26.2d.52.2
:505 amino acids
:SECSTR
:PSIPRED
:BLT:PDB   3->503 1gpmA PDBj e-103 42.2 %
:RPS:PDB   3->113 1aa7B PDBj 2e-15 6.3 %
:RPS:PDB   92->502 3dlaB PDBj 4e-44 10.0 %
:RPS:SCOP  3->185 1gpmA2  c.23.16.1 * 4e-37 41.0 %
:RPS:SCOP  191->384 1gpmA1  c.26.2.1 * 4e-23 42.5 %
:RPS:SCOP  385->503 1gpmA3  d.52.2.1 * 7e-22 43.7 %
:HMM:SCOP  1->220 1l9xA_ c.23.16.1 * 1.6e-54 37.6 %
:HMM:SCOP  176->427 2nsyA_ c.26.2.1 * 7.9e-57 38.1 %
:HMM:SCOP  385->503 1gpmA3 d.52.2.1 * 3.2e-40 59.7 %
:RPS:PFM   17->180 PF00117 * GATase 1e-16 38.4 %
:RPS:PFM   227->382 PF02540 * NAD_synthase 8e-08 35.4 %
:RPS:PFM   412->503 PF00958 * GMP_synt_C 4e-25 53.3 %
:HMM:PFM   6->183 PF00117 * GATase 5.2e-38 32.8 177/192  
:HMM:PFM   413->503 PF00958 * GMP_synt_C 5e-35 56.0 91/93  
:HMM:PFM   203->277 PF02540 * NAD_synthase 1.3e-11 32.0 75/242  
:HMM:PFM   353->382 PF02540 * NAD_synthase 0.00011 40.0 30/242  
:BLT:SWISS 1->505 GUAA_PYRAE 0.0 100.0 %
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID AAL64871.1 GT:GENE AAL64871.1 GT:PRODUCT GMP synthetase (glutamine-hydrolysing) GT:DATABASE GIB00076CH01 GT:ORG paer1 GB:ACCESSION GIB00076CH01 GB:LOCATION 2017200..2018717 GB:FROM 2017200 GB:TO 2018717 GB:DIRECTION + GB:PRODUCT GMP synthetase (glutamine-hydrolysing) GB:NOTE Purines, pyrimidines, nucleosides, and nucleotides; Purine ribonucleotide biosynthesis GB:PROTEIN_ID AAL64871.1 GB:DB_XREF GI:18161600 LENGTH 505 SQ:AASEQ MEKVLVVNFGGQYAHLIARRIREVGVYAEIASPEEAVIKASKEEVKAVILSGGPSSVYEPGAPDIDEGIFALSKPVLGICYGHQMIAKKLGGKVERGKGEYGKTIVKILVNDPLFDGWKPEEAVWMSHSDFVEEPPPGFHVLAISENGYIAAMRKGLIYGVQFHPEVHHTSKGRVMFENFLRKIARISDVWRPEDQITRIVEEIRSRVKGGDVIVGVSGGVDSTVTAVLLYKAVGQRVKAVFIDHGLFREGEPEEAASLLKSIGIDVVYIDAKERFLKRLEGVADCEEKRRIIGETFAEVFSDAVKQMPNVKYLAQGTLYPDVVESGAVKGADKIKSHHNVGGLPPWFQLELIEPLREFYKDEVRRIAKALGLPEDVVYRHPFPGPGLAVRIIGPFTREKLAIVRKATKIVEEELRKAGLFRKVWQAFATVGEDKWVGVKGDRRAMGYIVTVRIVESEDAMTADWSRIPFEILEKISSRITSEIPEVTMVTYAVTSKPPSTIEPC GT:EXON 1|1-505:0| SW:ID GUAA_PYRAE SW:DE RecName: Full=GMP synthase [glutamine-hydrolyzing]; EC=6.3.5.2;AltName: Full=Glutamine amidotransferase;AltName: Full=GMP synthetase; SW:GN Name=guaA; OrderedLocusNames=PAE3369; SW:KW ATP-binding; Complete proteome; Glutamine amidotransferase;GMP biosynthesis; Ligase; Nucleotide-binding; Purine biosynthesis. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->505|GUAA_PYRAE|0.0|100.0|505/505| GO:SWS:NREP 6 GO:SWS GO:0005524|"GO:ATP binding"|ATP-binding| GO:SWS GO:0006541|"GO:glutamine metabolic process"|Glutamine amidotransferase| GO:SWS GO:0006177|"GO:GMP biosynthetic process"|GMP biosynthesis| GO:SWS GO:0016874|"GO:ligase activity"|Ligase| GO:SWS GO:0000166|"GO:nucleotide binding"|Nucleotide-binding| GO:SWS GO:0006164|"GO:purine nucleotide biosynthetic process"|Purine biosynthesis| SEG 210->226|ggdvivgvsggvdstvt| BL:PDB:NREP 1 BL:PDB:REP 3->503|1gpmA|e-103|42.2|481/501| RP:PDB:NREP 2 RP:PDB:REP 3->113|1aa7B|2e-15|6.3|111/157| RP:PDB:REP 92->502|3dlaB|4e-44|10.0|390/649| RP:PFM:NREP 3 RP:PFM:REP 17->180|PF00117|1e-16|38.4|159/185|GATase| RP:PFM:REP 227->382|PF02540|8e-08|35.4|130/208|NAD_synthase| RP:PFM:REP 412->503|PF00958|4e-25|53.3|92/93|GMP_synt_C| HM:PFM:NREP 4 HM:PFM:REP 6->183|PF00117|5.2e-38|32.8|177/192|GATase| HM:PFM:REP 413->503|PF00958|5e-35|56.0|91/93|GMP_synt_C| HM:PFM:REP 203->277|PF02540|1.3e-11|32.0|75/242|NAD_synthase| HM:PFM:REP 353->382|PF02540|0.00011|40.0|30/242|NAD_synthase| GO:PFM:NREP 