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Streptomyces avermitilis MA-4680 (save0)
Gene : BAC68795.1
DDBJ      :             putative two-component system sensor kinase
Swiss-Prot:             

Homologs  Archaea  26/68 : Bacteria  842/915 : Eukaryota  126/199 : Viruses  1/175   --->[See Alignment]
a.154.1a.30.2c.23.1d.110.2d.122.1d.58.54h.4.5
:1424 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   641->769 1vhmB PDBj 5e-04 32.2 %
:BLT:PDB   860->1100 3dgeA PDBj 2e-27 34.8 %
:BLT:PDB   1306->1423 3gt7A PDBj 7e-16 37.9 %
:RPS:PDB   55->571 3c3lA PDBj 3e-16 12.6 %
:RPS:PDB   565->614 2aswA PDBj 6e-05 24.0 %
:RPS:PDB   635->774 3eeaA PDBj 1e-11 15.7 %
:RPS:PDB   858->1147 2bu2A PDBj 1e-34 12.2 %
:RPS:PDB   1281->1323 3crlB PDBj 1e-05 7.0 %
:RPS:PDB   1303->1422 1b00A PDBj 1e-23 32.8 %
:RPS:SCOP  31->120 1l8wA  a.154.1.1 * 8e-05 8.8 %
:RPS:SCOP  99->161 1rwuA  d.58.54.1 * 1e-14 20.3 %
:RPS:SCOP  191->253 1rwuA  d.58.54.1 * 6e-16 23.8 %
:RPS:SCOP  283->345 1rwuA  d.58.54.1 * 6e-15 21.9 %
:RPS:SCOP  375->437 1rwuA  d.58.54.1 * 4e-12 18.8 %
:RPS:SCOP  467->529 1rwuA  d.58.54.1 * 2e-15 21.9 %
:RPS:SCOP  559->605 1rwuA  d.58.54.1 * 1e-06 23.4 %
:RPS:SCOP  619->773 1f5mA  d.110.2.1 * 3e-15 23.3 %
:RPS:SCOP  858->931 2c2aA1  a.30.2.1 * 2e-07 21.6 %
:RPS:SCOP  938->1097 1b3qA3  d.122.1.3 * 4e-31 16.9 %
:RPS:SCOP  1306->1422 1a0oA  c.23.1.1 * 2e-25 35.3 %
:HMM:SCOP  32->123 2ch7B1 h.4.5.1 * 1.8e-06 26.4 %
:HMM:SCOP  124->215 2ch7B1 h.4.5.1 * 6.9e-08 31.0 %
:HMM:SCOP  216->307 2ch7B1 h.4.5.1 * 4e-08 27.6 %
:HMM:SCOP  308->399 2ch7B1 h.4.5.1 * 4.9e-08 27.6 %
:HMM:SCOP  400->491 2ch7B1 h.4.5.1 * 8.6e-08 29.9 %
:HMM:SCOP  492->616 2ch7B1 h.4.5.1 * 2.8e-14 33.3 %
:HMM:SCOP  603->777 1f5mA_ d.110.2.1 * 3.6e-29 28.7 %
:HMM:SCOP  843->931 2c2aA1 a.30.2.1 * 6.7e-22 43.8 %
:HMM:SCOP  918->1109 1jm6A2 d.122.1.4 * 1.2e-46 44.3 %
:HMM:SCOP  1301->1423 1s8nA_ c.23.1.1 * 7.9e-39 41.2 %
:RPS:PFM   18->59 PF00672 * HAMP 2e-04 38.1 %
:RPS:PFM   102->153 PF00672 * HAMP 9e-08 48.1 %
:RPS:PFM   193->245 PF00672 * HAMP 6e-09 49.1 %
:RPS:PFM   286->337 PF00672 * HAMP 1e-08 50.0 %
:RPS:PFM   377->429 PF00672 * HAMP 7e-08 43.4 %
:RPS:PFM   470->519 PF00672 * HAMP 1e-07 48.0 %
:RPS:PFM   562->612 PF00672 * HAMP 5e-08 49.0 %
:RPS:PFM   640->763 PF01590 * GAF 2e-05 28.7 %
:RPS:PFM   979->1098 PF02518 * HATPase_c 2e-26 55.0 %
:RPS:PFM   1306->1419 PF00072 * Response_reg 9e-18 41.8 %
:HMM:PFM   18->59 PF00672 * HAMP 1.1e-05 35.7 42/70  
:HMM:PFM   95->152 PF00672 * HAMP 1.3e-12 29.3 58/70  
:HMM:PFM   191->244 PF00672 * HAMP 1.3e-12 33.3 54/70  
:HMM:PFM   283->336 PF00672 * HAMP 8.2e-13 33.3 54/70  
:HMM:PFM   375->428 PF00672 * HAMP 1.8e-11 27.8 54/70  
:HMM:PFM   470->520 PF00672 * HAMP 3.5e-11 33.3 51/70  
:HMM:PFM   562->613 PF00672 * HAMP 1.9e-11 42.3 52/70  
:HMM:PFM   977->1097 PF02518 * HATPase_c 2.1e-32 49.5 109/111  
:HMM:PFM   1178->1253 PF00072 * Response_reg 0.00057 19.2 73/112  
:HMM:PFM   1306->1418 PF00072 * Response_reg 6.6e-26 36.4 110/112  
:HMM:PFM   862->929 PF00512 * HisKA 1.1e-20 47.0 66/68  
:HMM:PFM   640->774 PF01590 * GAF 2.7e-09 25.6 133/154  
:HMM:PFM   790->856 PF03938 * OmpH 1e-05 36.2 58/158  
:BLT:SWISS 16->620,858->1075,1306->1422 DHKJ_DICDI 0.0 65.0 %
:BLT:SWISS 655->772 YTSP_BACSU 4e-05 35.5 %
:BLT:SWISS 786->836 YH19_RHOCA 4e-04 43.1 %
:COIL
:REPEAT 7|17->108|109->200|201->292|293->384|385->476|477->568|569->654
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID BAC68795.1 GT:GENE BAC68795.1 GT:PRODUCT putative two-component system sensor kinase GT:DATABASE GIB00135CH01 GT:ORG save0 GB:ACCESSION GIB00135CH01 GB:LOCATION 1368024..1372298 GB:FROM 1368024 GB:TO 1372298 GB:DIRECTION + GB:PRODUCT putative two-component system sensor kinase GB:NOTE PF00672: HAMP domain GB:PROTEIN_ID BAC68795.1 LENGTH 1424 SQ:AASEQ MNSKTAEAESRTPGDQELRQLLAGLTAVRDGDFGTRLPDDTDGLLGEIATVFNGMIDQLSVFTSEVTRVAREVGTEGTLGGQAEVPGVSGTWADLTDSVNAMAGNLTTQVRDIAQVATAVAKGDLSQKIDVPARGEILELKETVNTMVDQLSAFADEVTRVAREVGSEGRLGGQAQVPGVGGVWRDLTDSVNLMAGNLTAQVRNVAQVTTAVAKGDLSQKITVDARGEILELKNTINTMVDQLSAFADEVTRVAREVGTDGRLGGQADVKDVRGTWRDLTDSVNFMAGNLTAQVRSIAQVATAVAKGDLSQKITVDARGEILELKDTINTMVDQLSAFADEVTRVAREVGTAGNLGGQATVRGVSGTWKDLTDNVNVMASNLTGQVRSIAQVATAVARGDLSQKITVEAKGEVAALADVINTMVDTLSAFADEVTRVAREVGTEGRLGGQAHVPNVAGTWKDLTDNVNSMANNLTGQVRNIALVTTAVANGDLSKKIDVDARGEILELKTTINTMVDQLSSFAAEVTRVAREVGSEGRLGGQAEVEGVSGTWKRLTENVNELAGNLTRQVRAIAEVASAVAEGDLTRSITVDASGEVAELKDNINSMVGSLRETTRANQEQDWLKSNLARISGLMQGHRDLAVVAELIMEELTPLVSAQYGAFYLAEETGRGTQLRLIGSYGYPDDTQRPDRIPLGRSLVGQAARNRRPITVDDLPPAYVTISSGLGQISPTALKVLPIVVDEQVLGVIELASVTRFTQIHEDFLGQLMETIGVNVNTIVANGRTDELLGESQRLTAELQSRSEELQVQQDELQRSNAELEEKATLLATQNRDIEAKNLQIEQARQELEARAQQLSLASKYKSEFLANMSHELRTPLNSLLILAQLLAQNPSHNLTPKQVEYAGIIHSAGSDLLQLINDILDLSKVEAGKMDISPERVALRRLLDYVEATFRPMTSQKSLEFTMSTAPGVPVDLLTDDSRLRQVLRNLLSNAVKFTERGGVGLHIEPAVDQNIPAAVHRGGAVVAFHVKDTGIGIPEQQLETIFGAFQQADGTTSRKYGGTGLGLSITREIAHLLGGAVTVDSTPGQGSTFTLYLPVARADFEELAQGAQPGEASQGDGAADHPRGSQALTGAGGPTHRRRRILVVEERPRGLLTLVAESTVANLTRGHHGGDPREVIDVTTTVDAQEAAGALAAEPCHCVVLELGMSGGEASRFLDALDGDPALASVPVLVHNGQRADVTLDPALRSRSAARSLEIFSSLDELRERIALHLSAEEPGDVLPLVRPEKPQPEQTLVVDGTFTGRTVLVVDDDARNLFALSGILELHGFKVLHAENGRKGVDTLLAHPEICLVLMDVMMPEMDGYAATTEIRSMSQYTDLPVVAVTAKAMPGDREKALQSGASDYVTKPVDANDLIACVRRWLSA GT:EXON 1|1-1424:0| BL:SWS:NREP 3 BL:SWS:REP 16->620,858->1075,1306->1422|DHKJ_DICDI|0.0|65.0|930/2062| BL:SWS:REP 655->772|YTSP_BACSU|4e-05|35.5|107/163| BL:SWS:REP 786->836|YH19_RHOCA|4e-04|43.1|51/952| COIL:NAA 74 COIL:NSEG 1 COIL:REGION 781->854| NREPEAT 1 REPEAT 7|17->108|109->200|201->292|293->384|385->476|477->568|569->654| SEG 172->183|ggqaqvpgvggv| SEG 839->855|lqieqarqelearaqql| SEG 877->890|lnsllilaqllaqn| SEG 912->923|dllqlindildl| SEG 1186->1195|aqeaagalaa| BL:PDB:NREP 3 BL:PDB:REP 641->769|1vhmB|5e-04|32.2|115/160| BL:PDB:REP 860->1100|3dgeA|2e-27|34.8|233/237| BL:PDB:REP 1306->1423|3gt7A|7e-16|37.9|116/132| RP:PDB:NREP 6 RP:PDB:REP 55->571|3c3lA|3e-16|12.6|508/1089| RP:PDB:REP 565->614|2aswA|6e-05|24.0|50/56| RP:PDB:REP 635->774|3eeaA|1e-11|15.7|140/153| RP:PDB:REP 858->1147|2bu2A|1e-34|12.2|255/358| RP:PDB:REP 1281->1323|3crlB|1e-05|7.0|43/383| RP:PDB:REP 1303->1422|1b00A|1e-23|32.8|119/122| RP:PFM:NREP 10 RP:PFM:REP 18->59|PF00672|2e-04|38.1|42/69|HAMP| RP:PFM:REP 102->153|PF00672|9e-08|48.1|52/69|HAMP| RP:PFM:REP 193->245|PF00672|6e-09|49.1|53/69|HAMP| RP:PFM:REP 286->337|PF00672|1e-08|50.0|52/69|HAMP| RP:PFM:REP 377->429|PF00672|7e-08|43.4|53/69|HAMP| RP:PFM:REP 470->519|PF00672|1e-07|48.0|50/69|HAMP| RP:PFM:REP 562->612|PF00672|5e-08|49.0|51/69|HAMP| RP:PFM:REP 640->763|PF01590|2e-05|28.7|122/143|GAF| RP:PFM:REP 979->1098|PF02518|2e-26|55.0|109/112|HATPase_c| RP:PFM:REP 1306->1419|PF00072|9e-18|41.8|110/111|Response_reg| HM:PFM:NREP 13 HM:PFM:REP 18->59|PF00672|1.1e-05|35.7|42/70|HAMP| HM:PFM:REP 95->152|PF00672|1.3e-12|29.3|58/70|HAMP| HM:PFM:REP 191->244|PF00672|1.3e-12|33.3|54/70|HAMP| HM:PFM:REP 283->336|PF00672|8.2e-13|33.3|54/70|HAMP| HM:PFM:REP 375->428|PF00672|1.8e-11|27.8|54/70|HAMP| HM:PFM:REP 470->520|PF00672|3.5e-11|33.3|51/70|HAMP| HM:PFM:REP 562->613|PF00672|1.9e-11|42.3|52/70|HAMP| HM:PFM:REP 977->1097|PF02518|2.1e-32|49.5|109/111|HATPase_c| HM:PFM:REP 1178->1253|PF00072|0.00057|19.2|73/112|Response_reg| HM:PFM:REP 1306->1418|PF00072|6.6e-26|36.4|110/112|Response_reg| HM:PFM:REP 862->929|PF00512|1.1e-20|47.0|66/68|HisKA| HM:PFM:REP 640->774|PF01590|2.7e-09|25.6|133/154|GAF| HM:PFM:REP 790->856|PF03938|1e-05|36.2|58/158|OmpH| GO:PFM:NREP 25 GO:PFM GO:0004871|"GO:signal transducer activity"|PF00672|IPR003660| GO:PFM GO:0007165|"GO:signal transduction"|PF00672|IPR003660| GO:PFM GO:0016021|"GO:integral to membrane"|PF00672|IPR003660| GO:PFM GO:0004871|"GO:signal transducer activity"|PF00672|IPR003660| GO:PFM GO:0007165|"GO:signal transduction"|PF00672|IPR003660| GO:PFM GO:0016021|"GO:integral to membrane"|PF00672|IPR003660| GO:PFM GO:0004871|"GO:signal transducer activity"|PF00672|IPR003660| GO:PFM GO:0007165|"GO:signal transduction"|PF00672|IPR003660| GO:PFM GO:0016021|"GO:integral to membrane"|PF00672|IPR003660| GO:PFM GO:0004871|"GO:signal transducer activity"|PF00672|IPR003660| GO:PFM GO:0007165|"GO:signal transduction"|PF00672|IPR003660| GO:PFM GO:0016021|"GO:integral to membrane"|PF00672|IPR003660| GO:PFM GO:0004871|"GO:signal transducer activity"|PF00672|IPR003660| GO:PFM GO:0007165|"GO:signal transduction"|PF00672|IPR003660| GO:PFM GO:0016021|"GO:integral to membrane"|PF00672|IPR003660| GO:PFM GO:0004871|"GO:signal transducer activity"|PF00672|IPR003660| GO:PFM GO:0007165|"GO:signal transduction"|PF00672|IPR003660| GO:PFM GO:0016021|"GO:integral to membrane"|PF00672|IPR003660| GO:PFM GO:0004871|"GO:signal transducer activity"|PF00672|IPR003660| GO:PFM GO:0007165|"GO:signal transduction"|PF00672|IPR003660| GO:PFM GO:0016021|"GO:integral to membrane"|PF00672|IPR003660| GO:PFM GO:0005524|"GO:ATP binding"|PF02518|IPR003594| GO:PFM GO:0000156|"GO:two-component response regulator activity"|PF00072|IPR001789| GO:PFM GO:0000160|"GO:two-component signal transduction system (phosphorelay)"|PF00072|IPR001789| GO:PFM GO:0006355|"GO:regulation of transcription, DNA-dependent"|PF00072|IPR001789| RP:SCP:NREP 11 RP:SCP:REP 31->120|1l8wA|8e-05|8.8|75/271|a.154.1.1| RP:SCP:REP 99->161|1rwuA|1e-14|20.3|63/87|d.58.54.1| RP:SCP:REP 191->253|1rwuA|6e-16|23.8|63/87|d.58.54.1| RP:SCP:REP 283->345|1rwuA|6e-15|21.9|63/87|d.58.54.1| RP:SCP:REP 375->437|1rwuA|4e-12|18.8|63/87|d.58.54.1| RP:SCP:REP 467->529|1rwuA|2e-15|21.9|63/87|d.58.54.1| RP:SCP:REP 559->605|1rwuA|1e-06|23.4|47/87|d.58.54.1| RP:SCP:REP 619->773|1f5mA|3e-15|23.3|146/176|d.110.2.1| RP:SCP:REP 858->931|2c2aA1|2e-07|21.6|74/89|a.30.2.1| RP:SCP:REP 938->1097|1b3qA3|4e-31|16.9|160/174|d.122.1.3| RP:SCP:REP 1306->1422|1a0oA|2e-25|35.3|116/128|c.23.1.1| HM:SCP:REP 32->123|2ch7B1|1.8e-06|26.4|87/0|h.4.5.1|1/6|Methyl-accepting chemotaxis protein (MCP) signaling domain| HM:SCP:REP 124->215|2ch7B1|6.9e-08|31.0|87/0|h.4.5.1|2/6|Methyl-accepting chemotaxis protein (MCP) signaling domain| HM:SCP:REP 216->307|2ch7B1|4e-08|27.6|87/0|h.4.5.1|3/6|Methyl-accepting chemotaxis protein (MCP) signaling domain| HM:SCP:REP 308->399|2ch7B1|4.9e-08|27.6|87/0|h.4.5.1|4/6|Methyl-accepting chemotaxis protein (MCP) signaling domain| HM:SCP:REP 400->491|2ch7B1|8.6e-08|29.9|87/0|h.4.5.1|5/6|Methyl-accepting chemotaxis protein (MCP) signaling domain| HM:SCP:REP 492->616|2ch7B1|2.8e-14|33.3|120/0|h.4.5.1|6/6|Methyl-accepting chemotaxis protein (MCP) signaling domain| HM:SCP:REP 603->777|1f5mA_|3.6e-29|28.7|167/0|d.110.2.1|1/1|GAF domain-like| HM:SCP:REP 843->931|2c2aA1|6.7e-22|43.8|89/0|a.30.2.1|1/1|Homodimeric domain of signal transducing histidine kinase| HM:SCP:REP 918->1109|1jm6A2|1.2e-46|44.3|185/190|d.122.1.4|1/1|ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase| HM:SCP:REP 1301->1423|1s8nA_|7.9e-39|41.2|119/190|c.23.1.1|2/2|CheY-like| OP:NHOMO 14884 OP:NHOMOORG 995 OP:PATTERN -----------------------21----3-5--12-1333355I-7R5PH5D-1-1-11-------1 7St3D55688974677666-6D2298666667DBBB3AA7ABCB866669558AC678--8AS6I47GDE8444488833HAA12685ed*a-k113--E6N8DDtJmVe--------------1532D96595I9yxvwrE6C*5*r**nnJRUHI6677A7jmKf***U666655576666PF655443ABHccdcdbdYJbdefZZGKAADBbbdCGGQBPKB99A9Bni78889888888888897788B5A8BB965369966CB8678A6473AAA57574447777777777723333333343336323333336AeLE*LLLNNRRKOHMQSRCFICRKN65IGIL5eaWJL967A6DBE9--3MJLfaaR45445KJXVYJGDTWPPRDDDDDDCBDDE-USjSVVVgCJQ5PMMQMMPVTOPQFPDDTI9AHEGFAGD999999996AA79*WS22122222325A3333333332322222214FE5646347SNMPUPOCCCAQPYfHGGH7FQQaLNVN-3DGGoJKCCSONQQ8GHPAFHGY4-------88MIb*P*pSHCqTB*mSQg3*t**pupJijh*l**HY24231111112121111111CC42A33TKBaRYIBYTJKBCDEHJILGHDJJJNFRR--5DBLC------CD798B8EEDDFDDEDE-EFDDEDEDDDEDEDEEEEAGGH68AA8DDCDDFDDCDDCDCDEEDDBCBCE8-BCDEEDCCEEED--456766644448LrAW333211121122111DECCE9E7C6MKTRWTQibfVZTcRYUTX2112-11-1JKKIOMNNNNTQTUUTQVUYUVMPO8888--*3OO89CC1111111131--------------------------5E433545553*4 --1-GG1-------NEHIFA9BBC9BB4433434446555555444GF99DC7LBB877A9A343221-5225231212224445422-382H4634333863B9E-A1L1-----------------------------------------------8----3---------611666Z22224sACLI9J31F3542 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------2- STR:NPRED 1424 STR:RPRED 100.0 SQ:SECSTR HHHHHHHTccccHHHHHHHHHHHHHHHHHHHTTTcHHHHHHHHHHHHHHHHHcTEEEccEEEEEEccHHHHHHHHHHcHcccccHHHHHHTTccHHHHHHHTccccHHHHHHHHHHHHHHHHTTcccHHHHHHHHHHHHHHHHHcTTEEEETTTEEEEcTHHHHHHHHHHHTTccHHHHHHHHHHHHHHHHHHHHHHHHHHHTTcTTccHHHHHccHHHHHHHHTTccccccEEcHHHHHHHHTTcccHHHHHHHHHHHHHHHHHTTcHHTcHHHHHHHHHHHHHHHHHHTTccccTTcTTTTHHHHHHHHHHHHHTTTHHHHHHHHHHHHHHHHccGcccEEccccEEcccccEEcTTTEEEccTTccccEEccEEcccccTTTHHHHHHHHHTHHcHHHHHHHHHHcTTcccccEEcccEEEEETTTHHHHHHHHHHHHHHHTTTHHccHHHHHHHHHHHHHTTccTTcccHHHHHHHHHHHccGGGGTTccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTccEEEccEEccccEEcccccccccccHHHHHHHHHHHHHHHHHHHccHHHHHHHHHHHHHHHHHHHHHHHHccEEEccEEcccccEEcccccccccccHHHHHHHHHHHHHGGccHHHHHHHHHHHHHHHccccEEEEEEEccccEEEEEEEcccGGGHHHHHHccccTTTcHHHHHHHHHTccEEEccGGGcTTccHHHHHHTTTEEEEEEEEEETTEEEEEEHHHHHHTTcccccccHHHHHHHHcccccHHHHHHHHHHHHHHHHHHHHHHHTccHHHHTcHHHHHHHHHHHHHHHHHHHGGGGccTTcHHHHHHHHHHHTTTTccTTcTTHHHHHHHHHHHHHTTTHHHHHHHHHHHHHHHccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTcTcEEEEEHHHHHHHHHHHHHHHHHHHHcccccEEEEEEEcTTTTcccEEEEcHHHHHHHHHHHHHHHHHHHHHTTTTccccccEEEEEEEEcccEEEEEEEcccEEEEEEEEEEEcccHHHHGGGGcTTTTcccccccHHHHHHHHHHHTTcEEEEEEETTEEEEEEEEEEccTTTcccccccccHHHHHHccccccccccHHHHcEEEEHHHGGGcccccccccHHHHHHHHHcccccEEEEEEcccTTTcEEEEEEHHHHTccccHHHHHHHHHHHHHHHHHHHHTccGGGGcTTcccccEEEccEEEccccEEccHHHHHHHHHHcTTHHHHHHHHTTccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccTccEEEEccccTTcEEccccEEEEETTEEEEEEEHHHHTccccccccccEEEEEEETTEEEEEEEcEEEEEEEEETTccccccTTGGGGcccEEEEEEcTTccEEEEEcHHHHcHHHHHHHcc DISOP:02AL 1-16, 1051-1058, 1107-1115| PSIPRED cccccccccccccHHHHHHHHHHHHHHHHccccccccccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccccccEEEcccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccccEEEEccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccEEccEEEccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccccEEEEccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccccccEEEEccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccccEEEEEcccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccccccEEEEcccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccccEEEEEcccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccccccEEEcccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccccEEEEEEEccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccEEEcEEEEcccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccccEEEccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccHHHHHHHHHHHHHHHHccccEEEEEEEcccccEEEEEEEEccccccccccccccccccHHHHHHHcccEEEEcccHHHHHHHHHHHHHHHHHHHHHHHHHccccEEEEEEEcccccccHHHHHHHHHHHHHHHHHHHHHHHHcHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcHHHHHHHHHHHHHccccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccEEEEEEEEccHHHHHHHHHHHHHHHHHHcccEEEEEEccccccEEEEcHHHHHHHHHHHHHccEEEccccEEEEEEEEEccccccccccccccEEEEEEEEccccccHHHHHHHHHHHHHccccccccccccccHHHHHHHHHHHcccEEEEEEEccccEEEEEEEEEcccccccccccccccccccccccccHHHHHHcccccccccccccEEEEEcccHHHHHHHHHHHHHHHHHHHHHHHcccccEEEEEEccHHHHHHHHHcccccEEEEEcccccccHHHHHHHHHccccccccEEEEHHHHHHHHHHHHHHHHHccccHHHHHHHHHHHHHHHHHHHHHHHcccccccccHHHcccccccccHHHccccEEEEEcccHHHHHHHHHHHHHcccEEEEEccHHHHHHHHHHcccccEEEEEcccccccHHHHHHHHHHcccccccEEEEEEccccHHHHHHHHHccccEEEEccccHHHHHHHHHHHHcc //