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Candidatus Pelagibacter ubique HTCC1062 (pubi0)
Gene : leuA
DDBJ      :leuA         2-isopropylmalate synthase
Swiss-Prot:             

Homologs  Archaea  56/68 : Bacteria  693/915 : Eukaryota  129/199 : Viruses  0/175   --->[See Alignment]
c.1.10d.270.1
:414 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   7->168 3ewbX PDBj 2e-38 47.8 %
:BLT:PDB   286->395 3f6hA PDBj 4e-04 26.6 %
:RPS:PDB   30->392 3bg9A PDBj 8e-63 15.1 %
:RPS:SCOP  1->182 1sr9A2  c.1.10.5 * 2e-46 24.2 %
:RPS:SCOP  288->393 1sr9A3  d.270.1.1 * 3e-19 25.7 %
:HMM:SCOP  1->184 1sr9A2 c.1.10.5 * 6.3e-61 49.4 %
:HMM:SCOP  286->395 1sr9A3 d.270.1.1 * 2.5e-22 33.0 %
:RPS:PFM   1->143 PF00682 * HMGL-like 1e-38 55.0 %
:RPS:PFM   264->395 PF08502 * LeuA_dimer 5e-19 42.3 %
:HMM:PFM   1->145 PF00682 * HMGL-like 1.5e-55 53.5 142/237  
:HMM:PFM   264->394 PF08502 * LeuA_dimer 3.4e-36 42.6 129/133  
:BLT:SWISS 1->406 LEU1_BRASO e-147 63.3 %
:PROS 93->106|PS00816|AIPM_HOMOCIT_SYNTH_2

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID AAZ22177.1 GT:GENE leuA GT:PRODUCT 2-isopropylmalate synthase GT:DATABASE GIB00256CH01 GT:ORG pubi0 GB:ACCESSION GIB00256CH01 GB:LOCATION complement(1307340..1308584) GB:FROM 1307340 GB:TO 1308584 GB:DIRECTION - GB:GENE leuA GB:PRODUCT 2-isopropylmalate synthase GB:PROTEIN_ID AAZ22177.1 GB:DB_XREF GI:71063174 GB:GENE:GENE leuA LENGTH 414 SQ:AASEQ MKHKLNKTPEQVLDAIKESVTYARNLTDDVEWSCEDGTRTDMDFMCKIVETAISSGAKTINIPDTVGYTIPSEFTKIITTLKNKVPNIDKAILSVHCHNDLGLAVANSLAGVAAGARQVECTINGIGERAGNAALEEIVMAIRTRNDLMPFTTGIKTELLSKASKVVSNATFPVQFNKAIVGKNAFAHEAGIHQDGMLKNRETYEIMTPESVGVKKTSLVMGKHSGRHAFKEKLNDLGYADVTDDVIQSAFGKFKVLADKKKHVYDDDIMALVDDSLISDNKINAINLKSLKVFAGTGEPQKAEMTLDVYGEVKSTSETGDGPVDAIFKCIKVLYPHDVKLQLYQVHAVTEGTDAQATVSVRIEEEGKTTVGQAADTDTLVASANAYLSALNKMIIKRKKTVPMEHETQKVKGI GT:EXON 1|1-414:0| BL:SWS:NREP 1 BL:SWS:REP 1->406|LEU1_BRASO|e-147|63.3|403/525| PROS 93->106|PS00816|AIPM_HOMOCIT_SYNTH_2|PDOC00643| BL:PDB:NREP 2 BL:PDB:REP 7->168|3ewbX|2e-38|47.8|161/268| BL:PDB:REP 286->395|3f6hA|4e-04|26.6|109/119| RP:PDB:NREP 1 RP:PDB:REP 30->392|3bg9A|8e-63|15.1|351/601| RP:PFM:NREP 2 RP:PFM:REP 1->143|PF00682|1e-38|55.0|140/237|HMGL-like| RP:PFM:REP 264->395|PF08502|5e-19|42.3|130/132|LeuA_dimer| HM:PFM:NREP 2 HM:PFM:REP 1->145|PF00682|1.5e-55|53.5|142/237|HMGL-like| HM:PFM:REP 264->394|PF08502|3.4e-36|42.6|129/133|LeuA_dimer| GO:PFM:NREP 3 GO:PFM GO:0003824|"GO:catalytic activity"|PF00682|IPR000891| GO:PFM GO:0003852|"GO:2-isopropylmalate synthase activity"|PF08502|IPR013709| GO:PFM GO:0009098|"GO:leucine biosynthetic process"|PF08502|IPR013709| RP:SCP:NREP 2 RP:SCP:REP 1->182|1sr9A2|2e-46|24.2|178/310|c.1.10.5| RP:SCP:REP 288->393|1sr9A3|3e-19|25.7|105/115|d.270.1.1| HM:SCP:REP 1->184|1sr9A2|6.3e-61|49.4|180/0|c.1.10.5|1/1|Aldolase| HM:SCP:REP 286->395|1sr9A3|2.5e-22|33.0|109/152|d.270.1.1|1/1|2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain| OP:NHOMO 1615 OP:NHOMOORG 878 OP:PATTERN ---4--3323333333-43333322--212213333333333333333446643331-1-12-13-22 11323111111-111-------11-1-------111221112231-2-2111221111--112121211211111111-121222222222232---11--2-1211222---------------33234334434222223333323423323322111111222254531111111111112223333121111111111111111111112111111131--11111143-2222221222222211111--------------------111-1--------11112-1111-----------------111111111-43-5511111112124255----3-3--212444554333-333324--1-321111-----342332223333322222222222-11111111222-2113112111223411122243332221111111112211432-----------------------------2111111111-1222314-1111132222212124121111222311223221112241211111111111111144-3322333233333-333333333333314332111111111--1-------12111221121211-1121111111211111121112---1221-11--111311211111111111-11-1111111111111111232222111111111111111111311111111-11111111111111-1---------21113111111-111-11111111111--14-22221211221123111211--21-1211111111111111111111111111111141443333--------------------------------------3--21222322 ------1-----1123222222123212222122222212222222222324222222211123434324434344444434444422-23122221112212333-121---------------------------------------------11--11--1-1-1-----1-2122I1211122312442221113 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 395 STR:RPRED 95.4 SQ:SECSTR GGHHHHHHHHHTTcEEEEEEEcccEEHccccTTcccccTTcHHHHHHHHHHHHHccccEEEEEcTTccccHHHHHHHHHHHHHHcTTccEHHEEEEccTTcccTHHHHHHHHHTTccEEEEccGGGccTTccccHHHHHHHHTTcTTcccTcccccHHHHHHHHHHHHHHHHHGGGGcGGGTcccccTTHHHHcccHHHHHHHHHHHHTHHTTcccccHHHHHHHHHHHHHHHHTTccHHHHHHGGGcHHHHHHTTcccccTTcccHHHHHHHHcccccccccTHTTTcccccHHHHHHHHHTTTccccTcHHHHHHHHHcHHHHHHHHHHHHHHccTTccccccHHHHHHcccTTcEEEcccTTTcccEEEccccccTTTTccEEEEEccTHHc################### DISOP:02AL 397-410| PSIPRED ccccccccHHHHHHHHHHHHHHHHHcccEEEEEccccccccHHHHHHHHHHHHHccccEEEEEcccccccHHHHHHHHHHHHHHcccccccEEEEEccccHHHHHHHHHHHHHccccEEEEEccccccccccccHHHHHHHHHHHcccccccccccHHHHHHHHHHHHHHcccccccccEEEcccEEHcccccHHHHcccHHHcccccHHHHcccEEEEEEEcHHHHHHHHHHHHHcccccccHHHHHHHHHHHHHHHHccccccHHHHHHHHHHHHHcccccccEEEEEEEEEEccccEEEEEEEEEEccEEEEEEEEcccHHHHHHHHHHHHccccEEEEEEEEEEccccccEEEEEEEEEEEccEEEEEEEccHHHHHHHHHHHHHHHHHHHHHHHHccccccccHHcccc //