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Salmonella enterica subsp. enterica serovar Heidelberg str. SL476 (sent8)
Gene : mdtC
DDBJ      :mdtC         multidrug resistance protein MdtC
Swiss-Prot:MDTC_SALHS   RecName: Full=Multidrug resistance protein mdtC;AltName: Full=Multidrug transporter mdtC;

Homologs  Archaea  0/68 : Bacteria  661/915 : Eukaryota  8/199 : Viruses  0/175   --->[See Alignment]
b.163.1d.225.1d.58.44f.35.1
:1026 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   7->991 2v50B PDBj 1e-84 27.4 %
:RPS:PDB   34->984 3d9bA PDBj e-168 19.8 %
:RPS:SCOP  40->135 1iwgA1  d.58.44.1 * 9e-24 29.5 %
:RPS:SCOP  133->245 1zruA3  b.163.1.2 * 3e-14 8.3 %
:RPS:SCOP  226->324 1iwgA2  d.58.44.1 * 5e-19 21.2 %
:RPS:SCOP  313->491 1iwgA7  f.35.1.1 * 3e-28 31.3 %
:RPS:SCOP  555->650 1iwgA3  d.58.44.1 * 7e-21 20.8 %
:RPS:SCOP  703->786 1iwgA6  d.225.1.1 * 6e-17 20.2 %
:RPS:SCOP  846->993 1iwgA7  f.35.1.1 * 5e-21 16.2 %
:HMM:SCOP  40->136 1iwgA1 d.58.44.1 * 5.8e-24 36.5 %
:HMM:SCOP  135->324 1iwgA2 d.58.44.1 * 8.6e-24 31.4 %
:HMM:SCOP  290->491 1iwgA7 f.35.1.1 * 1.5e-47 38.2 %
:HMM:SCOP  555->651 1iwgA3 d.58.44.1 * 2.5e-18 36.1 %
:HMM:SCOP  702->789 1iwgA6 d.225.1.1 * 1.6e-14 26.1 %
:HMM:SCOP  811->1010 1iwgA7 f.35.1.1 * 2.4e-43 31.2 %
:RPS:PFM   7->993 PF00873 * ACR_tran e-172 36.8 %
:HMM:PFM   4->1008 PF00873 * ACR_tran 0 39.0 1004/1021  
:BLT:SWISS 1->1026 MDTC_SALHS 0.0 100.0 %
:TM
:SEG

SeqInfo AminoSeq See neighboring genes
Links DAD Abbreviations Back to title page
GT:ID ACF66623.1 GT:GENE mdtC GT:PRODUCT multidrug resistance protein MdtC GT:DATABASE GIB00763CH01 GT:ORG sent8 GB:ACCESSION GIB00763CH01 GB:LOCATION 2266237..2269317 GB:FROM 2266237 GB:TO 2269317 GB:DIRECTION + GB:GENE mdtC GB:PRODUCT multidrug resistance protein MdtC GB:NOTE identified by match to protein family HMM PF00873 GB:PROTEIN_ID ACF66623.1 GB:DB_XREF GI:194406404 GB:GENE:GENE mdtC LENGTH 1026 SQ:AASEQ MRFFALFIYRPVATILIAAAITLCGILGFRLLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVNEMTSSSSLGSTRIILEFNFDRDINGAARDVQAAINAAQSLLPGGMPSRPTYRRANPSDAPIMILTLTSESWSQGKLYDFASTQLAQTIAQIDGVGDVDVGGSSLPAVRVGLNPQALFNQGVSLDEVREAIDSANVRRPQGAIEDSVHRWQIQTNDELKTAAEYQPLIIHYNNGAAVRLGDVASVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDGIRAKLPELRAMIPAAIDLQIAQDRSPTIRASLQEVEETLAISVALVILVVFLFLRSGRATLIPAVAVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVVDDAIVVLENIARHLEAGMKPLQAALQGTREVGFTVISMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISLVVSLTLTPMMCGWMLKSSKPRTQLRKRGVGRLLVALQQGYGTSLKWVLNHTRLVGVVFLGTVALNIWLYIAIPKTFFPEQDTGVLMGGIQADQSISFQAMRGKLQDFMKIIRDDPAVNNVTGFTGGSRVNSGMMFITLKPRGERKETAQQVIDRLRVKLAKEPGARLFLMAVQDIRVGGRQANASYQYTLLSDSLAALREWEPKIRKALSALPQLADVNSDQQDNGAEMNLIYDRDTMSRLGIDVQAANSLLNNAFGQRQISTIYQPMNQYKVVMEVDPRYTQDISALEKMFVINRDGKAIPLSYFAQWRPANAPLSVNHQGLSAASTIAFNLPTGTSLSQATEAINRTMTQLGVPPTVRGSFSGTAQVFQQTMNSQLILIVAAIATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRSGGLTPEQAIFQACLLRFRPIMMTTLAALFGALPLVLSDGDGSELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRLRLRFSRKNSKPVVEI GT:EXON 1|1-1026:0| SW:ID MDTC_SALHS SW:DE RecName: Full=Multidrug resistance protein mdtC;AltName: Full=Multidrug transporter mdtC; SW:GN Name=mdtC; OrderedLocusNames=SeHA_C2358; SW:KW Cell inner membrane; Cell membrane; Complete proteome; Membrane;Transmembrane; Transport. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->1026|MDTC_SALHS|0.0|100.0|1026/1026| GO:SWS:NREP 5 GO:SWS GO:0005886|"GO:plasma membrane"|Cell inner membrane| GO:SWS GO:0005886|"GO:plasma membrane"|Cell membrane| GO:SWS GO:0016020|"GO:membrane"|Membrane| GO:SWS GO:0016021|"GO:integral to membrane"|Transmembrane| GO:SWS GO:0006810|"GO:transport"|Transport| TM:NTM 10 TM:REGION 8->30| TM:REGION 33->55| TM:REGION 330->352| TM:REGION 358->380| TM:REGION 432->454| TM:REGION 465->487| TM:REGION 529->551| TM:REGION 850->872| TM:REGION 886->908| TM:REGION 985->1007| SEG 13->28|atiliaaaitlcgilg| SEG 170->179|dgvgdvdvgg| SEG 338->353|laisvalvilvvflfl| SEG 439->461|slslvavflplllmgglpgrllr| SEG 904->916|lialigimlligi| SEG 995->1015|lltlyttpvvylffdrlrlrf| BL:PDB:NREP 1 BL:PDB:REP 7->991|2v50B|1e-84|27.4|975/1030| RP:PDB:NREP 1 RP:PDB:REP 34->984|3d9bA|e-168|19.8|948/1045| RP:PFM:NREP 1 RP:PFM:REP 7->993|PF00873|e-172|36.8|985/1014|ACR_tran| HM:PFM:NREP 1 HM:PFM:REP 4->1008|PF00873|0|39.0|1004/1021|ACR_tran| GO:PFM:NREP 3 GO:PFM GO:0005215|"GO:transporter activity"|PF00873|IPR001036| GO:PFM GO:0006810|"GO:transport"|PF00873|IPR001036| GO:PFM GO:0016020|"GO:membrane"|PF00873|IPR001036| RP:SCP:NREP 7 RP:SCP:REP 40->135|1iwgA1|9e-24|29.5|95/97|d.58.44.1| RP:SCP:REP 133->245|1zruA3|3e-14|8.3|108/129|b.163.1.2| RP:SCP:REP 226->324|1iwgA2|5e-19|21.2|99/104|d.58.44.1| RP:SCP:REP 313->491|1iwgA7|3e-28|31.3|179/199|f.35.1.1| RP:SCP:REP 555->650|1iwgA3|7e-21|20.8|96/107|d.58.44.1| RP:SCP:REP 703->786|1iwgA6|6e-17|20.2|84/88|d.225.1.1| RP:SCP:REP 846->993|1iwgA7|5e-21|16.2|148/199|f.35.1.1| HM:SCP:REP 40->136|1iwgA1|5.8e-24|36.5|96/0|d.58.44.1|1/1|Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains| HM:SCP:REP 135->324|1iwgA2|8.6e-24|31.4|105/0|d.58.44.1|2/2|Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains| HM:SCP:REP 290->491|1iwgA7|1.5e-47|38.2|199/200|f.35.1.1|1/2|Multidrug efflux transporter AcrB transmembrane domain| HM:SCP:REP 555->651|1iwgA3|2.5e-18|36.1|97/0|d.58.44.1|1/1|Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains| HM:SCP:REP 702->789|1iwgA6|1.6e-14|26.1|88/88|d.225.1.1|2/2|Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains| HM:SCP:REP 811->1010|1iwgA7|2.4e-43|31.2|199/200|f.35.1.1|2/2|Multidrug efflux transporter AcrB transmembrane domain| OP:NHOMO 4389 OP:NHOMOORG 669 OP:PATTERN -------------------------------------------------------------------- D9K-------------------------------------------11-1--111-11--11-----1111------------44366FGGD-H23---23F4B7LBJ8C--------------342344533464111111--1-58555451122222534362E46A3-2-----2-----2111--11212222222222222221111212212112121------6311111111111111111111-----------------------------------------------------------------------6116-------1-1-1221--------1-13122522213-1-----31E3BF66B11111AEOKPI9FLIHFC46574664547-MPGFOKLL5A9-FAACBBBBBA89BK7A87495655424777777777CB866A61111111111--1-221641115411-111338936755BCHIGIAA7776BBFEAAAA7BDAGCGGM-5GHE7CA9BMD9797AGG9F9C89111111196A5BF75A246764895531694779B779B8AE92962111222222333333333553478B875H98IBCB6CEFFEFEJLFFHHDGOKJG--1C85B------76667B67999788A77-6887789768797777777BCB763456545666666546455A64564761-877777765777--17343335989G9C651111121111111117778759222A8DEEEBCDFBCFDB89BB111111111A5AAB666669CCCBFHC9D998AA44342297BB46BB11111111-----------------------------1----111-8B6 -------------1------------------------------------------------------------------------------------------------------------------------------------------------5----7-2-------5-----------1--9-----7---- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 983 STR:RPRED 95.8 SQ:SECSTR ######HHTcHHHHHHHHHHHHHHHHHHHHHcccccccccccccEEEEcccTTccHHHHHTTTHHHHHccccccTTEEEcccEETTTEEEcccEEcTTccHHHHHHHHHHHHHTTGGGccHHHHHHcEEEEccccccEEEEEEEccccccHHHHHHHHHHHTHHHHHHcTTcccEEEEccccEEEEEEEcHHHHHHTTccHHHHHHHHHHHcccccccEETcccccEEcccccccccHHHHHTcEEEEcTccEEEGGGGEEEEEEEcccccEEEETTEEEEEEEEccccccccTHHHHHHHHHHHTTTTcccTTEEEEEEEETTHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccTTTTHHHHHHHHHHHHHHHHHHHTTTccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccHHHHHHHHHHHHHHHHHHHHHHHHHHHGGGGcccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccccTTcccccccHHHHHHHHHHHHHHHHHHHHHTTTHHHHHHHHHHHHHHHHHHHccccccccccccEEEEEEEccccccHHHHHHHHHHHHHHHHcTTTEEEEEEEETcccTTEEEEEEEEccGGGccGcHHHHHHHHHHHHTTcTTcEEEEEcccccTTccccccEEEEEEEcccTTHHHHHHHHHHHHHHTTcTccEEEEEcccccccEEEEEEcHHHHHHHTccHHHHHHHHHHHHHcEEcccEEccccEEEEEEEEcGGGcccGGGGGGcEEEcccccEEEHHHHEEEEEEccccEEEEETTEEEEEEEEEccTTccHHHHHHHHHHHTTTc##cTTEEEEEcTHHHHcccTTTcHHHHHHHHHHHHHHHHHHHHTcccHHHHHHTTHHHHHHHHHHHHHTTcccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTcccHHHHHHHHHHHHHHHHHHHHHHHHHHHTTTTTcccccHHHHHHHHHHHHHHHH################################### DISOP:02AL 648-655,1014-1027| PSIPRED ccHHHHHHHcHHHHHHHHHHHHHHHHHHHHcccHHHcccccccEEEEEEEEccccHHHHHHHHHHHHHHHHHccccEEEEEEEEEccEEEEEEEEEccccHHHHHHHHHHHHHHHHHHcccccccccEEEEEccccEEEEEEEEEcccccHHHHHHHHHHHHHHHHHcccccEEEEEEccccEEEEEEEcHHHHHHccccHHHHHHHHHHcccccccEEEEcccEEEEEEEcHHcccHHHHHcccEEcccccEEEEEEEEEEEEccccHHHEEEEccEEEEEEEEEEcccccHHHHHHHHHHHHHHHHHHcccccEEEEEEcccHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccHHHHHHHHHHHHHHHHHHHHHHHccccHHHHHHHHHHHHHHHHHccHHHHHHHHHHHHHccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccccccccHHHHHHHHHHHHHHHHHHHHHHHHHccHHHHHHHHHHHHHHHHHHHHccccccccccccEEEEEEEccccccHHHHHHHHHHHHHHHHcccccEEEEEEEccccccEEEEEEEEEEHHHccccHHHHHHHHHHHHHcccccEEEEEEccccccccccccccEEEEEEcccHHHHHHHHHHHHHHHHccccEEEcccccccccEEEEEEEcHHHHHHccccHHHHHHHHHHHHcccEEEEEEEccEEEEEEEEEcHHHHccHHHHHccEEEcccccEEEEEEEEEEEEEcccccEEEEccEEEEEEEEEEcccccHHHHHHHHHHHHHHccccccEEEEEcccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccHHHHHHHHHHHHHHHHHHHHHHHccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccccccccccc //