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Streptomyces avermitilis MA-4680 (save0)
Gene : folD2
DDBJ      :folD2        putative methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase
Swiss-Prot:FOLD1_STRAW  RecName: Full=Bifunctional protein folD 1;Includes:  RecName: Full=Methylenetetrahydrofolate dehydrogenase;           EC=1.5.1.5;Includes:  RecName: Full=Methenyltetrahydrofolate cyclohydrolase;           EC=3.5.4.9;

Homologs  Archaea  27/68 : Bacteria  886/915 : Eukaryota  184/199 : Viruses  0/175   --->[See Alignment]
c.2.1c.58.1
:287 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   32->279 1a4iA PDBj 6e-57 46.4 %
:RPS:PDB   7->283 1b0aA PDBj 1e-40 39.7 %
:RPS:SCOP  5->151 1edzA2  c.58.1.2 * 3e-31 15.3 %
:RPS:SCOP  133->271 1a4iA1  c.2.1.7 * 3e-16 52.5 %
:HMM:SCOP  5->126 1a4iA2 c.58.1.2 * 2.7e-36 45.9 %
:HMM:SCOP  127->284 1a4iA1 c.2.1.7 * 1.5e-44 48.1 %
:RPS:PFM   9->125 PF00763 * THF_DHG_CYH 2e-24 45.3 %
:RPS:PFM   128->279 PF02882 * THF_DHG_CYH_C 3e-44 61.2 %
:HMM:PFM   134->282 PF02882 * THF_DHG_CYH_C 1.2e-62 55.7 149/161  
:HMM:PFM   9->125 PF00763 * THF_DHG_CYH 1.2e-39 44.0 116/117  
:BLT:SWISS 1->287 FOLD1_STRAW e-157 100.0 %
:PROS 260->268|PS00767|THF_DHG_CYH_2
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID BAC68253.1 GT:GENE folD2 GT:PRODUCT putative methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase GT:DATABASE GIB00135CH01 GT:ORG save0 GB:ACCESSION GIB00135CH01 GB:LOCATION complement(687276..688139) GB:FROM 687276 GB:TO 688139 GB:DIRECTION - GB:GENE folD2 GB:PRODUCT putative methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase GB:NOTE PF02882: Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain GB:PROTEIN_ID BAC68253.1 LENGTH 287 SQ:AASEQ MSATQTAQLMDGTGHARRIVEEAAAKAAEISQRTGTAPCLATVLVGDDPASVTYVRMKRARCAKAGIRSRHIALPATTTTAELIDSLSGLSGDPEVHGILLQHPCGPHIDERAAFEAIAPAKDVDGVTMHSFAAMSFGLPGFVSCTPGGIMRLLEAYDVDLAGKHAVVVGRSAILGKPVGMLLLAKDATVTYCHSRTADLSAMVREADVVVAAVGRPRLIRGEDIKPGAVVIDAGYNPGNVGDVDFDAVLTRARLITPVPGGVGPMTIAVLLEQTVDAAANQLGVQQ GT:EXON 1|1-287:0| SW:ID FOLD1_STRAW SW:DE RecName: Full=Bifunctional protein folD 1;Includes: RecName: Full=Methylenetetrahydrofolate dehydrogenase; EC=1.5.1.5;Includes: RecName: Full=Methenyltetrahydrofolate cyclohydrolase; EC=3.5.4.9; SW:GN Name=folD1; OrderedLocusNames=SAV_543; SW:KW Amino-acid biosynthesis; Complete proteome; Histidine biosynthesis;Hydrolase; Methionine biosynthesis; Multifunctional enzyme; NADP;One-carbon metabolism; Oxidoreductase; Purine biosynthesis. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->287|FOLD1_STRAW|e-157|100.0|287/287| GO:SWS:NREP 9 GO:SWS GO:0008652|"GO:cellular amino acid biosynthetic process"|Amino-acid biosynthesis| GO:SWS GO:0000105|"GO:histidine biosynthetic process"|Histidine biosynthesis| GO:SWS GO:0016787|"GO:hydrolase activity"|Hydrolase| GO:SWS GO:0009086|"GO:methionine biosynthetic process"|Methionine biosynthesis| GO:SWS GO:0003824|"GO:catalytic activity"|Multifunctional enzyme| GO:SWS GO:0006730|"GO:one-carbon metabolic process"|One-carbon metabolism| GO:SWS GO:0016491|"GO:oxidoreductase activity"|Oxidoreductase| GO:SWS GO:0055114|"GO:oxidation reduction"|Oxidoreductase| GO:SWS GO:0006164|"GO:purine nucleotide biosynthetic process"|Purine biosynthesis| PROS 260->268|PS00767|THF_DHG_CYH_2|PDOC00616| SEG 21->29|eeaaakaae| BL:PDB:NREP 1 BL:PDB:REP 32->279|1a4iA|6e-57|46.4|248/285| RP:PDB:NREP 1 RP:PDB:REP 7->283|1b0aA|1e-40|39.7|277/287| RP:PFM:NREP 2 RP:PFM:REP 9->125|PF00763|2e-24|45.3|117/118|THF_DHG_CYH| RP:PFM:REP 128->279|PF02882|3e-44|61.2|152/160|THF_DHG_CYH_C| HM:PFM:NREP 2 HM:PFM:REP 134->282|PF02882|1.2e-62|55.7|149/161|THF_DHG_CYH_C| HM:PFM:REP 9->125|PF00763|1.2e-39|44.0|116/117|THF_DHG_CYH| GO:PFM:NREP 4 GO:PFM GO:0003824|"GO:catalytic activity"|PF00763|IPR000672| GO:PFM GO:0009396|"GO:folic acid and derivative biosynthetic process"|PF00763|IPR000672| GO:PFM GO:0003824|"GO:catalytic activity"|PF02882|IPR000672| GO:PFM GO:0009396|"GO:folic acid and derivative biosynthetic process"|PF02882|IPR000672| RP:SCP:NREP 2 RP:SCP:REP 5->151|1edzA2|3e-31|15.3|144/146|c.58.1.2| RP:SCP:REP 133->271|1a4iA1|3e-16|52.5|139/160|c.2.1.7| HM:SCP:REP 5->126|1a4iA2|2.7e-36|45.9|122/125|c.58.1.2|1/1|Aminoacid dehydrogenase-like, N-terminal domain| HM:SCP:REP 127->284|1a4iA1|1.5e-44|48.1|158/170|c.2.1.7|1/1|NAD(P)-binding Rossmann-fold domains| OP:NHOMO 1535 OP:NHOMOORG 1097 OP:PATTERN ------------------11111-21111111-----------11-1111111--------111--11 1111211111111111111-11111111111111111222122111111111221111112221222211111111111112311111111111111--1111111111111111111111111111111111111111111121111111111111111111111111111111111111112211111121111111111111111111111111111111111111111211111111111111111111111111111221111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111222111211111111111111111111111111111111111111111111111-1-------1211311122211322111111121111313111111111111-11111111111111111111111111111111112311112211111111111111121111111111111111112111111111111111111111-1111111111111111111111111212122111111122111111111111111111111111111111111112111111111111111111111111-1111111111111111111111111111-111111111111111111111111111111111111111111111111111111111111111111111111111111-11111111121111111111111112111111111111332211122211111111121111111111111111111111111111111111111111111111111----1-111-1-1---111111---1111111111111 ----321-311-11211-1-11111111111111111111-111111221221111111222232332122121222-2232222122-111111111112-1323-16245747653242443763E1Gb5-7563442624552432253264553333223242633D21121333Y222216363-431134433 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 279 STR:RPRED 97.2 SQ:SECSTR ####cccEEccHHHHHHHHHHHHHHHHHHHHHTTccccEEEEEEEcccHHHHHHHHHHHHHHHHHTcEEccEEEcTTccHHHHHHHHHHHHTcTTccEEEEcccccTTccHHHHHTTccTTTcTTcccHHHHHHHHTTccccccHHHHHHHHHHHHTTcccTTcEEEEEcccTTTHHHHHHHHHTTTcEEEEEccccccHHHHHHHccEEEEccccTTcTccTTcEEEEcccEEcTTccEEccccHHHHHHHccEEcccccccHHHHHHHHHHHHHHHHHHTT#### DISOP:02AL 1-4, 285-287| PSIPRED ccccccEEEEcHHHHHHHHHHHHHHHHHHHHHccccccEEEEEEEcccHHHHHHHHHHHHHHHHcccEEEEEEccccccHHHHHHHHHHHcccccccEEEEEccccccccHHHHHHHcccccccccccHHHHHHHHccccccccccHHHHHHHHHHHcccccccEEEEEEccccHHHHHHHHHHHcccEEEEEEcccccHHHHHHHccEEEEEEcccccccccccccccEEEEccccccccccccHHHHHHHccEEccccccccHHHHHHHHHHHHHHHHHHHcccc //