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Salmonella enterica subsp. enterica serovar Heidelberg str. SL476 (sent8)
Gene : mfd
DDBJ      :mfd          transcription-repair coupling factor
Swiss-Prot:MFD_ECOLI    RecName: Full=Transcription-repair-coupling factor;         Short=TRCF;         EC=3.6.1.-;AltName: Full=ATP-dependent helicase mfd;

Homologs  Archaea  6/68 : Bacteria  880/915 : Eukaryota  22/199 : Viruses  0/175   --->[See Alignment]
b.34.18c.37.1d.315.1
:1148 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   2->1147 2eyqA PDBj 0.0 95.4 %
:RPS:PDB   26->332 2b2nB PDBj 7e-39 90.2 %
:RPS:PDB   547->953 3bxzB PDBj 7e-59 14.5 %
:RPS:PDB   1034->1146 1b24A PDBj 7e-04 18.8 %
:RPS:SCOP  26->332 2b2nA1  c.37.1.19 * e-112 90.2 %
:RPS:SCOP  349->465 2eyqA2  c.37.1.19 * 1e-21 89.7 %
:RPS:SCOP  466->545 2eyqA1  b.34.18.1 * 7e-34 96.2 %
:RPS:SCOP  546->778 2eyqA3  c.37.1.19 * e-101 97.4 %
:RPS:SCOP  779->989 2eyqA5  c.37.1.19 * 8e-94 99.5 %
:RPS:SCOP  990->1147 2eyqA6  d.315.1.1 * 1e-47 94.9 %
:HMM:SCOP  2->348 2eyqA4 c.37.1.19 * 4.8e-101 37.2 %
:HMM:SCOP  349->465 2eyqA2 c.37.1.19 * 1.7e-28 42.7 %
:HMM:SCOP  466->545 2eyqA1 b.34.18.1 * 5.4e-25 53.8 %
:HMM:SCOP  545->838 1z3iX2 c.37.1.19 * 4.5e-74 30.8 %
:HMM:SCOP  779->989 2eyqA5 c.37.1.19 * 3.3e-57 37.9 %
:HMM:SCOP  990->1147 2eyqA6 d.315.1.1 * 1.4e-47 41.8 %
:RPS:PFM   480->572 PF02559 * CarD_TRCF 2e-23 54.8 %
:RPS:PFM   602->765 PF00270 * DEAD 4e-10 33.3 %
:RPS:PFM   837->906 PF00271 * Helicase_C 3e-05 33.3 %
:RPS:PFM   1005->1105 PF03461 * TRCF 2e-24 54.5 %
:HMM:PFM   1005->1101 PF03461 * TRCF 1.4e-31 46.4 97/101  
:HMM:PFM   476->573 PF02559 * CarD_TRCF 1.1e-30 53.1 98/98  
:HMM:PFM   602->762 PF00270 * DEAD 1.3e-25 26.8 149/167  
:HMM:PFM   836->906 PF00271 * Helicase_C 1.3e-17 32.9 70/78  
:BLT:SWISS 1->1148 MFD_ECOLI 0.0 95.4 %
:SEG

SeqInfo AminoSeq See neighboring genes
Links DAD Abbreviations Back to title page
GT:ID ACF68479.1 GT:GENE mfd GT:PRODUCT transcription-repair coupling factor GT:DATABASE GIB00763CH01 GT:ORG sent8 GB:ACCESSION GIB00763CH01 GB:LOCATION complement(1303235..1306681) GB:FROM 1303235 GB:TO 1306681 GB:DIRECTION - GB:GENE mfd GB:PRODUCT transcription-repair coupling factor GB:NOTE identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF02559; match to protein family HMM PF03461; match to protein family HMM PF04851; match to protein family HMM TIGR00580 GB:PROTEIN_ID ACF68479.1 GB:DB_XREF GI:194408260 GB:GENE:GENE mfd LENGTH 1148 SQ:AASEQ MPEKQRYTLPTKAGDQRQLGELTGAACATLVAEIAERHAGPVVLIAPDMQNALRLHDEIRQFTDQMVMNLADWETLPYDSFSPHQEIISSRLSTLYQLPSMQRGVLIVPVNTLMQRVCPHSYLHGHALVMKKGQRLSRDALRAQLDSAGYRHVDQVMEHGEYATRGALLDLFPMGSEQPYRLDFFDDEIDSLRLFDADTQRTLEEVEAINLLPAHEFPTDKAAIELFRSQWRDTFEVKRDAEHIYQQVSKGTLPAGIEYWQPLFFSEPLPPLFSYFPANTLVVNTGSLETSAERFQADTLARFENRGVDPMRPLLPPEALWLRVDELFSELKRWPRLQLKTDHLPEKAANTNLGFQKLPDLAIQAQQKAPLDALRKFLESFSGPVIFSVESEGRREALGELLARIKIAPKRILRLDEAQDAGRYLMIGAAEHGFIDTQRNLALICESDLLGERVARRRLDSRRTINPDTLIRNLAELHVGQPVVHLEHGVGRYAGMTTLEAGGIKGEYLMLTYANDAKLYVPVSSLHLISRYAGGAEESAPLHKLGGDAWSRARQKAAEKVRDVAAELLDIYAQRAAKEGFAFKHDREQYQLFCDSFPFETTPDQAQAINAVLSDMCQPLAMDRLVCGDVGFGKTEVAMRAAFLAVENHKQVAVLVPTTLLAQQHYDNFRDRFANWPVRIEMLSRFRSAKEQTQILAEAAEGKIDILIGTHKLLQSDVKLRDLGLLIVDEEHRFGVRHKERIKAMRADVDILTLTATPIPRTLNMAMSGMRDLSIIATPPARRLAVKTFVREYDSLVVREAILREILRGGQVYYLYNDVENIQKAAERLAELVPEARIAIGHGQMRERELERVMNDFHHQRFNVLVCTTIIETGIDIPTANTIIIERADHFGLAQLHQLRGRVGRSHHQAYAWLLTPHPKAMTTDAQKRLEAIASLEDLGAGFALATHDLEIRGAGELLGEEQSGSMETIGFSLYMELLENAVDALKAGREPSLEDLTSQQTEVELRMPSLLPDDFIPDVNTRLSFYKRIASAKNENELEEIKVELIDRFGLLPDPARNLLDIARLRQQAQKLGIRKLEGNEKGGTIEFAEKNHVDPAWLIGLLQKQPQHFRLDGPTRLKFIQDLSERKTRIDWVRQFMQQLEENAIA GT:EXON 1|1-1148:0| SW:ID MFD_ECOLI SW:DE RecName: Full=Transcription-repair-coupling factor; Short=TRCF; EC=3.6.1.-;AltName: Full=ATP-dependent helicase mfd; SW:GN Name=mfd; OrderedLocusNames=b1114, JW1100; SW:KW 3D-structure; ATP-binding; Complete proteome; DNA damage; DNA repair;DNA-binding; Helicase; Hydrolase; Nucleotide-binding. SW:EXACT F SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->1148|MFD_ECOLI|0.0|95.4|1148/1148| GO:SWS:NREP 7 GO:SWS GO:0005524|"GO:ATP binding"|ATP-binding| GO:SWS GO:0006974|"GO:response to DNA damage stimulus"|DNA damage| GO:SWS GO:0006281|"GO:DNA repair"|DNA repair| GO:SWS GO:0003677|"GO:DNA binding"|DNA-binding| GO:SWS GO:0004386|"GO:helicase activity"|Helicase| GO:SWS GO:0016787|"GO:hydrolase activity"|Hydrolase| GO:SWS GO:0000166|"GO:nucleotide binding"|Nucleotide-binding| SEG 262->277|plffseplpplfsyfp| BL:PDB:NREP 1 BL:PDB:REP 2->1147|2eyqA|0.0|95.4|1146/1146| RP:PDB:NREP 3 RP:PDB:REP 26->332|2b2nB|7e-39|90.2|307/309| RP:PDB:REP 547->953|3bxzB|7e-59|14.5|401/440| RP:PDB:REP 1034->1146|1b24A|7e-04|18.8|101/169| RP:PFM:NREP 4 RP:PFM:REP 480->572|PF02559|2e-23|54.8|93/100|CarD_TRCF| RP:PFM:REP 602->765|PF00270|4e-10|33.3|153/167|DEAD| RP:PFM:REP 837->906|PF00271|3e-05|33.3|69/76|Helicase_C| RP:PFM:REP 1005->1105|PF03461|2e-24|54.5|101/101|TRCF| HM:PFM:NREP 4 HM:PFM:REP 1005->1101|PF03461|1.4e-31|46.4|97/101|TRCF| HM:PFM:REP 476->573|PF02559|1.1e-30|53.1|98/98|CarD_TRCF| HM:PFM:REP 602->762|PF00270|1.3e-25|26.8|149/167|DEAD| HM:PFM:REP 836->906|PF00271|1.3e-17|32.9|70/78|Helicase_C| GO:PFM:NREP 12 GO:PFM GO:0003700|"GO:transcription factor activity"|PF02559|IPR003711| GO:PFM GO:0006355|"GO:regulation of transcription, DNA-dependent"|PF02559|IPR003711| GO:PFM GO:0003676|"GO:nucleic acid binding"|PF00270|IPR011545| GO:PFM GO:0005524|"GO:ATP binding"|PF00270|IPR011545| GO:PFM GO:0008026|"GO:ATP-dependent helicase activity"|PF00270|IPR011545| GO:PFM GO:0003676|"GO:nucleic acid binding"|PF00271|IPR001650| GO:PFM GO:0004386|"GO:helicase activity"|PF00271|IPR001650| GO:PFM GO:0005524|"GO:ATP binding"|PF00271|IPR001650| GO:PFM GO:0003684|"GO:damaged DNA binding"|PF03461|IPR005118| GO:PFM GO:0004386|"GO:helicase activity"|PF03461|IPR005118| GO:PFM GO:0005524|"GO:ATP binding"|PF03461|IPR005118| GO:PFM GO:0006281|"GO:DNA repair"|PF03461|IPR005118| RP:SCP:NREP 6 RP:SCP:REP 26->332|2b2nA1|e-112|90.2|307/308|c.37.1.19| RP:SCP:REP 349->465|2eyqA2|1e-21|89.7|117/117|c.37.1.19| RP:SCP:REP 466->545|2eyqA1|7e-34|96.2|80/80|b.34.18.1| RP:SCP:REP 546->778|2eyqA3|e-101|97.4|233/233|c.37.1.19| RP:SCP:REP 779->989|2eyqA5|8e-94|99.5|211/211|c.37.1.19| RP:SCP:REP 990->1147|2eyqA6|1e-47|94.9|158/158|d.315.1.1| HM:SCP:REP 2->348|2eyqA4|4.8e-101|37.2|347/0|c.37.1.19|1/1|P-loop containing nucleoside triphosphate hydrolases| HM:SCP:REP 349->465|2eyqA2|1.7e-28|42.7|117/0|c.37.1.19|1/1|P-loop containing nucleoside triphosphate hydrolases| HM:SCP:REP 466->545|2eyqA1|5.4e-25|53.8|80/0|b.34.18.1|1/1|CarD-like| HM:SCP:REP 545->838|1z3iX2|4.5e-74|30.8|276/0|c.37.1.19|1/1|P-loop containing nucleoside triphosphate hydrolases| HM:SCP:REP 779->989|2eyqA5|3.3e-57|37.9|211/0|c.37.1.19|2/2|P-loop containing nucleoside triphosphate hydrolases| HM:SCP:REP 990->1147|2eyqA6|1.4e-47|41.8|158/0|d.315.1.1|1/1|TRCF domain-like| OP:NHOMO 2430 OP:NHOMOORG 908 OP:PATTERN ------------------------11111--------------------------------1------ 3333222222222221222-22222222222222222222222222222222222222222223322222221222223333211222222232223--2333332333322111121212222222232323333333223322343333333333333233333233333323333333332222222223233333333333333322222233342333323333332222222222222222222222333322334333333222333333333333333333333433333333333333333333344333333332223333334333322332333332323232322324141322222233322233333232224332222323233323333333-33333333333233322223432223232222223322233333333222323223322222211--2212222222222212222222233333333333333333343333323343333333333343333333343333333343333333344533221132121112221222322333222222121222322222222222222222233333334344443334333333433333333332-34433-1111133332433333333333-33333333333333333333334434433333333333333334333444341444444444444--43444444444333335444434443234443333433444334444434443333333333333333333333233334434344344443333333431222333322222222322---1---------------------3433332333413 ---------------------------------------------------------------------------------------------------------------1---------------------------------------------1-----1---------2-1-12A2221-1224-22112---1 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 1146 STR:RPRED 99.8 SQ:SECSTR #cccHHHHTTHHTTccEEEEEcTTccHHHHHHHHHHHHcccEEEEcccHHHHHHHHHHHHHHccEEEEEccTTcccccccEETTTTEEccccccccTHHHHHHcEEEEEcGGGGccccccTTTccccEEEEccccccTTTHHHHTTTTTcccccccccccccccccTTccccEEcccTTcccccEEEccccEcEEEcccccccccccEEEEcccccccccHHHHHHHHHcTTcccccHHHHHHHHHHHHTccccccGGGGHGGGcccccccGGGGccTTcEEEEccccHHHHHHHHHHHHHHHHHHTTcTTcccccGGGTcccHHHHHHHHHTccEEEEccccccccTTcccccEEcccccccccccccTTHHHHHHHTTccccccEEEccHHHHHHHHHHHGGGTcccEEcccGGGccTTccEEEEccccccEEETTTTEEEEEHHHHcccccccccccGGGcccHHHHHHTcTTccTTcEEEETTTEEEEEEEEEEEEccccEEEEEEEEcTTccEEEEEEEccccccEEEEEETTccccccTTcHHHHHHHHHHHHHHHHTHHHHTTccHHHHHTHHHHHHHHHHTTccGGGcHHHHHcccHHHHHHHHHTTTcTTccETEEEEccTTccHHHHTHHHHHHHTTccccEEEEEccHHHHHHHHHTTHHHHHHTTccEEEccTTccHHHHHHHHHcHHHHHHHHHHHHTcccGGGcccccccEEEEETccEEccEEccTTTGGGcccEEEEEEccccTTccHHHHHcccEEEEcccccccccEEcccEEEccHHHHHHHHHHHHHHHHHHTccEEEEcccHHHHHHHHHHHHHTcccccccccHHHHHHHHTTTTccccEEEEcTTccTTccccTTccTHHHHTTcccccTTTTHHHHTTHHHHHHHHHHTTccEEcccTTHHHHHHHTccGGGcccEEEEEEEHHHHccccccccccHHHHHHHHHTcccccHHHHHccHHHHHHHHHccccHHHHHHHHHHHHHTTcccccccGGGGGGGGGGGGccccTTEEcccccccccccEEcccHHHHHHHHHHTTccEEEEHHHHHHHHHHHHHHHHHHHHHccHHHHHHHTccccccHHHHHHHHHHHHHHHHTcccHHHHHHHHHHHcEEEcccc# DISOP:02AL 1-2,9-11,451-471,535-549,571-583,1148-1149| PSIPRED ccHHHHHHcccccccEEEEccccccHHHHHHHHHHHHHcccEEEEEccHHHHHHHHHHHHHHccccEEEcccccccccccccccHHHHHHHHHHHHHHHcccccEEEEcHHHHHHccccHHHHHHcEEEEEEcccccHHHHHHHHHHcccEEccccccccEEEEEccEEEEEcccccccEEEEEEccEEEEEEEEEcccccEEccccEEEEEccccccccHHHHHHHHHHHHHHcccccccHHHHHHHHHccccccHHHHHHHHccccccHHHHHcccccEEEEccHHHHHHHHHHHHHHHHHHHHHccccccccccccccccHHHHHHHHcccEEEEEEcccccccccccccccEEcccccccccHHHHHHHHHHHHHHcccEEEEEEccHHHHHHHHHHHHHccccccccccHHHcccccEEEEEEcHHccEEcccccEEEEEHHHHHHHHHcccccHHHHccccccccccHHHcccccEEEEcccccEEEEEEEEEEcccccEEEEEEEEEcccEEEEEHHHHHHHccccccccccccHHHcccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccccccccHHHHHHHHHHccccccHHHHHHHHHHHHHHHcccccEEEEEEcccccHHHHHHHHHHHHHHccccEEEEEccHHHHHHHHHHHHHHccccccEEEEEEccccHHHHHHHHHHHccccccEEEccHHHHHHcccHHHccEEEEEcHHHHHHHHHHHHHHccccccEEEEEccccHHHHHHHHHccccEEEEEEccccccccEEEEEEccHHHHHHHHHHHHHccccEEEEEEccccHHHHHHHHHHHcccccEEEEEccccHHHHHHHHHHHHHccccEEEEHHHHHHccccccccEEEEEccccccHHHHHHHHHHHccccccEEEEEEEcccccccHHHHHHHHHHHHHHcccccHHHHHHHHHcccccHHHcHHHcccHHHccHHHHHHHHHHHHHHHHHcccccccccccccccEEccccccccHHHcccHHHHHHHHHHHHccccHHHHHHHHHHHHHHcccccHHHHHHHHHHHHHHHHHHcccEEEEEcccEEEEEEcccccccHHHHHHHHHHcccEEEEccccEEEEEEccccHHHHHHHHHHHHHHHHHHHcc //