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Streptococcus pneumoniae G54 (spne4)
Gene : carB
DDBJ      :carB         carbamoyl-phosphate synthase pyrimidine-specific large chain
Swiss-Prot:CARB_STRP4   RecName: Full=Carbamoyl-phosphate synthase large chain;         EC=6.3.5.5;AltName: Full=Carbamoyl-phosphate synthetase ammonia chain;

Homologs  Archaea  55/68 : Bacteria  821/915 : Eukaryota  191/199 : Viruses  0/175   --->[See Alignment]
a.92.1c.24.1c.30.1d.142.1f.6.1
:1058 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   1->1050 1bxrA PDBj 0.0 49.8 %
:RPS:PDB   1->1051 1c30A PDBj 0.0 47.1 %
:RPS:SCOP  1->127 1a9xA3  c.30.1.1 * 2e-18 63.8 %
:RPS:SCOP  128->400 1a9xA5  d.142.1.2 * 2e-69 56.8 %
:RPS:SCOP  479->683 1lkfA  f.6.1.1 * 3e-44 16.6 %
:RPS:SCOP  670->928 1a9xA6  d.142.1.2 * 3e-58 47.5 %
:RPS:SCOP  926->1049 1b93A  c.24.1.2 * 5e-26 18.5 %
:HMM:SCOP  4->130 1a9xA4 c.30.1.1 * 3e-52 62.0 %
:HMM:SCOP  128->400 1a9xA5 d.142.1.2 * 1.8e-108 55.3 %
:HMM:SCOP  394->548 1a9xA1 a.92.1.1 * 7.7e-56 51.3 %
:HMM:SCOP  548->668 1a9xA4 c.30.1.1 * 2.4e-52 62.8 %
:HMM:SCOP  666->928 1a9xA5 d.142.1.2 * 6.3e-106 56.7 %
:HMM:SCOP  935->1054 1wo8A1 c.24.1.2 * 4.9e-31 36.7 %
:RPS:PFM   6->123 PF00289 * CPSase_L_chain 1e-18 41.5 %
:RPS:PFM   128->332 PF02786 * CPSase_L_D2 4e-38 43.6 %
:RPS:PFM   420->540 PF02787 * CPSase_L_D3 2e-33 57.0 %
:RPS:PFM   550->650 PF00289 * CPSase_L_chain 7e-20 52.9 %
:RPS:PFM   666->865 PF02786 * CPSase_L_D2 1e-30 36.4 %
:RPS:PFM   951->1033 PF02142 * MGS 1e-04 30.1 %
:HMM:PFM   128->333 PF02786 * CPSase_L_D2 5.5e-80 44.1 204/211  
:HMM:PFM   666->867 PF02786 * CPSase_L_D2 4.7e-40 29.0 200/211  
:HMM:PFM   6->123 PF00289 * CPSase_L_chain 4.5e-23 33.3 102/110  
:HMM:PFM   552->659 PF00289 * CPSase_L_chain 4.9e-23 37.2 94/110  
:HMM:PFM   421->540 PF02787 * CPSase_L_D3 1.1e-45 55.8 120/121  
:HMM:PFM   950->1036 PF02142 * MGS 5.6e-19 32.2 87/95  
:BLT:SWISS 1->1058 CARB_STRP4 0.0 100.0 %
:PROS 164->178|PS00866|CPSASE_1
:PROS 702->716|PS00866|CPSASE_1
:PROS 296->303|PS00867|CPSASE_2
:PROS 830->837|PS00867|CPSASE_2
:REPEAT 2|4->527|548->1043
:SEG

SeqInfo AminoSeq See neighboring genes
Links DAD Abbreviations Back to title page
GT:ID ACF56322.1 GT:GENE carB GT:PRODUCT carbamoyl-phosphate synthase pyrimidine-specific large chain GT:DATABASE GIB00761CH01 GT:ORG spne4 GB:ACCESSION GIB00761CH01 GB:LOCATION complement(1142837..1146013) GB:FROM 1142837 GB:TO 1146013 GB:DIRECTION - GB:GENE carB GB:PRODUCT carbamoyl-phosphate synthase pyrimidine-specific large chain GB:NOTE identified by match to protein family HMM PF00289; match to protein family HMM PF01071; match to protein family HMM PF02142; match to protein family HMM PF02222; match to protein family HMM