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Salmonella enterica subsp. enterica serovar Heidelberg str. SL476 (sent8)
Gene : menD
DDBJ      :menD         2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylic acid synthase/2-oxoglutarate decarboxylase
Swiss-Prot:MEND_SALHS   RecName: Full=2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase;         Short=SEPHCHC synthase;         EC=2.2.1.9;AltName: Full=Menaquinone biosynthesis protein menD;

Homologs  Archaea  8/68 : Bacteria  347/915 : Eukaryota  16/199 : Viruses  0/175   --->[See Alignment]
c.31.1c.36.1
:556 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   1->556 2jlcB PDBj 0.0 90.6 %
:RPS:PDB   10->537 1bfdA PDBj 1e-56 17.6 %
:RPS:SCOP  10->170 1bfdA2  c.36.1.5 * 4e-24 20.9 %
:RPS:SCOP  223->354 1upaA1  c.31.1.3 * 9e-05 12.9 %
:RPS:SCOP  371->549 1ozfA3  c.36.1.9 * 1e-18 16.9 %
:HMM:SCOP  7->175 1ybhA2 c.36.1.5 * 9.3e-30 26.4 %
:HMM:SCOP  357->553 1n0hA3 c.36.1.9 * 4.1e-31 21.8 %
:RPS:PFM   11->169 PF02776 * TPP_enzyme_N 3e-22 40.5 %
:RPS:PFM   434->534 PF02775 * TPP_enzyme_C 5e-04 27.7 %
:HMM:PFM   9->128 PF02776 * TPP_enzyme_N 1.5e-24 30.0 120/172  
:HMM:PFM   415->534 PF02775 * TPP_enzyme_C 3.3e-10 27.5 120/150  
:BLT:SWISS 1->556 MEND_SALHS 0.0 100.0 %

SeqInfo AminoSeq See neighboring genes
Links DAD Abbreviations Back to title page
GT:ID ACF68842.1 GT:GENE menD GT:PRODUCT 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylic acid synthase/2-oxoglutarate decarboxylase GT:DATABASE GIB00763CH01 GT:ORG sent8 GB:ACCESSION GIB00763CH01 GB:LOCATION complement(2463188..2464858) GB:FROM 2463188 GB:TO 2464858 GB:DIRECTION - GB:GENE menD GB:PRODUCT 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylic acid synthase/2-oxoglutarate decarboxylase GB:NOTE identified by match to protein family HMM TIGR00173 GB:PROTEIN_ID ACF68842.1 GB:DB_XREF GI:194408623 GB:GENE:GENE menD LENGTH 556 SQ:AASEQ MSVSAFNRRWAAVILEALTRHGVRHVCIAPGSRSTPLTLAAAENPAFIHHTHFDERGLGHLALGLAKVSQQPVAVIVTSGTAVANLYPALIEAGLTGEKLILLTADRPPELIDCGANQAIRQAGMFASHPSQTLSLPRPTQDIPARWLVSTIDNALAMLHAGALHINCPFAEPLYGDMNDTGLVWQQRLGDWWQDEKPWLREARRLASDKQRDWFFWRQKRGVVVAGRMSAEEGKKVAQWAQTLGWPLIGDVLSQTGQPLPCADLWLGNAKAVTELQQAQIVVQLGSSLTGKRLLQWQATCEPEEYWVIDNIEGRLDPAHHRGRRLVAKIADWLELHPAEKRKPWCVEIPRLAELAWQRVVAQRDTFGEAQLAHRIRDYLPEQGQLFVGNSLVVRLIDALSQLPAGYPVYSNRGASGIDGLLSTAAGVQRASAKSTLAIVGDLSALYDLNALALLRQVSAPFVLIVVNNNGGQIFSLLPTPQSKRERFYLMPQNVHFDHAAAMFNLRYHRPENWEELESALAGAWRTPAATVIELVVNDTDGAQTLQQLLAQVSHL GT:EXON 1|1-556:0| SW:ID MEND_SALHS SW:DE RecName: Full=2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; Short=SEPHCHC synthase; EC=2.2.1.9;AltName: Full=Menaquinone biosynthesis protein menD; SW:GN Name=menD; OrderedLocusNames=SeHA_C2549; SW:KW Complete proteome; Magnesium; Manganese; Menaquinone biosynthesis;Metal-binding; Thiamine pyrophosphate; Transferase. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->556|MEND_SALHS|0.0|100.0|556/556| GO:SWS:NREP 3 GO:SWS GO:0009234|"GO:menaquinone biosynthetic process"|Menaquinone biosynthesis| GO:SWS GO:0046872|"GO:metal ion binding"|Metal-binding| GO:SWS GO:0016740|"GO:transferase activity"|Transferase| BL:PDB:NREP 1 BL:PDB:REP 1->556|2jlcB|0.0|90.6|556/556| RP:PDB:NREP 1 RP:PDB:REP 10->537|1bfdA|1e-56|17.6|505/523| RP:PFM:NREP 2 RP:PFM:REP 11->169|PF02776|3e-22|40.5|153/170|TPP_enzyme_N| RP:PFM:REP 434->534|PF02775|5e-04|27.7|101/139|TPP_enzyme_C| HM:PFM:NREP 2 HM:PFM:REP 9->128|PF02776|1.5e-24|30.0|120/172|TPP_enzyme_N| HM:PFM:REP 415->534|PF02775|3.3e-10|27.5|120/150|TPP_enzyme_C| GO:PFM:NREP 3 GO:PFM GO:0030976|"GO:thiamin pyrophosphate binding"|PF02776|IPR012001| GO:PFM GO:0003824|"GO:catalytic activity"|PF02775|IPR011766| GO:PFM GO:0030976|"GO:thiamin pyrophosphate binding"|PF02775|IPR011766| RP:SCP:NREP 3 RP:SCP:REP 10->170|1bfdA2|4e-24|20.9|153/180|c.36.1.5| RP:SCP:REP 223->354|1upaA1|9e-05|12.9|132/177|c.31.1.3| RP:SCP:REP 371->549|1ozfA3|1e-18|16.9|178/188|c.36.1.9| HM:SCP:REP 7->175|1ybhA2|9.3e-30|26.4|163/0|c.36.1.5|1/2|Thiamin diphosphate-binding fold (THDP-binding)| HM:SCP:REP 357->553|1n0hA3|4.1e-31|21.8|197/227|c.36.1.9|1/1|Thiamin diphosphate-binding fold (THDP-binding)| OP:NHOMO 373 OP:NHOMOORG 371 OP:PATTERN ------------------------11111111------------------------------------ ---1-11111111111111-11111111111111111111----1111111111111111--11111---1------1-11-1-----1111-11----111111-111---------------11111111111111111----111111111111111111111-1111111111111111--------111111111111111111--11111111111111111111--111111111111111111111-------------------11-111-----------------------------------------------------------------------------11------------------------------11111111-1---------------------------------------------------------------------------------------------------------------------------------------------------------1------------------111--1-11--------------------111----------------------------111-------111111-1111111111111-----1-------111111-1111111111-111111111111111111111111111111111111111111111111111--111111111111------------------111111111111111---------------------------------------11111111111111-----------------------------------------------------------------------1- -----------------------------------------------------------------------------------------1-------------------------------------------------------------------------------------11-13-11111111-11------1 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 556 STR:RPRED 100.0 SQ:SECSTR ccHHHHHHHHHHHHHHHHHHTTccEEEEcccGGGHHHHTTccTTcEEEEcccccHHHHHHHHHHHHHHHTccEEEEEEHHHHHHHTHHHHHHHHHHTccEEEEEEEccHHHHTTTcTccTTGGGTTTTcccEEEccccGcGGHHHTEEEEHHHHHHHHHccccEEEEEEGGccccEHHHHcEEGTTccccGGGGGGTTccccccccccHHHHHHHHHHccccEEEEcHHHHTcHHHHHHHHHHHTccccccccccTTcTTEEEEccccHHHHHHHHTTccEEEEEcccTTccccccccccccTTcEEEEEEccHHHHHHccccEEEEccHHHHHHHHHHHHHccccccccccccccccccccccccccHHHHHHHHHHHccTTcEEEEEcGGGHHHHHHHHcccccTTcEEEcTTcccccHHHHHHHHHHHcTccEEEEEEHHHHTTTGGGHHHHHHHTcccEEEEEEccccHHHHHHHHHTTcccccccccccccHHHHHHHTTcEEEEEccHHHHHHHHHHHHHccccEEEEEEccTTcccccccGGGHHHTTc DISOP:02AL 1-3| PSIPRED cccccccccHHHHHHHHHHHccccEEEEcccccHHHHHHHHHHccccEEEEcccHHHHHHHHHHHHHHcccEEEEEEcccHHHHHHHHHHHHHHHHcccEEEEEccccHHHccccccccccHHHHHHHccEEEEEEccHHHHccHHHHHHHHHHHHHHccccEEEEEccccccccccccccccccccccccccccccccccccccHHHHHHHHHHHHHccccEEEEEcccHHHHHHHHHHHHHHcccEEEEccccccccccccccccccHHHHHHHHHccEEEEEccccccccHHHccccccccEEEEEcccHHHccccccccHHHHccHHHHHHHHHccccHHHHHHHHHHHHHHHHHHHHccccccHHHHHHHHHHHcccccEEEEcccEEEHHHHHHHHcccccEEEcccccccccHHHHHHHHHHHcccccEEEEEccHHHHccHHHHHHHHHccccEEEEEEEccccHHHHHHHHHcccccccccccccccHHHHHHHccccEEEEccHHHHHHHHHHHHHccccEEEEEEccHHHHHHHHHHHHHHHHcc //