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Streptomyces avermitilis MA-4680 (save0)
Gene : aveA4
DDBJ      :aveA4        type I polyketide synthase AVES 4
Swiss-Prot:             

Homologs  Archaea  0/68 : Bacteria  859/915 : Eukaryota  185/199 : Viruses  0/175   --->[See Alignment]
a.121.1a.25.1a.28.1a.38.2b.61.4c.1.19c.19.1c.2.1c.69.1c.95.1d.358.1e.62.1
:4881 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   17->456 2hg4F PDBj e-121 56.9 %
:BLT:PDB   578->933 2qo3B PDBj 8e-40 31.1 %
:BLT:PDB   997->1461 2fr0A PDBj 4e-62 46.5 %
:BLT:PDB   1482->1568 2ju1A PDBj 9e-15 46.0 %
:BLT:PDB   1591->2492 2hg4F PDBj 0.0 55.4 %
:BLT:PDB   2520->2610 2ju1A PDBj 3e-13 44.0 %
:BLT:PDB   2636->3093 2hg4F PDBj e-125 56.8 %
:BLT:PDB   3263->3630 2qo3B PDBj 1e-42 33.6 %
:BLT:PDB   3639->3938 3el6A PDBj 4e-43 40.6 %
:BLT:PDB   4085->4377 2fr0A PDBj 8e-22 37.3 %
:BLT:PDB   4456->4557 2ju1A PDBj 8e-13 43.1 %
:BLT:PDB   4618->4873 1kezA PDBj 3e-34 36.9 %
:RPS:PDB   29->456 2c9hA PDBj 5e-81 19.1 %
:RPS:PDB   526->599 3c5oA PDBj 7e-04 9.5 %
:RPS:PDB   571->885 3eenA PDBj 2e-61 27.6 %
:RPS:PDB   856->932 1cjaA PDBj 2e-10 13.6 %
:RPS:PDB   1238->1389 2e6gC PDBj 5e-20 19.8 %
:RPS:PDB   1517->2017 1e1cA PDBj 5e-87 10.8 %
:RPS:PDB   2135->2421 3eenA PDBj 2e-58 24.5 %
:RPS:PDB   2553->3157 1e1cA PDBj 4e-90 10.6 %
:RPS:PDB   3165->3283 3c5oB PDBj 5e-08 9.1 %
:RPS:PDB   3260->3560 2c2nB PDBj 7e-68 23.9 %
:RPS:PDB   3541->3637 1cjaA PDBj 2e-10 14.6 %
:RPS:PDB   3638->3789 3citB PDBj 4e-10 11.1 %
:RPS:PDB   4063->4178 3bk9C PDBj 2e-16 13.0 %
:RPS:PDB   4243->4398 2ddxA PDBj 2e-14 12.8 %
:RPS:PDB   4437->4557 1e1cB PDBj 2e-14 5.8 %
:RPS:PDB   4663->4875 3bf7A PDBj 1e-05 14.5 %
:RPS:SCOP  34->456 1e1cA1  c.1.19.1 * 7e-76 9.8 %
:RPS:SCOP  575->838 1nm2A1  c.19.1.1 * 2e-48 15.0 %
:RPS:SCOP  816->934 2hh8A1  d.358.1.1 * 3e-17 6.7 %
:RPS:SCOP  995->1199 2fr0A2  c.2.1.2 * 3e-16 25.7 %
:RPS:SCOP  1204->1461 2fr0A1  c.2.1.2 * 7e-23 44.9 %
:RPS:SCOP  1511->2017 1e1cA1  c.1.19.1 * 3e-91 9.8 %
:RPS:SCOP  2136->2393 1nm2A1  c.19.1.1 * 2e-52 17.4 %
:RPS:SCOP  2373->2491 2hh8A1  d.358.1.1 * 4e-07 8.4 %
:RPS:SCOP  2553->3077 1e1cA1  c.1.19.1 * 5e-95 10.1 %
:RPS:SCOP  3214->3343 1jmxA5  b.61.4.1 * 7e-14 10.0 %
:RPS:SCOP  3326->3673 1u9tA1  e.62.1.1 * 8e-61 10.4 %
:RPS:SCOP  3954->4167 2fr0A2  c.2.1.2 * 5e-18 20.8 %
:RPS:SCOP  4243->4302 2ib0A1  a.25.1.9 * 4e-05 23.3 %
:RPS:SCOP  4326->4398 2g7gA2  a.121.1.1 * 5e-12 8.2 %
:RPS:SCOP  4497->4557 1klpA  a.28.1.1 * 5e-12 19.7 %
:RPS:SCOP  4653->4876 1jmkC  c.69.1.22 * 6e-17 18.0 %
:HMM:SCOP  4->34 1pzrA_ a.38.2.1 * 5.5e-06 51.6 %
:HMM:SCOP  26->407 1tedA_ c.95.1.2 * 2.4e-104 50.3 %
:HMM:SCOP  574->894 1mlaA1 c.19.1.1 * 1.3e-67 47.4 %
:HMM:SCOP  995->1196 2fr1A2 c.2.1.2 * 6.2e-39 38.3 %
:HMM:SCOP  1205->1442 1gz6A_ c.2.1.2 * 1.3e-46 33.2 %
:HMM:SCOP  1488->1607 1klpA_ a.28.1.1 * 3.5e-25 41.2 %
:HMM:SCOP  1583->1965 1tedA_ c.95.1.2 * 1.1e-104 50.6 %
:HMM:SCOP  2135->2440 1mlaA1 c.19.1.1 * 1.9e-64 45.1 %
:HMM:SCOP  2530->2652 1klpA_ a.28.1.1 * 5.1e-27 41.2 %
:HMM:SCOP  2628->3007 1tedA_ c.95.1.2 * 3e-103 48.8 %
:HMM:SCOP  3259->3569 1mlaA1 c.19.1.1 * 2.8e-67 46.8 %
:HMM:SCOP  3950->4168 2fr1A2 c.2.1.2 * 5e-36 40.8 %
:HMM:SCOP  4174->4395 2fr1A1 c.2.1.2 * 5.3e-40 30.5 %
:HMM:SCOP  4464->4561 1af8A_ a.28.1.1 * 7.6e-18 46.5 %
:HMM:SCOP  4515->4876 1kezA_ c.69.1.22 * 4.7e-40 29.5 %
:RPS:PFM   1->27 PF08990 * Docking 7e-08 81.5 %
:RPS:PFM   36->275 PF00109 * ketoacyl-synt 7e-61 57.0 %
:RPS:PFM   293->409 PF02801 * Ketoacyl-synt_C 5e-29 62.4 %
:RPS:PFM   576->870 PF00698 * Acyl_transf_1 2e-49 45.3 %
:RPS:PFM   1227->1392 PF08659 * KR 5e-36 48.8 %
:RPS:PFM   1499->1564 PF00550 * PP-binding 4e-06 42.4 %
:RPS:PFM   1593->1841 PF00109 * ketoacyl-synt 1e-65 61.4 %
:RPS:PFM   1850->1967 PF02801 * Ketoacyl-synt_C 6e-28 61.9 %
:RPS:PFM   2137->2419 PF00698 * Acyl_transf_1 9e-61 49.6 %
:RPS:PFM   2555->2606 PF00550 * PP-binding 3e-06 44.2 %
:RPS:PFM   2638->2886 PF00109 * ketoacyl-synt 1e-64 58.6 %
:RPS:PFM   2895->3012 PF02801 * Ketoacyl-synt_C 1e-27 60.2 %
:RPS:PFM   3261->3555 PF00698 * Acyl_transf_1 1e-58 49.3 %
:RPS:PFM   4243->4362 PF08659 * KR 2e-28 53.7 %
:RPS:PFM   4500->4553 PF00550 * PP-binding 5e-06 44.4 %
:RPS:PFM   4679->4860 PF00975 * Thioesterase 1e-07 31.3 %
:HMM:PFM   34->284 PF00109 * ketoacyl-synt 6.2e-101 58.5 246/253  
:HMM:PFM   1590->1841 PF00109 * ketoacyl-synt 9.9e-102 59.5 247/253  
:HMM:PFM   2635->2886 PF00109 * ketoacyl-synt 2.5e-102 59.9 247/253  
:HMM:PFM   578->899 PF00698 * Acyl_transf_1 6.1e-66 36.0 311/318  
:HMM:PFM   2139->2457 PF00698 * Acyl_transf_1 4.7e-105 49.1 316/318  
:HMM:PFM   3263->3599 PF00698 * Acyl_transf_1 5e-65 36.2 315/318  
:HMM:PFM   292->409 PF02801 * Ketoacyl-synt_C 1.1e-49 66.1 118/119  
:HMM:PFM   1849->1967 PF02801 * Ketoacyl-synt_C 1.3e-49 65.3 118/119  
:HMM:PFM   2894->3012 PF02801 * Ketoacyl-synt_C 1.2e-48 62.7 118/119  
:HMM:PFM   1212->1391 PF08659 * KR 3e-60 51.1 180/181  
:HMM:PFM   4183->4362 PF08659 * KR 1.3e-59 52.5 179/181  
:HMM:PFM   1498->1564 PF00550 * PP-binding 1.3e-10 34.8 66/67  
:HMM:PFM   2540->2606 PF00550 * PP-binding 1.8e-12 36.4 66/67  
:HMM:PFM   4499->4553 PF00550 * PP-binding 2.2e-13 40.0 55/67  
:HMM:PFM   4670->4873 PF00975 * Thioesterase 9.8e-25 24.3 202/229  
:HMM:PFM   1->26 PF08990 * Docking 2.6e-14 80.8 26/27  
:BLT:SWISS 34->456 ERYA1_SACER e-119 58.0 %
:BLT:SWISS 527->2015,2139->2490,2563->3095,3215->3606,4243->4557 ERYA1_SACER 0.0 45.7 %
:BLT:SWISS 4675->4799 ACSA1_PSEAE 9e-05 32.2 %
:PROS 2565->2580|PS00012|PHOSPHOPANTETHEINE
:PROS 4512->4527|PS00012|PHOSPHOPANTETHEINE
:PROS 197->213|PS00606|B_KETOACYL_SYNTHASE
:PROS 1754->1770|PS00606|B_KETOACYL_SYNTHASE
:PROS 2799->2815|PS00606|B_KETOACYL_SYNTHASE
:TM
:REPEAT 3|34->936|1591->2493|2636->3661
:REPEAT 3|1483->1590|2525->2635|4460->4557
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID BAC68653.1 GT:GENE aveA4 GT:PRODUCT type I polyketide synthase AVES 4 GT:DATABASE GIB00135CH01 GT:ORG save0 GB:ACCESSION GIB00135CH01 GB:LOCATION complement(1187928..1202573) GB:FROM 1187928 GB:TO 1202573 GB:DIRECTION - GB:GENE aveA4 GB:PRODUCT type I polyketide synthase AVES 4 GB:NOTE avermectin gene cluster GB:PROTEIN_ID BAC68653.1 LENGTH 4881 SQ:AASEQ MANEEKLRDYLKRVTADLLNVRRRLQQIESGEQEPIAIVGMACRFPGGVESAEDFWELIASGRDAVGEFPVDRGWDVEAFYDPEPGRAGSSYTRRGGFLEGAAEFDAGFFGISPREALAMDPQQRLMLEVSWEALERAGIDPATLRGSRTGVFAGLMSQDYATRLLSVPDDLAGYLGNGNAGSILSGRVAYTFGFEGPAVTVDTACSSSLVALHLACQSLRTGESSFALAGGVTVMSTPGMFVEFSRQRGLSPDGRCKAYASAADGTGMSEGVGILLLERLSEAERRGHRVLAVVRGSAVNQDGASNGLTAPNGPSQQRVIRQALACAGLSVADVDVVEGHGTGTTLGDPIEAQALLATYGQRAGDTPVWLGSVKSNIGHAQAAAGVAGVIKMVMALRAGVLPRTLHVDEPSSQVDWSSGSVRVLADEVEWPGVEGRLRRAGVSAFGVSGTNAHVILEEASGGAGGGAGRLQELGPGVVSGSGVVPWVVSARSELALRGQARRLRGVVAVGGGADGVGVSPAGVGRALVSERSVFEHRAVVVAEDRDEFLHALDALAGGRPVPGVVEGRTTSGELAVLFAGQGTQRAGMGRELYEAYPVFAQAIDEICAEADTARTDPGAPGLRDVLFAPQDSPEGRLIEDTGFAQPALFAFEVALFRLLETWGLTPDYVLGHSVGELAAAHVAGMLCLADAVALVVARGRLMQGLPSGGAMVAIEASEDEILPLPDEYASRVAHAAVNGPRSIVLSGDEDAVLDLAQQWAARGRRTRRLRTSHAFHSPHMDAMLGDFRRAAEQVTFSAPRIPVVSNVTGAPLPAETMCTPDYWVEHARSTVRFADGISWLQEQGVTTCLEIGPDGTLSALAQDSLSAPARAIPALRPDQPEARSVMTALAELFVAGTAVEWAGVFEGTAREVGDGCGVELPTYAFERERFWLDVEEGSAGGSGVSGMWGGPLWEAVECGDAGVVASLLGVDEGASLGAVVSALGEWGRVRHEREVVDGWRYREVWRPVSGGGVGGLSGAWLVVSEGEAGPVDVVAEGLERCGARVVRVEVEAGCVSREVLAGHLREAVDGEAVGGVVSLVGWGSGVVQAGVASVGLVQALGDVGVGARLWCVTGGAVSVGGRDAVWGPASGVVWGLGRVVGAEAPDRWGGLVDVPELVDERVVDGLVGVLAGVGGGGESEFAVRSSGAFVRRLVRAPLEEAVAEREWRPRGTVLVTGGTGELGAHVARWMARRGAEHLLLVSRRGESAQGVEELRADLMGLGARVSVVACDAADREALAEVLRSAVPAECPLGVVVHAAGVVDDGVLEGLSSERVTGVLRAKALAAWNLHELTRGADLSGFVVFSSAAATFGPAGQGSYAAANAYVEAIVRHRRGEGLPGLAVAWGPWAGGGMAEGAVGQMRRRGLAAMTPETALVALGQALDHDETCVTVADIDWDRFTANSLPGSRLSPLISDIPEARLARETTGLDTATASPDSFSARLKAMDTAEQERALLDLVRTYAATVLGHSTPTAVRPERAFRDLGFVSVSAVELRNRLNAVTGLLLPTTLIFDYPTPSALAGYLKEQLEEGAGGQRDIAPPVPASRVDVDEPIAIVGMACRFPGGVESAEDLWELVASGRDAVGEFPVDRGWDVEAFYDPEPGRAGSSYTRRGGFLEGAAEFDAGFFGISPREALAMDPQQRLMLEVSWEALERAGIDPATLRGSTTGVFAGMCSQDYADLVRRATEDLEGYAMTGLSSSVTSGRVAYTLGLEGPAVTVDTACSSSLVALHLACQALRSGECSLALAGGVTVMSTPGAFVEFSRQRGLSPDGRCKAYGSGADGVGWAEGVGVLLVERLSEAERRGHRVLAVVRGSAVNQDGASNGLTAPNGPSQQRVIRQALACAGLSVADVDVVEGHGTGTTLGDPIEAQALLATYGQGRSGERPVWLGSVKSNIGHAQAAAGVAGVIKMVMALRAGVLPRTLHVDEPSSQVDWSSGSVRVLADEVEWPGVEGRLRRAGVSAFGVSGTNAHVILEEASGGADGGAGRLQELGPGVVSGSGVVPWVVSARSELALRGQARRLRGVVAVGGGADGVGVSPAGVGRALVSERSVFEHRAVVVAEDRDEFLHALDALAEGAPTAGVVQGVAGPAADGKIAMLFGGQGTHWEGMAQELLGSSPVFAQQMSDCAQALEPYLDWSLLDVLRGAPDAPPLQRVDVVQPVLFAVMVSLAALWRSYGVHPDAVAGHSQGEIAAAYVAGALSLDDAARVTALRSQALAALAGQGAMASVGLPVEKLEPRLATWGDRLVIAAVNGARSAVVSGEPEAVDALVEELSHEDVPARRLMVDWASHSPQVEAIQGRLLELLAPIRARTGDVPFYSTVTGERIDGTELDADYWYRNLRQVVRFRDATQALVRAGHTVFIEACPHPAVAVGVQETLDEMGDLDSLVVGSLRRGEGGLRRFLMSVAELFVGGVAVEWSGVFGSVGRGVAGGCGVELPTYAFERERFWLDVEGAPRGSGVSGQWGGQLSEAVDTVRGGMLRDCLAGLDPAAQAETVLDLVLTHAAAVLGHGTADAVVPERAFRDLGFDSLTAVELRNRLNTATGLRFPRTLVFDHPRPVALAAHIHEQLSGGSPTTGTALALALRAPAPRVDVDEPIAIVGMACRFPGGVESAEDFWELIASGRDAVGEFPVDRGWDVEAFYDPEPGRAGTSYTRCGGFLQGAAEFDAGFFGISPREALAMDPQQRLMLEVSWEALERAGIDPATLHGSTTGVFAGVSQQDYAELLRRGTQDHEGYALTGVSNSVVSGRLSYTFGFEGPAVTVDTACSSSLVALHLACQALRSGECSLALAGGVTVMSTPGAFVEFSRQRGLSPDGRCKAYGSGADGVGWAEGVGVLLVERLSEAERRGHRVLAVVRGSAVNQDGASNGLTAPNGPSQQRVIRQALACAGLSVADVDVVEGHGTGTTLGDPIEAQALLATYGQGRSGERPVWLGSVKSNIGHAQAAAGVAGVIKMVMALNHELLPTSLHIDEPSPHIDWSSGGVRLLTEPVPWQQNGRPRRAGVSAFGVSGTNAHVIIEQAPVEAHVISEPVPAEAHVIVEQAPVEAPHVVDATGPADLTEPQEEAAEPECVADAVTEMSAEPECVADAMSEMSAECVAEAVSDKSAEPECVADAMSDKPALLPIPWLLSAKSERALRGQARRLRQFAARASDARPADVAHALAAQRSVFDHRAVVVAEDRDGFLQALDALAEGRSADGLIEGSVGPRGGHSGRRRGKTAMLFAGQGTQRVGMGRQLYAAHPAYADALDQVLAELDGHLDQPLRPLIHASADLADVADAADVLDRTRYAQPALFAVQVALFRHLERLGVRADFVAGHSIGELAAAHVAGVLPLAAACRLVAARGRLMEQLAPGGAMVAVRASEAEARQALDGREARVSVAAVNGPASVVFSGAEDEVGNMADWFAERGRRVKRLRTGHAFHSPLMDPMLEEFQQVAASLTYSEPAIPMVSTLTGDIVAAGELSDPEYWVRQVRRTVRFGDAISRLHTDGVRTFMELGPDGTLSALAEECLEATADSHPADDDTGTPQENLLIPLLRPDSPEPGTLLTGLARLHTHGAAAVNWPAALPERDRARHLDLPTYAFDHHRYWVDTSAGHPGDLSAAGLGTAGHPLLGSAVALAESQELLFTGRLSLRTHPWLADHAIFGTVLLPGTAILELAVRAGDEVDCGTVEELTLRTPLVLPEQGSVILQLSVGAPQGPQTPEEPERRTFALYAREDDGLSSSSAAATGTEWTCHATGVLTGTARPAEEHTQEPWPPADAAPVDLDGWYEQLAGAGLGYGPVFQGLREVWRRGDEVFAVVTLPESTEGQAADAARYALHPALLDAALHPVVLRHEGDAAADGHGWLPFSWTGVTVAASGASTLHVRLTVRTDEDAVGLLATDASGRIVISAGSLAFRPVSAEQLQAARTGYHDHLFRIEWRPLHLPTTPARTADWALIGPGARRTAAVLERNGASWQAYPDPAALAEALAAGAPAPGMVVISCEPDGASAPTDSALTDSALTDSAPAGSAPADSTALADATRQATTRVLALLQEWVADERLAACRLALLTHGSVTATPDEPVSDLAHAAVWGLVRSVQTENPDRFLLADTDDTDASRNALPLLAGEPQIALRNGAVRIPRMTRVPVRQPQPSTTDADWDPEATVLITGGTGVLGRLVARHLATAHGVRHLLLATRRGTAADGAADLVAELAGLGAEATVAACDIGDRAAVAALLDQVPAQHPLKAVIHTAGVVDDGILTSLTPERMEAVLHAKAFGAAHLHDLTRDAGLTTFTVFSSAAASFGSPGQGNYTAANAFLDALMQHRHTQALPGRSLAWGLWGEADGMTRNLAGTDFARMARGGLLPLSNAQGLALLDTADRLGPFGDGLLLATRLDAATLHAQATAGALPRILHGLIRIPARRSADHGIATDTPATLRERLAGLTIPAQRTGLLLELVRTHAAAVLGHPTSAVTAADGALPDDLVPADTEFRDLGFDSLTAVELRNRINAVTGLRLPATLIFDQPSPAALADHLATRLTAEAGTPDEPAPAAAAAGAGSAGSAETGQQRSTGSEKQQTRGGTSTETVESLFWIGHDTRRIEESMALLSAASFFRPAFTDPSDIPEPTFVRLAQGEARAQGEALARGETRPALICLPTVAAVSSVYQYSRFAAGLNGHRDVWYVPAPGFLEGEPLPSGIGAVTRMFADAIVRFTDGAPFALAGHSAGGWFVYAVTSHLERLGVRPEAVVTMDAYLPDDGIAPVASALTSEIFDRVTQFVDVDYTRLVAMGGYFRIFSGWSPPDITTPALFLRGRDGEQMPPPWGVPHTVLDIQGNHFTMLEQFADSTARHVDEWLTEIASVRR GT:EXON 1|1-4881:0| BL:SWS:NREP 3 BL:SWS:REP 34->456|ERYA1_SACER|e-119|58.0|419/3491| BL:SWS:REP 