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Streptomyces avermitilis MA-4680 (save0)
Gene : ispG2
DDBJ      :ispG2        putative 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase
Swiss-Prot:ISPG2_STRAW  RecName: Full=4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 2;         EC=1.17.7.1;AltName: Full=1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase 2;

Homologs  Archaea  0/68 : Bacteria  736/915 : Eukaryota  25/199 : Viruses  0/175   --->[See Alignment]
c.1.21d.134.1
:385 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   243->350 2b8eC PDBj 1e-04 36.5 %
:RPS:PDB   25->320 3e59B PDBj 3e-39 13.9 %
:RPS:SCOP  18->266 1q7mA1  c.1.21.2 * 3e-18 8.8 %
:RPS:SCOP  271->367 1aopA4  d.134.1.1 * 7e-09 17.5 %
:HMM:SCOP  24->218 1q7zA1 c.1.21.2 * 1.4e-07 22.8 %
:HMM:SCOP  273->364 1aopA4 d.134.1.1 * 1.8e-10 33.0 %
:RPS:PFM   22->361 PF04551 * GcpE 8e-85 51.8 %
:HMM:PFM   22->364 PF04551 * GcpE 8.5e-136 53.1 341/359  
:BLT:SWISS 1->385 ISPG2_STRAW 0.0 100.0 %

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID BAC69358.1 GT:GENE ispG2 GT:PRODUCT putative 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase GT:DATABASE GIB00135CH01 GT:ORG save0 GB:ACCESSION GIB00135CH01 GB:LOCATION complement(2017360..2018517) GB:FROM 2017360 GB:TO 2018517 GB:DIRECTION - GB:GENE ispG2 GB:PRODUCT putative 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase GB:NOTE gcpE, non-mevalonate pathway GB:PROTEIN_ID BAC69358.1 LENGTH 385 SQ:AASEQ MTAISLGVPEVPVRPIAERRVSRQIQVGPLAVGGTAPVSVQSMTTTRTSDIGATLQQIAELTASGCQIVRVACPTQDDADALAVIARKSQIPVVADIHFQPKYVFAAIEAGCAAVRVNPGNIKQFDDKVKEIARAAKEHGTPIRIGVNAGSLDRRLLEKYGKATPEALVESALWEASLFEEHDFRDIKISVKHNDPVVMVNAYRQLAAQCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSEGIGDTIRVSLSAPPVEEIKVGIQILESLGLRQRRLEIVSCPSCGRAQVDVYKLAEEVTAGLEGMEVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFVKGEVIKTVPESKIVETLIEEAMKIAEQMEQNGVASGEPAVTVS GT:EXON 1|1-385:0| SW:ID ISPG2_STRAW SW:DE RecName: Full=4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 2; EC=1.17.7.1;AltName: Full=1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase 2; SW:GN Name=ispG2; OrderedLocusNames=SAV_1647; SW:KW 4Fe-4S; Complete proteome; Iron; Iron-sulfur; Isoprene biosynthesis;Metal-binding; Oxidoreductase. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->385|ISPG2_STRAW|0.0|100.0|385/385| GO:SWS:NREP 6 GO:SWS GO:0051539|"GO:4 iron, 4 sulfur cluster binding"|4Fe-4S| GO:SWS GO:0051536|"GO:iron-sulfur cluster binding"|Iron-sulfur| GO:SWS GO:0008299|"GO:isoprenoid biosynthetic process"|Isoprene biosynthesis| GO:SWS GO:0046872|"GO:metal ion binding"|Metal-binding| GO:SWS GO:0016491|"GO:oxidoreductase activity"|Oxidoreductase| GO:SWS GO:0055114|"GO:oxidation reduction"|Oxidoreductase| BL:PDB:NREP 1 BL:PDB:REP 243->350|2b8eC|1e-04|36.5|96/250| RP:PDB:NREP 1 RP:PDB:REP 25->320|3e59B|3e-39|13.9|281/305| RP:PFM:NREP 1 RP:PFM:REP 22->361|PF04551|8e-85|51.8|334/353|GcpE| HM:PFM:NREP 1 HM:PFM:REP 22->364|PF04551|8.5e-136|53.1|341/359|GcpE| GO:PFM:NREP 3 GO:PFM GO:0016114|"GO:terpenoid biosynthetic process"|PF04551|IPR004588| GO:PFM GO:0046429|"GO:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity"|PF04551|IPR004588| GO:PFM GO:0055114|"GO:oxidation reduction"|PF04551|IPR004588| RP:SCP:NREP 2 RP:SCP:REP 18->266|1q7mA1|3e-18|8.8|240/259|c.1.21.2| RP:SCP:REP 271->367|1aopA4|7e-09|17.5|97/145|d.134.1.1| HM:SCP:REP 24->218|1q7zA1|1.4e-07|22.8|180/0|c.1.21.2|1/1|Dihydropteroate synthetase-like| HM:SCP:REP 273->364|1aopA4|1.8e-10|33.0|88/145|d.134.1.1|1/1|Sulfite reductase hemoprotein (SiRHP), domains 2 and 4| OP:NHOMO 788 OP:NHOMOORG 761 OP:PATTERN -------------------------------------------------------------------- 111121111111-111111-1111211111111111111111111111111111111111111111122111111111111111111111111111---------1111111111111111111111111111111-----111-11111111111111111111111111111111111111111111111111111111111111111111111111111-11-111--111-----------------------------------------------------------------------------------------1111111111111111111111111111111111111111111111111-111111111111111111111111111111111111-11111111111-11111111111111111111111111111111111111111111111111111---------------111111111111111111111111111111111111111111111111111111111111111111111111111211111-111111111111111111111111111--111111111111111111111111111111111111111111111111111111111111--11111--11111111111111111111-11111111111111111111111111111111111111111111111111111111111111111-111---------1111111111111111111111111111111111111111111111111111111111-11111111111111111111111111111111111111--------11------------1------1------1111111111111 11------1---------------------------------------------------------------------------------------------------3-------------------------------------------------1---------------11111F111113122-2111----1 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 360 STR:RPRED 93.5 SQ:SECSTR #####HHEEEEEccccHHHHHHHHHHHHHHHHHHTTccccccHHHHHHHHHHHHHHHHHHHHHHTEEEcccccccccTTTcccccccHHHHHHHHHHHHHHHHHHTTcTTcEEEEEEccHHHHHHGGGGTccHHHHHHHHHHHHHHHHHTTcTTEEEEcGGGcGGGGGGcHHHHHHHHHHHHcccHHHHHHHHTTcHHHHHHHHHHHHHHHHHccTTccccHHHHHHHHHHHHHHHHHHHHHcTTcEEEEcccccTTccEEEccccTTccccccGGGcEEEEETTEEEEEcHHHHHHTTcHHHHHcccHTTTcEEEEETTTTcGGGccEEEEEEEETTEEEcccccTHHHccTHHHHHHHHHHHH#################### DISOP:02AL 1-4, 368-380, 384-385| PSIPRED cccccccccccccccccccccccEEEEccEEEcccccEEEEEEcccccccHHHHHHHHHHHHHHcccEEEEEcccHHHHHHHHHHHHHccccEEEEEcccHHHHHHHHHHcccEEEcccccccHHHHHHHHHHHHHHHccccEEEEcccccHHHHHHHHHccccHHHHHHHHHHHHHHHHHccccEEEEEEEEccHHHHHHHHHHHHHHccccEEEEEEccccccccHHHHHHHHHHHHHHccccEEEEEcccccHHHHHHHHHHHHHHcccccccEEEEccccccccccHHHHHHHHHHHHcccccccEEEEEEEEEccccccccccEEEEcccccEEEEEccEEEEEccHHHHHHHHHHHHHHHHHHHHHcccccccccEEcc //