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Candidatus Pelagibacter ubique HTCC1062 (pubi0)
Gene : fhs
DDBJ      :fhs          formate-tetrahydrofolate ligase
Swiss-Prot:FTHS_PELUB   RecName: Full=Formate--tetrahydrofolate ligase;         EC=6.3.4.3;AltName: Full=Formyltetrahydrofolate synthetase;         Short=FHS;         Short=FTHFS;

Homologs  Archaea  7/68 : Bacteria  350/915 : Eukaryota  187/199 : Viruses  0/175   --->[See Alignment]
c.37.1
:561 amino acids
:SECSTR
:PSIPRED
:BLT:PDB   7->559 1fp7A PDBj 0.0 59.4 %
:RPS:PDB   7->559 1eg7A PDBj 8e-77 57.6 %
:RPS:SCOP  7->559 1eg7A  c.37.1.10 * 9e-76 57.4 %
:HMM:SCOP  7->559 1eg7A_ c.37.1.10 * 2.4e-257 63.8 %
:RPS:PFM   6->561 PF01268 * FTHFS 0.0 64.9 %
:HMM:PFM   4->561 PF01268 * FTHFS 2.6e-273 62.5 555/555  
:BLT:SWISS 1->561 FTHS_PELUB 0.0 100.0 %
:PROS 108->118|PS00721|FTHFS_1
:PROS 333->344|PS00722|FTHFS_2
:TM
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID AAZ22089.1 GT:GENE fhs GT:PRODUCT formate-tetrahydrofolate ligase GT:DATABASE GIB00256CH01 GT:ORG pubi0 GB:ACCESSION GIB00256CH01 GB:LOCATION 1218954..1220639 GB:FROM 1218954 GB:TO 1220639 GB:DIRECTION + GB:GENE fhs GB:PRODUCT formate-tetrahydrofolate ligase GB:PROTEIN_ID AAZ22089.1 GB:DB_XREF GI:71063086 GB:GENE:GENE fhs LENGTH 561 SQ:AASEQ MSEVKSDIQIAREAKMQPINDILAKINVPDESSAFSPMGRHIAKINLEYLDTLKDKPNGKLVLVTAITPTPAGEGKTTTSVGLNDGLNKIGKKSIVCLREPSLGPSFGMKGGAAGGGYAQVVPMEQINLHFTGDFHAITSAHNLLSALIDNHIYWGNKLDIDVRRIVWKRVMDMNDRSLRSININLGGVANGFPREDGFDITVASEIMAIFCLSNDLEDLEKRIGNITIAYTRDKKPVYAKDLKAQGPMTVLLKDAIRPNVTQTLENNPAIIHGGPFANIAHGCNSVIATKTGLKLADYVVTEAGFGADLGAEKFLDIKCRKSDLKPSCVVIVATIRALKMHGGVAKDDLKTENVEALKKGLVNLQRHVENVKKFGLPVAVAVNHFIKDTENEVKALIEFCDTIGVKASLCTHWANGGEGTKELASHVAELCEKNEDKFKFLYESKTPLFKKIETIAKEIYRADEVIADTKIRDQLKSFEDAGYGDFPICIAKTQYSFSTDPSLKGAPTGHSLPIREIKLSSGAEFIVVICGAVMTMPGLPRVPAADSIKLNKDGEIEGLF GT:EXON 1|1-561:0| SW:ID FTHS_PELUB SW:DE RecName: Full=Formate--tetrahydrofolate ligase; EC=6.3.4.3;AltName: Full=Formyltetrahydrofolate synthetase; Short=FHS; Short=FTHFS; SW:GN Name=fhs; OrderedLocusNames=SAR11_1285; SW:KW ATP-binding; Complete proteome; Ligase; Nucleotide-binding;One-carbon metabolism. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->561|FTHS_PELUB|0.0|100.0|561/561| GO:SWS:NREP 4 GO:SWS GO:0005524|"GO:ATP binding"|ATP-binding| GO:SWS GO:0016874|"GO:ligase activity"|Ligase| GO:SWS GO:0000166|"GO:nucleotide binding"|Nucleotide-binding| GO:SWS GO:0006730|"GO:one-carbon metabolic process"|One-carbon metabolism| PROS 108->118|PS00721|FTHFS_1|PDOC00595| PROS 333->344|PS00722|FTHFS_2|PDOC00595| TM:NTM 1 TM:REGION 519->541| SEG 111->117|ggaaggg| BL:PDB:NREP 1 BL:PDB:REP 7->559|1fp7A|0.0|59.4|549/549| RP:PDB:NREP 1 RP:PDB:REP 7->559|1eg7A|8e-77|57.6|549/549| RP:PFM:NREP 1 RP:PFM:REP 6->561|PF01268|0.0|64.9|553/553|FTHFS| HM:PFM:NREP 1 HM:PFM:REP 4->561|PF01268|2.6e-273|62.5|555/555|FTHFS| GO:PFM:NREP 3 GO:PFM GO:0004329|"GO:formate-tetrahydrofolate ligase activity"|PF01268|IPR000559| GO:PFM GO:0005524|"GO:ATP binding"|PF01268|IPR000559| GO:PFM GO:0009396|"GO:folic acid and derivative biosynthetic process"|PF01268|IPR000559| RP:SCP:NREP 1 RP:SCP:REP 7->559|1eg7A|9e-76|57.4|549/549|c.37.1.10| HM:SCP:REP 7->559|1eg7A_|2.4e-257|63.8|549/0|c.37.1.10|1/1|P-loop containing nucleoside triphosphate hydrolases| OP:NHOMO 762 OP:NHOMOORG 544 OP:PATTERN ------------------------1---1-1--------------1---------------111---- 1----11----111--------------------------------11----111--1----11--1----111111111123-----1111-111----1-----------------------------------1111111211----------------------------------------1-111-1-111111111111111--111-111---2-111111111-1111111111111111111212111111121111111111111111111211121111111111111222222222222221111111111211111111111111111111111111111122211111111111111111------1--111-----------------------1111111111--1--11111111111-111121111112--------1---1--------------------------------1----1---------------------------------------1-------------1-1-11111111-------1111-1-1-----1-------------1-11-11------------------------11---------11111--111111111111-----------------1---------------------------------------1--------------------------1------------------------1----111---1-----------------1-----------------------------11111111111121-----------------1--------------1-1------------------1---1111111111111111 ----111-21--1111111111111111111111111111-111111111111111111111222222122121222-3222222122-12111111111111212-12223334342222222552836R6-6242222322322222222242223313311153411332111111H1111111521211112113 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 557 STR:RPRED 99.3 SQ:SECSTR ###ccEcccTTcccccccHHHHHHTTTccGGGEGEEEcccccEEEcTHHHHHHTTccccEEEEEEEccccTTcccHHHHHHHHHHHHHHTTccEEEEEcccccTHHHHTTccccEETTEEEEcHHHHHTTTTcHHHHHHHHHHHHHHHHHHHHHTTcTTcccGGGccccEEEccccGGGccEEEccccTTccccEEEcEEEGGGcHHHHHHHHcccHHHHHHHHHTcEEEEcTTccEEETGGGTcHHHHHHHTTTTTccEEEEETTccEEEEccccccccccccccHHHHHHHHHHccEEEEEccccTTTHHHHHHHTHHHHHTccccEEEEEEcHHHHHHTTTccGGGTTcccHHHHHHHHHHHHHHHHHHHTTTccEEEEEEccTTccHHHHHHHHHHTTTcEEEEEEEccTTTGGGGGHHHHHHHHHHHHHccccccccccTTccHHHHHHHHHHHTTcccEEEEcHHHHHHHHHHHHTTcTTccEEEEccTTcccccTTccccccccEEEEcccEEETTTEEEEEcccTTccccccccccGGGTcEEccccEEccc# PSIPRED ccccccHHHHHHHcccccHHHHHHHccccccHHHHHcccccEEEEcHHHHHHHccccccEEEEEEEccccccccccHHHHHHHHHHHHHcccEEEEEEccccccccccccccccccccEEEEcHHHccccccccHHHHHHHHHHHHHHHHHHHHccccccccccEEEEEEEEEcccHHHHccccccccccccEEEccccEEEHHHHHHHHHHHHccHHHHHHHHHcEEEEEEcccccEEEEccccHHHHHHHHHHHccccEEEEEcccEEEEEccccHHHHccccHHHHHHHHHHHccEEEEcccccccccccEEEEEEcccccccccEEEEEEccHHHHHcccccHHHHccccHHHHHHHHHHHHHHHHHHHHccccEEEEEEccccccHHHHHHHHHHHHHccccEEEEEHHHccccHHHHHHHHHHHHHHccccccEEcccccccHHHHHHHHHHHHcccccEEEcHHHHHHHHHHHHcccccccEEEEEccccccccHHHcccccccEEEEEEEEEEccccEEEEEEccccccccccccccHHccEEccccEEEEcc //