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Salmonella enterica subsp. enterica serovar Heidelberg str. SL476 (sent8)
Gene : ligA.1
DDBJ      :ligA         DNA ligase, NAD-dependent
Swiss-Prot:DNLJ_SALHS   RecName: Full=DNA ligase;         EC=6.5.1.2;AltName: Full=Polydeoxyribonucleotide synthase [NAD+];

Homologs  Archaea  6/68 : Bacteria  897/915 : Eukaryota  24/199 : Viruses  2/175   --->[See Alignment]
a.60.2b.40.4c.15.1d.142.2
:671 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   1->586 2owoA PDBj 0.0 91.6 %
:BLT:PDB   600->657 1l7bA PDBj 2e-10 54.4 %
:RPS:PDB   2->669 1dgtB PDBj 0.0 45.5 %
:RPS:SCOP  2->318 1b04A  d.142.2.2 * 3e-89 49.4 %
:RPS:SCOP  317->402 1dgsA2  b.40.4.6 * 6e-15 52.3 %
:RPS:SCOP  404->583 1dgsA1  a.60.2.2 * 3e-40 40.1 %
:RPS:SCOP  591->671 1l7bA  c.15.1.2 * 4e-19 46.2 %
:HMM:SCOP  1->316 1v9pA3 d.142.2.2 * 1.3e-120 59.2 %
:HMM:SCOP  317->402 1dgsA2 b.40.4.6 * 1.4e-30 58.1 %
:HMM:SCOP  403->583 1dgsA1 a.60.2.2 * 9.5e-64 50.0 %
:HMM:SCOP  591->671 1l7bA_ c.15.1.2 * 4.7e-19 50.0 %
:RPS:PFM   5->318 PF01653 * DNA_ligase_aden e-112 62.5 %
:RPS:PFM   322->401 PF03120 * DNA_ligase_OB 3e-25 67.5 %
:RPS:PFM   407->434 PF03119 * DNA_ligase_ZBD 1e-08 71.4 %
:RPS:PFM   597->662 PF00533 * BRCT 2e-10 50.8 %
:HMM:PFM   4->318 PF01653 * DNA_ligase_aden 1.4e-133 56.4 312/315  
:HMM:PFM   321->401 PF03120 * DNA_ligase_OB 6e-38 59.3 81/82  
:HMM:PFM   596->668 PF00533 * BRCT 1.8e-14 27.8 72/78  
:HMM:PFM   407->434 PF03119 * DNA_ligase_ZBD 1.5e-14 60.7 28/28  
:HMM:PFM   534->562 PF00633 * HHH 5.3e-07 34.5 29/30  
:BLT:SWISS 1->671 DNLJ_SALHS 0.0 100.0 %
:PROS 115->144|PS01055|DNA_LIGASE_N1
:PROS 331->346|PS01056|DNA_LIGASE_N2

SeqInfo AminoSeq See neighboring genes
Links DAD Abbreviations Back to title page
GT:ID ACF68112.1 GT:GENE ligA.1 GT:PRODUCT DNA ligase, NAD-dependent GT:DATABASE GIB00763CH01 GT:ORG sent8 GB:ACCESSION GIB00763CH01 GB:LOCATION complement(2596804..2598819) GB:FROM 2596804 GB:TO 2598819 GB:DIRECTION - GB:GENE ligA GB:PRODUCT DNA ligase, NAD-dependent GB:NOTE identified by match to protein family HMM PF00533; match to protein family HMM PF00633; match to protein family HMM PF01653; match to protein family HMM PF03119; match to protein family HMM PF03120; match to protein family HMM TIGR00575 GB:PROTEIN_ID ACF68112.1 GB:DB_XREF GI:194407893 GB:GENE:GENE ligA LENGTH 671 SQ:AASEQ MEPIEQQLTELRTTLRHHEYLYHVMDAPEIPDAEYDRLMRELRELEAQRPDLITPDSPTQRVGAAPLTAFNQIRHEVPMLSLDNVFDEESFLAFNKRVQDRLKSTENVIWCCELKLDGLAVSILYENGVLVSAATRGDGTTGEDITSNVRTIRAIPLKLHGDNIPARLEVRGEVFLPQAGFEKINEDARRTGGKVFANPRNAAAGSLRQLDPRITAKRPLTFFCYGVGILEGGELPDTHLGRLLQFKAWGLPVSDRVTLCDSPQAVLDFYRNVEKDRPTLGFDIDGVVIKVNSLALQEQLGFVARAPRWAVAFKFPAQEQMTFVRDVEFQVGRTGAITPVARLEPVQVAGVLVSNATLHNADEIERLGLRIGDKVVIRRAGDVIPQVVNVVLSERPEETRPIVFPTHCPVCGSDVERVEGEAVTRCTGGLICGAQRKESLKHFVSRRAMDVDGMGDKIIDQLVEREYVHTPADLFRLTAGKLTGLDRMGPKSAQNVVNALEKAKATTFARFLYALGIREVGEATAAGLAAYFGTLEALQTATIDELQKVPDVGIVVATHVFNFFAEESNRDVIGQLLAEGVHWPAPVVINVQEIDSPFAGKTVVLTGSLSQMSRDDAKARLAALGAKVAGSVSKKTDLVIAGEAAGSKLAKAQELGITVIDEAEMIRLLGA GT:EXON 1|1-671:0| SW:ID DNLJ_SALHS SW:DE RecName: Full=DNA ligase; EC=6.5.1.2;AltName: Full=Polydeoxyribonucleotide synthase [NAD+]; SW:GN Name=ligA; OrderedLocusNames=SeHA_C2686; SW:KW Complete proteome; DNA damage; DNA repair; DNA replication; Ligase;Magnesium; Manganese; Metal-binding; NAD; Zinc. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->671|DNLJ_SALHS|0.0|100.0|671/671| GO:SWS:NREP 5 GO:SWS GO:0006974|"GO:response to DNA damage stimulus"|DNA damage| GO:SWS GO:0006281|"GO:DNA repair"|DNA repair| GO:SWS GO:0006260|"GO:DNA replication"|DNA replication| GO:SWS GO:0016874|"GO:ligase activity"|Ligase| GO:SWS GO:0046872|"GO:metal ion binding"|Metal-binding| PROS 115->144|PS01055|DNA_LIGASE_N1|PDOC00809| PROS 331->346|PS01056|DNA_LIGASE_N2|PDOC00809| BL:PDB:NREP 2 BL:PDB:REP 1->586|2owoA|0.0|91.6|586/586| BL:PDB:REP 600->657|1l7bA|2e-10|54.4|57/92| RP:PDB:NREP 1 RP:PDB:REP 2->669|1dgtB|0.0|45.5|651/660| RP:PFM:NREP 4 RP:PFM:REP 5->318|PF01653|e-112|62.5|312/314|DNA_ligase_aden| RP:PFM:REP 322->401|PF03120|3e-25|67.5|80/82|DNA_ligase_OB| RP:PFM:REP 407->434|PF03119|1e-08|71.4|28/28|DNA_ligase_ZBD| RP:PFM:REP 597->662|PF00533|2e-10|50.8|65/76|BRCT| HM:PFM:NREP 5 HM:PFM:REP 4->318|PF01653|1.4e-133|56.4|312/315|DNA_ligase_aden| HM:PFM:REP 321->401|PF03120|6e-38|59.3|81/82|DNA_ligase_OB| HM:PFM:REP 596->668|PF00533|1.8e-14|27.8|72/78|BRCT| HM:PFM:REP 407->434|PF03119|1.5e-14|60.7|28/28|DNA_ligase_ZBD| HM:PFM:REP 534->562|PF00633|5.3e-07|34.5|29/30|HHH| GO:PFM:NREP 8 GO:PFM GO:0003911|"GO:DNA ligase (NAD+) activity"|PF01653|IPR013839| GO:PFM GO:0003911|"GO:DNA ligase (NAD+) activity"|PF03120|IPR004150| GO:PFM GO:0006260|"GO:DNA replication"|PF03120|IPR004150| GO:PFM GO:0006281|"GO:DNA repair"|PF03120|IPR004150| GO:PFM GO:0003911|"GO:DNA ligase (NAD+) activity"|PF03119|IPR004149| GO:PFM GO:0006260|"GO:DNA replication"|PF03119|IPR004149| GO:PFM GO:0006281|"GO:DNA repair"|PF03119|IPR004149| GO:PFM GO:0005622|"GO:intracellular"|PF00533|IPR001357| RP:SCP:NREP 4 RP:SCP:REP 2->318|1b04A|3e-89|49.4|308/310|d.142.2.2| RP:SCP:REP 317->402|1dgsA2|6e-15|52.3|86/86|b.40.4.6| RP:SCP:REP 404->583|1dgsA1|3e-40|40.1|177/181|a.60.2.2| RP:SCP:REP 591->671|1l7bA|4e-19|46.2|80/92|c.15.1.2| HM:SCP:REP 1->316|1v9pA3|1.3e-120|59.2|314/317|d.142.2.2|1/1|DNA ligase/mRNA capping enzyme, catalytic domain| HM:SCP:REP 317->402|1dgsA2|1.4e-30|58.1|86/86|b.40.4.6|1/1|Nucleic acid-binding proteins| HM:SCP:REP 403->583|1dgsA1|9.5e-64|50.0|178/181|a.60.2.2|1/1|RuvA domain 2-like| HM:SCP:REP 591->671|1l7bA_|4.7e-19|50.0|80/92|c.15.1.2|1/1|BRCT domain| OP:NHOMO 1037 OP:NHOMOORG 929 OP:PATTERN ------------------------1--11111------------------------------------ 1111111111111111-11-11111111111111112111111111111111121111111111211122111111111111111111111111111--111111111111111111111111111111112111111111111111121112111111111112111111-111---1-11-21111--111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111121111111111111111111111111111111111111111111111111111111111111111111111111111111111-11112111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111112111111111111111111111111111111111111111111111211112111111112111111111111111111-11111-1111122221222222222222-222222222222322222122222221222222222221212211-1222211222222222222111111111111111121111111111111111111111111121111122222222222121111111111111111111111111111111111111111111111111111111111111111-11111111111111211111111111111121 -1--11-------------------------------------------------1--1111--------------------------------------------1----1-1--------------------------------------------1----------1---1--1114111--1------11----- ----------------------------------------------------------------------------------------------------------------------------------------------------------------1---------1---- STR:NPRED 671 STR:RPRED 100.0 SQ:SECSTR HGGHHHHHHHHHHHHHHHHHHHHTTccccccTTHHHHHHHHHHHHHHHcGGGccTTcGGGccTTcccccccEEEcccccccccEEccHHHHHHHHHTTccccccccccEEEEEEEcccEEEEEEEETTEEEEEEEcccccEEEccHHHHTTcTTccccccccccccEEEEEEEEEccHHHHHHHHHHHHTTTccccccHHHHHHHHHccccTHHHHccccEEEEEEEcccccccccccHHHHHHHHHHHTccccccEEEEEHHHHHHHHHHHHHHTGGGccccccEEEEEEccGGGTTTccccccccccEEEEEccccEEEEEccEEEEEEcTTccEEEEEEEEEEEccccEEEEEEccccTTTTTTTccTTcEEEEEcTTccccEEEEEcTTcccccccccccccccTTTccccccEEcccccccccTTTcTTcHHHHHHHHccTTccccTTccHHHHHHHHTTTccccTTTTcccccHHHHTTcccccHHHHHHHHHHHTGGGccHHHHHHHHTcTTccTTHHHHHHHHHccHHHHHTccHHHHcccccccHHHHHHHHHHHHcHHHHHHHHHHHTTTccccccHHHHHcccccTTcccccccccTcccccTTHHHHcccccccccccccccccccccccTTTcccccccTTTccccccccccTTTTHT DISOP:02AL 1-2,587-594| PSIPRED ccHHHHHHHHHHHHHHHHHHHHHHcccccccHHHHHHHHHHHHHHHHHccccccccccccccccccccccccEEcccccccHHHcccHHHHHHHHHHHHHHcccccccEEEEEEEccEEEEEEEEEccEEEEEEEcccccccccHHHHHHHHHHHHHHccccccccEEEEEEEEEEcHHHHHHHHHHHHHccccccccHHHHHHHHHHcccccHHHHccccEEEEEEEEcccccccccHHHHHHHHHHccccccccEEEEccHHHHHHHHHHHHHHHccccccccEEEEEEccHHHHHHcccEEccccEEEEEEccccEEEEEEEEEEEEEccccEEEEEEEEEEEEEccEEEEEEEcccHHHHHHcccccccEEEEEEccccccEEccccccccccccccEEccccccccccccccccccEEEEcccccccHHHHHHHHHHHHcccccccccccHHHHHHHHHccccccHHHHHcccHHHHHcccccccHHHHHHHHHHHHHccccHHHHHHHcccccccHHHHHHHHHHcccHHHHHHccHHHHHHcccccHHHHHHHHHHHHcHHHHHHHHHHHHcccccccccccccccccccccccEEEEEEEcccccHHHHHHHHHHcccEEEEcccccccEEEEccccccHHHHHHHcccEEEcHHHHHHHHcc //