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Salmonella enterica subsp. enterica serovar Heidelberg str. SL476 (sent8)
Gene : mdtB
DDBJ      :mdtB         multidrug resistance protein MdtB
Swiss-Prot:MDTB_SALHS   RecName: Full=Multidrug resistance protein mdtB;AltName: Full=Multidrug transporter mdtB;

Homologs  Archaea  0/68 : Bacteria  665/915 : Eukaryota  8/199 : Viruses  0/175   --->[See Alignment]
c.55.1d.225.1d.58.44f.35.1
:1040 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   13->1025 2v50B PDBj 2e-95 26.7 %
:RPS:PDB   13->1040 3d9bA PDBj 0.0 22.7 %
:RPS:SCOP  71->225 1mwkA2  c.55.1.1 * 5e-29 17.2 %
:RPS:SCOP  232->333 1iwgA2  d.58.44.1 * 3e-22 23.5 %
:RPS:SCOP  324->499 1iwgA7  f.35.1.1 * 3e-39 40.3 %
:RPS:SCOP  565->664 1iwgA3  d.58.44.1 * 3e-20 18.0 %
:RPS:SCOP  720->800 1iwgA6  d.225.1.1 * 2e-16 19.8 %
:RPS:SCOP  860->1024 1iwgA7  f.35.1.1 * 1e-13 11.5 %
:HMM:SCOP  49->145 1iwgA1 d.58.44.1 * 2.9e-24 40.6 %
:HMM:SCOP  144->333 1iwgA2 d.58.44.1 * 7.2e-24 34.3 %
:HMM:SCOP  299->500 1iwgA7 f.35.1.1 * 7.5e-44 36.2 %
:HMM:SCOP  565->665 1iwgA3 d.58.44.1 * 4.1e-16 24.8 %
:HMM:SCOP  716->803 1iwgA6 d.225.1.1 * 2.2e-15 29.5 %
:HMM:SCOP  798->1024 1iwgA8 f.35.1.1 * 6.1e-45 32.6 %
:RPS:PFM   13->1021 PF00873 * ACR_tran e-177 37.7 %
:HMM:PFM   13->1022 PF00873 * ACR_tran 0 40.6 1009/1021  
:BLT:SWISS 1->1040 MDTB_SALHS 0.0 100.0 %
:TM
:SEG

SeqInfo AminoSeq See neighboring genes
Links DAD Abbreviations Back to title page
GT:ID ACF65976.1 GT:GENE mdtB GT:PRODUCT multidrug resistance protein MdtB GT:DATABASE GIB00763CH01 GT:ORG sent8 GB:ACCESSION GIB00763CH01 GB:LOCATION 2263114..2266236 GB:FROM 2263114 GB:TO 2266236 GB:DIRECTION + GB:GENE mdtB GB:PRODUCT multidrug resistance protein MdtB GB:NOTE identified by match to protein family HMM PF00873 GB:PROTEIN_ID ACF65976.1 GB:DB_XREF GI:194405757 GB:GENE:GENE mdtB LENGTH 1040 SQ:AASEQ MQVLPPGSTGGPSRLFILRPVATTLLMAAILLAGIIGYRFLPVAALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQSSGGASVVTLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPIYSKVNPADPPIMTLAVTSNAMPMTQVEDMVETRVAQKISQVSGVGLVTLAGGQRPAVRVKLNAQAVAALGLTSETVRTAITGANVNSAKGSLDGPERAVTLSANDQMQSADEYRRLIIAYQNGAPVRLGDVATVEQGAENSWLGAWANQAPAIVMNVQRQPGANIIATADSIRQMLPQLTESLPKSVKVTVLSDRTTNIRASVRDTQFELMLAIALVVMIIYLFLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVTLAVAILISAVVSLTLTPMMCARMLSQQSLRKQNRFSRACERMFDRVIASYGRGLAKVLNHPWLTLSVAFATLLLSVMLWIVIPKGFFPVQDNGIIQGTLQAPQSSSYASMAQRQRQVAERILQDPAVQSLTTFVGVDGANPTLNSARLQINLKPLDARDDRVQQVISRLQTAVATIPGVALYLQPTQDLTIDTQVSRTQYQFTLQATTLDALSHWVPKLQNALQSLPQLSEVSSDWQDRGLAAWVNVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTASTPGLAALETIRLTSRDGGTVPLSAIARIEQRFAPLSINHLDQFPVTTFSFNVPEGYSLGDAVQAILDTEKTLALPADITTQFQGSTLAFQAALGSTVWLIVAAVVAMYIVLGVLYESFIHPITILSTLPTAGVGALLALIIAGSELDIIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPRDAIFQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIAMVGGLLVSQVLTLFTTPVIYLLFDRLSLYVKSRFPRHKEEA GT:EXON 1|1-1040:0| SW:ID MDTB_SALHS SW:DE RecName: Full=Multidrug resistance protein mdtB;AltName: Full=Multidrug transporter mdtB; SW:GN Name=mdtB; OrderedLocusNames=SeHA_C2357; SW:KW Cell inner membrane; Cell membrane; Complete proteome; Membrane;Transmembrane; Transport. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->1040|MDTB_SALHS|0.0|100.0|1040/1040| GO:SWS:NREP 5 GO:SWS GO:0005886|"GO:plasma membrane"|Cell inner membrane| GO:SWS GO:0005886|"GO:plasma membrane"|Cell membrane| GO:SWS GO:0016020|"GO:membrane"|Membrane| GO:SWS GO:0016021|"GO:integral to membrane"|Transmembrane| GO:SWS GO:0006810|"GO:transport"|Transport| TM:NTM 11 TM:REGION 21->43| TM:REGION 344->366| TM:REGION 371->393| TM:REGION 399->421| TM:REGION 441->463| TM:REGION 471->493| TM:REGION 539->561| TM:REGION 860->882| TM:REGION 900->922| TM:REGION 960->982| TM:REGION 1002->1024| SEG 22->37|attllmaaillagiig| SEG 901->913|agvgallaliiag| SEG 918->930|iiaiigiilligi| SEG 969->987|lmttlaallgalplmlstg| BL:PDB:NREP 1 BL:PDB:REP 13->1025|2v50B|2e-95|26.7|1005/1030| RP:PDB:NREP 1 RP:PDB:REP 13->1040|3d9bA|0.0|22.7|1016/1045| RP:PFM:NREP 1 RP:PFM:REP 13->1021|PF00873|e-177|37.7|1004/1014|ACR_tran| HM:PFM:NREP 1 HM:PFM:REP 13->1022|PF00873|0|40.6|1009/1021|ACR_tran| GO:PFM:NREP 3 GO:PFM GO:0005215|"GO:transporter activity"|PF00873|IPR001036| GO:PFM GO:0006810|"GO:transport"|PF00873|IPR001036| GO:PFM GO:0016020|"GO:membrane"|PF00873|IPR001036| RP:SCP:NREP 6 RP:SCP:REP 71->225|1mwkA2|5e-29|17.2|145/163|c.55.1.1| RP:SCP:REP 232->333|1iwgA2|3e-22|23.5|102/104|d.58.44.1| RP:SCP:REP 324->499|1iwgA7|3e-39|40.3|176/199|f.35.1.1| RP:SCP:REP 565->664|1iwgA3|3e-20|18.0|100/107|d.58.44.1| RP:SCP:REP 720->800|1iwgA6|2e-16|19.8|81/88|d.225.1.1| RP:SCP:REP 860->1024|1iwgA7|1e-13|11.5|165/199|f.35.1.1| HM:SCP:REP 49->145|1iwgA1|2.9e-24|40.6|96/0|d.58.44.1|1/1|Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains| HM:SCP:REP 144->333|1iwgA2|7.2e-24|34.3|105/0|d.58.44.1|1/1|Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains| HM:SCP:REP 299->500|1iwgA7|7.5e-44|36.2|199/200|f.35.1.1|1/2|Multidrug efflux transporter AcrB transmembrane domain| HM:SCP:REP 565->665|1iwgA3|4.1e-16|24.8|101/0|d.58.44.1|1/1|Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains| HM:SCP:REP 716->803|1iwgA6|2.2e-15|29.5|88/88|d.225.1.1|2/2|Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains| HM:SCP:REP 798->1024|1iwgA8|6.1e-45|32.6|218/223|f.35.1.1|2/2|Multidrug efflux transporter AcrB transmembrane domain| OP:NHOMO 4496 OP:NHOMOORG 673 OP:PATTERN -------------------------------------------------------------------- D9K-------------------------------------------11-1--111-11--11--1--1111------------44366GHHD-I24---23F4B8LBJ8C--------------342344533465111111--1-68556551122222534362E46A4-2-----2-----2111--11212222222222222221111212212112122------6311111111111111111111-----------------------------------------------------------------------6116-------1-1-1221--------1-13122522213-1-----31E3CG77C11111BEOIQI9HLIJGD46574664547-MPGFOKML5A9-GAACBBDBBA8ABL7AA6395655434777777778CB866B61111111111--11221541115511-1113389367559DHIGIBA7776CCGGAAAA7BDBHCGGM-5GHF7CA9BNFA7A7AGG9GAC8A111111196B6BF75A2467648A5531694779B77AB9AE92A72111222222333333333753598B875IE9JCDB6DEFFEHFJLFFHHDIQKMG--1C85B------76676B67899788A77-6887789768797777777CDC773456545666666546455A64564761-877777765777--17343335989H9C661111121111111117779759222A8DEEECCEFCDFEB99BC111111111B5AAB666669CDBBGHDAEAA79954542297BB46BB11111111-----------------------------1---111118C6 -------------1------------------------------------------------------------------------------------------------------------------------------------------------6----7-2-------4-----------1--9-----7---- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 1022 STR:RPRED 98.3 SQ:SECSTR ############HHHHcccHHHHHHHHHHHHHHHHHHHHHcccccccccccccEEEEcccTTccHHHHHTTTHHHHHccccccTTEEEcccEETTTEEEcccEEcTTccHHHHHHHHHHHHHTTGGGccHHHHHHccEEEccccccEEEEEEEccccccHHHHHHHHHHHTHHHHHHcTTcccEEEEcccEcEEEEEEcHHHHHHTTccHHHHHHHHHHHcccccccEETcccccEEcccccccccHHHHHTcEEEcTTccEEEGGGGEEEEEEEcccccEEEETTEEEEEEEEccccccccTHHHHHHHHHHHTTTTcccTTEEEEEEEETTHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccTTTTHHHHHHHHHHHHHHHHHHHTTTccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccHHHHHHHHHHHHHHHHHHHHHHHHHHHGGGGcccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccTTccccccccccHHHHHHHHHHHHHHHHHHHHHHHHHTTTHHHHHHHHHHHHHHHHHHHccccccccccccEEEEEEEccccccHHHHHHHHHHHHHHHHcTTTEEEEEEEETcccccccTTEEEEEEEEccGGGcccGHHHHHHHHHHHHTTcTTcEEEEEcccccTTccccccEEEEEEEccccTHHHHHHHHHHHHHHTcTTccEEEEEcccccccEEEEEEcHHHHHHHTccHHHHHHHHHHHHHcEEcccEEccccEEEEEEEEcGGGcccGGGGGGcEEEcccccEEEHHHHEEEEEEccccEEEEETTEEEEEEEEEccTTccHHHHHHHHHHHTTTHTccTTEEEEEcTHHHHcccTTTcHHHHHHHHHHHHHHHHHHHHTcccHHHHHHTTHHHHHHHHHHHHHTTcccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTcccHHHHHHHHHHHHHHHHHHHHHHHHHHHTTTTTcccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHc######Hcccccccc DISOP:02AL 1-8,861-861,1029-1041| PSIPRED ccccccccccHHHHHHHHcHHHHHHHHHHHHHHHHHHHHcccHHHcccccccEEEEEEEEccccHHHHHHHHHHHHHHHHHccccEEEEEEEEEccEEEEEEEEEccccHHHHHHHHHHHHHHHHcccccccccccEEEEEccccEEEEEEEEccccccHHHHHHHHHHHHHHHHHccccEEEEEEEccccEEEEEEEcHHHHHHccccHHHHHHHHHHcccccccEEEEcccEEEEEEEccccccHHHHHcccEEEcccEEEEEEEcEEEEEccccccEEEEEccEEEEEEEEEEcccccHHHHHHHHHHHHHHHHHHcccccEEEEEccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccHHHHHHHHHHHHHHHHHHHHHHHHcccHHHHHHHHHHHHHHHHHccHHHHHHHHHHHHHccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccHHHHHHHHHHHHHHHHHHHccccccccccccEEEEEEEccccccHHHHHHHHHHHHHHHHcccccEEEEEEEccccccccccEEEEEEEEEcHHHccccHHHHHHHHHHHHHccccEEEEEEccccccccccccccEEEEEEccccHHHHHHHHHHHHHHHHccccEEEEEccccccccEEEEEEcHHHHHHccccHHHHHHHHHHHHcccEEEEEEEccEEEEEEEEEcHHHHccHHHHHccEEEcccccEEEEEEEEEEEEEccccEEEccccEEEEEEEEEEcccccHHHHHHHHHHHHHHccccccEEEEEcccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccHHHHHHHHHHHHHHHHHHHHHHHccccccHHHHHHHHHHHHHHHccHHHHHHHHHHHHHHccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcc //