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Salmonella enterica subsp. enterica serovar Heidelberg str. SL476 (sent8)
Gene : nrdA
DDBJ      :nrdA         ribonucleoside-diphosphate reductase, alpha subunit
Swiss-Prot:RIR1_SALTY   RecName: Full=Ribonucleoside-diphosphate reductase 1 subunit alpha;         EC=1.17.4.1;AltName: Full=Ribonucleoside-diphosphate reductase 1 R1 subunit;AltName: Full=Ribonucleotide reductase 1;AltName: Full=Protein B1;

Homologs  Archaea  32/68 : Bacteria  757/915 : Eukaryota  193/199 : Viruses  19/175   --->[See Alignment]
a.98.1c.7.1
:761 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   1->738 7r1rA PDBj 0.0 96.3 %
:BLT:PDB   737->761 1qfnB PDBj 1e-08 92.0 %
:RPS:PDB   80->735 2cvtA PDBj e-169 29.6 %
:RPS:SCOP  4->221 1r1rA1  a.98.1.1 * 2e-44 95.4 %
:RPS:SCOP  222->737 1r1rA2  c.7.1.2 * e-163 96.7 %
:HMM:SCOP  10->221 1rlrA1 a.98.1.1 * 5.3e-74 42.5 %
:HMM:SCOP  222->740 1rlrA2 c.7.1.2 * 1.3e-167 39.5 %
:RPS:PFM   5->91 PF03477 * ATP-cone 2e-07 37.8 %
:RPS:PFM   143->220 PF00317 * Ribonuc_red_lgN 9e-06 36.0 %
:RPS:PFM   223->732 PF02867 * Ribonuc_red_lgC 3e-82 41.2 %
:HMM:PFM   222->731 PF02867 * Ribonuc_red_lgC 1.2e-139 38.0 490/533  
:HMM:PFM   6->92 PF03477 * ATP-cone 6.5e-18 30.5 82/89  
:HMM:PFM   142->219 PF00317 * Ribonuc_red_lgN 3.1e-15 32.5 77/83  
:BLT:SWISS 1->761 RIR1_SALTY 0.0 99.9 %
:PROS 599->621|PS00089|RIBORED_LARGE

SeqInfo AminoSeq See neighboring genes
Links DAD Abbreviations Back to title page
GT:ID ACF67497.1 GT:GENE nrdA GT:PRODUCT ribonucleoside-diphosphate reductase, alpha subunit GT:DATABASE GIB00763CH01 GT:ORG sent8 GB:ACCESSION GIB00763CH01 GB:LOCATION 2428962..2431247 GB:FROM 2428962 GB:TO 2431247 GB:DIRECTION + GB:GENE nrdA GB:PRODUCT ribonucleoside-diphosphate reductase, alpha subunit GB:NOTE identified by match to protein family HMM PF00317; match to protein family HMM PF02867; match to protein family HMM PF03477; match to protein family HMM TIGR02506 GB:PROTEIN_ID ACF67497.1 GB:DB_XREF GI:194407278 GB:GENE:GENE nrdA LENGTH 761 SQ:AASEQ MNQSLLVTKRDGRTERINLDKIHRVLDWAAEGLNNVSVSQVELRSHIQFYDGIKTSDIHETIIKAAADLISRDAPDYQYLAARLAIFHLRKKAFGQFEPPALYHHVVKMVELGKYDNHLLEDYTEEEFKQMDSFIVHDRDMTFSYAAVKQLEGKYLVQNRVTGEIYESAQFLYILVAACLFSNYPRETRLDYVKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATSSAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPMWHLEVESLLVLKNNRGVEGNRVRHMDYGVQINKLMYTRLLKGGDITLFSPSDVPGLYDAFFADQDEFERLYVKYEHDDSIRKQRVKAVELFSLMMQERASTGRIYIQNVDHCNTHSPFDPVVAPVRQSNLCLEIALPTKPLNDVNDENGEIALCTLSAFNLGAIKTLDELEELAILAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYWLAKNGKRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQGACPWFNETTYAKGILPIDTYKKDLDAIVNEPLHYDWQQLRESIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGYVSIKASKDGILRQVVPDYEHLKDAYELLWEMPNNDGYLQLVGIMQKFIDQSISANTNYDPSRFPSGKVPMQQLLKDLLTAYKFGVKTLYYQNTRDGAEDAQDDLAPSIQDDGCESGACKI GT:EXON 1|1-761:0| SW:ID RIR1_SALTY SW:DE RecName: Full=Ribonucleoside-diphosphate reductase 1 subunit alpha; EC=1.17.4.1;AltName: Full=Ribonucleoside-diphosphate reductase 1 R1 subunit;AltName: Full=Ribonucleotide reductase 1;AltName: Full=Protein B1; SW:GN Name=nrdA; OrderedLocusNames=STM2277; SW:KW Allosteric enzyme; ATP-binding; Complete proteome; Disulfide bond;DNA replication; Nucleotide-binding; Oxidoreductase. SW:EXACT F SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->761|RIR1_SALTY|0.0|99.9|761/761| GO:SWS:NREP 5 GO:SWS GO:0005524|"GO:ATP binding"|ATP-binding| GO:SWS GO:0006260|"GO:DNA replication"|DNA replication| GO:SWS GO:0000166|"GO:nucleotide binding"|Nucleotide-binding| GO:SWS GO:0016491|"GO:oxidoreductase activity"|Oxidoreductase| GO:SWS GO:0055114|"GO:oxidation reduction"|Oxidoreductase| PROS 599->621|PS00089|RIBORED_LARGE|PDOC00084| BL:PDB:NREP 2 BL:PDB:REP 1->738|7r1rA|0.0|96.3|738/738| BL:PDB:REP 737->761|1qfnB|1e-08|92.0|25/25| RP:PDB:NREP 1 RP:PDB:REP 80->735|2cvtA|e-169|29.6|621/637| RP:PFM:NREP 3 RP:PFM:REP 5->91|PF03477|2e-07|37.8|82/89|ATP-cone| RP:PFM:REP 143->220|PF00317|9e-06|36.0|75/80|Ribonuc_red_lgN| RP:PFM:REP 223->732|PF02867|3e-82|41.2|480/506|Ribonuc_red_lgC| HM:PFM:NREP 3 HM:PFM:REP 222->731|PF02867|1.2e-139|38.0|490/533|Ribonuc_red_lgC| HM:PFM:REP 6->92|PF03477|6.5e-18|30.5|82/89|ATP-cone| HM:PFM:REP 142->219|PF00317|3.1e-15|32.5|77/83|Ribonuc_red_lgN| GO:PFM:NREP 7 GO:PFM GO:0004748|"GO:ribonucleoside-diphosphate reductase activity"|PF00317|IPR013509| GO:PFM GO:0005524|"GO:ATP binding"|PF00317|IPR013509| GO:PFM GO:0006260|"GO:DNA replication"|PF00317|IPR013509| GO:PFM GO:0055114|"GO:oxidation reduction"|PF00317|IPR013509| GO:PFM GO:0004748|"GO:ribonucleoside-diphosphate reductase activity"|PF02867|IPR000788| GO:PFM GO:0005971|"GO:ribonucleoside-diphosphate reductase complex"|PF02867|IPR000788| GO:PFM GO:0006260|"GO:DNA replication"|PF02867|IPR000788| RP:SCP:NREP 2 RP:SCP:REP 4->221|1r1rA1|2e-44|95.4|218/218|a.98.1.1| RP:SCP:REP 222->737|1r1rA2|e-163|96.7|516/516|c.7.1.2| HM:SCP:REP 10->221|1rlrA1|5.3e-74|42.5|212/0|a.98.1.1|1/1|R1 subunit of ribonucleotide reductase, N-terminal domain| HM:SCP:REP 222->740|1rlrA2|1.3e-167|39.5|519/525|c.7.1.2|1/1|PFL-like glycyl radical enzymes| OP:NHOMO 1276 OP:NHOMOORG 1001 OP:PATTERN ------1111111111-1---1-1122--1--------------1-1----11-1111111--11-11 1---121111111111122-211112222221122211111---111111111211111111-11111112-111111--1-11122111-1----1--1-111111111111111111111111-----------111--22111111-111----------11-------------------11--11-111111111121121112121112111121211111111112111111111111111112111-1-11-2-1-11111111111111122221221111111111111122222222222221111111111---1111-111111111--11111-1111----------1111111--1123-211211111--1--111-1---11111111111---------1-21111111-111----1211121111111111111112111112211111111111111111111111111111111111111111111111111111222222121222222112122222222431211121112211111111111111-1--11111-11111-1---1------111-1111111111111111111111111111111111111111111111111111111111-111-111-11122121222222222222-222222222222222222222222222222222222213222222222222112223222332221111111111111211211111111111--111111111111111111111111111111111111111111111111111112112211111111111111-1---------1--1-11111111---11-11111111111---1-111111111-- 1111111-311-1111112111111111121111111111111111111111111111111122222212122222212222222211-111111111111114231131223222111111111-111291-112111111111111111112111111643111-111111221111H1111121241112241116 ---1-1-1--------1--1-1-11-----------21-1--------------------------------------------------------------------------1-----------1---------------------------------1---1-----1111- STR:NPRED 761 STR:RPRED 100.0 SQ:SECSTR cccccEEEETTTEEEEccHHHHHHHHHHHHTTcccccHHHHHHHHHTTccTTccHHHHHHHHHHHHHHTcccccccHHHcTTTHHHHTccccccccHHHHHHHHcccTTTcccccccHHHHHHHHTTHHHHHHHccGGGGGcccHHHHHHHHHHTcccccccccccccHHHHHHHHHHHHccccHHHHHHHHHHHHHHHHHTTcEEEcHHHHHHTTcccccccccEEEEccccHHHHHHHHHHHHHTTTccccEEEEcTTcccTTcccccccccccccHHHHHHHHHHHHHTTTTTTccccEEEEEcTTcTTHHHHHHTTccccTTccccTTEEEEEEEcHHHHHHHHTTcEEccccTTTcTTTTTccHGGHHHHHHHHHHHHHTTccccEEEEHHHHHHHHHHHHHHHcccEEEEHHHHHHTcTTcTTTcccccccccTTccccccTcEEcEEEcTccEEccEEEEETTTEEcHHHHHHHHHHHHHHHHHHHHHcccccHHHHHHHHHHcccEEEEEcHHHHHHHTTccTTcTTHHHHHHHHHHHHHHHHHHHHHHHHHHHcccTTcTTcTGGGTccHHHHTTcccccccccccTccHHHHHHHHHHHccccccccccccccccccHHHHHHHccccTTcccHHHHccccccccTTccHHHHHHcccTTTcccHHHHHHHHHHHGGGcccccccccccccccHGGTTccTTHHHHHHHHHHHTTcccccccccccccHHccccccTTHHHHGGGcccccc DISOP:02AL 1-3| PSIPRED cccEEEEEEccccEEEccHHHHHHHHHHHHcccccccHHHHHHHHHHcccccccHHHHHHHHHHHHHHHHccccccHHHHHHHHHHHHHHHHHHccccHHHHHHHHHHHHHccccHHHHHHHHHHHHHHHHHHHHHHHHHccccHHHHHHHHHHHccccccccEEEEcHHHHHHHHHHHHHcccccccHHHHHHHHHHHHHcccEEccccEEEccccccccEEEEEEEcccccHHHHHHHHHHHHHHHHHccEEEEEcccccccccccccccccccccHHHHHHHHHHHHHHHHccccccEEEEEEEccHHHHHHHHHHccccccHHHHHHHccHHHcccHHHHHHHHccccEEEEccccccccccccHHHHHHHHHHHHHHHHccccEEEEEEHHHHHHHHHHHHHcccccEEEEHHHHHccccccccccEEEccccccccccccccccccccccccEEEEEcccccHHHHccHHHHHHHHHHHHHHHHHHHHHccccHHHHHHHHHHHcccEEEEccHHHHHHHcccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccccccccccccccccccccccccccccccHHHHHHHHHHHHHHHccccEEEEEEcccHHHHHHHccccccccccccEEEEEccccEEEcccccHHHHHHHHHHHHHcccHHHHHHHHHHHHcHHHccEEEEEEEcccccccccccHHHHHHHHHHHHHccccEEEEEcccccccHHHHHHcccccccccccccccc //