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Streptococcus pneumoniae G54 (spne4)
Gene : ACF56816.1
DDBJ      :             3-isopropylmalate dehydrogenase, point mutation
Swiss-Prot:LEU3_STRR6   RecName: Full=3-isopropylmalate dehydrogenase;         EC=1.1.1.85;AltName: Full=Beta-IPM dehydrogenase;         Short=IMDH;AltName: Full=3-IPM-DH;

Homologs  Archaea  60/68 : Bacteria  774/915 : Eukaryota  189/199 : Viruses  0/175   --->[See Alignment]
c.77.1
:263 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   2->263 1v53A PDBj 1e-75 53.8 %
:RPS:PDB   2->263 1dr8A PDBj 1e-91 52.3 %
:RPS:SCOP  4->263 1ai2A  c.77.1.1 * 7e-68 30.7 %
:HMM:SCOP  2->264 2ayqA_ c.77.1.1 * 7.5e-89 50.6 %
:RPS:PFM   2->259 PF00180 * Iso_dh 1e-64 52.6 %
:HMM:PFM   2->259 PF00180 * Iso_dh 1.4e-106 60.5 258/347  
:BLT:SWISS 2->263 LEU3_STRR6 e-138 96.2 %
:PROS 73->82|PS00230|MAP1B_NEURAXIN
:PROS 154->173|PS00470|IDH_IMDH

SeqInfo AminoSeq See neighboring genes
Links DAD Abbreviations Back to title page
GT:ID ACF56816.1 GT:GENE ACF56816.1 GT:PRODUCT 3-isopropylmalate dehydrogenase, point mutation GT:DATABASE GIB00761CH01 GT:ORG spne4 GB:ACCESSION GIB00761CH01 GB:LOCATION complement(1125757..1126548) GB:FROM 1125757 GB:TO 1126548 GB:DIRECTION - GB:PRODUCT 3-isopropylmalate dehydrogenase, point mutation GB:NOTE identified by similarity to SP:Q8DPJ4; match to protein family HMM PF00180; match to protein family HMM TIGR00169 GB:PROTEIN_ID ACF56816.1 GB:DB_XREF GI:194358368 LENGTH 263 SQ:AASEQ MVRPEQGLMALRKELNLYANIRPVKIFDSLKHLSLLKLERIAGVDFVVVRELTGGIYFGDHILEERNARDINDYSYEEVERIIRKAFEIARNRRKIVTSIDKQNVLATSKLWRKVAEEVAQDFPDVTLEHQLVDSAAMLMITNPAKFDVIVTENLFGDILSDESSVLSGTLGVMPSASHSENGPSLYEPIHSSAPDIAGQGIANPISMILSVSMMLRDSFGRYEDAERIKRAVETSLAAGILTRDIGGQASTKEMTEAIIARL GT:EXON 1|1-263:0| SW:ID LEU3_STRR6 SW:DE RecName: Full=3-isopropylmalate dehydrogenase; EC=1.1.1.85;AltName: Full=Beta-IPM dehydrogenase; Short=IMDH;AltName: Full=3-IPM-DH; SW:GN Name=leuB; OrderedLocusNames=spr1135; SW:KW Amino-acid biosynthesis; Branched-chain amino acid biosynthesis;Complete proteome; Cytoplasm; Leucine biosynthesis; Magnesium;Manganese; Metal-binding; NAD; Oxidoreductase. SW:EXACT F SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 2->263|LEU3_STRR6|e-138|96.2|262/345| GO:SWS:NREP 7 GO:SWS GO:0008652|"GO:cellular amino acid biosynthetic process"|Amino-acid biosynthesis| GO:SWS GO:0009082|"GO:branched chain family amino acid biosynthetic process"|Branched-chain amino acid biosynthesis| GO:SWS GO:0005737|"GO:cytoplasm"|Cytoplasm| GO:SWS GO:0009098|"GO:leucine biosynthetic process"|Leucine biosynthesis| GO:SWS GO:0046872|"GO:metal ion binding"|Metal-binding| GO:SWS GO:0016491|"GO:oxidoreductase activity"|Oxidoreductase| GO:SWS GO:0055114|"GO:oxidation reduction"|Oxidoreductase| PROS 73->82|PS00230|MAP1B_NEURAXIN|PDOC00202| PROS 154->173|PS00470|IDH_IMDH|PDOC00389| BL:PDB:NREP 1 BL:PDB:REP 2->263|1v53A|1e-75|53.8|262/356| RP:PDB:NREP 1 RP:PDB:REP 2->263|1dr8A|1e-91|52.3|260/344| RP:PFM:NREP 1 RP:PFM:REP 2->259|PF00180|1e-64|52.6|253/338|Iso_dh| HM:PFM:NREP 1 HM:PFM:REP 2->259|PF00180|1.4e-106|60.5|258/347|Iso_dh| GO:PFM:NREP 4 GO:PFM GO:0000287|"GO:magnesium ion binding"|PF00180|IPR001804| GO:PFM GO:0016616|"GO:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"|PF00180|IPR001804| GO:PFM GO:0051287|"GO:NAD or NADH binding"|PF00180|IPR001804| GO:PFM GO:0055114|"GO:oxidation reduction"|PF00180|IPR001804| RP:SCP:NREP 1 RP:SCP:REP 4->263|1ai2A|7e-68|30.7|254/414|c.77.1.1| HM:SCP:REP 2->264|2ayqA_|7.5e-89|50.6|263/0|c.77.1.1|1/1|Isocitrate/Isopropylmalate dehydrogenase-like| OP:NHOMO 2442 OP:NHOMOORG 1023 OP:PATTERN 11-2--2222222222-2222222211222222222222222222222323332221-1--2112-22 4443111111111221111-111113111111133322531111211-1111121111--111-13411111111111-22-422121222211---11--2-1111131--------------111111111121222332224321321122211111111112222322122222122223333311141311111111211111132333311132433-11111113212222222222222222222-------2------------12-211-------222-1111111111-------------222222222-23-21111111111122111---2-11-411222211212-221112--32221111-1--1117441132222111111111111-23422433222-3222225424221111131241342112222222253322221111111111111111111111111111111131123543445554433333554533331333745532222553444444774333222212111111122223312311222222222-111111121212224131111111111-1111111111211122232221312312222222222222222222-1-2532-11--132332223332322233-3323322333323333333344222322222222222222222233322231-233333333333111111111222224132111113-111-2112333331212111222233232232323431-1--1---111121111111111222222222222222211112222-------------------------------------22--1-111212 ----224-21--3347867778688876645555555555455444546777896665444433444434424442433344444424-46484456564416667-3234583333323127233232Ed6-5452323823641332331165323536424333A3784443333191112374986931121111 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 263 STR:RPRED 100.0 SQ:SECSTR cGcHHHHHHHHHHHTTEEEEEEEEEccTTcGGGccccHHHHTTcEEEEEEEcccGGGTcccccccccccccccccHHHHHHHHHHHHHHHHHTTcEEEEEEcTTTcHHHHHHHHHHHHHHTTcTTcEEEEEEHHHHHHHHHHcGGGccEEEEcHHHHHHHHHHHHHTTccGGGcccEEEETccccEEcccccccTTTTTTTcccTHHHHHHHHHHHHHTTccHHHHHHHHHHHHHHHHHccccGGGccccTHHHHHHHHHHTc DISOP:02AL 1-1| PSIPRED ccccHHHHHHHHHHcccEEEEEEEEEccccccccccccccccccEEEEEEcccccEEccccEEEcccEEEEEEEEHHHHHHHHHHHHHHHHccccEEEEEEcHHHHHHHHHHHHHHHHHHHHccccEEEHHHHHHHHHHHHHccccccEEEEccccHHHHHHHHHHHcccHHHcccccccccccEEEEEcccccccccccccccHHHHHHHHHHHHHHHccccHHHHHHHHHHHHHHHcccccHHHcccccHHHHHHHHHHHc //