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Streptococcus pneumoniae G54 (spne4)
Gene : alaS
DDBJ      :alaS         alanyl-tRNA synthetase
Swiss-Prot:SYA_STRPS    RecName: Full=Alanyl-tRNA synthetase;         EC=6.1.1.7;AltName: Full=Alanine--tRNA ligase;         Short=AlaRS;

Homologs  Archaea  68/68 : Bacteria  907/915 : Eukaryota  195/199 : Viruses  0/175   --->[See Alignment]
a.203.1b.43.3d.104.1d.67.1
:872 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   4->440 1yfrA PDBj e-109 47.7 %
:BLT:PDB   491->698 2e1bA PDBj 2e-08 37.9 %
:RPS:PDB   5->443 2cvsA PDBj 6e-62 11.9 %
:RPS:PDB   480->700 2e1bA PDBj 2e-32 26.9 %
:RPS:PDB   676->872 3c9iF PDBj 9e-13 9.3 %
:RPS:SCOP  4->248 1riqA2  d.104.1.1 * e-100 48.9 %
:RPS:SCOP  249->463 1riqA1  a.203.1.1 * 9e-64 43.5 %
:RPS:SCOP  480->555 2e1bA1  b.43.3.6 * 3e-12 27.9 %
:RPS:SCOP  555->725 1nyqA3  d.67.1.1 * 1e-30 19.0 %
:HMM:SCOP  3->248 1riqA2 d.104.1.1 * 3.7e-78 49.1 %
:HMM:SCOP  249->468 1riqA1 a.203.1.1 * 1.4e-66 46.6 %
:HMM:SCOP  555->726 1nyrA3 d.67.1.1 * 1.8e-53 47.3 %
:RPS:PFM   8->559 PF01411 * tRNA-synt_2c e-150 53.2 %
:RPS:PFM   656->698 PF07973 * tRNA_SAD 4e-11 55.8 %
:RPS:PFM   821->869 PF02272 * DHHA1 5e-08 44.9 %
:HMM:PFM   8->558 PF01411 * tRNA-synt_2c 1.8e-185 45.2 538/551  
:HMM:PFM   656->698 PF07973 * tRNA_SAD 1.5e-22 72.1 43/44  
:HMM:PFM   806->868 PF02272 * DHHA1 7.8e-15 33.3 63/68  
:HMM:PFM   735->761 PF05812 * Herpes_BLRF2 0.00065 37.0 27/118  
:BLT:SWISS 1->872 SYA_STRPS 0.0 99.2 %
:COIL
:SEG

SeqInfo AminoSeq See neighboring genes
Links DAD Abbreviations Back to title page
GT:ID ACF55360.1 GT:GENE alaS GT:PRODUCT alanyl-tRNA synthetase GT:DATABASE GIB00761CH01 GT:ORG spne4 GB:ACCESSION GIB00761CH01 GB:LOCATION complement(1290585..1293203) GB:FROM 1290585 GB:TO 1293203 GB:DIRECTION - GB:GENE alaS GB:PRODUCT alanyl-tRNA synthetase GB:NOTE identified by match to protein family HMM PF01411; match to protein family HMM PF02272; match to protein family HMM PF07973; match to protein family HMM TIGR00344 GB:PROTEIN_ID ACF55360.1 GB:DB_XREF GI:194356912 GB:GENE:GENE alaS LENGTH 872 SQ:AASEQ MKQLSSAQVRQMWLDFWATKGHSVEPSVSLVPVNDPTLLWINSGVATLKKYFDGTIIPENPRITNAQKAIRTNDIENVGKTARHHTMFEMLGNFSIGDYFRDEAITWAYELLTSPEWFDFPAEKLYMTYYPDDKDSYNRWIEVGVDPSHLIPIEDNFWEIGAGPSGPDTEIFFDRGEAFDPENIGLRLLAEDIENDRYIEIWNIVLSQFNADPAVPRSEYKELPHKNIDTGAGLERLVAVIQGAKTNFETDLFMPIIREVEKLSGKVYDQDGDNMSFKVIADHIRSLSFAIGDGALPGNEGRGYVLRRLLRRASMHGQKLGINEPFLYKLVPTVGNIMESYYPEVLEKRDFIEKIVKSEEESFARTLHSGQHFAQGIVADLKEKGQSVIAGQDVFKLYDTYGFPVELTEEIAEEAGMTVDREGFEAAMKEQQERARASAVKGGSMGMQNETLQNITVESVFNYNASQLSSKLVAIVADNAEVGAVSEGTASLIFAETSFYAEMGGQVADYGQILDESGKVVATVTNVQKAPNGQALHTVEVLAPLALNQEYTLAIDSNRRHRVMKNHTATHLLHAALHNILGNHATQAGSLNEVEFLRFDFTHFQAVTAEELRAIEQQVNEKIWEALEVKTVETDIDTAKEMGAMALFGEKYGKEVRVVTIGDYSIELCGGTHVGNTSEIGLFKIVKEEGIGSGTRRILAVTGKEAFEAYREQEDALKAVAATLKAPQVKEVPHKVEGLQEQLRQLQKENAELKEKAAAAAAGDIFKDAKEVNGHRYIASQLSVSDAGALRTFADNWKQKDYSDLLVLVAAIGDKVNVLVASKTKDLHAGNLVKELAPIIDGRGGGKPDMAMAGGRNQAKIQELLDAVAGKL GT:EXON 1|1-872:0| SW:ID SYA_STRPS SW:DE RecName: Full=Alanyl-tRNA synthetase; EC=6.1.1.7;AltName: Full=Alanine--tRNA ligase; Short=AlaRS; SW:GN Name=alaS; OrderedLocusNames=SPCG_1372; SW:KW Aminoacyl-tRNA synthetase; ATP-binding; Complete proteome; Cytoplasm;Ligase; Nucleotide-binding; Protein biosynthesis. SW:EXACT F SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->872|SYA_STRPS|0.0|99.2|872/872| GO:SWS:NREP 6 GO:SWS GO:0004812|"GO:aminoacyl-tRNA ligase activity"|Aminoacyl-tRNA synthetase| GO:SWS GO:0005524|"GO:ATP binding"|ATP-binding| GO:SWS GO:0005737|"GO:cytoplasm"|Cytoplasm| GO:SWS GO:0016874|"GO:ligase activity"|Ligase| GO:SWS GO:0000166|"GO:nucleotide binding"|Nucleotide-binding| GO:SWS GO:0006412|"GO:translation"|Protein biosynthesis| COIL:NAA 30 COIL:NSEG 1 COIL:REGION 734->763| SEG 306->312|lrrllrr| SEG 566->585|nhtathllhaalhnilgnha| SEG 748->762|kenaelkekaaaaaa| BL:PDB:NREP 2 BL:PDB:REP 4->440|1yfrA|e-109|47.7|419/448| BL:PDB:REP 491->698|2e1bA|2e-08|37.9|182/216| RP:PDB:NREP 3 RP:PDB:REP 5->443|2cvsA|6e-62|11.9|429/657| RP:PDB:REP 480->700|2e1bA|2e-32|26.9|193/216| RP:PDB:REP 676->872|3c9iF|9e-13|9.3|194/221| RP:PFM:NREP 3 RP:PFM:REP 8->559|PF01411|e-150|53.2|538/546|tRNA-synt_2c| RP:PFM:REP 656->698|PF07973|4e-11|55.8|43/44|tRNA_SAD| RP:PFM:REP 821->869|PF02272|5e-08|44.9|49/67|DHHA1| HM:PFM:NREP 4 HM:PFM:REP 8->558|PF01411|1.8e-185|45.2|538/551|tRNA-synt_2c| HM:PFM:REP 656->698|PF07973|1.5e-22|72.1|43/44|tRNA_SAD| HM:PFM:REP 806->868|PF02272|7.8e-15|33.3|63/68|DHHA1| HM:PFM:REP 735->761|PF05812|0.00065|37.0|27/118|Herpes_BLRF2| GO:PFM:NREP 12 GO:PFM GO:0000166|"GO:nucleotide binding"|PF01411|IPR018164| GO:PFM GO:0004813|"GO:alanine-tRNA ligase activity"|PF01411|IPR018164| GO:PFM GO:0005524|"GO:ATP binding"|PF01411|IPR018164| GO:PFM GO:0005737|"GO:cytoplasm"|PF01411|IPR018164| GO:PFM GO:0006412|"GO:translation"|PF01411|IPR018164| GO:PFM GO:0006419|"GO:alanyl-tRNA aminoacylation"|PF01411|IPR018164| GO:PFM GO:0005524|"GO:ATP binding"|PF07973|IPR012947| GO:PFM GO:0005737|"GO:cytoplasm"|PF07973|IPR012947| GO:PFM GO:0006412|"GO:translation"|PF07973|IPR012947| GO:PFM GO:0016876|"GO:ligase activity, forming aminoacyl-tRNA and related compounds"|PF07973|IPR012947| GO:PFM GO:0043039|"GO:tRNA aminoacylation"|PF07973|IPR012947| GO:PFM GO:0003676|"GO:nucleic acid binding"|PF02272|IPR003156| RP:SCP:NREP 4 RP:SCP:REP 4->248|1riqA2|e-100|48.9|227/236|d.104.1.1| RP:SCP:REP 249->463|1riqA1|9e-64|43.5|207/212|a.203.1.1| RP:SCP:REP 480->555|2e1bA1|3e-12|27.9|68/87|b.43.3.6| RP:SCP:REP 555->725|1nyqA3|1e-30|19.0|168/179|d.67.1.1| HM:SCP:REP 3->248|1riqA2|3.7e-78|49.1|228/0|d.104.1.1|1/1|Class II aaRS and biotin synthetases| HM:SCP:REP 249->468|1riqA1|1.4e-66|46.6|219/0|a.203.1.1|1/1|Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)| HM:SCP:REP 555->726|1nyrA3|1.8e-53|47.3|169/179|d.67.1.1|1/1|ThrRS/AlaRS common domain| OP:NHOMO 1370 OP:NHOMOORG 1170 OP:PATTERN 11111111111111111111111121112211111111111111111121121111212111111111 2121111111111111111-1111111111111111111111111111111111111111111111112211-111111111111111211111111-111111111111111111111111111111111111111221111111111111111111111111112111111111111111111111111111222221122111111112211111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111112221111111112121111112111111111111121111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111-1111111111111111111111111111111111111111111111111221111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111-111111111111111111111-111111-11111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111-11111111111111111112122222222111 1111241-31111111112-111111111111111111111111111111111111111111112111-3111121111111111111-12111111111111222123133332611221223542223D212232312322422222142223322122222332322322122222I2221222431212223222 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 866 STR:RPRED 99.3 SQ:SECSTR ###cHHHHHHHHHHHHHHTcccEEEEcTTcccTTccccccccccHHHHHHHHHHHHEEEcTTcTTHHHHHTcccccccccccccccEEEccEEEEcHHHHHHHHTTcEEEEccTTTccHHHHHHHHHHHHHTEEEHHHHHHHHHHHHHHHcHHTcTTTTTccccccTTccccccccTTccEEcEEEEEGGGGEEcHHHHHHHHHHHHHHHHHHHHccHHHHHHHHHHcccEEEEEcHHHHHHHTTccTTcHHHHHHHHHHHHHHHHHHHHHcccTTcTTcGGGGTccTGGGGTccccccccHHHHHHHHHHHcccccccccccccTTHHHHTTcccccccccHTTcHccEEcccEEcHHHHHHHHHTTcccHHHHHHHHHTTTccTTTccHHHHHHTccTTcccHHHHHHHHHHHHTTcccEEcccccHHHHHHHHHHHHHHTcccccEEEEEEEEEccGGGGTEEEEEEEEEEEETTEEccccccccc#EccccccccccccTTcccccEEEEETTEETTEEEEEEEccTTcccEEEEccGGGccccccEEEEEcHHHHHHHHHHHHHHHHHHHHHHHHHTTTccEEEccccccEEEEEEEccccGGHGGHHHHHHHHHHHHHHcccEEEEEccccccEEEEEEEEEEEHcTTccEEEEETTccEEcccccccccGGGTccEEEEEEEEEETTEEEEEEHHHHHHHHHHHGGGHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH#HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH#HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccccccccccEEETTEEEEcccccccccccccccccccccTTHHHHHHHHHHHHHH DISOP:02AL 1-4,379-387,431-444| PSIPRED cccccHHHHHHHHHHHHHHcccEEcccccccccccccEEEEEccccccccEEccccccccccccccccccccccHHHccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccHHHcccccHHEEEEEEcccHHHHHHHHHccccHHHEEEccccccccccccccccEEEEEEccccccccccccccccccccccEEEEEEEHHHEEcccccccccccEEEcccccccccccHHHHHHHHccccccHHHHHHHHHHHHHHHHHccccccccccEEEEEEHHHHHHHHHHHHcccccccccccHHHHHHHHHHHHHHHHccccccHHHHHHHHHHHHHHHHcHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccccccHHHEEEEHHcccccHHHHHHHHHHccccccHHHHHHHHHHHHHHHHHcccccccccccHHHHHcccccccccccEEEEEEEEEEEEEccEEEEEEEcccEEEEEcccccccccccccccEEEEEEccccEEEEEEEEEEEcccEEEEEEEEccccccccEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHcccccEEEcccccccEEEEEccccccccHHHHHHHHHHHHHHHHccccEEEEEccHHHHHHHccHHccccccccEEEEEEEccEEEccccccccccHHccccEEEEEEEccccccEEEEEEEcHHHHHHHHHHHHHHHHHHHHHccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccEEEEEEEcccccHHHHHHHHHHHHHHcccEEEEEEEEccccEEEEEEEccccccHHHHHHHHHHHHcccccccHHHHccccccHHHHHHHHHHHHHHc //