527->2015,2139->2490,2563->3095,3215->3606,4243->4557|ERYA1_SACER|0.0|45.7|2913/3491| BL:SWS:REP 4675->4799|ACSA1_PSEAE|9e-05|32.2|118/651| PROS 2565->2580|PS00012|PHOSPHOPANTETHEINE|PDOC00012| PROS 4512->4527|PS00012|PHOSPHOPANTETHEINE|PDOC00012| PROS 197->213|PS00606|B_KETOACYL_SYNTHASE|PDOC00529| PROS 1754->1770|PS00606|B_KETOACYL_SYNTHASE|PDOC00529| PROS 2799->2815|PS00606|B_KETOACYL_SYNTHASE|PDOC00529| TM:NTM 1 TM:REGION 678->699| NREPEAT 2 REPEAT 3|34->936|1591->2493|2636->3661| REPEAT 3|1483->1590|2525->2635|4460->4557| SEG 276->287|lllerlseaerr| SEG 381->390|aqaaagvagv| SEG 457->490|leeasggagggagrlqelgpgvvsgsgvvpwvvs| SEG 498->525|rgqarrlrgvvavgggadgvgvspagvg| SEG 558->569|ggrpvpgvvegr| SEG 687->698|lcladavalvva| SEG 763->772|rgrrtrrlrt| SEG 938->951|gsaggsgvsgmwgg| SEG 1009->1025|vsgggvgglsgawlvvs| SEG 1067->1102|eavdgeavggvvslvgwgsgvvqagvasvglvqalg| SEG 1163->1178|vvdglvgvlagvgggg| SEG 1212->1224|gtvlvtggtgelg| SEG 1294->1307|gvvvhaagvvddgv| SEG 1939->1948|aqaaagvagv| SEG 2018->2027|asggadggag| SEG 2033->2048|gpgvvsgsgvvpwvvs| SEG 2056->2083|rgqarrlrgvvavgggadgvgvspagvg| SEG 2117->2134|gaptagvvqgvagpaadg| SEG 2251->2268|alrsqalaalagqgamas| SEG 2428->2444|lvvgslrrgegglrrfl| SEG 2461->2476|gvfgsvgrgvaggcgv| SEG 2611->2631|sggspttgtalalalrapapr| SEG 2984->2993|aqaaagvagv| SEG 3176->3192|ralrgqarrlrqfaara| SEG 3244->3258|gsvgprgghsgrrrg| SEG 3312->3325|adladvadaadvld| SEG 3762->3768|ssssaaa| SEG 3858->3873|alhpalldaalhpvvl| SEG 3999->4017|aypdpaalaealaagapap| SEG 4043->4057|tdsapagsapadsta| SEG 4184->4198|tvlitggtgvlgrlv| SEG 4213->4242|latrrgtaadgaadlvaelaglgaeatvaa| SEG 4311->4323|ttftvfssaaasf| SEG 4405->4428|gdglllatrldaatlhaqatagal| SEG 4558->4585|taeagtpdepapaaaaagagsagsaetg| BL:PDB:NREP 12 BL:PDB:REP 17->456|2hg4F|e-121|56.9|418/859| BL:PDB:REP 578->933|2qo3B|8e-40|31.1|332/873| BL:PDB:REP 997->1461|2fr0A|4e-62|46.5|458/468| BL:PDB:REP 1482->1568|2ju1A|9e-15|46.0|87/95| BL:PDB:REP 1591->2492|2hg4F|0.0|55.4|838/859| BL:PDB:REP 2520->2610|2ju1A|3e-13|44.0|91/95| BL:PDB:REP 2636->3093|2hg4F|e-125|56.8|433/859| BL:PDB:REP 3263->3630|2qo3B|1e-42|33.6|342/873| BL:PDB:REP 3639->3938|3el6A|4e-43|40.6|271/271| BL:PDB:REP 4085->4377|2fr0A|8e-22|37.3|286/468| BL:PDB:REP 4456->4557|2ju1A|8e-13|43.1|90/95| BL:PDB:REP 4618->4873|1kezA|3e-34|36.9|241/267| RP:PDB:NREP 16 RP:PDB:REP 29->456|2c9hA|5e-81|19.1|406/426| RP:PDB:REP 526->599|3c5oA|7e-04|9.5|48/148| RP:PDB:REP 571->885|3eenA|2e-61|27.6|302/314| RP:PDB:REP 856->932|1cjaA|2e-10|13.6|70/327| RP:PDB:REP 1238->1389|2e6gC|5e-20|19.8|131/225| RP:PDB:REP 1517->2017|1e1cA|5e-87|10.8|462/727| RP:PDB:REP 2135->2421|3eenA|2e-58|24.5|282/314| RP:PDB:REP 2553->3157|1e1cA|4e-90|10.6|558/727| RP:PDB:REP 3165->3283|3c5oB|5e-08|9.1|86/152| RP:PDB:REP 3260->3560|2c2nB|7e-68|23.9|285/308| RP:PDB:REP 3541->3637|1cjaA|2e-10|14.6|82/327| RP:PDB:REP 3638->3789|3citB|4e-10|11.1|117/148| RP:PDB:REP 4063->4178|3bk9C|2e-16|13.0|115/272| RP:PDB:REP 4243->4398|2ddxA|2e-14|12.8|136/324| RP:PDB:REP 4437->4557|1e1cB|2e-14|5.8|108/619| RP:PDB:REP 4663->4875|3bf7A|1e-05|14.5|207/255| RP:PFM:NREP 16 RP:PFM:REP 1->27|PF08990|7e-08|81.5|27/27|Docking| RP:PFM:REP 36->275|PF00109|7e-61|57.0|232/245|ketoacyl-synt| RP:PFM:REP 293->409|PF02801|5e-29|62.4|117/118|Ketoacyl-synt_C| RP:PFM:REP 576->870|PF00698|2e-49|45.3|283/297|Acyl_transf_1| RP:PFM:REP 1227->1392|PF08659|5e-36|48.8|166/181|KR| RP:PFM:REP 1499->1564|PF00550|4e-06|42.4|65/67|PP-binding| RP:PFM:REP 1593->1841|PF00109|1e-65|61.4|241/245|ketoacyl-synt| RP:PFM:REP 1850->1967|PF02801|6e-28|61.9|117/118|Ketoacyl-synt_C| RP:PFM:REP 2137->2419|PF00698|9e-61|49.6|282/297|Acyl_transf_1| RP:PFM:REP 2555->2606|PF00550|3e-06|44.2|52/67|PP-binding| RP:PFM:REP 2638->2886|PF00109|1e-64|58.6|241/245|ketoacyl-synt| RP:PFM:REP 2895->3012|PF02801|1e-27|60.2|117/118|Ketoacyl-synt_C| RP:PFM:REP 3261->3555|PF00698|1e-58|49.3|285/297|Acyl_transf_1| RP:PFM:REP 4243->4362|PF08659|2e-28|53.7|120/181|KR| RP:PFM:REP 4500->4553|PF00550|5e-06|44.4|53/67|PP-binding| RP:PFM:REP 4679->4860|PF00975|1e-07|31.3|182/219|Thioesterase| HM:PFM:NREP 16 HM:PFM:REP 34->284|PF00109|6.2e-101|58.5|246/253|ketoacyl-synt| HM:PFM:REP 1590->1841|PF00109|9.9e-102|59.5|247/253|ketoacyl-synt| HM:PFM:REP 2635->2886|PF00109|2.5e-102|59.9|247/253|ketoacyl-synt| HM:PFM:REP 578->899|PF00698|6.1e-66|36.0|311/318|Acyl_transf_1| HM:PFM:REP 2139->2457|PF00698|4.7e-105|49.1|316/318|Acyl_transf_1| HM:PFM:REP 3263->3599|PF00698|5e-65|36.2|315/318|Acyl_transf_1| HM:PFM:REP 292->409|PF02801|1.1e-49|66.1|118/119|Ketoacyl-synt_C| HM:PFM:REP 1849->1967|PF02801|1.3e-49|65.3|118/119|Ketoacyl-synt_C| HM:PFM:REP 2894->3012|PF02801|1.2e-48|62.7|118/119|Ketoacyl-synt_C| HM:PFM:REP 1212->1391|PF08659|3e-60|51.1|180/181|KR| HM:PFM:REP 4183->4362|PF08659|1.3e-59|52.5|179/181|KR| HM:PFM:REP 1498->1564|PF00550|1.3e-10|34.8|66/67|PP-binding| HM:PFM:REP 2540->2606|PF00550|1.8e-12|36.4|66/67|PP-binding| HM:PFM:REP 4499->4553|PF00550|2.2e-13|40.0|55/67|PP-binding| HM:PFM:REP 4670->4873|PF00975|9.8e-25|24.3|202/229|Thioesterase| HM:PFM:REP 1->26|PF08990|2.6e-14|80.8|26/27|Docking| GO:PFM:NREP 7 GO:PFM GO:0016740|"GO:transferase activity"|PF08990|IPR015083| GO:PFM GO:0048037|"GO:cofactor binding"|PF08990|IPR015083| GO:PFM GO:0048037|"GO:cofactor binding"|PF00550|IPR006163| GO:PFM GO:0048037|"GO:cofactor binding"|PF00550|IPR006163| GO:PFM GO:0048037|"GO:cofactor binding"|PF00550|IPR006163| GO:PFM GO:0009058|"GO:biosynthetic process"|PF00975|IPR001031| GO:PFM GO:0016788|"GO:hydrolase activity, acting on ester bonds"|PF00975|IPR001031| RP:SCP:NREP 16 RP:SCP:REP 34->456|1e1cA1|7e-76|9.8|388/559|c.1.19.1| RP:SCP:REP 575->838|1nm2A1|2e-48|15.0|234/243|c.19.1.1| RP:SCP:REP 816->934|2hh8A1|3e-17|6.7|99/127|d.358.1.1| RP:SCP:REP 995->1199|2fr0A2|3e-16|25.7|203/209|c.2.1.2| RP:SCP:REP 1204->1461|2fr0A1|7e-23|44.9|256/259|c.2.1.2| RP:SCP:REP 1511->2017|1e1cA1|3e-91|9.8|470/559|c.1.19.1| RP:SCP:REP 2136->2393|1nm2A1|2e-52|17.4|238/243|c.19.1.1| RP:SCP:REP 2373->2491|2hh8A1|4e-07|8.4|99/127|d.358.1.1| RP:SCP:REP 2553->3077|1e1cA1|5e-95|10.1|486/559|c.1.19.1| RP:SCP:REP 3214->3343|1jmxA5|7e-14|10.0|113/119|b.61.4.1| RP:SCP:REP 3326->3673|1u9tA1|8e-61|10.4|307/327|e.62.1.1| RP:SCP:REP 3954->4167|2fr0A2|5e-18|20.8|197/209|c.2.1.2| RP:SCP:REP 4243->4302|2ib0A1|4e-05|23.3|60/142|a.25.1.9| RP:SCP:REP 4326->4398|2g7gA2|5e-12|8.2|67/132|a.121.1.1| RP:SCP:REP 4497->4557|1klpA|5e-12|19.7|61/115|a.28.1.1| RP:SCP:REP 4653->4876|1jmkC|6e-17|18.0|211/222|c.69.1.22| HM:SCP:REP 4->34|1pzrA_|5.5e-06|51.6|31/60|a.38.2.1|1/1|Docking domain B of the erythromycin polyketide synthase (DEBS)| HM:SCP:REP 26->407|1tedA_|2.4e-104|50.3|342/0|c.95.1.2|1/3|Thiolase-like| HM:SCP:REP 574->894|1mlaA1|1.3e-67|47.4|234/0|c.19.1.1|1/3|FabD/lysophospholipase-like| HM:SCP:REP 995->1196|2fr1A2|6.2e-39|38.3|196/0|c.2.1.2|1/3|NAD(P)-binding Rossmann-fold domains| HM:SCP:REP 1205->1442|1gz6A_|1.3e-46|33.2|229/302|c.2.1.2|1/2|NAD(P)-binding Rossmann-fold domains| HM:SCP:REP 1488->1607|1klpA_|3.5e-25|41.2|114/115|a.28.1.1|2/4|ACP-like| HM:SCP:REP 1583->1965|1tedA_|1.1e-104|50.6|342/0|c.95.1.2|2/3|Thiolase-like| HM:SCP:REP 2135->2440|1mlaA1|1.9e-64|45.1|235/0|c.19.1.1|2/3|FabD/lysophospholipase-like| HM:SCP:REP 2530->2652|1klpA_|5.1e-27|41.2|114/115|a.28.1.1|3/4|ACP-like| HM:SCP:REP 2628->3007|1tedA_|3e-103|48.8|340/0|c.95.1.2|3/3|Thiolase-like| HM:SCP:REP 3259->3569|1mlaA1|2.8e-67|46.8|235/0|c.19.1.1|3/3|FabD/lysophospholipase-like| HM:SCP:REP 3950->4168|2fr1A2|5e-36|40.8|191/0|c.2.1.2|3/3|NAD(P)-binding Rossmann-fold domains| HM:SCP:REP 4174->4395|2fr1A1|5.3e-40|30.5|220/0|c.2.1.2|2/2|NAD(P)-binding Rossmann-fold domains| HM:SCP:REP 4464->4561|1af8A_|7.6e-18|46.5|86/86|a.28.1.1|3/3|ACP-like| HM:SCP:REP 4515->4876|1kezA_|4.7e-40|29.5|258/267|c.69.1.22|5/5|alpha/beta-Hydrolases| OP:NHOMO 5367 OP:NHOMOORG 1044 OP:PATTERN -------------------------------------------------------------------- 4482L1231121-1EDENN-NFCCVAOMNNOFHDCD73463MCN112-221234311411MG22W5Pc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aQ441322211111121222222221222334442375234577777677666777767672-33332211111D3D5364355C3AA433-533333434454633333554694CA634333333333333336334333331868788767787223446444766743D4622224222222233233553233325A45358F7836474398A422222222334472333334744555454444422222222--1111--------2-2-------------------------2222222222292 1152ly3-211-2129DUBYGLMcjVW213444LOEABCCCCB545PKGQHKGGEAVSG999122111-211212111-112222222-2D3D212------6222-1L3V5454313221222412213D2-2231221222421212-4115263322323AD19547A5598334O*73IFN9458O57324223* ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 4562 STR:RPRED 93.5 SQ:SECSTR ###cHHHHHHcHHHHHTTHHHHHHHTTTccccHHcccEEEEETEEETccccHHHHHHHHHHHTTcEEEccTTccccHHHHHHHHTTcccccEEEEEEcccHHHHHHTHHHHHHHHHHHHTTTTEEEEEcHHHHTTccEEEEEcEcEEEEcccHHHHHHTTcHHHHHHcGGGcccccccHHHHHHHHHHHHHHHHHHcTTEEcEEEEcHHHHHHHHHHTccHHHHHHHHHHHHHHccccHHHHHHHHHHTTccGGGTGGGEEEEEcccHHHHHHHHHHHHHHHHHHHHTTcccccGGGGcccEEEEEcccccccTTcEEEEEEEEEETTEEEEEEEcccccTTccccEEEEEEccEEEEEEEEEccGGccEEccccccccccccTTTTcHHHHHHHHHHHHHHHHHHHHHHTTcHHHHccHHTTHHHHHHHHHcHHHHHHHHHHTcccccTTTccccEEEEEEEEEETTEEEEEccccEEEEEEcTTccEEEEEEEEETTccEEEEEEEEEEEccHHHHHHHH###HTccccGGGcEEEEEEEEEcccTTTGGGccTTcTTTTHHHHHHHHTcGGGcccEEEEccccTTHHHHHHHHHHHHHHHHHHHHHHccccTTcccccccEEEEEETTEEEEEEcTTcccEEEEEEEcHHHHHHHHHHHTTccHHHHHHHHHHHHHTTccGGcccHHHHHHHHHHHHHHHHHHHHHEEEEEEEccTTccHHHHHHHHHHHHHEEEEETTEEEEEEEHHHHHHHHHHGGGGTccEEEEcccccTTcGGGGGGHHHHHHHHHTccccccccEEEcTTTccccccTTTHHHHHHHHHTTccEEHHHHHHHHHcccEcEEEEEccccHHHHHHHHHcHHHHTTEEEEHHHHHHHHHEEEEccEEEccccEEETTTTcEEEEccccccccTTccccEEEETTccEEc#############################################################TTccEEEEEEEEcccccccccccEEEEEETTccHHHHHHHHHHHTTTcEEEEEEEcTTc#cHHHHHHHHTTcccccEEEEcTTTTcccccccGGGcHHHHHHHHHHcHHHHHHHHHHHHHHHHHTcEEEEEETTccHHHHHHHHHHHHHcTTccEEEEcccccccccccHHHHHHTccGGGcTTcccHHHHHHHHTTccccccccHHHHHHHHHHcEEEEEcccTTTHHHHHHHHHHTTcEEEEEEccccTTcHHHHHHHHHHGGGcEEEEEEEEccccccccEEEcccEEEEcccccccEEEEEcccEEEEEccHHHHHHHHHHHTccccEEEEEEEEccccGGGGGGcHHHHHHHHHHHHHTTTcEEEEEEEccccccccGGHHEEGTHHHcHHHHccHHHHHHHHHHHTcccTTccHHHHccEEEEcccEEEEEEccHHHHHHcHTccccccccccEEEEEEEcccccEEEEGGGccTTccccHHHHHHHHHHHHHHHHHHHHHHHHHHTcGGGccGGGEEEccGGGcTTcTTccHHHHHHHHHHHHHHHHccccEEEEHHHHHHHHTcHHHHTTGGGcccccccHHHHHcccEEEEEEEEEcTTccTcHHHHHHHHHTTcccEEEcccGGccccTTccGGGGccccGGGccEEEccccHHHcccTTTHccHHHHTTccHHHHHHHHHHHHHHHHHTccccTTTGGGEEEEEEHHHHHHHHHHHHcGGGccTTTTTTTcTTHHHHHHHHHHTccccEEccccGGGHHHHHHHHHHHHHHHTcccEEEEEEEEccccHHHHHHHHHTcTTcGGGcccTTcTTccccccccEEEEEEEEEHHHHHHHTccccEEEEEEEEEEcccccccccTTcHHHHHHHHHHHHHHTccGGGEEEEEccccccHHHHHHHHHHHHHHHGGGGGcGcTcEEEcGGGTccccGGGHHHHHHHHHHHHHHHcEEcccTTcccccTTccccccccccccccEEcccHHccccEEEEEEEETTTEEEEEEEEcHHHHHHHTTcccGGGcccTTccccccGGGccccccccccccHHHHHHHHHHHHTTTccHHHHHHHHHHHHTTccTTTTccccTccGGGcTTGGGccTHTTTcTTTTHHHHHHHHHHHHHHHHHHccTTccccHHHHHHTHHHHHHHHHHHHHTTcccccccccccccccGGGccHGGGTEEcccccccHHHHHHHHHHHTTccHHHHHHHHHHHHHTTGccTTTTTHHHHHHHHHHHHHcTTccHHHHHHHHHHHHHTTcccccccccccccTTccEEcTTTcccccccHHHHHHHHHTTTccHHHHHHHHHGGGccEEcHHHHcccEEccccTTccccHHHHHHHHcccEEEEcTTccEEEEcTTccEEcHHHHHHHHcHHHHHHHHHcHHHHHHHHHHHHHHHHHTTHHHHHHHTccEEEEEccEEEccccEEETTTcEEEEcccccccccTTccccTccccEEEETTccEEcccEEETTTTEEEEEE############cHHHHHTTTccTTccccHHHHHHHHcEEcTTcccccccGGGcccccccccTTHHHHHHcHHHHHHTccccEEcTTccEEcccccGGGHHHGTTcccTTccTTcTTcTTcccccHHHHcccEEccEEccccHHHHHHHHHHHHHTTcccEEEEccGGcHHHHTTccTTcTTTGGGTTccccccccHHHHHHHcTTccTTTcEEccTTHHHHHHHHHHHHHHHTccGGGcEEEEcccHHHHHHTTcHHHHHHcGGGcccccccHHHHHHHHHHHHHHHHHHcTTEEcEEEEcHHHHHHHHHHTccHHHHHHHHHHHHHEccccHHHHHHHHHHTTccGGGTGGGEEEEEcccHHHHHHHHHHHHHHHHHHHHHTTccccGGGGcccEEEEEccTTcccccTTHHHHHHHHHHHHHHHHTccEEEcccTTTTTccccHHHHHHHHHHHGGGTHGTcHHHHHTccccccccTTTTcHHHHHHHHHHHHHHHHHHHHHHTTcHHHHHHTTHcHHHHHHHHHHHHHHHHHHHTcccccTTTcccccccccccccccccHHHHHHHHHHHHHHHHHHccHHHHHHHHHHHHcccTTcGGGcHHHHHHHHHHTTccHHHHHHHHHHHHHHHHHcccccccccccccHTTTccTTccEEEEEEEEEEETTccEEEEEEEEEEcHcTTccccHHHHHHHHHHHTTccccccccHHHHHHHHHHHTTTTGGGcHHETTEcEEEHHHHHHHcEEEEEccTTcccTTTTTTTTTHcTTHHHHHHHHHHHHHHHHcccHHHHHHHccHHHHTTTcHHHHHcHHHHHHHHHHHHHHHHHHHHHHHHTEEEEEEcTTHHHHHHHHHTcccHHHHHHHHHHHHHHHHHHHHHEEEEEEEccTTccHHHHHHHHHcEEEEEEEETTEEEEEEEHHHHHHHHHHGGGGTcEEEEccccccTTcGGGGGGHHHHHHHHHTccccccccEEEcTTTccccccTTTcHHHHHHHHTTccEEHHHHHHHHHcccEcEEEEEccccHHHHHHHHHcHHHHTTEEEcHHHHTTcccccccHHHHHHHTccEEEEEccEEEcccTTTcEEEEccccccEcccTTccccEEEETTccEEcccEEEEETTTTEEEEEEEccEEEEEccGHGEEEEETTTcccEEEEEEcccEETTEEEEcHHcccEEEEEEccHHHHHTcccTTccccEEEEcccEEEEEEEEEEE##cTTccccEEEEEEEccccccc####cccGcEEEEEEEccccccccHHHHHccccc#cccTTcEEcccTTHHHHHHHTTEEEcGGGccEEEEEEETTEEEEEEEc#######ccccccccccHHHHHHHHHGGGGcTTccc#######cEEEEEEEEEccccccEEEE#EEEEccTTEEEEEEEcTTccEEEEEEEEEEc#######################################################################################################################HHHHHGTTcHHHHHHHHHHHTcccHHHHHHHHHHHTTcccccccTcccTTcHHHHHHHHHcTTTcHHHHHHHHHHHHHHHHHHHcHHHHHHHHHHHTccccHHHHHHHHTccccHHHHHGGcccccEEccEEEEcccTTcTTHHHHcEEEEEETTEEEEEETTEEEEEEcHHHHHHccTTcEEEEcccccTTcHHHHHHTcccEcEEEEEGGGccHHHHHHHTccEEEEcccccccTTcccEEEEcHHHHcccGGGGGGcHHHHHHHHHHHHHTTTcEEEEEEEccccccccGGEEEEEEccccHHTcGGGcccHHHHHHHHHHHHHHHHHHTcTTTEEEE######################################ccGGGcccccH##HHHHHHHHHHHTTTcHcTTccccHHHHHHHHHHHHHcccGGGGcT###cEGGGccTTccTTTTTcccHHHHHHHHHHHHHHHTccccHHHHTTcccHHHHHHHHHTTc##################################################HHHHHHHHTTccHHHHHHHHHHHTTcccccccccccccccccccccccccccccEccccccccEEEEccTTcTccTTTTHHHHHHHTTTccEEEEccTTcTTccccccccHHHHHHHHHHHHHHHTcccEEEEEETHHHHHHHHHHHHHHHcGGGEEEEEEEccccccccccccHHHHHHHHHHHHcccccHHHHHHHHHHTHHHHHcccccccccccEEEEccTTccTTcGGHHcTTEEEccTccccHHHHcTHHHHHHHHHHHHHTH##### DISOP:02AL 1-5, 15-36, 1467-1488, 2028-2031, 2622-2631, 3637-3647, 4441-4469, 4559-4596, 4880-4881| PSIPRED cccHHHHHHHHHHHHHHHHHHHHHHHHccccccccEEEEEEEEEcccccccHHHHHHHHHccccEEEcccccccccHHHHcccccccccccccccccEEccHHHccHHHHcccHHHHHHHcHHHHHHHHHHHHHHHHccccHHHcccccEEEEEEcccHHHHHHHHccHHHcccEEEEcHHHHHHHHHHHHHHcccccEEEEHHHHHHHHHHHHHHHHHHHcccccEEEEEcccccccHHHHHHHHHcccccccccccccccccccEEEEccEEEEEEEcHHHHHHcccEEEEEEEEEEEcccccccccccccHHHHHHHHHHHHHHccccHHHccEEEEEEcccccccHHHHHHHHHHHccccccccEEEEEccHHHHHHHHHHHHHHHHHHHHHHHcccccccccccccccccccccccEEEcccccccccccccEEEEEEEcccHHHHHHHHHHHHcccccccccccccccccccccccccEEEEEEcccHHHHHHHHHHHHHHHHHccccccccccHHHHHHHHHccccccccEEEEEEccHHHHHHHHHHHHcccccccEEEccccccEEEEEEccccccHHHHHHHHHHHcHHHHHHHHHHHHHHHHHHHHcccccHHHHHccccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHccccEEEEEEccHHHHHHHHHHccccHHHHHHHHHHHHHHHHHcccccEEEEEEccHHHHHHHHHcccccEEEEEEEccccEEEEccHHHHHHHHHHHHHcccEEEEEcccccccHHHHHHHHHHHHHHHHcccccccccEEEEccccEEccccccccHHHHHHHHHccccHHHHHHHHHHccccEEEEEccHHHHHHHHHHHcccccEEEEEccccccHHHHHHHHHHHHHHccccccHHHcccccccccccccccccccccccccccccccccccccccccccccccccccccccccHHHHHHHcccccHHHcccHHcccccHHHHcccHHHHHHHHHHHccccccccccccccccEEEEEcccccHHHHHHHHHHHccccEEEEEcccccccHHHHHHHHHHcccccccccEEEEccccccccHHHHHHHHHHHHHHHccccccEEEEccccEEccccccccccHHHHHHHHHHHHHHHccccEEEEEEccccccHHHHHHHHHHHHHcccccccEEEEccccEEEHHcccccccccccccEEccccEEEEEcccHHHHHHHHHHHHHccccEEEEEEcccccHHHHHHHHHHHHHcccEEEEEEcccccHHHHHHHHHHHHHHcccEEEEEEccccccccHHHHccHHHHHHHHHHHHHHHHHHHHHcccccccEEEEEEcHHHHccccccccHHHHHHHHHHHHHHHHHccccEEEEEccccccccccHHHHHHHHHcccccccHHHHHHHHHHHHHcccccEEEEcccHHHHccccccccccHHHHHHHHHHHHHHHccccccccccHHHHHHHHHcccHHHHHHHHHHHHHHHHHHHHccccHHHccHHHHHHHcccHHHHHHHHHHHHHHHHccEEEHHHHHccccHHHHHHHHHHHHcccccccHHHHHHHcccccccccEEEEEEEEEEcccccccHHHHHHHHHccccEEEcccccccccHHHHcccccccccccccccccEEccHHcccHHHHcccHHHHHHHcHHHHHHHHHHHHHHHHccccHHHcccccEEEEEEcccHHHHHHHHccHHHcccccHHHHHHHHHHHHHHHHHcccccEEEEEcHHHHHHHHHHHHHHHHHcccccEEEEEcccccccHHHHHHHHHcccccccccccccccccccEEEEcEEEEEEEEcHHHHHHcccEEEEEEEEEEEcccccccccccccHHHHHHHHHHHHHHccccHHHccEEEEEEccccccHHHHHHHHHHHHcccccccccEEEEEccHHHHHHHHHHHHHHHHHHHHHHHcccccccccccccccccccccccEEEcccccccccccccEEEEEEEcccHHHHHHHHHHHHcccccccccccccccccccccccccEEEEEEcccHHHHHHHHHHHHHHHHHccccccccccHHHHHHHHHccccccccEEEEEEccHHHHHHHHHHHHcccccccEEEcccccccccEEEEEEcccccccHHHHHHHHHHcHHHHHHHHHHHHHHHHHccccHHHHHccccccccHHHHHHHHHHHHHHHHHHHHHHHHccccEEEEEEccHHHHHHHHHHccccHHHHHHHHHHHHHHHHHHccccEEEEEEccHHHHHHHHHcccccEEEEEEEccccEEEEccHHHHHHHHHHHHHcccEEEEEcccccccHHHHHHHHHHHHHHHHccccccccEEEEEccccEEcccccccHHHHHHHHHcHHHHHHHHHHHHHccccEEEEEcccHHHHHHHHHHHHHcccccEEEEEccccccccHHHHHHHHHHHHHccccccHHHHccccccccccccEEcccccccHHHHHcccccccccccccccccccccccccccccccccccccccccccHHHHHHHHHHHHHHHHHHHcccccccccccHHHHccccHHHHHHHHHHHHHHHccEEEEHHHcccccHHHHHHHHHHHccccccccccccccHHHHccccccccccEEEEEEEEEcccccccHHHHHHHHHccccEEEcccccccccHHHHcccccccccccccccccEEccHHcccHHHHcccHHHHHHHHHHHHHHHHHHHHHHHHccccHHHcccccEEEEEEcccHHHHHHHHccccccccEEHHHHHHHHHHHHHHHHHcccccEEEEHHHHHHHHHHHHHHHHHHHcccccEEEEEcccccccHHHHHHHHHcccccccccccccccccccEEEEcEEEEEEEEcHHHHHHcccEEEEEEEEEEEcccccccccccccHHHHHHHHHHHHHHccccHHHccEEEEEEcccccccHHHHHHHHHHHcccccccccEEEEEccHHHHHHHHHHHHHHHHHHHHHHHcccccccccccccccccccccccEEEccccccccccccEEEEEEEccccccccEEEEEEcccccccccccccccccccEEEcccccHHHHHHHHHHHHHHHHHHcccccccccccccccccccccccccccccHHHHHHHHHHHHccccccccccccccccccccEEEEccccHHHHHHHHHHHHHHHHHcccccHHHHHHHHHcccccccccEEEEEccHHHHHHHHHHHHcccccccEEEccccccccccccccccEEEEEcccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccHHHHHccccccccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHccccEEEEEEccHHHHHHHHHHccccHHHHHHHHHHHHHHHHHccccccEEEEEccHHHHHHHHHcccccEEEEEEEccccEEEEccHHHHHHHHHHHHHcccEEEEEcccccccHHHHHHHHHHHHHHHHccccccccEEEEEccccEEEcccccccHHHHHHHHHHHHHHHHHHHHHHHccccEEEEEccHHHHHHHHHHHHHHHcccccccccccccccEEEEEcccccccHHHHHHHHHHHHHHccccccccHHHccccccccEEEcccccccccccccccccccccccccccccccccccccccccccccccEEEEEEEcccccccHHccccccEEEcHHHHHHHHHHHHHHHccccEEEEEEEEccEEEcccccEEEEEEEEEcccccccccccEEEEEEEEccccccEEcccccccccEEEEEEEEEEEcccccccccHHHHcccccccccHHHHHHHHHHHccccccHHHHHHHHHHccccEEEEEEEcccccccccccccccccHHHHHHHHHHHHHHcccccccccccEEEEEEcccEEccccHHHHHHEEEEcccccEEEEEEEcccccEEEEEEHHHHHHHHHHHHHHHHcccccccEEEEcccccccccccccccEEEEEcccccHHHHHHHccccEEEEccccHHHHHHHccccccccEEEEEccccccccHHHHHHHcccccccccccccccccccHHHHHHHHHHHHHHHHHHHccccccccEEEEEEcccEEccccccccHHHHHHHHHHHHHHHHcccccEEEEEEcccccHHHHHHHHccccEEEEEccEEEEEcccccccccccccccccccccccEEEEEEccHHHHHHHHHHHHHHccccEEEEEcccccccHHHHHHHHHHHHcccEEEEEEcccccHHHHHHHHHHHHHccccEEEEEccccccccHHHHccHHHHHHHHHHHHHHHHHHHHHcccccccEEEEHHHHHHHcccccHHHHHHHHHHHHHHHHHHHHccccEEEEEEcccccccccccHHHHHHHHHHHHcccccccHHHHHHHHHHHHHcccccccEEEEEccccHHHHHHcccccccHHHHHHHccHHHHHHcccccccccHHHHHHHHccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccHHcccccccHHHHccHHHHHHHHHHHHHHHHcccccHHHHHccccHHHHHHHHHHHccccccccccccccccccccccccccccccccccccccccccccccHHHHHHHHHHccccccHHHHHHHHHHHHHcccccccHHHHHHccccccHHHHccccccccccccccEEEEEccccccccccHHHHHHHHHcccccEEEEEEcccccccccccccHHHHHHHHHHHHHHHcccccEEEEHHHHHHHHHHHHHHHHHHccccEEEEEEEcccccccccHHHHHHHHHHHHHHccccccccHHHHHHHHHHHHHHcccccccccccEEEEEEccccccccccccccEEEEcccHHHHHHHHHHHHHHHHHHHHHHHHHHccc 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