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Streptomyces avermitilis MA-4680 (save0)
Gene : dxs1
DDBJ      :dxs1         putative 1-deoxy-D-xylulose 5-phosphate synthase
Swiss-Prot:DXS1_STRAW   RecName: Full=1-deoxy-D-xylulose-5-phosphate synthase 1;         EC=2.2.1.7;AltName: Full=1-deoxyxylulose-5-phosphate synthase 1;         Short=DXP synthase 1;         Short=DXPS 1;

Homologs  Archaea  38/68 : Bacteria  792/915 : Eukaryota  59/199 : Viruses  0/175   --->[See Alignment]
c.36.1c.48.1
:632 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   3->607 2o1xA PDBj e-99 41.0 %
:RPS:PDB   28->616 2e6kA PDBj 1e-63 20.4 %
:RPS:SCOP  10->342 1ni4A  c.36.1.11 * 1e-34 14.0 %
:RPS:SCOP  316->475 1dtwB1  c.36.1.7 * 4e-28 19.0 %
:RPS:SCOP  499->632 1ay0A3  c.48.1.1 * 1e-12 22.8 %
:HMM:SCOP  1->378 1w85A_ c.36.1.11 * 6.8e-73 38.2 %
:HMM:SCOP  288->481 1qgdA1 c.36.1.6 * 4.6e-52 36.4 %
:HMM:SCOP  483->620 1dtwB2 c.48.1.2 * 1.4e-24 35.9 %
:RPS:PFM   90->179 PF00676 * E1_dh 1e-07 37.5 %
:RPS:PFM   317->476 PF02779 * Transket_pyr 8e-13 39.5 %
:RPS:PFM   499->608 PF02780 * Transketolase_C 1e-07 36.1 %
:HMM:PFM   316->478 PF02779 * Transket_pyr 9.7e-36 28.4 162/178  
:HMM:PFM   499->611 PF02780 * Transketolase_C 1.3e-29 40.2 112/124  
:HMM:PFM   93->175 PF00676 * E1_dh 1.7e-08 33.3 81/300  
:HMM:PFM   241->285 PF00456 * Transketolase_N 6.6e-05 31.1 45/333  
:BLT:SWISS 1->632 DXS1_STRAW 0.0 100.0 %
:PROS 29->48|PS00801|TRANSKETOLASE_1
:PROS 422->438|PS00802|TRANSKETOLASE_2
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID BAC69357.1 GT:GENE dxs1 GT:PRODUCT putative 1-deoxy-D-xylulose 5-phosphate synthase GT:DATABASE GIB00135CH01 GT:ORG save0 GB:ACCESSION GIB00135CH01 GB:LOCATION complement(2015433..2017331) GB:FROM 2015433 GB:TO 2017331 GB:DIRECTION - GB:GENE dxs1 GB:PRODUCT putative 1-deoxy-D-xylulose 5-phosphate synthase GB:NOTE non-mevalonate pathway, EC 4.1.3.37 GB:PROTEIN_ID BAC69357.1 LENGTH 632 SQ:AASEQ MTMLENIRGPRDLKALSEAELGELAEEIREFLVHAVARTGGHLGPNLGVVELSVALHRAFESPVDRILWDTGHQSYVHKLLTGRQDFSKLRSKGGLSGYPSREESEHDVIENSHASTVLGWADGLAKARQVQGEKGHVVAVIGDGALTGGMAWEALNNIAAAKDRPLIIVVNDNERSYSPTIGGLANHLATLRTTDSYEKVLAWGKDVLLRTPVVGNTLYESLHGAKKGFKDAFAPQGMFEDLGLKYVGPIDGHDMKAMESAFRRAKRFHGPVLIHCLTEKGRGYEPALAHDEDRFHTVGVMDPLTCEPLAPSNGPSWTSVFGDEIVRIGEEREDVVAITAAMLHPVGLNKFAEKFPGRVWDVGIAEQHAAVSAAGLATGGLHPVVAVYATFLNRAFDQLLMDVALHRCGVTFVLDRAGVTGVDGASHNGMWDMSILQVVPGLRIAAPRDADQLRAQLREAVAVDDAPTLLRFPKESVGPAIPAVDHVGGMDVLHRFPESPQVLLVAVGVMAPVCLQAAELLEARGIGCTVVDPRWVKPVDPSLPGLAAEHRLVAVVEDNSRAAGVGAAVALALSDAEVDVPVRRFGIPEQFLAHAKRAEVLADIGLTPVEIAGRISAGLATKEELSKEKQE GT:EXON 1|1-632:0| SW:ID DXS1_STRAW SW:DE RecName: Full=1-deoxy-D-xylulose-5-phosphate synthase 1; EC=2.2.1.7;AltName: Full=1-deoxyxylulose-5-phosphate synthase 1; Short=DXP synthase 1; Short=DXPS 1; SW:GN Name=dxs1; OrderedLocusNames=SAV_1646; SW:KW Complete proteome; Isoprene biosynthesis; Thiamine biosynthesis;Thiamine pyrophosphate; Transferase. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->632|DXS1_STRAW|0.0|100.0|632/632| GO:SWS:NREP 3 GO:SWS GO:0008299|"GO:isoprenoid biosynthetic process"|Isoprene biosynthesis| GO:SWS GO:0009228|"GO:thiamin biosynthetic process"|Thiamine biosynthesis| GO:SWS GO:0016740|"GO:transferase activity"|Transferase| PROS 29->48|PS00801|TRANSKETOLASE_1|PDOC00635| PROS 422->438|PS00802|TRANSKETOLASE_2|PDOC00635| SEG 15->27|alseaelgelaee| SEG 563->574|aagvgaavalal| BL:PDB:NREP 1 BL:PDB:REP 3->607|2o1xA|e-99|41.0|549/578| RP:PDB:NREP 1 RP:PDB:REP 28->616|2e6kA|1e-63|20.4|560/632| RP:PFM:NREP 3 RP:PFM:REP 90->179|PF00676|1e-07|37.5|88/298|E1_dh| RP:PFM:REP 317->476|PF02779|8e-13|39.5|147/172|Transket_pyr| RP:PFM:REP 499->608|PF02780|1e-07|36.1|108/122|Transketolase_C| HM:PFM:NREP 4 HM:PFM:REP 316->478|PF02779|9.7e-36|28.4|162/178|Transket_pyr| HM:PFM:REP 499->611|PF02780|1.3e-29|40.2|112/124|Transketolase_C| HM:PFM:REP 93->175|PF00676|1.7e-08|33.3|81/300|E1_dh| HM:PFM:REP 241->285|PF00456|6.6e-05|31.1|45/333|Transketolase_N| GO:PFM:NREP 4 GO:PFM GO:0008152|"GO:metabolic process"|PF00676|IPR001017| GO:PFM GO:0016624|"GO:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"|PF00676|IPR001017| GO:PFM GO:0003824|"GO:catalytic activity"|PF02780|IPR005476| GO:PFM GO:0008152|"GO:metabolic process"|PF02780|IPR005476| RP:SCP:NREP 3 RP:SCP:REP 10->342|1ni4A|1e-34|14.0|322/362|c.36.1.11| RP:SCP:REP 316->475|1dtwB1|4e-28|19.0|158/188|c.36.1.7| RP:SCP:REP 499->632|1ay0A3|1e-12|22.8|114/146|c.48.1.1| HM:SCP:REP 1->378|1w85A_|6.8e-73|38.2|314/0|c.36.1.11|1/1|Thiamin diphosphate-binding fold (THDP-binding)| HM:SCP:REP 288->481|1qgdA1|4.6e-52|36.4|187/195|c.36.1.6|1/1|Thiamin diphosphate-binding fold (THDP-binding)| HM:SCP:REP 483->620|1dtwB2|1.4e-24|35.9|128/138|c.48.1.2|1/1|TK C-terminal domain-like| OP:NHOMO 1421 OP:NHOMOORG 889 OP:PATTERN 11-1--1111111111-111111------1-----11111111-----------11-111-111--11 1-22411111111111122-2111232122211111224212242122211152311111422133543411111111422231112222231111--11222322231411111111111111122122222232222--223122112112111111111111212211212112111111111111111221111121111112213233121121112-1112221112111111111111111---11-2-----31-211111--1----221111--11---11111111111-------------------111121224222222243413222222113--2242222222232224312233121111111111213331121211211111111112-33333433221-2221232232221411122122332123333333324512232-----------------------------11221221111444132222223322222212113121111221211112121221111111121111111111111-21211111131111344233334113111111111111111111111111111111111121211121124222223222212212111--21111--11121112311111111111-11111111111111111133332111132222222222222221111111111221222222222111111111----1111111112111111111122222111113122221122122321221111111111-11111111111111111111111111111122222233--------11------------1------1------1211113121111 11--1---2---------------------------------------------------------------------------------------------------2-21-1-21----11-21-1-161-11411-12--2----1211-------11-1121-4-11--412221S221135376-42-1----1 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 632 STR:RPRED 100.0 SQ:SECSTR cccHHHHHHHHHHHHHHHHHHTTcHHHHHHHHHHHHHHHTcccHHHHHHHHHHHHTTcccTTTccEEEEccGGGHHHHHHHHHTHHTTTTcTTcccccccccTTcTTcccccccTTHHHHHHHHHHHHHHHHHHHHcEEEEEcHHHHcHHHHHHHHHHHHHTTcTTEEEEEEEccEETTEGGGTccEEGGGTccccHHHHHHHTTcEEEEEccTTcHHHHHHHHHHHHccccEETTTcTTTTcGGGTccccHHHHHHHHHHHHTcccTTcccHHHHHHHcHHHHHHHHHHHHHHHHHHHTcccccccccccccccccHHHHHHHHHHHHGGGcTTEEEcHHHHTcccTTccccTTcTccEEEccccHHHHHHHHHHHHHcccEEEEEEEGGGHGGGGGHHHHHHHHHTcccEEEEEcccGGcTTcTTTccccHHHHHTcTTTcEEEccccHHHHHHHHHHHHHcccccEEEEcccccccccHHHHGGGGGccEEEEccccccEEEEEcTTHHHHHHHHHHHHHHTTccEEEEEcccHHHHHTccHHHHHHTccEEEEcccccTTGGGHHHHHHHcGGGGGTTccEEEccccccccccTTHHHHHTTccHHHHHHHHHHHHTHHHHHHHHTTc DISOP:02AL 620-632| PSIPRED cccccccccHHHHHcccHHHHHHHHHHHHHHHHHHHHHccccccHHHHHHHHHHHHHccccccccEEEEEccccHHHHHHHHHHHHHHHHHHcccccccccccccccEEEcccccHHHHHHHHHHHHHHHHHccccEEEEEEEccccccHHHHHHHHHHHHcccccEEEEEEcccEEEcccHHHHHHHHHHHHccHHHHHHHHHHHHHHHccccccHHHHHHHHHHHHHcccHHcccHHHHHccccEEcccccccHHHHHHHHHHHHHccccEEEEEEEEccccccccccccHHHHHHccccccccccccccccHHHHHHHHHHHHHHHHHccccEEEEcccccccccHHHHHHHccccEEEcccHHHHHHHHHHHHHHccccEEHHHHHHHHHHHHHHHHHHHHHcccccEEEEEcccccccccHHHccccHHHHHHHHcccEEEEEccHHHHHHHHHHHHHcccccEEEEEcccccccccccccEEEccEEEEEEcccccEEEEEEcHHHHHHHHHHHHHHHccccEEEEccccccHHHHHHHHHHHHcccEEEEEccccEEcHHHHHHHHHHHccccccEEEEEEEccccccccHHHHHHHHcccHHHHHHHHHHHHHccccccHHccc //