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Streptomyces avermitilis MA-4680 (save0)
Gene : pteA3
DDBJ      :pteA3        modular polyketide synthase
Swiss-Prot:             

Homologs  Archaea  0/68 : Bacteria  863/915 : Eukaryota  183/199 : Viruses  0/175   --->[See Alignment]
a.121.1a.28.1a.38.2c.1.19c.19.1c.2.1c.95.1d.110.8d.94.1e.62.1
:1835 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   34->903 2qo3A PDBj 0.0 48.5 %
:BLT:PDB   909->1172 3el6A PDBj 4e-42 42.0 %
:BLT:PDB   1423->1614 2fr0A PDBj 2e-20 44.6 %
:BLT:PDB   1659->1741 2ju1A PDBj 6e-09 34.9 %
:RPS:PDB   34->456 2c9hA PDBj 6e-91 25.1 %
:RPS:PDB   571->852 2c2nA PDBj 2e-76 28.5 %
:RPS:PDB   830->901 1cjaA PDBj 2e-15 15.7 %
:RPS:PDB   905->1046 3citB PDBj 5e-09 11.7 %
:RPS:PDB   1263->1372 3bk9C PDBj 1e-09 10.3 %
:RPS:PDB   1423->1561 2e6eA PDBj 8e-14 22.2 %
:RPS:PDB   1691->1737 2cgqA PDBj 1e-08 17.0 %
:RPS:SCOP  34->549,1688->1735 1e1cA1  c.1.19.1 * 6e-99 12.3 %
:RPS:SCOP  572->631 2ea9A1  d.110.8.1 * 2e-10 20.0 %
:RPS:SCOP  620->945 1u9tA1  e.62.1.1 * 2e-68 14.5 %
:RPS:SCOP  1219->1372 2fr0A2  c.2.1.2 * 3e-09 22.2 %
:RPS:SCOP  1423->1484 1cm2A  d.94.1.1 * 2e-05 6.5 %
:RPS:SCOP  1540->1611 2g7gA2  a.121.1.1 * 1e-09 10.6 %
:HMM:SCOP  1->33 1pzrA_ a.38.2.1 * 3.8e-09 54.5 %
:HMM:SCOP  25->459 1tedA_ c.95.1.2 * 5.6e-105 48.8 %
:HMM:SCOP  571->866 1nm2A1 c.19.1.1 * 4.6e-73 52.7 %
:HMM:SCOP  1184->1372 2fr1A2 c.2.1.2 * 4e-30 39.9 %
:HMM:SCOP  1377->1653 1gz6A_ c.2.1.2 * 2e-43 33.2 %
:HMM:SCOP  1660->1755 1nq4A_ a.28.1.1 * 4.6e-19 41.3 %
:RPS:PFM   35->283 PF00109 * ketoacyl-synt 6e-67 62.7 %
:RPS:PFM   292->407 PF02801 * Ketoacyl-synt_C 2e-32 66.4 %
:RPS:PFM   575->834 PF00698 * Acyl_transf_1 7e-54 57.3 %
:RPS:PFM   1428->1563 PF08659 * KR 2e-16 43.4 %
:RPS:PFM   1688->1734 PF00550 * PP-binding 1e-05 46.8 %
:HMM:PFM   33->283 PF00109 * ketoacyl-synt 8.3e-101 60.2 246/253  
:HMM:PFM   1384->1563 PF08659 * KR 2.7e-64 58.1 179/181  
:HMM:PFM   575->875 PF00698 * Acyl_transf_1 7.9e-63 37.2 301/318  
:HMM:PFM   291->407 PF02801 * Ketoacyl-synt_C 7.1e-51 65.0 117/119  
:HMM:PFM   2->26 PF08990 * Docking 3.6e-14 68.0 25/27  
:HMM:PFM   1672->1737 PF00550 * PP-binding 1.2e-13 30.8 65/67  
:BLT:SWISS 34->1322,1424->1833 ERYA2_SACER 0.0 44.9 %
:PROS 1696->1711|PS00012|PHOSPHOPANTETHEINE
:PROS 196->212|PS00606|B_KETOACYL_SYNTHASE
:COIL
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID BAC68127.1 GT:GENE pteA3 GT:PRODUCT modular polyketide synthase GT:DATABASE GIB00135CH01 GT:ORG save0 GB:ACCESSION GIB00135CH01 GB:LOCATION complement(527468..532975) GB:FROM 527468 GB:TO 532975 GB:DIRECTION - GB:GENE pteA3 GB:PRODUCT modular polyketide synthase GB:NOTE filipin gene cluster GB:PROTEIN_ID BAC68127.1 LENGTH 1835 SQ:AASEQ MNEDKLRDYLKRTTTDLRQARRRVRELEARAQEPIAIVGMSCRFPGGVGSPEELWRLLAEGEDAISQFPVDRGWDVDALYDPDPEQPGKVYTRQGGFLHDAADFDAEFFGISPREALAMDPQQRLLLEAAWEAFEHAGIDPAGLKGSRTGVFAGLMYHDYGFTPGVLPEGVEGLMSTGNSGSVASGRIAYTFGFEGPAVTVDTACSSSLVALHLAVQALRTGECSMALAGGVTVMAGPSAFVEFSRQRGLAPDGRCKSFAAAADGASWSEGTGLLLVERLRDARRLGHKVLAVVRGSAVNQDGASNGLTAPNGPSQQRVILEALAGARLSAEEVDAVEAHGTGTSLGDPIEAQALLATYGQERERPLLLGSLKSNIGHTQAAAGVAGVIKMVLAMQHGVLPKTLHVDRPTPRVDWSVGSVDLLTEAIAWPETDHPRRAGVSSFGISGTNAHIILEQAPEPEAGDPADDTAEGEGVAEELLRARTTVVPWVLSAKNGAALREQAQRLLSSVDLAAASPADVGFSLAATRSALEHRAAVVGADGEELRAILTALAAGEPAAQVVTGRAGADRGKVGFLFSGQGSQRIGMGRELYEAYPVFAAAYNEVCALLDLPVDVDAETLHQTGSTQPALFAMEVALFRLLESWAIRPDYVAGHSVGEIAAAHVAGVLSLGDAARLVSVRAALMQALPAGGAMVAVQAAEDEVLPYLTGEVGIAAINGPQSVVVSGAEDAVMAVAEVFAAQGRKTSRLKVSHAFHSPLMDPMLEEFAAVVRGLTFGEPRIPVVSNLTGRLAEPYTPEHWVRHVREAVRFADGVRTLHELGVTTFVEVGPGGVLSALAQGCLDDADIVTVPALRTDRPEPQALTLAVGQLHTRGVSPDWQALFPGALRVDLPTYAFQRERYWLKGTTAVDVSSAGLDSSGHALLGAVVETAGAQDVLFTGRLSPADLPWIAEHTVGGVPVLPVAAFVELALSAGRQAGFPYLEQLDVDAPLVLAEQGAVRIQVQIGADDDPDRRSVRVFSRPAAGSSGEPWVRHVTGKLTRNAPAPEFDQMIWPPTGAEPGDVEGRPGLRAAWRAGDELYAEAELPVTERDRADRYALHPVLLDAALGMATSDRAADPGEVLMPHAWSGMSVHTPGPGAVRIRIRPVGDDAVAIELSDADGSPVASVASVRTRTMTAQQVLASRVAHQDWMFEIDWVEHTAASAPATAAVADWAVLGDEGVHSDIDALRKAVDGGAATPAHVLLPCAPSEGDAAAATRGALAGVLSVVQEWVADERFSDARLVVMTRGAVELDGTALDLAHVAVSGLVKSAQTEHPDRLLLVDADDSVTNGGTVTDGGVDPALAAALAALDEPQAAVRDGKLYVPRLARITPPEEPTGHAWDPEGTVLLTGATGGLGRSLARHLVAERGARRLLLASRRGPAAEGVGELVAALSELGAHVDVAACDIADRDALAELLASVPAEHPLVAVVHAAAALDDGVITALTPGRLDTVLRPKADGALHLHELTRDLNLSAFVLFSSLAGVLGSAGAAGYAAANAFLDGLARQRRAAGLPGTSLAWGLWTDNGGMGDRITDADRNRMGRAGVVPFSPAEGLALFDAALTVDRPVIVPVRLDVPGLRAMARAGMLPAVLRGLVGDTGAAAGEAAAAGTTALARRLAGIPEADQEKVMLDLVRHQAAAALGHATAARIEPTTAFRDIGFDSLTAVELRNRLKAATGLRLKPTLVFDHPNPVAIARLLHKDLVLDLTAEAPPVLGELDRLEAQLAALAPQDAVRDKITARLKALLWKWTDTHQDAAANTADDGHGTDRDFDLDLDRIDAATDDEMFDLIDQELGSH GT:EXON 1|1-1835:0| BL:SWS:NREP 1 BL:SWS:REP 34->1322,1424->1833|ERYA2_SACER|0.0|44.9|1629/3567| PROS 1696->1711|PS00012|PHOSPHOPANTETHEINE|PDOC00012| PROS 196->212|PS00606|B_KETOACYL_SYNTHASE|PDOC00529| COIL:NAA 30 COIL:NSEG 1 COIL:REGION 4->33| SEG 17->33|lrqarrrvrelearaqe| SEG 1200->1213|aasapataavadwa| SEG 1250->1262|gdaaaatrgalag| SEG 1324->1339|ddsvtnggtvtdggvd| SEG 1341->1349|alaaalaal| SEG 1384->1396|gtvlltgatgglg| SEG 1403->1422|lvaergarrlllasrrgpaa| SEG 1459->1475|vpaehplvavvhaaaal| SEG 1515->1539|vlfsslagvlgsagaagyaaanafl| SEG 1638->1658|gaaageaaaagttalarrlag| SEG 1676->1686|aaaalghataa| SEG 1806->1817|drdfdldldrid| BL:PDB:NREP 4 BL:PDB:REP 34->903|2qo3A|0.0|48.5|844/869| BL:PDB:REP 909->1172|3el6A|4e-42|42.0|255/271| BL:PDB:REP 1423->1614|2fr0A|2e-20|44.6|186/468| BL:PDB:REP 1659->1741|2ju1A|6e-09|34.9|83/95| RP:PDB:NREP 7 RP:PDB:REP 34->456|2c9hA|6e-91|25.1|403/426| RP:PDB:REP 571->852|2c2nA|2e-76|28.5|281/317| RP:PDB:REP 830->901|1cjaA|2e-15|15.7|70/327| RP:PDB:REP 905->1046|3citB|5e-09|11.7|120/148| RP:PDB:REP 1263->1372|3bk9C|1e-09|10.3|97/272| RP:PDB:REP 1423->1561|2e6eA|8e-14|22.2|108/221| RP:PDB:REP 1691->1737|2cgqA|1e-08|17.0|47/74| RP:PFM:NREP 5 RP:PFM:REP 35->283|PF00109|6e-67|62.7|241/245|ketoacyl-synt| RP:PFM:REP 292->407|PF02801|2e-32|66.4|116/118|Ketoacyl-synt_C| RP:PFM:REP 575->834|PF00698|7e-54|57.3|260/297|Acyl_transf_1| RP:PFM:REP 1428->1563|PF08659|2e-16|43.4|136/181|KR| RP:PFM:REP 1688->1734|PF00550|1e-05|46.8|47/67|PP-binding| HM:PFM:NREP 6 HM:PFM:REP 33->283|PF00109|8.3e-101|60.2|246/253|ketoacyl-synt| HM:PFM:REP 1384->1563|PF08659|2.7e-64|58.1|179/181|KR| HM:PFM:REP 575->875|PF00698|7.9e-63|37.2|301/318|Acyl_transf_1| HM:PFM:REP 291->407|PF02801|7.1e-51|65.0|117/119|Ketoacyl-synt_C| HM:PFM:REP 2->26|PF08990|3.6e-14|68.0|25/27|Docking| HM:PFM:REP 1672->1737|PF00550|1.2e-13|30.8|65/67|PP-binding| GO:PFM:NREP 1 GO:PFM GO:0048037|"GO:cofactor binding"|PF00550|IPR006163| RP:SCP:NREP 6 RP:SCP:REP 34->549,1688->1735|1e1cA1|6e-99|12.3|517/559|c.1.19.1| RP:SCP:REP 572->631|2ea9A1|2e-10|20.0|60/103|d.110.8.1| RP:SCP:REP 620->945|1u9tA1|2e-68|14.5|303/327|e.62.1.1| RP:SCP:REP 1219->1372|2fr0A2|3e-09|22.2|144/209|c.2.1.2| RP:SCP:REP 1423->1484|1cm2A|2e-05|6.5|62/85|d.94.1.1| RP:SCP:REP 1540->1611|2g7gA2|1e-09|10.6|66/132|a.121.1.1| HM:SCP:REP 1->33|1pzrA_|3.8e-09|54.5|33/60|a.38.2.1|1/1|Docking domain B of the erythromycin polyketide synthase (DEBS)| HM:SCP:REP 25->459|1tedA_|5.6e-105|48.8|365/0|c.95.1.2|1/1|Thiolase-like| HM:SCP:REP 571->866|1nm2A1|4.6e-73|52.7|237/254|c.19.1.1|1/1|FabD/lysophospholipase-like| HM:SCP:REP 1184->1372|2fr1A2|4e-30|39.9|178/0|c.2.1.2|1/1|NAD(P)-binding Rossmann-fold domains| HM:SCP:REP 1377->1653|1gz6A_|2e-43|33.2|262/302|c.2.1.2|1/1|NAD(P)-binding Rossmann-fold domains| HM:SCP:REP 1660->1755|1nq4A_|4.6e-19|41.3|92/95|a.28.1.1|1/1|ACP-like| OP:NHOMO 5531 OP:NHOMOORG 1046 OP:PATTERN -------------------------------------------------------------------- 3482L1233341-1FDENN-NFBBU9NLMMNFHDCD73463MDN1111232234311311NI31Y4Qb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aQ442432222222121222222222222334442375334677777677777777777672-33332211111E3D5364366D3AA433-733333434474633333554694CA634333333333333336334333332868788767787223546444877853E4622224222222233233553243325C55468G88364744A9C422222222334472333334755555555544433333323--1111--------2-2-------------------------22222222222A2 1152kz4-211-2238ERBXHLMakVW333665LOE8BCCCCB555OKHPHJFGCCVSG999222111-211212-11-112222212-1D3E212------6222--M3V6555413221333522314B3-3242221323521222-41162633334339E2B558B56B8345N*85JFN9589N68434233* ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 1597 STR:RPRED 87.0 SQ:SECSTR ##cHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccEEEEEEEEEETTEEcHHHHHHHHHHTTcccEEEcccGGGTcTTccGTTccccEEGGGcEcccccccTTcccGGGTHccTTHHHHccHHHHHHHHHHHHHHHHHTcccccHHHHHTEEEEHHHHHHHHHHHHHcGGGccTTHHHHHcTTHHHHHHHHHHTccccEEccccGGHHTHHHHHHHHHHHHHTcccEEEEEEEEccccHHHHHHHHHTTcccTTTcccTTcTTccccccccEEEEEEEEEHHHHHHHTccccEEEEEEEEEEcccccccccTTcHHHHHHHHHHHHHHTccGGGEEEEEccccccHHHHHHHHHHHHHHHGGGGGGTcEEEccHHHHcccGGGHHHHHHHHHHHHHHHTEEcccTTcccccTTccccccccccccccEEccHcccccEEEEEEEETTTEEEEEEEEcHHHHHHTTcccGGGcccTTccccccGGGccccccccccccHHHHHHHHHHHHTTTccHHHHHHHHHHHHTTccTTTTccccTccGGGcTTGGGccTTcTTTTHHHHHHHHHHHHHHHHHHHHccTTccccHHHHHHHHTHHHHHHHHHHHTTccccccccccccccGGGccHHHHGGGcccEEGGGTEEccccccHHcHHHHHHHHHHHTTccHHHHHHHHHHHHHTTcTTTTEEcccccccHHHHHHHHHcccHHHTTccHHHHHHHHHHHHHHTccGGGcccTcccccccccccHHHHHHTcGGHHHHHHHHHTccccccccEEEcTTTccccccGHHHHHHHHTTccEEHHHHHHHHTcccccEEEEEccccHHHHHHHHHcHHHTEEEEcccHHHHHHHHHHEEEccEEEccccEEETTTTccccccTTccccEEEETTccEEcccEEETTTTEEEEEEEccEEEEEccGHGEEEEETTTcccEEEEEEcccccTTEEEEcHHHHcEEEEEEccHHHHHTcccTTccccEEEEcTTcEEEEEEEEEEcccEEEEEEEcccccccGcEEEEEEEccccccccHHHHHccccccccTTHHTTEEEcGccEEEEEEETTEEEEEEEccccc####ccccccHHHHHH###HHHGGGGcTTcccc#EEEEEEEEEccccccEEEEEEEEccTTEEEEEEEcTTccEEEEEEEEEEc##########################################################################################HHHHHHHHHTcccHHHHHHHHHHHTTcccccccccTTcHHHHHHHHHcTTTcHHHHHHHHH#############HHHHHHHHHHHHHHHHHHHHHTccccHHHHHHHHTcGGGGGGGccTT###ccEEEEcccTTcTTHHHHcEEEEEETTEEEEEETTEHHHHHHHHHHTTTccEEEEEEEccHccccEEEEccccTTcccccEEEEcHEEEHEccHHHHHHHHHHHTccccEEcHEEEEEEEEccccGGGGGGcHHHEcTTcHHHHHTTTTHHHHHHHHHHHHHTTcEEEEEEEcccTcGGGcccHHHHHHHHHHHHHcGGHHHHHTcTTTEEEEEEccccTTccccccGccGGGT######################################HccTTccccHHHHHHHHcEEcTTccEEccccGGcccccccccTTHHHHHHcHHHHHHTccccEEcTTccEEcccccGHHHHHHcccccccccc#################################################################################### DISOP:02AL 13-34, 464-479, 1635-1662, 1741-1776, 1834-1835| PSIPRED ccHHHHHHHHHHHHHHHHHHHHHHHHccccccccEEEEEEEEEcccccccHHHHHHHHHccccEEEcccccccccHHHHcccccccccccccccccEEccHHcccHHHccccHHHHHHHcHHHHHHHHHHHHHHHHccccHHHcccccEEEEEEcccHHHHHHHHcccccccccEEEcHHHHHHHHHHHHHHcccccEEEEHHHHHHHHHHHHHHHHHHHcccccEEEEEcccccccHHHHHHHHHcccccccccccccccccccEEEEcEEEEEEEEcHHHHHHcccEEEEEEEEEEEcccccccccccccHHHHHHHHHHHHHHccccHHHccEEEccccccccccHHHHHHHHHHHcccccccEEEEEccccHHHHHHHHHHHHHHHHHHHHHcccccccccccccccccccccccEEEccccccccccccEEEEEEEccccHHHHHHHHEEHHcccccccccccccccccccccccccccccEEEEEEcccHHHHHHHHHHHHHHHHcccccHHHHHHHHHccccccccEEEEEEccHHHHHHHHHHHHcccccccEEEcccccccccEEEEEcccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccccHHHccHHHHHHHHHHHHHHHHHHHHHccccEEEEEEccHHHHHHHHHHccccHHHHHHHHHHHHHHHHHHcccccEEEEEccHHHHHHHHcccEEEEEEEccccEEEEccHHHHHHHHHHHHHcccEEEEEcccccccHHHHHHHHHHHHHHHHccccccccEEEEEcccccccccccHHHHHHcccccccHHHHHHHHHHccccEEEEEcccHHHHHHHHHHHHHcccEEEccccccccHHHHHHHHHHHHHHccccccHHHHcccccccccccccccccccccccccccccccccccccHHHHccccccccccccEEEEEcccccccccHHccccccEEEccHHHHHHHHHHHHHHccccEEEEEEEEccEEEcccccEEEEEEEEEccccccEEEEEEEEEcccccccccEEEEEEEEEcccccccHHHHHHcHHHcccccccHHHHHHHHHHcccEEEEEEEcccccccccccccccHHHHHHHHHHHHHccccccccEEEEEEEEcEEEccccccEEEEEEEEccccEEEEEEEcccccEEEEEEEEEEEEEccHHHHHHHcccccccEEcccccccccccccccccccEEEEcccccccHHHHHHHHHccccccccEEEEccccccccHHHHHHHHHHHHHHHHHHHHcccccccccEEEEEccccccccccccHHHHHHHHHHHHHHHHccccEEEEEcccccccccHHHHHHHHHHHHHHHHcccccEEEEcccEEEEEEcccccccccccccccccccEEEEEccccHHHHHHHHHHHHHccccEEEEEEccccccHHHHHHHHHHHHcccEEEEEEcccccHHHHHHHHHHHHHccccEEEEEcccHHcccHHHcccHHHHHHHHHHHHHHHHHHHHHcccccccEEEHHHHHHHHHccccHHHHHHHHHHHHHHHHHHHHccccEEEEEcHHHccccHHHHHHHHHHHHHHHHcccccccHHHHHHHHHHHHHccccEEEEEccccHHHHHHHccccccHHHHHHHcccHHHcccccccccHHHHHHHHcccHHHHHHHHHHHHHHHHHHHHccccHHHccccccHHHHcccHHHHHHHHHHHHHHHcccccHHHHHccccHHHHHHHHHHHHccccccccccccccHHHHHHHHHHHccHHHHHHHHccccHHHHHHHHHccccccccccccccccccccccccHHHHcccHHHHHHHHHHHHccc //