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Candidatus Pelagibacter ubique HTCC1062 (pubi0)
Gene : topA
DDBJ      :topA         DNA topoisomerase I
Swiss-Prot:             

Homologs  Archaea  66/68 : Bacteria  901/915 : Eukaryota  157/199 : Viruses  1/175   --->[See Alignment]
e.10.1g.41.3
:863 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   3->573 1cy8A PDBj e-126 45.8 %
:RPS:PDB   3->569 1cy1A PDBj e-152 45.7 %
:RPS:PDB   732->816 1bfdA PDBj 8e-04 16.5 %
:RPS:SCOP  1->567 1d6mA  e.10.1.1 * e-143 24.5 %
:RPS:SCOP  597->632 1yuaA1  g.41.3.3 * 1e-08 20.6 %
:HMM:SCOP  1->610 1mw9X_ e.10.1.1 * 3.9e-179 43.6 %
:HMM:SCOP  614->646 1yuaA1 g.41.3.3 * 9.2e-05 39.4 %
:RPS:PFM   3->89 PF01751 * Toprim 4e-08 46.7 %
:RPS:PFM   129->552 PF01131 * Topoisom_bac 7e-97 49.6 %
:RPS:PFM   597->632 PF01396 * zf-C4_Topoisom 3e-08 61.8 %
:HMM:PFM   134->552 PF01131 * Topoisom_bac 4e-125 42.6 392/404  
:HMM:PFM   2->112 PF01751 * Toprim 1.2e-27 43.6 94/96  
:HMM:PFM   597->635 PF01396 * zf-C4_Topoisom 1.2e-13 54.1 37/39  
:BLT:SWISS 1->785 TOP1_RICTY 0.0 47.0 %
:PROS 285->307|PS00396|TOPOISOMERASE_I_PROK
:REPEAT 3|647->690|730->755|794->819
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID AAZ21887.1 GT:GENE topA GT:PRODUCT DNA topoisomerase I GT:DATABASE GIB00256CH01 GT:ORG pubi0 GB:ACCESSION GIB00256CH01 GB:LOCATION 1048935..1051526 GB:FROM 1048935 GB:TO 1051526 GB:DIRECTION + GB:GENE topA GB:PRODUCT DNA topoisomerase I GB:PROTEIN_ID AAZ21887.1 GB:DB_XREF GI:71062884 GB:GENE:GENE topA LENGTH 863 SQ:AASEQ MNLVVVESPAKAKTINKYLGDDYIVLASYGHIRDLPSKNGSVDPENNFKMEWEVDSFSKKYLKEITDAAKISSKIILATDPDREGEAIAWHVKEYLNEKKLIKDKHIERVVFNEITKKAVIHGIENPRQIEPLLVDAYMARRALDYLVGFNISPILWTKLPGSKSAGRVQSVALKLITEREHEIELFDPEEFWTLSIQFNDSNKNSILASITQLNDKKIEKFSFKNKAEIDKAMKEVKSKNFNINDISSKVVNRNPSGPFTTSTLQQVSSGRLGFGASRTMQIAQKLYQGIEIDGETIGLITYMRTDGTNLSTDAIDTFRKYIKNEFGDEYVPDNAASYSGKKAKNAQEAHEAIRPTDIMRAPDTVKKYLSPDQHKLYDLIWSRALSSQMKPAQFDRNTITITSDDNGTICKASGSVIKFDGFLKVMKDTKKDDDEDILPEMNKGPVNIESLLDEQHFTQPPPRYSEASLVKKLEELGIGRPSTYASIISVISTRGYAETINKRFHPTDRGKLISAFLEKLFSKYVDYNFTASLENQLDDITTGKEGWIKVLELFWKDFNQNVSDVKEKRTREVLDLLNDSLGSLIFERDTEGNINRQCKLCNGGSLSLKNSFRGGAFIGCSNYPDCKFTRPLSKAKAAAQSQLAEPKFIGKHENGNDMYLKNGRFGPYLQYEKIEEIKDEIIIETKKKKKTKKKKIEKEDNNLRNVSIPKGITLDSVDLDRAKFLCSLPKSLGINPENQRDIILNSGRFGPYLKCENKSARIENVEEIFSIGLNRAITLIAEAKPGRMSASIIKDLGEHPEDKKPVRVMKGQYGPYIKYKSLNATIPEEKDPLELNMEEALILIEKRKEYDKNKKVKKKKKK GT:EXON 1|1-863:0| BL:SWS:NREP 1 BL:SWS:REP 1->785|TOP1_RICTY|0.0|47.0|757/779| PROS 285->307|PS00396|TOPOISOMERASE_I_PROK|PDOC00333| NREPEAT 1 REPEAT 3|647->690|730->755|794->819| SEG 633->645|lskakaaaqsqla| SEG 673->701|ekieeikdeiiietkkkkktkkkkieked| SEG 847->862|krkeydknkkvkkkkk| BL:PDB:NREP 1 BL:PDB:REP 3->573|1cy8A|e-126|45.8|542/563| RP:PDB:NREP 2 RP:PDB:REP 3->569|1cy1A|e-152|45.7|534/557| RP:PDB:REP 732->816|1bfdA|8e-04|16.5|79/523| RP:PFM:NREP 3 RP:PFM:REP 3->89|PF01751|4e-08|46.7|75/110|Toprim| RP:PFM:REP 129->552|PF01131|7e-97|49.6|405/407|Topoisom_bac| RP:PFM:REP 597->632|PF01396|3e-08|61.8|34/39|zf-C4_Topoisom| HM:PFM:NREP 3 HM:PFM:REP 134->552|PF01131|4e-125|42.6|392/404|Topoisom_bac| HM:PFM:REP 2->112|PF01751|1.2e-27|43.6|94/96|Toprim| HM:PFM:REP 597->635|PF01396|1.2e-13|54.1|37/39|zf-C4_Topoisom| GO:PFM:NREP 8 GO:PFM GO:0003677|"GO:DNA binding"|PF01131|IPR013497| GO:PFM GO:0003916|"GO:DNA topoisomerase activity"|PF01131|IPR013497| GO:PFM GO:0005694|"GO:chromosome"|PF01131|IPR013497| GO:PFM GO:0006265|"GO:DNA topological change"|PF01131|IPR013497| GO:PFM GO:0003677|"GO:DNA binding"|PF01396|IPR013498| GO:PFM GO:0003916|"GO:DNA topoisomerase activity"|PF01396|IPR013498| GO:PFM GO:0005694|"GO:chromosome"|PF01396|IPR013498| GO:PFM GO:0006265|"GO:DNA topological change"|PF01396|IPR013498| RP:SCP:NREP 2 RP:SCP:REP 1->567|1d6mA|e-143|24.5|548/603|e.10.1.1| RP:SCP:REP 597->632|1yuaA1|1e-08|20.6|34/65|g.41.3.3| HM:SCP:REP 1->610|1mw9X_|3.9e-179|43.6|559/0|e.10.1.1|1/1|Prokaryotic type I DNA topoisomerase| HM:SCP:REP 614->646|1yuaA1|9.2e-05|39.4|33/65|g.41.3.3|1/2|Zinc beta-ribbon| OP:NHOMO 1786 OP:NHOMOORG 1125 OP:PATTERN 333333223333333322222222111111111112211111111111122222222222211122-- 1121111111111111111-11111111111111111111111111111111111111111111111111111111111121231322445412341--1131112221211111111111111111111111111111111111132321111111111111111222211111111111111111222112234346343334434332222243413422221222223332222221232222223222311111211111211112211121111141122111111111111111111111121111111111111123333333334334326333333131231232133341211121122112111111111111111111112111111111111111-111121121121111111111111111111111111111111111111111111111112111111111111111111111111111111111151111122111111111111111421212111111325121111-2111112111211111121411112111221122221111111111111121111111211311111232121111221332321322122223232222222222222221-111121--11122233222222222222-3222222222222222222223322342222322232222222423222222-222222222422--1111111111111112222222232222332211211111111122222321112311121111111111242222222322221121322111312211211111111111111111111111-111-1111111111111112112121222121 -11211--632111--1--11111-1122111111-----1--11111111-1-111-1-1-1111111-1-11111--111111111-1211--111111-1212-11142311212-1122-63-3-7G2-322111-2-121-11-121-423122215-321-212322221122G222124335133312111- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------1---- STR:NPRED 710 STR:RPRED 82.3 SQ:SECSTR cEEEEEccHHHHHHHHTcccTTEEEEEcccccEEcccHHHTEETTTTTEEccEEcTTHHHHHHHHHHHHHTcccEEEcccccHHHHHHHHHHHHHHcccGcHHGGGEEEcccccccHHHHHHHHHccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHTcTTccccTTHHHHHHHHHHHHHHHHHccccEEEEEEEEEEcTTccEEEEEEEEETTEEccTcccccHHHHHHHHHHHHHccEEEEEEEEEEEEEcccccccHHHHHHHHHHHccccHHHHHHHHHHHHHTTcTTGHTcTcccccccccccccHHHHHHHHHHHHHHTcGGGcccccccccccccccccccccccccccTTccGGGccccccHHHHHHHHHHHHHHHHHTcccEEEEEEEEEEEETTTTEEEEEEEEEEEEcGGGGGcccccccccccccccccTTEEEEEEEEEEEEEccccccccHHHHHHHHHHTTcccTTTHHHHHHHHHTcccEEEccccEEEcHHHHHHHHHHHHHcHHHHcHHHHHHHHHHHHHHHTTcccHHHHHHHHHHHHHHHHHHHTccGGGGTccccccccccHHHHHHHHcccEEEEEcccEEcHHHHHTTcccEEEEccHHHHHHHHH####################################################################################################HHTTTcTTc##cTTGGGTTTTcccE###EEccccGGGHHHH#HHHHHHHHHccccccEEEEEEGGGTTccccGGGGGGTTccccc############################################### DISOP:02AL 250-254, 337-349, 783-796, 846-863| PSIPRED cEEEEEEcHHHHHHHHHHcccccEEEEEEccEEEcccccccccccccccccEEEcccHHHHHHHHHHHHHHccEEEEEccccccHHHHHHHHHHHHHcccccccccEEEEEEEcccHHHHHHHHHccccccHHHHHHHHHHHHHHHHHHHHHcHHHHHHHcccccccccHHHHHHHHHHHHHHHHccccccEEEEEEEEEcccccEEEEEEEccccccccccccccHHHHHHHHHHHccccEEEEEEEEEEEEEcccccccHHHHHHHHHHHHcccHHHHHHHHHHHHHHccccccccccEEccccccccccHHHHHHHHHHHHHHHccHHccHHHHHccccccccccccccccccccccccHHHHHHHccHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEEccccEEEEEEEEEEEEccHHHHcccccccccccccccccccEEEEEEEEEEcccccccccccHHHHHHHHHHccccccccHHHHHHHHcccccEEEEccEEEEcHHHHHHHHHHHHHccccccHHHHHHHHHHHHHHHHccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccccccccccccEEEEccccEEEEEEEccccEEEEcccccccccccccccccHHHHHHHccccEEcccccccEEEEEEccccccEEccccccccccccccccccccccccccccccccccccccccccccccccHHHHHHHcccccccccccccccEEEEEccccccEEccccccccccccccEEEccHHHHHHHHHcccccccccccccccccccccccEEEEEEcccccEEEcccEEEEccccccHHHccHHHHHHHHHHHHcccccccccccccc //