PF02655; match to protein family HMM PF02786; match to protein family HMM PF02787; match to protein family HMM TIGR01369 GB:PROTEIN_ID ACF56322.1 GB:DB_XREF GI:194357874 GB:GENE:GENE carB LENGTH 1058 SQ:AASEQ MPKRTDIQKIMVIGSGPIIIGQAAEFDYAGTQACLSLKEEGYEVVLVNSNPATIMTDKEIADKVYIEPITLEFVTRILRKERPDALLPTLGGQTGLNMAMELSKNGILDELGVELLGTRLSAIDQAEDRDLFKQLMEELEQPIPESEIVNTVEEAIAFAATIGYPVIVRPAFTLGGTGGGMCANEKELREITENGLKLSPVTQCLIERSIAGFKEIEYEVMRDSADNALVVCNMENFDPVGIHTGDSIVFAPAQTMSDYENQMLRDASLSIIRALKIEGGCNVQLALDPNSFKYYVIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLTLDEVINPVTGSTYAMFEPALDYVVAKIPRFPFDKFEKGERRLGTQMKATGEVMAIGRNIEESLLKACRSLEIGVHHNEIPELAAVSDDTLIEKVVKAQDDRLFYVSEAIRRGYTPEEIAELTKIDIFYLDKLLHIFEIEQELGAHPQDLEVLKIAKLNGFSDRKIAELWGTTDDQVRQLRLENKIVPVYKMVDTCAAEFDSETPYFYSTYGWENESIRSDKESVLVLGSGPIRIGQGVEFDYATVHSVKAIQAAGYEAIIMNSNPETVSTDFSVSDKLYFEPLTFEDVMNVIDLEQPKGVIVQFGGQTAINLAEPLAKAGVTILGTQVADLDRAEDRDLFEQALKELDIPQPPGQTATNEEEAALAARKIGFPVLVRPSYVLGGRAMEIVENEEDLRSYMRTAVKASPDHPVLVDSYIVGQECEVDAISDGKNVLIPGIMEHIERAGVHSGDSMAVYPPQTLSQKVQETIADYTKRLAIGLHCLGMMNIQFVIKDEKVYVIEVNPRASRTVPFLSKVTNIPMAQVATKLILGQSLSELGYQNGLYPESTRVHIKAPVFSFTKLAKVDSLLGPEMKSTGEVMGSDATLEKALYKAFEASYLHLPTFGNVVFTIADDAKEEALNLARRFQNIGYGILATEGTAAFFASHGLQAQPVGKIGDDDKDIPSFVRKGRIQAIINTVGTKRTADEDGEQIRRSAIEHGVPLFTALDTANAMLKVLESRSFVTEAI GT:EXON 1|1-1058:0| SW:ID CARB_STRP4 SW:DE RecName: Full=Carbamoyl-phosphate synthase large chain; EC=6.3.5.5;AltName: Full=Carbamoyl-phosphate synthetase ammonia chain; SW:GN Name=carB; OrderedLocusNames=SPG_1169; SW:KW Amino-acid biosynthesis; Arginine biosynthesis; ATP-binding;Complete proteome; Ligase; Magnesium; Manganese; Metal-binding;Nucleotide-binding; Pyrimidine biosynthesis; Repeat. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->1058|CARB_STRP4|0.0|100.0|1058/1058| GO:SWS:NREP 7 GO:SWS GO:0008652|"GO:cellular amino acid biosynthetic process"|Amino-acid biosynthesis| GO:SWS GO:0006526|"GO:arginine biosynthetic process"|Arginine biosynthesis| GO:SWS GO:0005524|"GO:ATP binding"|ATP-binding| GO:SWS GO:0016874|"GO:ligase activity"|Ligase| GO:SWS GO:0046872|"GO:metal ion binding"|Metal-binding| GO:SWS GO:0000166|"GO:nucleotide binding"|Nucleotide-binding| GO:SWS GO:0006221|"GO:pyrimidine nucleotide biosynthetic process"|Pyrimidine biosynthesis| PROS 164->178|PS00866|CPSASE_1|PDOC00676| PROS 702->716|PS00866|CPSASE_1|PDOC00676| PROS 296->303|PS00867|CPSASE_2|PDOC00676| PROS 830->837|PS00867|CPSASE_2|PDOC00676| NREPEAT 1 REPEAT 2|4->527|548->1043| SEG 690->697|eeeaalaa| BL:PDB:NREP 1 BL:PDB:REP 1->1050|1bxrA|0.0|49.8|1046/1073| RP:PDB:NREP 1 RP:PDB:REP 1->1051|1c30A|0.0|47.1|1034/1058| RP:PFM:NREP 6 RP:PFM:REP 6->123|PF00289|1e-18|41.5|102/102|CPSase_L_chain| RP:PFM:REP 128->332|PF02786|4e-38|43.6|202/207|CPSase_L_D2| RP:PFM:REP 420->540|PF02787|2e-33|57.0|121/123|CPSase_L_D3| RP:PFM:REP 550->650|PF00289|7e-20|52.9|87/102|CPSase_L_chain| RP:PFM:REP 666->865|PF02786|1e-30|36.4|198/207|CPSase_L_D2| RP:PFM:REP 951->1033|PF02142|1e-04|30.1|83/95|MGS| HM:PFM:NREP 6 HM:PFM:REP 128->333|PF02786|5.5e-80|44.1|204/211|CPSase_L_D2| HM:PFM:REP 666->867|PF02786|4.7e-40|29.0|200/211|CPSase_L_D2| HM:PFM:REP 6->123|PF00289|4.5e-23|33.3|102/110|CPSase_L_chain| HM:PFM:REP 552->659|PF00289|4.9e-23|37.2|94/110|CPSase_L_chain| HM:PFM:REP 421->540|PF02787|1.1e-45|55.8|120/121|CPSase_L_D3| HM:PFM:REP 950->1036|PF02142|5.6e-19|32.2|87/95|MGS| GO:PFM:NREP 12 GO:PFM GO:0003824|"GO:catalytic activity"|PF00289|IPR005481| GO:PFM GO:0008152|"GO:metabolic process"|PF00289|IPR005481| GO:PFM GO:0003824|"GO:catalytic activity"|PF02786|IPR005479| GO:PFM GO:0005524|"GO:ATP binding"|PF02786|IPR005479| GO:PFM GO:0008152|"GO:metabolic process"|PF02786|IPR005479| GO:PFM GO:0004086|"GO:carbamoyl-phosphate synthase activity"|PF02787|IPR005480| GO:PFM GO:0006807|"GO:nitrogen compound metabolic process"|PF02787|IPR005480| GO:PFM GO:0003824|"GO:catalytic activity"|PF00289|IPR005481| GO:PFM GO:0008152|"GO:metabolic process"|PF00289|IPR005481| GO:PFM GO:0003824|"GO:catalytic activity"|PF02786|IPR005479| GO:PFM GO:0005524|"GO:ATP binding"|PF02786|IPR005479| GO:PFM GO:0008152|"GO:metabolic process"|PF02786|IPR005479| RP:SCP:NREP 5 RP:SCP:REP 1->127|1a9xA3|2e-18|63.8|127/127|c.30.1.1| RP:SCP:REP 128->400|1a9xA5|2e-69|56.8|273/275|d.142.1.2| RP:SCP:REP 479->683|1lkfA|3e-44|16.6|175/292|f.6.1.1| RP:SCP:REP 670->928|1a9xA6|3e-58|47.5|242/244|d.142.1.2| RP:SCP:REP 926->1049|1b93A|5e-26|18.5|124/148|c.24.1.2| HM:SCP:REP 4->130|1a9xA4|3e-52|62.0|121/0|c.30.1.1|1/2|PreATP-grasp domain| HM:SCP:REP 128->400|1a9xA5|1.8e-108|55.3|273/0|d.142.1.2|1/2|Glutathione synthetase ATP-binding domain-like| HM:SCP:REP 394->548|1a9xA1|7.7e-56|51.3|150/153|a.92.1.1|1/1|Carbamoyl phosphate synthetase, large subunit connection domain| HM:SCP:REP 548->668|1a9xA4|2.4e-52|62.8|121/0|c.30.1.1|2/2|PreATP-grasp domain| HM:SCP:REP 666->928|1a9xA5|6.3e-106|56.7|263/0|d.142.1.2|2/2|Glutathione synthetase ATP-binding domain-like| HM:SCP:REP 935->1054|1wo8A1|4.9e-31|36.7|120/0|c.24.1.2|1/1|Methylglyoxal synthase-like| OP:NHOMO 1792 OP:NHOMOORG 1067 OP:PATTERN ---1-21111111111-1111111111111112222231111211232121113-1-----111--32 