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Salmonella enterica subsp. enterica serovar Heidelberg str. SL476 (sent8)
Gene : dxr
DDBJ      :dxr          1-deoxy-D-xylulose 5-phosphate reductoisomerase
Swiss-Prot:DXR_SALTY    RecName: Full=1-deoxy-D-xylulose 5-phosphate reductoisomerase;         Short=DXP reductoisomerase;         EC=1.1.1.267;AltName: Full=1-deoxyxylulose-5-phosphate reductoisomerase;AltName: Full=2-C-methyl-D-erythritol 4-phosphate synthase;

Homologs  Archaea  0/68 : Bacteria  719/915 : Eukaryota  24/199 : Viruses  0/175   --->[See Alignment]
a.69.3c.2.1d.81.1
:427 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   30->426 1q0qA PDBj 0.0 88.9 %
:RPS:PDB   35->426 2eghA PDBj 4e-58 88.8 %
:RPS:SCOP  31->179 1jvsA2  c.2.1.3 * 5e-44 73.0 %
:RPS:SCOP  156->304 1jvsA3  d.81.1.3 * 8e-79 88.6 %
:RPS:SCOP  331->426 1jvsA1  a.69.3.1 * 9e-35 82.3 %
:HMM:SCOP  31->179 1r0kA2 c.2.1.3 * 1.7e-51 58.9 %
:HMM:SCOP  155->303 1k5hA3 d.81.1.3 * 1.1e-62 59.7 %
:HMM:SCOP  330->427 1k5hA1 a.69.3.1 * 3.1e-33 53.1 %
:RPS:PFM   33->161 PF02670 * DXP_reductoisom 5e-39 64.1 %
:RPS:PFM   175->268 PF08436 * DXP_redisom_C 5e-28 66.7 %
:HMM:PFM   33->161 PF02670 * DXP_reductoisom 1.4e-50 55.8 129/129  
:HMM:PFM   175->268 PF08436 * DXP_redisom_C 2.4e-36 56.0 84/84  
:BLT:SWISS 30->427 DXR_SALTY 0.0 100.0 %
:TM

SeqInfo AminoSeq See neighboring genes
Links DAD Abbreviations Back to title page
GT:ID ACF67056.1 GT:GENE dxr GT:PRODUCT 1-deoxy-D-xylulose 5-phosphate reductoisomerase GT:DATABASE GIB00763CH01 GT:ORG sent8 GB:ACCESSION GIB00763CH01 GB:LOCATION 265496..266779 GB:FROM 265496 GB:TO 266779 GB:DIRECTION + GB:GENE dxr GB:PRODUCT 1-deoxy-D-xylulose 5-phosphate reductoisomerase GB:NOTE identified by match to protein family HMM PF02670; match to protein family HMM PF08436; match to protein family HMM TIGR00243 GB:PROTEIN_ID ACF67056.1 GB:DB_XREF GI:194406837 GB:GENE:GENE dxr LENGTH 427 SQ:AASEQ MYKAPRRRHYQVSCAAFCFLFRFNTSGRFMKQLTILGSTGSIGCSTLDVVRHNPDSFRVIALVAGKNVARMAEQCLEFSPRYAVMDDTSSAEQLKIMLQQHGSRTEVLSGQQAACEMAALDEVGHVMAAIVGAAGLLPTLAAIRAGKTILLANKESLVTCGRLFMDEVKRSNARLLPVDSEHNAIFQSLPQSIQHNLGYADLEQNGVTSILLTGSGGPFRETPMCDLAAMTPDQACRHPNWSMGRKISVDSATMMNKGLEYIEARWLFNASARQMEVLIHPQSVIHSMVRYQDGSVLAQLGEPDMRTPIAHTMAWPNRVTSGAQPLDFCKLSALTFSAPDYQRYPCLKLAMEAFEQGQAATTALNAANEITVAAFLAQQIRFTDIAGLNLAVLERMDLQEPASVEDVLQVDAIAREVARKQVIRLSR GT:EXON 1|1-427:0| SW:ID DXR_SALTY SW:DE RecName: Full=1-deoxy-D-xylulose 5-phosphate reductoisomerase; Short=DXP reductoisomerase; EC=1.1.1.267;AltName: Full=1-deoxyxylulose-5-phosphate reductoisomerase;AltName: Full=2-C-methyl-D-erythritol 4-phosphate synthase; SW:GN Name=dxr; OrderedLocusNames=STM0220; SW:KW Complete proteome; Isoprene biosynthesis; Metal-binding; NADP;Oxidoreductase. SW:EXACT F SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 30->427|DXR_SALTY|0.0|100.0|398/398| GO:SWS:NREP 4 GO:SWS GO:0008299|"GO:isoprenoid biosynthetic process"|Isoprene biosynthesis| GO:SWS GO:0046872|"GO:metal ion binding"|Metal-binding| GO:SWS GO:0016491|"GO:oxidoreductase activity"|Oxidoreductase| GO:SWS GO:0055114|"GO:oxidation reduction"|Oxidoreductase| TM:NTM 1 TM:REGION 126->148| BL:PDB:NREP 1 BL:PDB:REP 30->426|1q0qA|0.0|88.9|397/398| RP:PDB:NREP 1 RP:PDB:REP 35->426|2eghA|4e-58|88.8|392/400| RP:PFM:NREP 2 RP:PFM:REP 33->161|PF02670|5e-39|64.1|128/128|DXP_reductoisom| RP:PFM:REP 175->268|PF08436|5e-28|66.7|84/84|DXP_redisom_C| HM:PFM:NREP 2 HM:PFM:REP 33->161|PF02670|1.4e-50|55.8|129/129|DXP_reductoisom| HM:PFM:REP 175->268|PF08436|2.4e-36|56.0|84/84|DXP_redisom_C| GO:PFM:NREP 8 GO:PFM GO:0008299|"GO:isoprenoid biosynthetic process"|PF02670|IPR013512| GO:PFM GO:0030604|"GO:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"|PF02670|IPR013512| GO:PFM GO:0046872|"GO:metal ion binding"|PF02670|IPR013512| GO:PFM GO:0055114|"GO:oxidation reduction"|PF02670|IPR013512| GO:PFM GO:0008299|"GO:isoprenoid biosynthetic process"|PF08436|IPR013644| GO:PFM GO:0030604|"GO:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"|PF08436|IPR013644| GO:PFM GO:0046872|"GO:metal ion binding"|PF08436|IPR013644| GO:PFM GO:0055114|"GO:oxidation reduction"|PF08436|IPR013644| RP:SCP:NREP 3 RP:SCP:REP 31->179|1jvsA2|5e-44|73.0|148/152|c.2.1.3| RP:SCP:REP 156->304|1jvsA3|8e-79|88.6|149/149|d.81.1.3| RP:SCP:REP 331->426|1jvsA1|9e-35|82.3|96/99|a.69.3.1| HM:SCP:REP 31->179|1r0kA2|1.7e-51|58.9|146/151|c.2.1.3|1/2|NAD(P)-binding Rossmann-fold domains| HM:SCP:REP 155->303|1k5hA3|1.1e-62|59.7|149/149|d.81.1.3|1/1|Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain| HM:SCP:REP 330->427|1k5hA1|3.1e-33|53.1|98/0|a.69.3.1|1/1|1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain| OP:NHOMO 772 OP:NHOMOORG 743 OP:PATTERN -------------------------------------------------------------------- 111111111111-111111-1111111111111111111111112111111111111111111111111111111111111111111111111111---------1111111111111111111111111111111-----111-11111111111111111111111111111111111111111111111112222221221122221111112121111-11111111111-----------------------------------------------------------------------------------------11111111111111111111111111--111111111111111111111-1111111-----1111111111111------------11111111--1-11111111111111111111111111111111111111111111111111111---------------111111111111111111111111111111111111111111111111111111111111111111111111111111111-111111111111111111111111111--111111111111111111111111111111111111111111111111111111111111--11111--1111111111111-111111-111111111111111111111111111111111111111111111111111111111111111111111---------1111111111111111111111111111111111111111111111111111111111-11111111111111111111111111111111111111--------11------------1------1------1111111111111 11------1---------------------------------------------------------------------------------------------------1-----------------------------------------------------------------111119111112123-1211----1 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 397 STR:RPRED 93.0 SQ:SECSTR #############################cEEEEEETTTcHHHHHHHHHHHHcTTTEEEEEEEEcccHHHHHHHHHHHcccEEEEccHHHHHHHHHHHHHTTcccEEEEcHHHHHHHHTcTTccEEEEcccccTTHHHHHHHHHTTcEEEEcccHHHHHHHHHHHHHHHHHTcEEEEccHHHHHHHHTccHHHHTTTTTccTGGGTEEEEEEEEcccTTccccGGGGGGccHHHHTccccccccHHHHHHHHHTHHHHHHHHHHHHHHTccGGGEEEEEcTTccEEEEEEETTccEEEEEccccTHHHHHHHHHTTcccccccccccGGGccccccccccTTTcHHHHHHHHHHHHcHHHHHHHHHHHHHHHHHHHTTcccTTHHHHHHHHHHHHccccccccHHHHHHHHHHHHHHHHHHHHHHH# DISOP:02AL 1-6,426-428| PSIPRED ccccccccEEEEEEHHccccEEEccccccEEEEEEEEcccHHHHHHHHHHHHccccEEEEEEEccccHHHHHHHHHHHcccEEEEccHHHHHHHHHHHHHcccccEEEEcHHHHHHHHHcccccEEEEEHHHHHHHHHHHHHHHHcccEEHHHHHHHHHHHHHHHHHHHHcccEEEEEccHHHHHHHHccHHHHHcccccccccccccEEEEEccccccccccHHHHHcccHHHHHcccccccccEEcccHHHHHHHHHHHHHHHHHccccHHHEEEEEccccEEEEEEEEccccEEEEcccccHHHHHHHHcccccccccccccccHHHccccccccccHHHccHHHHHHHHHHcccccEEEEEcHHHHHHHHHHccccccccHHHHHHHHHHHccccccccHHHHHHHHHHHHHHHHHHHHHHcc //