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Salmonella enterica subsp. enterica serovar Heidelberg str. SL476 (sent8)
Gene : mrcB
DDBJ      :mrcB         penicillin-binding protein 1B
Swiss-Prot:PBPB_ECOLI   RecName: Full=Penicillin-binding protein 1B;         Short=PBP-1b;         Short=PBP1b;AltName: Full=Murein polymerase;Includes:  RecName: Full=Penicillin-insensitive transglycosylase;           EC=2.4.1.129;  AltName: Full=Peptidoglycan glycosyltransferase;  AltName: Full=Peptidoglycan TGase;Includes:  RecName: Full=Penicillin-sensitive transpeptidase;           EC=3.4.-.-;  AltName: Full=DD-transpeptidase;

Homologs  Archaea  0/68 : Bacteria  829/915 : Eukaryota  8/199 : Viruses  0/175   --->[See Alignment]
c.37.1c.50.1e.3.1
:840 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   70->789 3fwmA PDBj 0.0 90.8 %
:RPS:PDB   98->185 1d9xA PDBj 1e-04 24.1 %
:RPS:PDB   189->774 3dwkB PDBj 8e-92 23.5 %
:RPS:SCOP  98->182 2b2nA1  c.37.1.19 * 2e-06 20.8 %
:RPS:SCOP  154->334 1gytA1  c.50.1.1 * 3e-33 13.0 %
:RPS:SCOP  381->764 2bg1A1  e.3.1.1 * 2e-56 19.1 %
:HMM:SCOP  357->788 2bg1A1 e.3.1.1 * 1.6e-104 39.8 %
:RPS:PFM   196->362 PF00912 * Transgly 2e-41 50.3 %
:RPS:PFM   468->719 PF00905 * Transpeptidase 8e-29 42.0 %
:HMM:PFM   204->375 PF00912 * Transgly 1.8e-58 48.8 168/178  
:HMM:PFM   468->720 PF00905 * Transpeptidase 1e-28 27.2 243/304  
:HMM:PFM   31->87 PF09451 * ATG27 0.00091 25.0 56/269  
:BLT:SWISS 1->840 PBPB_ECOLI 0.0 92.7 %
:TM
:SEG

SeqInfo AminoSeq See neighboring genes
Links DAD Abbreviations Back to title page
GT:ID ACF68628.1 GT:GENE mrcB GT:PRODUCT penicillin-binding protein 1B GT:DATABASE GIB00763CH01 GT:ORG sent8 GB:ACCESSION GIB00763CH01 GB:LOCATION 228607..231129 GB:FROM 228607 GB:TO 231129 GB:DIRECTION + GB:GENE mrcB GB:PRODUCT penicillin-binding protein 1B GB:NOTE identified by match to protein family HMM PF00905; match to protein family HMM PF00912; match to protein family HMM TIGR02071 GB:PROTEIN_ID ACF68628.1 GB:DB_XREF GI:194408409 GB:GENE:GENE mrcB LENGTH 840 SQ:AASEQ MAGNDREPIGRKGKPSRPVKQKVSRRRQHDDDYDDDYEDEEPMPRKGKGKGRKPRGKRGWLWLLLKLFIVFVVLFAIYGVYLDQKIRSRIDGKVWQLPAAVYGRMVNLEPDMPVSKNEMVKLLEATQYRLVTKMTRPGEFTVQANSIEMIRRPFDFPDSKEGQVRARLTFSDGRLETIVNLDNNRQFGFFRLDPRLITMLSSPNGEQRLFVPRSGFPDLLVDTLLATEDRHFYEHDGISLYSIGRAVLANLTAGRTVQGASTLTQQLVKNLFLSSERSYWRKANEAYMALIMDARYSKDRILELYMNEVYLGQSGDNEIRGFPLASLYYFGRPVEELSLDQQALLVGMVKGASIYNPWRNPKLALERRNLVLRLLQQQKIIDQELYDMLSARPLGVQPRGGVISPQPAFMQMVRQELQAKLGDKIKDLSGVKIFTTFDSVAQDAAEKAVVEGIPALKKQRKLSDLETAMVVVDRFSGEVRAMVGGAEPQYAGYNRAMQARRSIGSLAKPATYLTALSQPNLYRLNTWIADAPISLRQPNGQVWSPQNDDHRYSESGKVMLVDALTRSMNVPTVNLGMALGLPAVTDTWTKLGVPKDQLNPVPAMLLGALNLTPIEVAQAFQTIASGGNRAPLSALRSVIAEDGKVLYQSYPQAERAVPAQAAYLTLWTMQQVVQRGTGRQLGAKYPGLHLAGKTGTTNNNVDTWFAGIDGSQVTITWVGRDNNQPTKLYGASGAMAIYQRYLANQTPTPLVLTPPEDVVDMGVDYDGNFVCSGGMRTLPVWTDDPNTLCQQGEMMQQQQQPSGNPFDQSSQPQQPAQQQPPKEEKSDGVAGWIKEMFGGN GT:EXON 1|1-840:0| SW:ID PBPB_ECOLI SW:DE RecName: Full=Penicillin-binding protein 1B; Short=PBP-1b; Short=PBP1b;AltName: Full=Murein polymerase;Includes: RecName: Full=Penicillin-insensitive transglycosylase; EC=2.4.1.129; AltName: Full=Peptidoglycan glycosyltransferase; AltName: Full=Peptidoglycan TGase;Includes: RecName: Full=Penicillin-sensitive transpeptidase; EC=3.4.-.-; AltName: Full=DD-transpeptidase; SW:GN Name=mrcB; Synonyms=pbpF, ponB; OrderedLocusNames=b0149, JW0145; SW:KW 3D-structure; Alternative initiation; Antibiotic resistance;Cell inner membrane; Cell membrane; Cell shape;Cell wall biogenesis/degradation; Complete proteome;Direct protein sequencing; Glycosyltransferase; Hydrolase; Membrane;Multifunctional enzyme; Peptidoglycan synthesis; Signal-anchor;Transferase; Transmembrane. SW:EXACT F SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->840|PBPB_ECOLI|0.0|92.7|837/844| GO:SWS:NREP 12 GO:SWS GO:0046677|"GO:response to antibiotic"|Antibiotic resistance| GO:SWS GO:0005886|"GO:plasma membrane"|Cell inner membrane| GO:SWS GO:0005886|"GO:plasma membrane"|Cell membrane| GO:SWS GO:0008360|"GO:regulation of cell shape"|Cell shape| GO:SWS GO:0007047|"GO:cellular cell wall organization"|Cell wall biogenesis/degradation| GO:SWS GO:0016757|"GO:transferase activity, transferring glycosyl groups"|Glycosyltransferase| GO:SWS GO:0016787|"GO:hydrolase activity"|Hydrolase| GO:SWS GO:0016020|"GO:membrane"|Membrane| GO:SWS GO:0003824|"GO:catalytic activity"|Multifunctional enzyme| GO:SWS GO:0009252|"GO:peptidoglycan biosynthetic process"|Peptidoglycan synthesis| GO:SWS GO:0016740|"GO:transferase activity"|Transferase| GO:SWS GO:0016021|"GO:integral to membrane"|Transmembrane| TM:NTM 1 TM:REGION 59->81| SEG 30->41|dddydddyedee| SEG 44->67|prkgkgkgrkprgkrgwlwlllkl| SEG 363->378|lalerrnlvlrllqqq| SEG 790->800|qqgemmqqqqq| SEG 808->821|qssqpqqpaqqqpp| BL:PDB:NREP 1 BL:PDB:REP 70->789|3fwmA|0.0|90.8|660/666| RP:PDB:NREP 2 RP:PDB:REP 98->185|1d9xA|1e-04|24.1|79/590| RP:PDB:REP 189->774|3dwkB|8e-92|23.5|566/621| RP:PFM:NREP 2 RP:PFM:REP 196->362|PF00912|2e-41|50.3|163/178|Transgly| RP:PFM:REP 468->719|PF00905|8e-29|42.0|243/289|Transpeptidase| HM:PFM:NREP 3 HM:PFM:REP 204->375|PF00912|1.8e-58|48.8|168/178|Transgly| HM:PFM:REP 468->720|PF00905|1e-28|27.2|243/304|Transpeptidase| HM:PFM:REP 31->87|PF09451|0.00091|25.0|56/269|ATG27| GO:PFM:NREP 5 GO:PFM GO:0003824|"GO:catalytic activity"|PF00912|IPR001264| GO:PFM GO:0009252|"GO:peptidoglycan biosynthetic process"|PF00912|IPR001264| GO:PFM GO:0009274|"GO:peptidoglycan-based cell wall"|PF00912|IPR001264| GO:PFM GO:0008658|"GO:penicillin binding"|PF00905|IPR001460| GO:PFM GO:0009273|"GO:peptidoglycan-based cell wall biogenesis"|PF00905|IPR001460| RP:SCP:NREP 3 RP:SCP:REP 98->182|2b2nA1|2e-06|20.8|77/308|c.37.1.19| RP:SCP:REP 154->334|1gytA1|3e-33|13.0|169/178|c.50.1.1| RP:SCP:REP 381->764|2bg1A1|2e-56|19.1|372/452|e.3.1.1| HM:SCP:REP 357->788|2bg1A1|1.6e-104|39.8|394/0|e.3.1.1|1/1|beta-lactamase/transpeptidase-like| OP:NHOMO 2513 OP:NHOMOORG 837 OP:PATTERN -------------------------------------------------------------------- 333-422222222222222-23222322222233333344233322212223233212115522424644321222221131311111444214111--23443236515---------------3322212223222233---216333333223312122243224673111-11111-11232111124346666676666666665444446673434433222222443333333333333333333332223422323222233322222333333333323333333333333333333333333343333333331212111111211212211111131111322212233222521111212145-766422222555555545555544444444445-7787887765415555666666674534433542443431111111111113334------------2222122211112----1324434444478878756665774566663686467772222243344463452333222232222222222222453532133222222133333333355454434122131111121211111111111122443243322233444333233332422322--11313-1-11144333434444444444-4444444444444344444444334444444444444444443443332343143444544444411131111122223642433333313332322423343333334433334435433433444---------122242222233222444444433333331-136666661111111121--------------------------1-11111111--3 -------------1-----------------------------------------------------------------------------------------------------------------------------------------------------1--------------11-----1--4--1--1---- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 721 STR:RPRED 85.8 SQ:SECSTR ####################################################################HcccGGGTTTTTTTTTHHHHTTccccccccHHHHTTcEEEEccccccTTTHHHHHHTTTcccccccccccTTccccTTcccEEccEEcEEccccTTEcccccEEEccccEEEcccccEccEEcTTccEEEEEcccTccccccccGGGccHHHHHHHHHHHccccTTcccccHHHHHHTTTTcTTccccccccccHHHHHHHHTcccccccHHHHHHHHHHHHHHHHHccHHHHHHHHHHHccccTETTTTcccHHHHHHHHTccccTTccHHHHHHHHHTTccHHHHcTTTcHHHHHHHHHHHHHHHHHTTcccHHHHHHHTTcccGGGcccccTTTTccccccccGGGHHHHHHHHHHHcccEEEEcccHHHHHHHHHHHHHccccccTTEcccTEEEEEEEEETTTccEEEEEccTTccTTTcccTTTccEEcGGGGHHHHTHHHHHHHccccTTcEEEccccccccccccccccccTTcccccccEEEHHHHHHTTcHHHHHHHHHHHHHHccTTHHHHHHHHTTcccHHHHTTcTTcEEcHHHHHHHHHHHTTTcEEEccccEEEEEcccccEEEcccccEEEcccHHHHHHHHHHHHTTccTTcTTTHTccccccccEEEEEETTEEEEEEEEEEcccEEEEEEEEEccccGGGHHHHTHHHHHHHHHHHHHccccccccccTTEEEETTEEEETTcccccEEEEEEEccEEccEE################################################### DISOP:02AL 1-5,8-29,38-60,791-830,840-841| PSIPRED ccccccccccccccccccHHHHHHHHHccccccccccccccccccccccccccccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccEEEEccHHHHccEEEEcccccccHHHHHHHHHHccccccccccccEEEEEEccEEEEEEccccccccccccEEEEEEEEccEEHHHHHccccccEEEEEccccccEEEEcccccEEEEEcHHHccHHHHHHHHHHHHHccHHcccccHHHHHHHHHHHHHcccccccccHHHHHHHHHHHccccccHHHHHHHHHHHHHHHHHHcHHHHHHHHccEEEccccccccEEcHHHHHHHHccccHHHccHHHHHHHHHHccccccccccccHHHHHHHHHHHHHHHHHcccccHHHHHHHHccccccccccccccccHHHHHHHHHHHHHHHccccccccccEEEEEEcHHHHHHHHHHHHHHHHHHHHccccccccEEEEEEEcccccEEEEEcccccccccccccEEccccccHHHHHHHHHHHHHccccccHHHEEccccEEEccccccEEEEEEccccccccEEEEHHHHHHHccHHHHHHHHHHccHHHHHHHHHHcccccccccccHHHHcccccccHHHHHHHHHHHHcccEEEccEEEEEEEcccccEEEcccccccccccHHHHHHHHHHHHHHHccccccHHccccccccEEEEEEcccccccEEEEEEcccEEEEEEEEccccccccccccccHHHHHHHHHHHcccccccccccccEEEEEEcccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccHHHHHHHHHccc //