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Candidatus Pelagibacter ubique HTCC1062 (pubi0)
Gene : leuC
DDBJ      :leuC         3-isopropylmalate dehydratase large subunit
Swiss-Prot:LEUC_PELUB   RecName: Full=3-isopropylmalate dehydratase large subunit;         EC=4.2.1.33;AltName: Full=Isopropylmalate isomerase;AltName: Full=Alpha-IPM isomerase;         Short=IPMI;

Homologs  Archaea  60/68 : Bacteria  770/915 : Eukaryota  176/199 : Viruses  0/175   --->[See Alignment]
c.83.1
:467 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   106->459 1nisA PDBj 1e-19 26.0 %
:RPS:PDB   1->467 2b3yA PDBj e-129 20.5 %
:RPS:SCOP  1->466 2b3xA2  c.83.1.1 * e-127 20.6 %
:HMM:SCOP  1->468 2b3yA2 c.83.1.1 * 9.2e-171 41.1 %
:RPS:PFM   28->457 PF00330 * Aconitase 1e-48 34.0 %
:HMM:PFM   4->457 PF00330 * Aconitase 3.5e-182 48.5 452/465  
:BLT:SWISS 1->467 LEUC_PELUB 0.0 100.0 %
:PROS 445->459|PS00211|ABC_TRANSPORTER_1
:PROS 339->355|PS00450|ACONITASE_1
:PROS 399->412|PS01244|ACONITASE_2
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID AAZ21074.1 GT:GENE leuC GT:PRODUCT 3-isopropylmalate dehydratase large subunit GT:DATABASE GIB00256CH01 GT:ORG pubi0 GB:ACCESSION GIB00256CH01 GB:LOCATION complement(255662..257065) GB:FROM 255662 GB:TO 257065 GB:DIRECTION - GB:GENE leuC GB:PRODUCT 3-isopropylmalate dehydratase large subunit GB:PROTEIN_ID AAZ21074.1 GB:DB_XREF GI:71062071 GB:GENE:GENE leuC LENGTH 467 SQ:AASEQ MPLTLYDKIWNDHLVDQQDDGTALLFVDRHLVHEVTSPQAFEGLRNSNRKVRQPGLTLAVADHNVPTTDRSKGIADAESKIQVDTLESNCKEFGVQYLGMNDKRQGIVHIIGPEQGFTQPGTVIVCGDSHTATHGAFGALAFGIGTSEVEHVLATQTLVQKKAKNFRINVNGKLPIGVTSKDVILQIIGQIGTAGGTGSVIEYAGSLISSLSVEQRMTICNMTIEGGARAGLIAPDEKIFEYLKGKPMSPKNENWDKAMKYWESLKTDDGAKFDKEINLVAEDILPMITWGTSPQDVITIDGKVPNPKNEQDEDKKNSLERSLNYMGLKADTLATDIKIDKVFIGSCTNGRIEDLREAAKILKDKKKASHVQAMVVPGSGLVKEQAEQEGLDKIFIASGFEWREPGCSMCLAMNADKLKPGERCASTSNRNFEGRQGRGGRTHLVSPGMAAAAAISGNLDDVRKYQN GT:EXON 1|1-467:0| SW:ID LEUC_PELUB SW:DE RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33;AltName: Full=Isopropylmalate isomerase;AltName: Full=Alpha-IPM isomerase; Short=IPMI; SW:GN Name=leuC; OrderedLocusNames=SAR11_0252; SW:KW 4Fe-4S; Amino-acid biosynthesis;Branched-chain amino acid biosynthesis; Complete proteome; Iron;Iron-sulfur; Leucine biosynthesis; Lyase; Metal-binding. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->467|LEUC_PELUB|0.0|100.0|467/467| GO:SWS:NREP 7 GO:SWS GO:0051539|"GO:4 iron, 4 sulfur cluster binding"|4Fe-4S| GO:SWS GO:0008652|"GO:cellular amino acid biosynthetic process"|Amino-acid biosynthesis| GO:SWS GO:0009082|"GO:branched chain family amino acid biosynthetic process"|Branched-chain amino acid biosynthesis| GO:SWS GO:0051536|"GO:iron-sulfur cluster binding"|Iron-sulfur| GO:SWS GO:0009098|"GO:leucine biosynthetic process"|Leucine biosynthesis| GO:SWS GO:0016829|"GO:lyase activity"|Lyase| GO:SWS GO:0046872|"GO:metal ion binding"|Metal-binding| PROS 