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Salmonella enterica subsp. enterica serovar Heidelberg str. SL476 (sent8)
Gene : ACF68086.1
DDBJ      :             bifunctional polymyxin resistance protein ArnA
Swiss-Prot:ARNA_SALHS   RecName: Full=Bifunctional polymyxin resistance protein arnA;Includes:  RecName: Full=UDP-4-amino-4-deoxy-L-arabinose formyltransferase;           EC=2.1.2.n1;  AltName: Full=UDP-L-Ara4N formyltransferase;  AltName: Full=ArnAFT;Includes:  RecName: Full=UDP-glucuronic acid oxidase, UDP-4-keto-hexauronic acid decarboxylating;           EC=1.1.1.n1;  AltName: Full=UDP-GlcUA decarboxylase;  AltName: Full=UDP-glucuronic acid dehydrogenase;  AltName: Full=ArnADH;

Homologs  Archaea  48/68 : Bacteria  895/915 : Eukaryota  119/199 : Viruses  0/175   --->[See Alignment]
b.46.1c.2.1c.65.1
:660 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   1->655 1z7eD PDBj 0.0 80.7 %
:RPS:PDB   1->294 2cfiA PDBj 2e-63 23.4 %
:RPS:PDB   317->651 2bllA PDBj 3e-27 85.1 %
:RPS:SCOP  1->203 1yrwA2  c.65.1.1 * 2e-15 74.6 %
:RPS:SCOP  204->299 1yrwA1  b.46.1.1 * 3e-23 76.3 %
:RPS:SCOP  317->651 1u9jA  c.2.1.2 * 2e-24 85.2 %
:HMM:SCOP  1->203 2blnA2 c.65.1.1 * 2e-57 36.0 %
:HMM:SCOP  204->304 2blnA1 b.46.1.1 * 6.9e-25 34.7 %
:HMM:SCOP  316->657 2bllA1 c.2.1.2 * 3e-72 29.0 %
:RPS:PFM   16->173 PF00551 * Formyl_trans_N 8e-24 40.3 %
:RPS:PFM   200->280 PF02911 * Formyl_trans_C 4e-14 43.8 %
:RPS:PFM   318->542 PF01370 * Epimerase 2e-14 32.4 %
:HMM:PFM   318->566 PF01370 * Epimerase 1.9e-42 30.3 228/238  
:HMM:PFM   64->173 PF00551 * Formyl_trans_N 6.7e-26 33.6 110/181  
:HMM:PFM   202->294 PF02911 * Formyl_trans_C 2.6e-22 33.7 92/100  
:BLT:SWISS 1->660 ARNA_SALHS 0.0 100.0 %

SeqInfo AminoSeq See neighboring genes
Links DAD Abbreviations Back to title page
GT:ID ACF68086.1 GT:GENE ACF68086.1 GT:PRODUCT bifunctional polymyxin resistance protein ArnA GT:DATABASE GIB00763CH01 GT:ORG sent8 GB:ACCESSION GIB00763CH01 GB:LOCATION 2453655..2455637 GB:FROM 2453655 GB:TO 2455637 GB:DIRECTION + GB:PRODUCT bifunctional polymyxin resistance protein ArnA GB:NOTE identified by match to protein family HMM PF00551; match to protein family HMM PF01370; match to protein family HMM PF02911; match to protein family HMM PF07993 GB:PROTEIN_ID ACF68086.1 GB:DB_XREF GI:194407867 LENGTH 660 SQ:AASEQ MKAVIFAYHDMGCQGVQAVLDAGYEIAAIFTHADNPAENTFFGSVSRLAAGLGIPVYAPDNVNHPIWIDRIAELAPDIIFSFYYRNLLSEEILHLAPAGAFNLHGSLLPAYRGRAPLNWVLVNGESETGVTLHRMVKRADAGEIVASQRVAIAQDDVALTLHHKLCQAARQLLNSILPTMKCGDIPSVPQRESDATYYGRRRPEDGLIDWHKPVSTVHNLVRAVAAPWPGAFSYNGSQKFTIWSSRICPDAQGALPGSVISVSPLRVACADGALEIITGQAGDGITVQGSQLAQTLGLVAGARLNRPPATSGKRRIRVLILGVNGFIGNHLTERLLNEENYEVYGMDIGSNAISRFLLHPRFHFVEGDISIHSEWIEYHVKKCDVVLPLVAIATPIEYTRNPLRVFELDFEENLRIIRYCVKYRKRVVFPSTSEVYGMCTDASFDEDKSNLIVGPVNKPRWIYSVSKQLLDRVIWAYGEKEGLRFTLFRPFNWMGPRLDSLNAARIGSSRAITQLILNLVEGTPIKLIDGGQQKRCFTDIRDGIEALFRIIVNDGDRCDGKIINIGNPDNEASIQELATLLLDSFDKHPLRCHFPPFAGFQVVESRSYYGKGYQDVAHRKPSIDNARRCLGWEPSIAMRDTVEETLDFFLRSVDVAERAS GT:EXON 1|1-660:0| SW:ID ARNA_SALHS SW:DE RecName: Full=Bifunctional polymyxin resistance protein arnA;Includes: RecName: Full=UDP-4-amino-4-deoxy-L-arabinose formyltransferase; EC=2.1.2.n1; AltName: Full=UDP-L-Ara4N formyltransferase; AltName: Full=ArnAFT;Includes: RecName: Full=UDP-glucuronic acid oxidase, UDP-4-keto-hexauronic acid decarboxylating; EC=1.1.1.n1; AltName: Full=UDP-GlcUA decarboxylase; AltName: Full=UDP-glucuronic acid dehydrogenase; AltName: Full=ArnADH; SW:GN Name=arnA; OrderedLocusNames=SeHA_C2539; SW:KW Antibiotic resistance; Complete proteome; Lipid A biosynthesis;Lipid synthesis; Lipopolysaccharide biosynthesis; Methyltransferase;Multifunctional enzyme; NAD; Oxidoreductase; Transferase. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->660|ARNA_SALHS|0.0|100.0|660/660| GO:SWS:NREP 9 GO:SWS GO:0046677|"GO:response to antibiotic"|Antibiotic resistance| GO:SWS GO:0009245|"GO:lipid A biosynthetic process"|Lipid A biosynthesis| GO:SWS GO:0008610|"GO:lipid biosynthetic process"|Lipid synthesis| GO:SWS GO:0009103|"GO:lipopolysaccharide biosynthetic process"|Lipopolysaccharide biosynthesis| GO:SWS GO:0008168|"GO:methyltransferase activity"|Methyltransferase| GO:SWS GO:0003824|"GO:catalytic activity"|Multifunctional enzyme| GO:SWS GO:0016491|"GO:oxidoreductase activity"|Oxidoreductase| GO:SWS GO:0055114|"GO:oxidation reduction"|Oxidoreductase| GO:SWS GO:0016740|"GO:transferase activity"|Transferase| BL:PDB:NREP 1 BL:PDB:REP 1->655|1z7eD|0.0|80.7|643/644| RP:PDB:NREP 2 RP:PDB:REP 1->294|2cfiA|2e-63|23.4|290/310| RP:PDB:REP 317->651|2bllA|3e-27|85.1|323/330| RP:PFM:NREP 3 RP:PFM:REP 16->173|PF00551|8e-24|40.3|154/179|Formyl_trans_N| RP:PFM:REP 200->280|PF02911|4e-14|43.8|80/100|Formyl_trans_C| RP:PFM:REP 318->542|PF01370|2e-14|32.4|207/232|Epimerase| HM:PFM:NREP 3 HM:PFM:REP 318->566|PF01370|1.9e-42|30.3|228/238|Epimerase| HM:PFM:REP 64->173|PF00551|6.7e-26|33.6|110/181|Formyl_trans_N| HM:PFM:REP 202->294|PF02911|2.6e-22|33.7|92/100|Formyl_trans_C| GO:PFM:NREP 7 GO:PFM GO:0009058|"GO:biosynthetic process"|PF00551|IPR002376| GO:PFM GO:0016742|"GO:hydroxymethyl-, formyl- and related transferase activity"|PF00551|IPR002376| GO:PFM GO:0009058|"GO:biosynthetic process"|PF02911|IPR005793| GO:PFM GO:0016742|"GO:hydroxymethyl-, formyl- and related transferase activity"|PF02911|IPR005793| GO:PFM GO:0003824|"GO:catalytic activity"|PF01370|IPR001509| GO:PFM GO:0044237|"GO:cellular metabolic process"|PF01370|IPR001509| GO:PFM GO:0050662|"GO:coenzyme binding"|PF01370|IPR001509| RP:SCP:NREP 3 RP:SCP:REP 1->203|1yrwA2|2e-15|74.6|197/197|c.65.1.1| RP:SCP:REP 204->299|1yrwA1|3e-23|76.3|93/94|b.46.1.1| RP:SCP:REP 317->651|1u9jA|2e-24|85.2|325/332|c.2.1.2| HM:SCP:REP 1->203|2blnA2|2e-57|36.0|203/0|c.65.1.1|1/1|Formyltransferase| HM:SCP:REP 204->304|2blnA1|6.9e-25|34.7|101/0|b.46.1.1|1/1|FMT C-terminal domain-like| HM:SCP:REP 316->657|2bllA1|3e-72|29.0|341/0|c.2.1.2|1/1|NAD(P)-binding Rossmann-fold domains| OP:NHOMO 2230 OP:NHOMOORG 1062 OP:PATTERN 111-1-1-1111-21-12---11-311212-1-12221----12132222122-12221221--2--1 342-221333331222211-11112211111122221222124311112221133211114311235132311111111111332523332214111--2132424535411111111111111111211231241644641115313333332222222222122433432332113322-22311112112133333424234334414222123323132221112115421111111111111121111211111111111311221231112113331111222111111111111111111111111211112111121152222326432331441121213112111111212612211112221124222311121212532322233632223233322-556646452311222378367544212311123333122222222222222143211111111111111111111111111111111121-2412544446455555537466653443554435543311111112121163111321111111212242252314232435423745673745222256431211112122312111111111111223221231111121211121111111111211-1221211111111422222222222232-222222222222222222233322352212222222222222122222222222222222222221121222221221221111111111111111111111111121212242343212221123311111111111111111111111112121221113323113222335511111111111----1-111-1-1---111-111111121211111262 --11--1-----2221-------2-21-----------------------2211--------22-----------------11----1-122-11222221-1222-24233344311-22342321729J3-546122-41343-22323115223232-33222-333423522232P443227889-B51323322 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 659 STR:RPRED 99.8 SQ:SECSTR cEEEEEccHHHHHHHHHHHHHTTcEEEEEEEcccccccccHHHHHHHHHHHHTccEEEcTTEEcHHHHHHHHHTcccEEEEccccccccHHHHTccTTcEEEEEcccTTTTccccHHHHHHHTTccEEEEEEEEcccccccccEEEEEEEEccTTccHHHHHHHTTTHHHHHHHHHHHHHHTTcccccccccTTccccccccGGGGcccccccHHHHHHHHHTTcTTTTcEEEEETTEEEEEEEEEcccTTcccccEEEETTEEEEEcTTccEEEEEEEEcTTccEEEGGGTTcHHTccTTcccccccTTcccEccEEEEETcccHHHHHHHHHHHHcTTcEEEEEEcccGGGGGGTTcTTEEEEEccTTTccHHHHHHHHHccEEEEccccccHHHHHHcHHHHHHHHTHHHHHHHHHHHHTTcEEEEEccGGGGcTcccccccTTTcccccccTTcGGGHHHHHHHHHHHHHHHHHHHHcccEEEEEEccEEccccccTTcccccccHHHHHHHHHHHHTccEEEGGGcccEEEcEEHHHHHHHHHHHHHcGGGTTTTEEEEEccTTcEEEHHHHHHHHHHHHHTcTTGGGccTTccTTcEEEEEccccEEEcccccccccHHHHHHHcccccccHHHHHHHHHHHHHHHHHHTHHH# DISOP:02AL 658-661| PSIPRED cEEEEEEccHHHHHHHHHHHHccccEEEEEEccccccccccccHHHHHHHHccccEEcccccccHHHHHHHHHccccEEEEEccHHcccHHHHHHccccEEEEcHHHccccccccHHHHHHHccccEEEEEEEEEccccccccEEEEEEEEccccccHHHHHHHHHHHHHHHHHHHHHHHHccccccEEcccccccccccccHHHEEEcccccHHHHHHHHccccccccEEEEEEccEEEEEEEEEEccccccccccEEEEcccEEEEcccccEEEEEEEEcccccccHHHHHHcccccccccccccccccccccEEEEEEccccHHHHHHHHHHHHHcccEEEEEEccccccHHHHccccEEEEEcccccHHHHHHHHHHcccEEEEccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccEEEEEccccccccccccccccccccccccccccccHHHHHHHHHHHHHHHHHHHHcccEEEEEcccccccccccccccccccccHHHHHHHHHHcccccEEEEccccEEEEEEHHHHHHHHHHHHHccccccccEEEEEcccccEEEHHHHHHHHHHHHcccccccccccccccEEEcccccccccccccccccccHHHHHHHHcccccccHHHHHHHHHHHHHHHHHHHHccc //