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Candidatus Pelagibacter ubique HTCC1062 (pubi0)
Gene : leuB
DDBJ      :leuB         3-isopropylmalate dehydrogenase
Swiss-Prot:LEU3_PELUB   RecName: Full=3-isopropylmalate dehydrogenase;         EC=1.1.1.85;AltName: Full=Beta-IPM dehydrogenase;         Short=IMDH;AltName: Full=3-IPM-DH;

Homologs  Archaea  60/68 : Bacteria  773/915 : Eukaryota  187/199 : Viruses  0/175   --->[See Alignment]
c.77.1
:368 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   14->367 1a05A PDBj 4e-79 46.0 %
:RPS:PDB   13->368 1cnzA PDBj 3e-96 43.1 %
:RPS:SCOP  13->367 1ai2A  c.77.1.1 * 3e-78 26.9 %
:HMM:SCOP  6->370 1a05A_ c.77.1.1 * 3.5e-121 47.1 %
:RPS:PFM   13->363 PF00180 * Iso_dh 3e-54 44.2 %
:HMM:PFM   8->363 PF00180 * Iso_dh 6.3e-137 54.9 346/347  
:BLT:SWISS 13->368 LEU3_PELUB 0.0 100.0 %
:PROS 249->268|PS00470|IDH_IMDH
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID AAZ21072.1 GT:GENE leuB GT:PRODUCT 3-isopropylmalate dehydrogenase GT:DATABASE GIB00256CH01 GT:ORG pubi0 GB:ACCESSION GIB00256CH01 GB:LOCATION complement(253956..255062) GB:FROM 253956 GB:TO 255062 GB:DIRECTION - GB:GENE leuB GB:PRODUCT 3-isopropylmalate dehydrogenase GB:PROTEIN_ID AAZ21072.1 GB:DB_XREF GI:71062069 GB:GENE:GENE leuB LENGTH 368 SQ:AASEQ MIKIKKRKILLLPGDGIGPEVIQEVKKVILWLNSNKSLDFEIDEDLAGGCSYDKHGTPITDEVFYKALESEFVMLGAVGGPKWDNLEFSKKPERALLKLRKELKLFANLRPAICFEQLVDASTLKPEIVSGLDIMIVRELTGGIYFGEPRGIKPIENGERKGINTHSYTTSEIVRVAKVAFDLARKRSNRVTSCEKSNVMEAGQLWKEEVQELHDKEYKDVELSHMLADNCAMQLLKNPKQFDVIVTDNLFGDMLSDQASMLTGSLGLLPSASLGAKNKDGEMRAMYEPIHGSAPDIAGKEIANPIASILSFAMALRYSLDLDSEADALEKAVQDVLNDGLRTKDILSQGKKEVSTSAMGDAIISKLQ GT:EXON 1|1-368:0| SW:ID LEU3_PELUB SW:DE RecName: Full=3-isopropylmalate dehydrogenase; EC=1.1.1.85;AltName: Full=Beta-IPM dehydrogenase; Short=IMDH;AltName: Full=3-IPM-DH; SW:GN Name=leuB; OrderedLocusNames=SAR11_0250; SW:KW Amino-acid biosynthesis; Branched-chain amino acid biosynthesis;Complete proteome; Cytoplasm; Leucine biosynthesis; Magnesium;Manganese; Metal-binding; NAD; Oxidoreductase. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 13->368|LEU3_PELUB|0.0|100.0|356/368| GO:SWS:NREP 7 GO:SWS GO:0008652|"GO:cellular amino acid biosynthetic process"|Amino-acid biosynthesis| GO:SWS GO:0009082|"GO:branched chain family amino acid biosynthetic process"|Branched-chain amino acid biosynthesis| GO:SWS GO:0005737|"GO:cytoplasm"|Cytoplasm| GO:SWS GO:0009098|"GO:leucine biosynthetic process"|Leucine biosynthesis| GO:SWS GO:0046872|"GO:metal ion binding"|Metal-binding| GO:SWS GO:0016491|"GO:oxidoreductase activity"|Oxidoreductase| GO:SWS GO:0055114|"GO:oxidation reduction"|Oxidoreductase| PROS 249->268|PS00470|IDH_IMDH|PDOC00389| SEG 2->12|ikikkrkilll| SEG 90->105|kkperallklrkelkl| SEG 262->275|ltgslgllpsaslg| BL:PDB:NREP 1 BL:PDB:REP 14->367|1a05A|4e-79|46.0|346/357| RP:PDB:NREP 1 RP:PDB:REP 13->368|1cnzA|3e-96|43.1|348/363| RP:PFM:NREP 1 RP:PFM:REP 13->363|PF00180|3e-54|44.2|328/338|Iso_dh| HM:PFM:NREP 1 HM:PFM:REP 8->363|PF00180|6.3e-137|54.9|346/347|Iso_dh| GO:PFM:NREP 4 GO:PFM GO:0000287|"GO:magnesium ion binding"|PF00180|IPR001804| GO:PFM GO:0016616|"GO:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"|PF00180|IPR001804| GO:PFM GO:0051287|"GO:NAD or NADH binding"|PF00180|IPR001804| GO:PFM GO:0055114|"GO:oxidation reduction"|PF00180|IPR001804| RP:SCP:NREP 1 RP:SCP:REP 13->367|1ai2A|3e-78|26.9|338/414|c.77.1.1| HM:SCP:REP 6->370|1a05A_|3.5e-121|47.1|357/0|c.77.1.1|1/1|Isocitrate/Isopropylmalate dehydrogenase-like| OP:NHOMO 2367 OP:NHOMOORG 1020 OP:PATTERN 11-2--2222222222-2212222211222222222222222222222323332221-1--2112-22 3443111111111121111-111113111111133322531111211-1111121111--111-13411111111111-22-322121222211---11--2-1111121--------------111111111121222332223311211112211111111112221321111111111113333311141211111111211111132222211121323-11111113212222222222222222212-------1------------11-221-------222-1111111111-------------222222222-23-21111111111122111---2-11-311221111212-221112--32221111-1--1117441132222111111111111-23422433222-3222225424221111131241342112222222253321221111111111111111111111111111111131113543445554433333554533331333745531222553444434774333222212111111122223311321222222221-111111121111124131111111111-111111-111211111222221312312222222222222222222-1-2532-11--132232223332322233-3323322333323333333344222322222222222222222233322231-233333333333111111111222223132111113-111-1112222221211111222233232232323431-1--1---111111111111111222222222222221111112222-------------------------------------22--1-111212 ----224-21--3347867778688876645555555555355545546777886665444443444434424442433344444424-46484456564416667-3234583333223127233232DZ6-545122382364123233--63313536424332A3764443333191112374986931121111 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 356 STR:RPRED 96.7 SQ:SECSTR ############EEcTTHHHHHHHHHHHHHHHHHHHTccEEEEEcccTHHHHHHHcccccHHHHHHHHTccEEEEEEcccGGGTTcGGGcTTHHHHHHHHHHHTccEEEEEEEccTTcGGGccccHHHHHccEEEEEEEcccGGGTccccEEEEccGGGcEEEccccccHHHHHHHHHHHHHHHHTTTcEEEEEEcTTTcHHHHHHHHHHHHHHHTTcTTcEEEEEEHHHHHHHHHHcGGGccEEEEcHHHHHHHHHHHHHHHTcGGGcEEEEEcTTcccEcccEEEEEcccccGGGTTTTccccHHHHHHHHHHHHHHcccHHHHHHHHHHHHHHHHTTcccGGGGTTTTTcccHHHHHHHHHHHHH DISOP:02AL 1-4| PSIPRED cccccccEEEEEEcccccHHHHHHHHHHHHHHHHccccEEEEEEEEccHHHHHHccccccHHHHHHHHHccEEEEEccccccccccccccccccHHHHHHHHHccEEEEEEEEEcccccccccccccccccEEEEEEEEccccEEEccccEEEEccccccEEEEEEEEcHHHHHHHHHHHHHHHHHccccEEEEEccHHHHHHHHHHHHHHHHHHHHcccccHHHHHHHHHHHHHHHcccccEEEEEccccHHHHHHHHHHHcccHHHHccccccccccccccccccccccccccccccccccccHHHHHHHHHHHHHHcccHHHHHHHHHHHHHHHHcccccHHHccccccEEcHHHHHHHHHHHcc //