445->459|PS00211|ABC_TRANSPORTER_1|PDOC00185| PROS 339->355|PS00450|ACONITASE_1|PDOC00423| PROS 399->412|PS01244|ACONITASE_2|PDOC00423| SEG 184->198|ilqiigqigtaggtg| BL:PDB:NREP 1 BL:PDB:REP 106->459|1nisA|1e-19|26.0|327/753| RP:PDB:NREP 1 RP:PDB:REP 1->467|2b3yA|e-129|20.5|463/888| RP:PFM:NREP 1 RP:PFM:REP 28->457|PF00330|1e-48|34.0|409/434|Aconitase| HM:PFM:NREP 1 HM:PFM:REP 4->457|PF00330|3.5e-182|48.5|452/465|Aconitase| GO:PFM:NREP 1 GO:PFM GO:0008152|"GO:metabolic process"|PF00330|IPR001030| RP:SCP:NREP 1 RP:SCP:REP 1->466|2b3xA2|e-127|20.6|462/629|c.83.1.1| HM:SCP:REP 1->468|2b3yA2|9.2e-171|41.1|465/0|c.83.1.1|1/1|Aconitase iron-sulfur domain| OP:NHOMO 2425 OP:NHOMOORG 1006 OP:PATTERN 11-2--2122222222-2222222211222322222222222222222332222221-1--2112-33 1312311111111112211-111114111111111111332111122--111111121--111312211112222222-111322222221112---1111213322131---------------22222222223222322224222222222222222222222222322222222222223233322122122222222222222211222222222222-12222122311111111111111121121-------1------------111212-------222------------------------222222122-24-22111111121232221---2-21-2322222222221222222--2-22322211111423331122122222222222222-224225222221222322322222315423222222223222222222222232211111111-1--1-111111111111111222422575342223223333322633333-344566762155322222323234333122243222333311143222321222222222-232333333223222232222222223-1211111112222222222333335333333333333333313333-1-3311-11--133333343333333333-3323332333333333336333333434343434443434334322233332-333333333333111311111111124312111213-11112112444444333352333333443334343322-1-11-1-222223333333333242222222233332221332222-------------------------------------12--2-222212 ----223-21--2245432544537433333333323444344333334655764456443434444434454455413444444444-46444455554434656-323426221211--11-23-2-3O2-213--211--12121--2-21-112425A23111522814122222k2221242273342233331 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 467 STR:RPRED 100.0 SQ:SECSTR ccHHHHHHHHTHHHHTTTTTcEEEEcccEEEEEHHHHHHHHHHHHHHHHGccccccEEEEccccccccccccTTHHHHHHHHHHHHHHHHHHcTTEEEEEEcTTcccHHcEEEETTEEEEcEEEEEccGGGGGGGGGTcEEEEccHHHHHHHHTTccEEEEcccEEEEEEEccccTTccHHHHHHHHHHHHHHHccTTcEEEEEcGGGTTccHHHHHHHHHTHHHHTccEEEccccHHHHHHHHHTTccHHHHHHHHHHTccccTTcGGcccccEEEEEEGGGcccEEEccccTTcEEEGGGHHHHHHHHHHccccTGTTcEEEEEETTEEEEEETTcEEEEEEccHHHHTcHHHHHHHHHHHHHcccTTcEEEEccccHHHHHHHHHTccHHHHHHTTccccccccGGGGTccccccHHHHHEEEccccccTTcccTTccEEEccHHHHHHHHHHccccccTTTcc DISOP:02AL 467-468| PSIPRED ccccHHHHHHHHHcccccccccEEEEEEEEEEEcccHHHHHHHHHHcccccccccccEEEEcccccccccccccccHHHHHHHHHHHHHHHHHcccccccccccccEEEEEEccccEEcccEEEEEccccccccccccEEEEcccHHHHHHHHHcccEEEccccEEEEEEEEEccccccHHHHHHHHHHHHccccccEEEEEEEccccccccHHHHHHHHHHHHHHccEEEEccccHHHHHHHHHccccHHHHHHHHHHHHHccccccccccccEEEEEEHHHccEEEcccccHHHEEEHHHHcccHHHHHcHHHHHHHHHHHHHccccccccccccEEEEEEEEcccccccHHHHHHHHHHHcccccccccEEEEcccHHHHHHHHHcccHHHHHHcccEEEccccHHHccccccccccccEEEEEccccccccccccccEEEccHHHHHHHHHHcccccHHHHcc //