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Salmonella enterica subsp. enterica serovar Heidelberg str. SL476 (sent8)
Gene : dxs
DDBJ      :dxs          1-deoxy-D-xylulose-5-phosphate synthase
Swiss-Prot:DXS_SALHS    RecName: Full=1-deoxy-D-xylulose-5-phosphate synthase;         EC=2.2.1.7;AltName: Full=1-deoxyxylulose-5-phosphate synthase;         Short=DXP synthase;         Short=DXPS;

Homologs  Archaea  36/68 : Bacteria  820/915 : Eukaryota  93/199 : Viruses  0/175   --->[See Alignment]
c.23.10c.36.1c.48.1
:620 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   3->620 2o1sA PDBj 0.0 94.6 %
:RPS:PDB   25->620 1ay0A PDBj 2e-82 17.4 %
:RPS:SCOP  16->257 1um9A  c.36.1.11 * 5e-27 14.8 %
:RPS:SCOP  252->476 2apjA1  c.23.10.7 * 4e-45 15.8 %
:RPS:SCOP  491->620 1dtwB2  c.48.1.2 * 2e-21 16.7 %
:HMM:SCOP  8->381 1w85A_ c.36.1.11 * 3.8e-81 34.3 %
:HMM:SCOP  290->485 1qgdA1 c.36.1.6 * 8.9e-67 42.6 %
:HMM:SCOP  489->621 1ik6A2 c.48.1.2 * 9.6e-32 40.8 %
:RPS:PFM   140->186 PF00676 * E1_dh 2e-04 38.3 %
:RPS:PFM   362->478 PF02779 * Transket_pyr 1e-15 40.5 %
:RPS:PFM   498->606 PF02780 * Transketolase_C 3e-12 42.5 %
:HMM:PFM   321->481 PF02779 * Transket_pyr 1.2e-40 29.4 160/178  
:HMM:PFM   495->611 PF02780 * Transketolase_C 6.2e-30 37.9 116/124  
:HMM:PFM   124->186 PF00676 * E1_dh 5.1e-09 34.9 63/300  
:BLT:SWISS 1->620 DXS_SALHS 0.0 100.0 %
:PROS 36->55|PS00801|TRANSKETOLASE_1
:PROS 425->441|PS00802|TRANSKETOLASE_2
:SEG

SeqInfo AminoSeq See neighboring genes
Links DAD Abbreviations Back to title page
GT:ID ACF70423.1 GT:GENE dxs GT:PRODUCT 1-deoxy-D-xylulose-5-phosphate synthase GT:DATABASE GIB00763CH01 GT:ORG sent8 GB:ACCESSION GIB00763CH01 GB:LOCATION complement(521765..523627) GB:FROM 521765 GB:TO 523627 GB:DIRECTION - GB:GENE dxs GB:PRODUCT 1-deoxy-D-xylulose-5-phosphate synthase GB:NOTE identified by match to protein family HMM PF02779; match to protein family HMM PF02780; match to protein family HMM TIGR00204 GB:PROTEIN_ID ACF70423.1 GB:DB_XREF GI:194410204 GB:GENE:GENE dxs LENGTH 620 SQ:AASEQ MSFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELTVALHYVYNTPFDQLIWDVGHQAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSVGHSSTSISAGIGIAVAAEKEGKDRRTVCVIGDGAITAGMAFEAMNHAGDIRPDMLVILNDNEMSISENVGALNNHLAQLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPGTLFEELGFNYIGPVDGHDVMGLISTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHAVPKFDPSSGCLPKSSGGLPGYSKIFGDWLCETAAKDSKLMAITPAMREGSGMVEFSRKFPDRYFDVAIAEQHAVTFAAGLAIGGYKPVVAIYSTFLQRAYDQVIHDVAIQKLPVMFAIDRAGIVGADGQTHQGAFDLSYLRCIPDMVIMTPSDENECRQMLLTGYHYNDGPTAVRYPRGNAQGVALTPLEKLPIGKGLVKRHGEKLAILNFGTLMPEAAKVAEALNATLVDMRFVKPLDDTLILEMAAQHDALVTLEENAIMGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEARAELGLDAAGIEAKIKAWLA GT:EXON 1|1-620:0| SW:ID DXS_SALHS SW:DE RecName: Full=1-deoxy-D-xylulose-5-phosphate synthase; EC=2.2.1.7;AltName: Full=1-deoxyxylulose-5-phosphate synthase; Short=DXP synthase; Short=DXPS; SW:GN Name=dxs; OrderedLocusNames=SeHA_C0524; SW:KW Complete proteome; Isoprene biosynthesis; Thiamine biosynthesis;Thiamine pyrophosphate; Transferase. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->620|DXS_SALHS|0.0|100.0|620/620| GO:SWS:NREP 3 GO:SWS GO:0008299|"GO:isoprenoid biosynthetic process"|Isoprene biosynthesis| GO:SWS GO:0009228|"GO:thiamin biosynthetic process"|Thiamine biosynthesis| GO:SWS GO:0016740|"GO:transferase activity"|Transferase| PROS 36->55|PS00801|TRANSKETOLASE_1|PDOC00635| PROS 425->441|PS00802|TRANSKETOLASE_2|PDOC00635| SEG 121->137|ghsstsisagigiavaa| BL:PDB:NREP 1 BL:PDB:REP 3->620|2o1sA|0.0|94.6|518/518| RP:PDB:NREP 1 RP:PDB:REP 25->620|1ay0A|2e-82|17.4|582/678| RP:PFM:NREP 3 RP:PFM:REP 140->186|PF00676|2e-04|38.3|47/298|E1_dh| RP:PFM:REP 362->478|PF02779|1e-15|40.5|116/172|Transket_pyr| RP:PFM:REP 498->606|PF02780|3e-12|42.5|106/122|Transketolase_C| HM:PFM:NREP 3 HM:PFM:REP 321->481|PF02779|1.2e-40|29.4|160/178|Transket_pyr| HM:PFM:REP 495->611|PF02780|6.2e-30|37.9|116/124|Transketolase_C| HM:PFM:REP 124->186|PF00676|5.1e-09|34.9|63/300|E1_dh| GO:PFM:NREP 4 GO:PFM GO:0008152|"GO:metabolic process"|PF00676|IPR001017| GO:PFM GO:0016624|"GO:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"|PF00676|IPR001017| GO:PFM GO:0003824|"GO:catalytic activity"|PF02780|IPR005476| GO:PFM GO:0008152|"GO:metabolic process"|PF02780|IPR005476| RP:SCP:NREP 3 RP:SCP:REP 16->257|1um9A|5e-27|14.8|229/331|c.36.1.11| RP:SCP:REP 252->476|2apjA1|4e-45|15.8|203/244|c.23.10.7| RP:SCP:REP 491->620|1dtwB2|2e-21|16.7|126/138|c.48.1.2| HM:SCP:REP 8->381|1w85A_|3.8e-81|34.3|315/0|c.36.1.11|1/1|Thiamin diphosphate-binding fold (THDP-binding)| HM:SCP:REP 290->485|1qgdA1|8.9e-67|42.6|188/195|c.36.1.6|1/1|Thiamin diphosphate-binding fold (THDP-binding)| HM:SCP:REP 489->621|1ik6A2|9.6e-32|40.8|130/135|c.48.1.2|1/1|TK C-terminal domain-like| OP:NHOMO 1639 OP:NHOMOORG 949 OP:PATTERN ---1--1111111111-112111------1-----11111111-----------11-111-122--11 122241111111-122233-31112432333133332362233521221111423111112132337543111111114222211122222311111122333533242511111111212222122122222242122--111221111112111111111111112211212112111111111111112211111111111111112233121113322-11122211232111111111111111111112-----31-2111121-1-1112212221-11-1111111111111--------------11111222121224222222243523222222113--2242222222212223212233131111111111114332122212311221222212-44344543331-2441333232331411122222332223333333324412222111---------1----111--11-----22241322121422122222223323222212113121111111211112121221111111121111111111111121231111231111344333324112121111112111111111111111111111111121111211112111112111111111111--21111--11121222311111111111-111111111111111111333321111322222222222222211111111112212222222221111-----11111111111122111111122122222111112111111122122221221111111111-11111111111111111111111111111132332233--------111-----------1------1------1211113121221 11--12--411--------------------------------111--111-1-11------1------1--------------1------------------112--2122511111---23133242AU3-43412-13135--1-1231-1-111311-1121-4219--412221S2211265C8-43-1----1 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 620 STR:RPRED 100.0 SQ:SECSTR TTTTEcccGGGcccccHHHHHHHHcHHHHHHHHHHHHHHHHHHHHHccccHHHHHHHHHHHHHHHTccTTccEEEEccGGGHHHHHHHTTccccHTTTTcTTccccccccTTcTTcHHHHHHHHHHHHHHHHHHccTTcccccccEEEEEcHHHHHcHHHHHHHHHHHHTTcTTEEEEEEccEETTEEGGTccccHHHHHHHHTcEEEEEccTTTcHHHHHTTcTTccEEEEEEccTTTTcTTTTcGGGTcccccHHHHHHHHHHTTccTTccccccHHHHHHHHHHTHHHHHHHHHHHcccTTGGGGcccccTTcccEEHHHHHHHHHHHHTTTcTTEEEEEcccHHHHTcccccEETTccEEEccccHHHHHHHHHHHHHHcTTcEEEEEHHHHGGGHHHHHHHHHHTcccEEEEEcccGGGcTTcTTcccccHHHHHTcccccEEEccccHHHHHHHHHHHHHcccccEEEEccccEEcccTTcHHHHTTccEEEEccccccEEEEEcTTHHHHHHHHHHHHcEEEEEcccHHHHHTccHHHHHHTTccEEEEcccccTGGGGGTccEEEccccHGcTccEEEccccccccccHHHHHHHHTccHHHHHHHHHHHHH DISOP:02AL 1-3| PSIPRED ccccccccccccccccHHHHHHccHHHHHHHHHHHHHHHHHHHHHcccccccHHHHHHHHHHHHccccccccEEEEEcccHHHHHHHHcccHHHHHHHHHHcccccccccccccccEEEccccHHHHHHHHHHHHHHHHHccccEEEEEEEcHHcccHHHHHHHHHHHHccccEEEEEEcccccccccHHHHHHHHHHHHHcccccEEEEccHHHHHHHHHHHHHHHHHHHccccccccccHHHccccccccccccccHHHHHHHHHHHHHccccEEEEEEEHHHccccHHHccHHHHccccHHHHHccccccccccHHHHHHHHHHHHHHHHHHcccEEEEcccccccccccHHcccccccEEEccccHHHHHHHHHHHHHcccEEEEEEEHHHHHHHHHHHHHHHHHHcccEEEEEEcccccccccHHHcccHHHHHHHHHcccEEEEEccHHHHHHHHHHHHHcccccEEEEEEcccccccccccccccccccEEEEEccccEEEEEccHHHHHHHHHHHHHcccEEEccccccccHHHHHHHHHHcccEEEEEcccccccHHHHHHHHHHHccccccEEEEEccccccccccHHHHHHHHcccHHHHHHHHHHHHc //