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Streptomyces avermitilis MA-4680 (save0)
Gene : hemC2
DDBJ      :hemC2        putative porphobilinogen deaminase
Swiss-Prot:HEM32_STRAW  RecName: Full=Porphobilinogen deaminase 2;         Short=PBG 2;         EC=2.5.1.61;AltName: Full=Hydroxymethylbilane synthase 2;         Short=HMBS 2;AltName: Full=Pre-uroporphyrinogen synthase 2;

Homologs  Archaea  55/68 : Bacteria  730/915 : Eukaryota  180/199 : Viruses  0/175   --->[See Alignment]
c.94.1d.50.2
:314 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   9->312 1pdaA PDBj 4e-40 35.5 %
:RPS:PDB   10->312 3ecrB PDBj 1e-63 33.9 %
:RPS:SCOP  8->224 1ah5A1  c.94.1.1 * 4e-53 35.8 %
:RPS:SCOP  226->312 1ah5A2  d.50.2.1 * 7e-17 34.9 %
:HMM:SCOP  7->224 1pdaA1 c.94.1.1 * 1.2e-68 50.5 %
:HMM:SCOP  225->315 1gtkA2 d.50.2.1 * 2.1e-18 39.1 %
:RPS:PFM   10->219 PF01379 * Porphobil_deam 1e-34 42.8 %
:RPS:PFM   234->304 PF03900 * Porphobil_deamC 2e-08 45.7 %
:HMM:PFM   10->220 PF01379 * Porphobil_deam 3.3e-65 48.3 209/214  
:HMM:PFM   232->304 PF03900 * Porphobil_deamC 4.6e-17 38.4 73/76  
:BLT:SWISS 1->314 HEM32_STRAW e-160 100.0 %
:PROS 236->252|PS00533|PORPHOBILINOGEN_DEAM
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID BAC68748.1 GT:GENE hemC2 GT:PRODUCT putative porphobilinogen deaminase GT:DATABASE GIB00135CH01 GT:ORG save0 GB:ACCESSION GIB00135CH01 GB:LOCATION complement(1312721..1313665) GB:FROM 1312721 GB:TO 1313665 GB:DIRECTION - GB:GENE hemC2 GB:PRODUCT putative porphobilinogen deaminase GB:NOTE PF01379: Porphobilinogen deaminase, dipyromethane cofactor binding domain GB:PROTEIN_ID BAC68748.1 LENGTH 314 SQ:AASEQ MSGMSALELIRIVSRDSPMALAQVARVRAELAALHPRTRTEVVAVKTTGDKWMGDLSKVDGKGAFTKEVDAALLAGEADLAVHCVKDVPADRPLPAGTMFAAFLKRDDIRDALVHPGGLTLDELPPGTRIGTSSVRRVAQLAAAYPHLECVPFRGNANRRLEKLAAGEADALLLAVSGLERIGREDVITEVLEPETMMPPIGAGILALQCREGDTGLIETISELGDPGTHREATAERMFLHVLQGHCNSPIAGYARTERNGELSLRASVFTLDGKTVLNAHEWAGRLDPATLGTSVAVALLRQGARELIDDIPH GT:EXON 1|1-314:0| SW:ID HEM32_STRAW SW:DE RecName: Full=Porphobilinogen deaminase 2; Short=PBG 2; EC=2.5.1.61;AltName: Full=Hydroxymethylbilane synthase 2; Short=HMBS 2;AltName: Full=Pre-uroporphyrinogen synthase 2; SW:GN Name=hemC2; OrderedLocusNames=SAV_1038; SW:KW Complete proteome; Porphyrin biosynthesis; Transferase. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->314|HEM32_STRAW|e-160|100.0|314/314| GO:SWS:NREP 2 GO:SWS GO:0006779|"GO:porphyrin biosynthetic process"|Porphyrin biosynthesis| GO:SWS GO:0016740|"GO:transferase activity"|Transferase| PROS 236->252|PS00533|PORPHOBILINOGEN_DEAM|PDOC00461| SEG 68->82|evdaallageadlav| SEG 161->175|leklaageadallla| BL:PDB:NREP 1 BL:PDB:REP 9->312|1pdaA|4e-40|35.5|293/296| RP:PDB:NREP 1 RP:PDB:REP 10->312|3ecrB|1e-63|33.9|286/310| RP:PFM:NREP 2 RP:PFM:REP 