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Streptococcus pneumoniae G54 (spne4)
Gene : ACF55618.1
DDBJ      :             2-isopropylmalate synthase
Swiss-Prot:             

Homologs  Archaea  55/68 : Bacteria  622/915 : Eukaryota  121/199 : Viruses  0/175   --->[See Alignment]
a.103.1c.1.10d.270.1
:364 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   16->121 3ewbX PDBj 3e-32 59.0 %
:RPS:PDB   18->340 3bg9A PDBj 6e-41 12.7 %
:RPS:SCOP  20->222 1k3pA  a.103.1.1 * 1e-35 13.1 %
:RPS:SCOP  231->340 1sr9A3  d.270.1.1 * 1e-12 15.7 %
:HMM:SCOP  18->137 1sr9A2 c.1.10.5 * 8.1e-33 46.6 %
:HMM:SCOP  234->345 1sr9A3 d.270.1.1 * 5.4e-11 20.7 %
:RPS:PFM   16->94 PF00682 * HMGL-like 3e-16 52.6 %
:RPS:PFM   213->340 PF08502 * LeuA_dimer 7e-13 32.5 %
:HMM:PFM   212->340 PF08502 * LeuA_dimer 6.3e-32 35.2 128/133  
:HMM:PFM   16->97 PF00682 * HMGL-like 7.9e-28 50.6 79/237  
:BLT:SWISS 16->360 LEU1_LACLS e-119 62.6 %

SeqInfo AminoSeq See neighboring genes
Links DAD Abbreviations Back to title page
GT:ID ACF55618.1 GT:GENE ACF55618.1 GT:PRODUCT 2-isopropylmalate synthase GT:DATABASE GIB00761CH01 GT:ORG spne4 GB:ACCESSION GIB00761CH01 GB:LOCATION complement(1126806..1127900) GB:FROM 1126806 GB:TO 1127900 GB:DIRECTION - GB:PRODUCT 2-isopropylmalate synthase GB:NOTE identified by match to protein family HMM PF00682; match to protein family HMM PF08502 GB:PROTEIN_ID ACF55618.1 GB:DB_XREF GI:194357170 LENGTH 364 SQ:AASEQ MNFQLAKYSLLKKFSENIGFTTPEEYGAIFKYLIENVKTDRQIIYSPHCHDDLGMAVANSLAAVKNGAGRVEGTINGIRERAENAALEEIAVALNIRQDYYQVETSIVLNETINTSEMVSRFSGIPVPKNKAVVGGNTFSHESGIHQDGVLKNPLTYEIITPELVGVKILLGKLSGRHAFVEKLRELALDFTEEDIKPLFAKFKALVDKKQEITDADIRALVAGTMVENPEGFHFDDLQLQTHADNDIEALVSLANMDGEKVEFNATGQGSVEAIFNVIDKFFNQSVRLVSYTIDAVTDGIDTQDRVLVTVENRDTETIFNAAGLDFDVLKASAIVYINANTFVQKENAGEMGRSVSYHDMPSV GT:EXON 1|1-364:0| BL:SWS:NREP 1 BL:SWS:REP 16->360|LEU1_LACLS|e-119|62.6|340/513| BL:PDB:NREP 1 BL:PDB:REP 16->121|3ewbX|3e-32|59.0|105/268| RP:PDB:NREP 1 RP:PDB:REP 18->340|3bg9A|6e-41|12.7|308/601| RP:PFM:NREP 2 RP:PFM:REP 16->94|PF00682|3e-16|52.6|76/237|HMGL-like| RP:PFM:REP 213->340|PF08502|7e-13|32.5|126/132|LeuA_dimer| HM:PFM:NREP 2 HM:PFM:REP 212->340|PF08502|6.3e-32|35.2|128/133|LeuA_dimer| HM:PFM:REP 16->97|PF00682|7.9e-28|50.6|79/237|HMGL-like| GO:PFM:NREP 3 GO:PFM GO:0003824|"GO:catalytic activity"|PF00682|IPR000891| GO:PFM GO:0003852|"GO:2-isopropylmalate synthase activity"|PF08502|IPR013709| GO:PFM GO:0009098|"GO:leucine biosynthetic process"|PF08502|IPR013709| RP:SCP:NREP 2 RP:SCP:REP 20->222|1k3pA|1e-35|13.1|199/426|a.103.1.1| RP:SCP:REP 231->340|1sr9A3|1e-12|15.7|108/115|d.270.1.1| HM:SCP:REP 18->137|1sr9A2|8.1e-33|46.6|116/0|c.1.10.5|1/1|Aldolase| HM:SCP:REP 234->345|1sr9A3|5.4e-11|20.7|111/152|d.270.1.1|1/1|2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain| OP:NHOMO 1345 OP:NHOMOORG 798 OP:PATTERN ---4--3323333333-43333322--212213333333333333333446643331-1--2-13-22 11322-----------------------------------1222--1-1-----------111111-1121--------121222222222232---11--2-1211222---------------33223333334222223333223423323322111111222254531111111111112223333111111111111111111111111111111131--11111133-2222221222222211111--------------------111-1--------11112-2112-----------------111111111-23-33-------1-13133----3-2--2-1434444333-333322--1-321111-----332332223333311111211111-11111111222-2--2112111123311122233222221111111112211432-----------------------------2--1-1-----1111111-1111112111111122211111111211222221111131111111111111111122-3322232133222-3333333333333-2221111111111-----------2111221121211-1111111111111111111111---1121-11--111211111111111111-11-1111111111111111121212111111111111111111111111111-11111111111111-1---------211-2111111-111-11111111111---2-11-1----1-1--2---111--11-1111111111111111111111111111111141333333--------------------------------------3--21222322 ------1-----11211111111212111111111211-1111111111213112111111122223323432344444434443321-13111111111211333-121---------------------------------------------------------------1-2111H1111121212432221113 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 333 STR:RPRED 91.5 SQ:SECSTR #######HHHHHHHTEETccccHHHHHHHHHHHHHHcTHHHTccEEEEccTTcccTHHHHHHHHHTTccEEEEccGGGccTTccccHHHHHHHHTTcTTccTTcccccHHHHHHHHHHHHHHHHHGGGGcGGEGTcccccTTHHHHcccHHHHHHHHHHHHHHTTcccHHHHHHHHHHHHHHHHTTccHHHHHHGGGHHHHHHTTcccccTTcccHHHHHHHHccccccccTTTTcccccHHHHHHHHHTTTccccHTcHHHHHHHHHcHHHHHHHHHHHHHHccTTcccHHHHHHHHHcccTTHHcEEEcccTTTcccEEEccccccTTTTccEEEEEc######################## DISOP:02AL 345-365| PSIPRED ccHHHccccEEEEEccccccccHHHHHHHHHHHHHHcccccccEEEEEccccccHHHHHHHHHHHccccEEEEEccccccccccccHHHHHHHHHHHHHcccccccccHHHHHHHHHHHHHHHccccccccccccccHHHHcccccHHHHHccccccccccHHHcccEEEEEcHHHHHHHHHHHHHccccccHHHHHHHHHHHHHHHHccccccHHHHHHHHHHHHccccccEEEEEEEEEEccccccEEEEEEEEEccEEEEEEEEcccHHHHHHHHHHHHccccEEEEEEEEEEcccccccEEEEEEEEEEccccEEEEEEEccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccccc //