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Streptomyces avermitilis MA-4680 (save0)
Gene : aveF
DDBJ      :aveF         C-5 ketoreductase
Swiss-Prot:             

Homologs  Archaea  49/68 : Bacteria  864/915 : Eukaryota  178/199 : Viruses  0/175   --->[See Alignment]
c.2.1
:302 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   39->297 3iccA PDBj 8e-50 46.5 %
:RPS:PDB   38->297 1dohB PDBj 5e-35 36.3 %
:RPS:SCOP  44->295 1pwxA  c.2.1.2 * 2e-41 24.2 %
:HMM:SCOP  37->294 1zemA1 c.2.1.2 * 5e-70 39.9 %
:RPS:PFM   42->222 PF00106 * adh_short 5e-12 40.4 %
:HMM:PFM   43->221 PF00106 * adh_short 3.5e-27 27.8 162/167  
:BLT:SWISS 37->297 T4HR_MAGGR 5e-35 39.8 %
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID BAC68646.1 GT:GENE aveF GT:PRODUCT C-5 ketoreductase GT:DATABASE GIB00135CH01 GT:ORG save0 GB:ACCESSION GIB00135CH01 GB:LOCATION complement(1134941..1135849) GB:FROM 1134941 GB:TO 1135849 GB:DIRECTION - GB:GENE aveF GB:PRODUCT C-5 ketoreductase GB:NOTE avermectin gene cluster GB:PROTEIN_ID BAC68646.1 LENGTH 302 SQ:AASEQ MRECGRGIPVAVTRMVESLITSGTPCLLSEKGNFIVADLKGRAALVTGASRGIGRAIAQRLAAEGLLVAVHYGSQEKAAAETVEAIERVGGEAFPVRADLRRDDAVDTLFAEVENRLDGRPLHVLVNNAGVQSPPAPEGAGGKGEDVTSVSGVTAAEFDHLFRINVRAPFFIIQRALRLIGEGGRVINVSSALTRIAWPLLPYAMSKGALEMIAPRLALELGARGITVNTVAPGITATDMNRAMRDVPGVEERISALTALRRLGRPGDIAGVVAFLASDEGRWVTGQLVDASGGLCIAPAMS GT:EXON 1|1-302:0| BL:SWS:NREP 1 BL:SWS:REP 37->297|T4HR_MAGGR|5e-35|39.8|246/283| SEG 96->107|vradlrrddavd| SEG 134->145|ppapegaggkge| BL:PDB:NREP 1 BL:PDB:REP 39->297|3iccA|8e-50|46.5|241/248| RP:PDB:NREP 1 RP:PDB:REP 38->297|1dohB|5e-35|36.3|245/271| RP:PFM:NREP 1 RP:PFM:REP 42->222|PF00106|5e-12|40.4|166/169|adh_short| HM:PFM:NREP 1 HM:PFM:REP 43->221|PF00106|3.5e-27|27.8|162/167|adh_short| GO:PFM:NREP 2 GO:PFM GO:0008152|"GO:metabolic process"|PF00106|IPR002198| GO:PFM GO:0016491|"GO:oxidoreductase activity"|PF00106|IPR002198| RP:SCP:NREP 1 RP:SCP:REP 44->295|1pwxA|2e-41|24.2|231/252|c.2.1.2| HM:SCP:REP 37->294|1zemA1|5e-70|39.9|243/0|c.2.1.2|1/1|NAD(P)-binding Rossmann-fold domains| OP:NHOMO 10437 OP:NHOMOORG 1091 OP:PATTERN 2211122987877774-9131--16--5334411---------11-22--322-23112132433-23 CAS4R--344A14-MhZCC-CY22R*CBDCDIdgniQc*q4a7*GJB52A82LDG53711HEK1HGSOUJ911111111175L11332564425221--45H26Aa7Q6D1111111---1111343244322442AAA9A2229988A86531122221322142A96H3-1111212-111A8578441C5L99A9BECEAAEBEGCHCJJFIBAC8EHDJD7566655DV6444443444444437997961814515-1-353335453678243545133322122232232222455545564555512211122233257A444333343463552465632115612296122224333334512B1CbDDL12112I8wRV469TIOOJGGIGFGHGIHP-EIMFEYEGIhT1qaaHTUckkhehPW8HCIBMHBEJF8AAAAAAAAAIONC66961121122211-1223312212211211115BZuE4EbVLTochfjeJNMNLXXikOOOOALuPsOndW58NNHG8EBAKEOAba7C34748A41111111235JA66F34311112422314653923648859EJ311332222222222222222211221559865ADB5K93487686A9666595776671-1333811-1119DBA4F6ABB8A888AA-B9AAA88BABB8A9AABA6ILJD63787567878778767677L897776A21777777777777111545334988938EIC111516111111231DEFIE4A374H7IIFIEJLWCEFJDDHGK54433443423348434437A689DDCDDCA77755551233995444--------1-2----------1--------------2231144474292 11--33B-312-277IRQLQNTHZYZUCD5BABBBC6KCGBGHABAGFLNUWqiEKLIFFCE325-13-4--334-----233353-9-JaFRAXA9987768CA8-7L3q9A9B9221--26295261DR7-47521318136412-2262-62424CbdQ5JCBD8689CKD94673f2336ABOEjLX786G7649 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 302 STR:RPRED 100.0 SQ:SECSTR ccHHcccccGGGcccccccccccccHHHHHHHHHHHTccTTcEEEETTTTcHHHHHHHHHHHHTTcEEEEEEcccHHHHHHHHHHHHHTTccEEEEEccTTcHHHHHHHHHHHHHHHHHccccEEEEcccccHGGGGTTccccccccccGGGccHHHHHHHHHHHTHHHHHHHHHHHHHcTcEEEEEccGGGTcccccccHHHHHHHHHHHHHHHHHHHHHGGGTcEEEEEEEcccccHHHHHHGGHHHHHHHHHHccTTcccccHHHHHHHHHHHHcGGGTTccccEEEEccccccccccc DISOP:02AL 1-10, 25-37| PSIPRED ccccccccccccccccccccccccccccccccccccccccccEEEEEccccHHHHHHHHHHHHcccEEEEEccccHHHHHHHHHHHHHcccEEEEEEEccccHHHHHHHHHHHHHHHcccccEEEEEcccccccccHHHHHHHHHccccHHcccHHHHHHHHHHccHHHHHHHHHHHHHHHccccEEEEcHHHHHccccccHHHHHHHHHHHHHHHHHHHHHHcccEEEEEccccccccccHHHcccHHHHHHHHHcccccccccHHHHHHHHHHHcccccccccEEEEEEccccEEccccc //