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Streptomyces avermitilis MA-4680 (save0)
Gene : poxB1
DDBJ      :poxB1        putative pyruvate dehydrogenase/oxidase FAD and thiamine PPi cofactors
Swiss-Prot:             

Homologs  Archaea  53/68 : Bacteria  749/915 : Eukaryota  163/199 : Viruses  0/175   --->[See Alignment]
c.31.1c.36.1
:587 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   3->583 3ey9A PDBj e-109 40.9 %
:RPS:PDB   4->550 1bfdA PDBj 4e-77 20.6 %
:RPS:SCOP  4->183 1bfdA2  c.36.1.5 * 3e-37 22.2 %
:RPS:SCOP  218->358 1powA1  c.31.1.3 * 4e-18 23.3 %
:RPS:SCOP  380->576 1powA3  c.36.1.9 * 3e-31 22.8 %
:HMM:SCOP  1->185 1ybhA2 c.36.1.5 * 2.5e-45 36.8 %
:HMM:SCOP  180->361 2djiA1 c.31.1.3 * 9.3e-38 33.3 %
:HMM:SCOP  378->558 2djiA3 c.36.1.9 * 7.4e-56 39.8 %
:RPS:PFM   4->163 PF02776 * TPP_enzyme_N 6e-20 35.6 %
:RPS:PFM   221->316 PF00205 * TPP_enzyme_M 5e-09 34.7 %
:RPS:PFM   420->547 PF02775 * TPP_enzyme_C 4e-16 39.1 %
:HMM:PFM   3->169 PF02776 * TPP_enzyme_N 2.5e-51 42.5 167/172  
:HMM:PFM   402->548 PF02775 * TPP_enzyme_C 4.1e-40 38.4 146/150  
:HMM:PFM   190->319 PF00205 * TPP_enzyme_M 8.4e-31 39.8 128/137  
:BLT:SWISS 1->583 POXB_ECOLI e-109 41.0 %
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID BAC68665.1 GT:GENE poxB1 GT:PRODUCT putative pyruvate dehydrogenase/oxidase FAD and thiamine PPi cofactors GT:DATABASE GIB00135CH01 GT:ORG save0 GB:ACCESSION GIB00135CH01 GB:LOCATION 1214909..1216672 GB:FROM 1214909 GB:TO 1216672 GB:DIRECTION + GB:GENE poxB1 GB:PRODUCT putative pyruvate dehydrogenase/oxidase FAD and thiamine PPi cofactors GB:NOTE PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain GB:PROTEIN_ID BAC68665.1 LENGTH 587 SQ:AASEQ MARTVARVIVDALSELGVRQVFGVVGDALNPVTDAIRTTEDVEWVGCRHEEAAAFAASAQSQLSGTLGVCMGTVGPGSVHLLNGLYDAAKSRTPVLAIAGQVPLAELGSDYFQEVDNDALFSDVAVFRATITSPDQLPQLLETAVRNALGRKGVAVLTVPGDLGDRELSADRPTRFSLSTPVSRPEESAVRRAAELLDRAERITLLVGRGARAARADVLTLADRLAAPMVLTLKAKEGFEGEANPFQVGQTGLIGNPAAASALQDADTLLLLGTDFPYRDWYPDGRTVIQVDSEAAHIGRRVPVEVGLVGDTGATVRDLLGHLATAPPGTEGARDRSHLEDARKSFGKWRASQARLADPAHDKGLVGRVRSALDNRAHDIRPEALAAVVDRVADENAVFTSDTGMATVWLSRFVEMRGDRRLLGSYNLGSMANAMPQALGAQCLDRGRQVVAFCGDGGLSMLLGDLMTLKTSRLPVKLVVFDNRRLGMVKLEQEQAGLPEFGTVLDNPDFAAVATAMGITGIRVTDPAELEESVRRAFATPGPVLLDVLTNPDEIAVPAKPTVEQGWGFAVAKVKEVVRSHGDSDGH GT:EXON 1|1-587:0| BL:SWS:NREP 1 BL:SWS:REP 1->583|POXB_ECOLI|e-109|41.0|559/572| SEG 52->62|aaafaasaqsq| SEG 189->202|avrraaelldraer| SEG 208->216|grgaraara| SEG 455->467|gdgglsmllgdlm| BL:PDB:NREP 1 BL:PDB:REP 3->583|3ey9A|e-109|40.9|557/571| RP:PDB:NREP 1 RP:PDB:REP 4->550|1bfdA|4e-77|20.6|509/523| RP:PFM:NREP 3 RP:PFM:REP 4->163|PF02776|6e-20|35.6|160/170|TPP_enzyme_N| RP:PFM:REP 221->316|PF00205|5e-09|34.7|95/138|TPP_enzyme_M| RP:PFM:REP 420->547|PF02775|4e-16|39.1|128/139|TPP_enzyme_C| HM:PFM:NREP 3 HM:PFM:REP 3->169|PF02776|2.5e-51|42.5|167/172|TPP_enzyme_N| HM:PFM:REP 402->548|PF02775|4.1e-40|38.4|146/150|TPP_enzyme_C| HM:PFM:REP 190->319|PF00205|8.4e-31|39.8|128/137|TPP_enzyme_M| GO:PFM:NREP 5 GO:PFM GO:0030976|"GO:thiamin pyrophosphate binding"|PF02776|IPR012001| GO:PFM GO:0000287|"GO:magnesium ion binding"|PF00205|IPR012000| GO:PFM GO:0030976|"GO:thiamin pyrophosphate binding"|PF00205|IPR012000| GO:PFM GO:0003824|"GO:catalytic activity"|PF02775|IPR011766| GO:PFM GO:0030976|"GO:thiamin pyrophosphate binding"|PF02775|IPR011766| RP:SCP:NREP 3 RP:SCP:REP 4->183|1bfdA2|3e-37|22.2|176/180|c.36.1.5| RP:SCP:REP 218->358|1powA1|4e-18|23.3|133/183|c.31.1.3| RP:SCP:REP 380->576|1powA3|3e-31|22.8|197/228|c.36.1.9| HM:SCP:REP 1->185|1ybhA2|2.5e-45|36.8|182/0|c.36.1.5|1/2|Thiamin diphosphate-binding fold (THDP-binding)| HM:SCP:REP 180->361|2djiA1|9.3e-38|33.3|174/0|c.31.1.3|1/1|DHS-like NAD/FAD-binding domain| HM:SCP:REP 378->558|2djiA3|7.4e-56|39.8|181/0|c.36.1.9|1/1|Thiamin diphosphate-binding fold (THDP-binding)| OP:NHOMO 2421 OP:NHOMOORG 965 OP:PATTERN ---1--2332232331-21221132--21122133121222221312213443111-----22-1-11 3251632222223244422-221138222223234353981222123-222163433211523125966421111111-111411111223112--111-1111132111---------------21111111111222111111532322222211112111222222421111111111111211111-123333333441363435223333334224242-3333332423333343443334433334112144111-27611443331343231112---22222222222222-------------211222111122-34-------2-221331---1-2--2122165222121221112--1-111112-11-1237762136235422222221215-44633826452-2332247454675312156832244453333333331112322-----------------------------2323226BA887777777444477AA66774476D566722443233224232852222111211111111112322-922212222333412213112322222342421111111111-1-------1111111322231312222332422222222322233---311111111145442544555465655-5535655545555554554556542245455545555555553654555541-64444443444411---1-------22521222212-122-2112111111211232666634443476532221----1---31223333332222233222222221111111-221122--------------------------------------1--1-111122 ----11--------14321212233251111-111111111111111212112111211111211112-1121212212221111121-11132111111111122-16-2111112-----1111---241-1111-1-1-11111-111---1111212315111112-122-21118111135113123113111- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 583 STR:RPRED 99.3 SQ:SECSTR ccEcHHHHHHHHHHHTTccEEEEcccGGGHHHHTTccHcTTcEEEEcccHHHHHHHHHHHHHHHTccEEEEEEHHHHHHHTHHHHHHHHHHTccEEEEEEEccHHHHTTTTTccTTGGGTTTTcccEEEccccGGGHHHHHHHHHHHHccccccEEEEEEGGGTTccccGGGGGGTccccccccccHHHHHHHHHHHHHccccEEEEHHHHHTcHHHHHHHHHHHTccEEEccccccccccTTcTTEEEEcccGcHHHHHHHHTTccEEEEEcccTTccccccTTcEEEEEEccHHHHHcHccccEEEEccHHHHHHHHHHHcHHHHHTTccccccHHHHccccccccccccccccccccccHHHHHHccccTTcccccccHHHHHHHHHHHccTTcEEEEEcGGGHHHHHHHcccccTTcEEcEcTTcccccHHHHHHHHHHHcTTccEEEEEEHHHHTTTGGGHHHHHHHTcccEEEEEEccccHHHHHHHHHTcccccccccccccHHHHHHHTTcEEEEEccHHHHHHHHHHHHHccccEEEEEEcccccccTTcccTTccGGGcccccTTGGGcccTc#### DISOP:02AL 1-2, 575-587| PSIPRED cccHHHHHHHHHHHHccccEEEEccccHHHHHHHHHHHccccEEEEEccHHHHHHHHHHHHHHccccEEEEEcccHHHHHHHHHHHHHHHccccEEEEEccccHHHccccccccccHHHHHHHHHHEEEEEccHHHHHHHHHHHHHHHcccccEEEEEEcHHHHccccccccccccccccccccccHHHHHHHHHHHHHccccEEEEcccccHHHHHHHHHHHHccccEEEEcccccccccccccccEEcccccccHHHHHHHHcccEEEEEccccccccccccccEEEEEcccHHHcccEEcccEEEEEcHHHHHHHHHHHHHcccccccccHHHHHHHHHHHHHHHHHHHHHcccccccHHHHHHHHHHHcccccccccHHHHHHHHHHHcccccEEEEcccHHHHHHHHHHccccccEEEEcccccHHHHHHHHHHHHHHHccccEEEEEEEcHHHHHcHHHHHHHHHccccEEEEEEEcccccHHHHHHHHccccccccccccccHHHHHHHccccEEEEccHHHHHHHHHHHHHccccEEEEEEEccccccccccccHHHHHHHHHHHHHHHHccccccccc //