8 GO:PFM GO:0003824|"GO:catalytic activity"|PF00117|IPR000991| GO:PFM GO:0003952|"GO:NAD+ synthase (glutamine-hydrolyzing) activity"|PF02540|IPR003694| GO:PFM GO:0005524|"GO:ATP binding"|PF02540|IPR003694| GO:PFM GO:0009435|"GO:NAD biosynthetic process"|PF02540|IPR003694| GO:PFM GO:0003922|"GO:GMP synthase (glutamine-hydrolyzing) activity"|PF00958|IPR001674| GO:PFM GO:0005524|"GO:ATP binding"|PF00958|IPR001674| GO:PFM GO:0006164|"GO:purine nucleotide biosynthetic process"|PF00958|IPR001674| GO:PFM GO:0006177|"GO:GMP biosynthetic process"|PF00958|IPR001674| RP:SCP:NREP 3 RP:SCP:REP 3->185|1gpmA2|4e-37|41.0|183/205|c.23.16.1| RP:SCP:REP 191->384|1gpmA1|4e-23|42.5|174/175|c.26.2.1| RP:SCP:REP 385->503|1gpmA3|7e-22|43.7|119/121|d.52.2.1| HM:SCP:REP 1->220|1l9xA_|1.6e-54|37.6|218/0|c.23.16.1|1/1|Class I glutamine amidotransferase-like| HM:SCP:REP 176->427|2nsyA_|7.9e-57|38.1|236/271|c.26.2.1|1/1|Adenine nucleotide alpha hydrolases-like| HM:SCP:REP 385->503|1gpmA3|3.2e-40|59.7|119/0|d.52.2.1|1/1|GMP synthetase C-terminal dimerisation domain| OP:NHOMO 1783 OP:NHOMOORG 1105 OP:PATTERN 2212--3343344443-322222343334335333222333332222323333233222222331-22 2211221222121112211-1122222222212222121221111111111211211122112111113313222222112221212222332311---112231211311-------111111-222222221222111122222114111222222121111212111112212222111232321211222222222222222222212222222222223333333322111111111111111111111111111-1111111111111113222222222222222222222222222222222222211222111123123111111111122321212212112112211222111222212121121222211111232111122121311111111112-22222232122122212211121112231111111111111111111111111121111111111---------------111112222232221222222322222211222222221221222112222222222222122222222222222221111121231111111111212221132221323122222233333212111111122222221111211211132222212222132221231-11321------12221112222222222-222221222222222222223222221111112111112121112222222111111111111111113221222222111122111112222212221111111111211111122121111122222222222212221111111111122222222221111112111111111111-1-1------1-------------1------1121121222131 1111111-311-11111111111111111111111111211121111112112111111111111211112212111-1121111111-11111131111111111-2212111111112111112-11251-11211111-1111111-1111111112641111111123322121191111222251321122221 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 504 STR:RPRED 99.8 SQ:SECSTR GccEEEEEccccTTcHHHHHHHHTTccccEEETTccccGGGGTTccEEEEccccGGGTGGGHHHHHHHHHHccccEEEETHHHHHHHHHTccTTccccccccccEEEEETTEEEEEccccccccEEEEEEEEHHHHHHHHHHcHHHHHHHHHHHHHccEEEEEccccccccccccccccccTTccccHHHHHHHHHHHHHHHHHHHHHHHTTccEEEEEccccHHHHHHHHHHHHHHTTccGGGEEEEEccccHHHHHHHHHHTcEEEEcccHHHHHHHTTcccHHHHHHHHHHHHHHHHHHHHHHHHHHHTEEEEEcccHHHHHcccHHHHHHTcccHTcccccccTTcccEEccTTccHHHHHHHHHHHHHHcTTHHHHHHHHHHHHHHHcccTTcccHHHHHHHHHHHHHcccHHHHHHHHHHHHccTTcccccccccGGGcccccHHHHHHHHHHHHHHTTcHHHHHTcHcccccccTTccccTTTTcccccccccHHHH# PSIPRED ccEEEEEEccccHHHHHHHHHHHcccEEEEEcccccHHHHHHccccEEEEcccccccccccccHHHHHHHHccccEEEEcHHHHHHHHHcccEEEEccccccccEEEEccccHHHccccccEEEEEEEEEEEEEcccccEEEEEEccccEEEEEcccEEEEcccccccccccHHHHHHHHHHHHccccccccccHHHHHHHHHHHHHccccEEEEEEcccHHHHHHHHHHHHHccccEEEEEEcccccccccHHHHHHHHHHccccEEEEccHHHHHHHHccccccHHHHHHHHHHHHHHHHHHHHHHcccEEEEEcccccHHHccccccccccccEEEEccccccccccEEEcHHHHHHHHHHHHHHHHHcccHHHHcccccccccEEEEEcccccHHHHHHHHHHHHHHHHHHHHcccccccHHHEEEccccccccccccccccccEEEEEEEEcccccccccccccHHHHHHHHHHHHcccccccEEEcccccccccccccc //