10->219|PF01379|1e-34|42.8|208/214|Porphobil_deam| RP:PFM:REP 234->304|PF03900|2e-08|45.7|70/75|Porphobil_deamC| HM:PFM:NREP 2 HM:PFM:REP 10->220|PF01379|3.3e-65|48.3|209/214|Porphobil_deam| HM:PFM:REP 232->304|PF03900|4.6e-17|38.4|73/76|Porphobil_deamC| GO:PFM:NREP 4 GO:PFM GO:0004418|"GO:hydroxymethylbilane synthase activity"|PF01379|IPR000860| GO:PFM GO:0033014|"GO:tetrapyrrole biosynthetic process"|PF01379|IPR000860| GO:PFM GO:0004418|"GO:hydroxymethylbilane synthase activity"|PF03900|IPR000860| GO:PFM GO:0033014|"GO:tetrapyrrole biosynthetic process"|PF03900|IPR000860| RP:SCP:NREP 2 RP:SCP:REP 8->224|1ah5A1|4e-53|35.8|204/205|c.94.1.1| RP:SCP:REP 226->312|1ah5A2|7e-17|34.9|86/94|d.50.2.1| HM:SCP:REP 7->224|1pdaA1|1.2e-68|50.5|216/217|c.94.1.1|1/1|Periplasmic binding protein-like II| HM:SCP:REP 225->315|1gtkA2|2.1e-18|39.1|87/0|d.50.2.1|1/1|Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain| OP:NHOMO 1048 OP:NHOMOORG 965 OP:PATTERN 11-1-11111111111-11111111111-1111111111111111111111111-------111--11 111-111111111111111-1111111111111111111111111-11111111111-1111111112211--------111111111----1------11111111111--------------11111111111111111---11111111111111111111111111111111111111111111---11111111111111111111111111111111111111111111111111111111111111-------------11---------------------------------------------1---------11111111111111111111111211---1111111111-1111--1-111111111-----1-1111111111111111111111-11111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111-11111111111111111111111111111111111111111111111111111111111111111111111111111111111111111-11111---11111111111111111111-11111111111111111111111111111111111111111111111111111111111111111111111111111111111111111-----11111111111111111111111111111111111111111111111111111111111111111111111111----------------------------------------------11-----111 -1--111-----1111211123232321111113211111111111112211211111111111111111111111111111111111-12121121-1-111231-11-211124-1121111221413E2-111111111111112121-1111112211121-11111--111221G1111131221111111122 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 308 STR:RPRED 98.1 SQ:SECSTR ######ccEEEEEEcccHHHHHHHHHHHHHHHHHcTTccEEEEEccTHHHHHHHHHTTcTccHHHHHHHHHHHHTTcccEEEEEGGGccccccccTTEEEEEEcccccccEEEEGGTTccTTTccTTcEEEcccHHHHHHHHHHcTTcEEEcccccHHHHHHHHHHcccccEEEEHHHHHHTTcGGGccEEccTTTccccTTTTcEEEEEETTcHHHHHHHGGGccHHHHHHHHHHHHHHHHHHHcccccEEEEEEEEETTEEEEEEEEEcTTcccEEEEEEEEHHHHHHHHHHHHHHHHHHTTHHHHHHccHT DISOP:02AL 1-11| PSIPRED ccccccccEEEEEEcccHHHHHHHHHHHHHHHHHccccEEEEEEEEEEcccccccHHHHccEEEEHHHHHHHHHcccccEEEEcccccccccccccccEEEEEcccccccEEEEEcccccHHHcccccEEEEcHHHHHHHHHHHccccEEEEccccHHHHHHHHHcccccHHHHHHHHHHHccccccEEEEccHHHccccccccEEEEEEEccHHHHHHHHHHHccHHHHHHHHHHHHHHHHccccccccEEEEEEEEEccEEEEEEEEEcccccEEEEEEEEccHHHHHHHHHHHHHHHHHHHHHHHHHHccc //