1131211111112211111-11111111111121111111132212222221212221331111211111311111111-1215323422221211-1121114111212---------------22222223222111222221111121111111111111111111112111211121111111111124322222222322222243443322244415332222223212222222222222221123321123232324322221142311233331111111111111111111111111111111111112111123-21---111-2-2343322222-2-12112133143211211112-11111211121111131111112221133233333333-22222111221133332343242211221232212222121222222111111111112111111---------------1111111111112211111111111111111111111111111121112211111112111112211112111111111111312111111111111111211112212112231111111111111111111222211111211211111211111111111112211111-112211111111211111111111111-11111111111111111111111122111111111111111112111111111111111111111111111111222212221---1-11----1--111211111111211112222222221222111111111111211111112111111111111111111121111122----------1---------------------------1--11111132 13--114-311-1123244333232332222322222222322222332222423223222222222323333223214223333232-3322324222232-443-323B3422442222222532519T3-5321222212211221222122423249A13211211A21712111K1111121442123263223 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 1058 STR:RPRED 100.0 SQ:SECSTR ccccccccEEEEEccccccTTccTHHHHHHHHHHHHHHHTTcEEEEEccccccGGGcGGGccEEEcccccHHHHHHHHHHHcccEEEccccHHHHHHHHHHHHHTTHHHHTTcEEccccHHHHHHHHcHHHHHHHHHHTTcccccEEEEccHHHHHHHHHHHcccEEEEETTccTTTTcEEEccHHHHHHHHHHHHHHcTTccEEEEEccTTcEEEEEEEEEcTTccEEEEEEEEEcccTTccGGGccEEEccccccHHHHHHHHHHHHHHHHHHTcccEEEEEEEEcTTTccEEEEEEEccccHHHHHHHHHHcccHHHHHHHHTTTccGGGcccGGGTccccccccccccEEEEEEEccGGGcTTccccccccccccEEEEEEEccHHHHHHHHHHHcccccccccccTTcTTHHHHHHHHHHcccTTHHHHHHHHHHHTccHHHHHHHHcccHHHHHHHHHHHHHHHHHHHHTGcHHHHHHHHHTTccHHHHHHHHTccHHHHHHHHHHTTcccEEEEccccTTcccccccEEEEEccccccccccccccEEEEccccccTTccHHHHHHHHHHHHHHHHTTcEEEEEcccTTccTTcGGGccEEEcccccHHHHHHHHHHHcccEEEcccccHHHHHHHHHHHHTTcccccccHHHHHHHHcHHHHHHHHHHHTcccccccccccHHHHHHHHHHHcccEEccccccEEccHHHHHHHHHHHHHHHHHHHHHcHHccccccccTTcEEEEEEEEEccccEEEEEEEEEEEETTccGGGccEEEccccccHHHHHHHHHHHHHHHHHHTccEEEEEEEEEETTEEEEEEEEccccTTHHHHHHHHcccHHHHHHHHHHTccHHHHTcccccccccccEEEEEEEcGGGGcTTccccccccccccEEEEEEEccHHHHHHHHHHHTTcccccccEEEEEccGGGHHHHHHHHHHHHHHTcEEEEcHHHHHHHHHTTcccEEcccTTTccccHHHHHHTTcccEEEEcccccHHHHHHHHHHHHHHHHTTcEEEccHHHHHHHHHHTTccccEEEEE DISOP:02AL 1-4,1055-1056,1058-1059| PSIPRED ccccccccEEEEEccccccccHHHHHHHHHHHHHHHHHHcccEEEEEcccHHHccccHHHccEEEEEcccHHHHHHHHHHHcccEEEEEEcccccccccHHHHHHHHHHHcccEEEcccHHHHHHHccHHHHHHHHHHcccccccccccccHHHHHHHHHHccccEEEEEccccccccEEEEccHHHHHHHHHHHHHHccccEEEEEEEccccEEEEEEEEEEccccEEEEccHHHcccccccccccEEEEccccccHHHHHHHHHHHHHHHHHHcccEEEEEEEEEEcccccEEEEEEcccccccHHHHHHHHcccHHHHHHHHHccccHHHcccccccccccccccccccEEEEcccccccccccccccccccccccEEEEEEEccHHHHHHHHHHHHHccccccccHHHHcccHHHHHHHHccccccHHHHHHHHHHccccHHHHHHHHcccHHHHHHHHHHHHHHHHHHHccccHHHHHHHHHccccHHHHHHHHcccHHHHHHHHHHccccEEEEEEcccccccccccccEEEEEccccccccccccEEEEEccccccccccHHHHHHHHHHHHHHHHcccEEEEEEcccccccccHHHccEEEEEcccHHHHHHHHHHHcccEEEEEcccccHHHHHHHHHHcccEEEEccHHHHHHcccHHHHHHHHHHcccccccccccccHHHHHHHHHHccccEEEEEccccccccEEEEccHHHHHHHHHHHHHHcccccEEEEEEcccEEEEEEEEEEcccEEEEEccccccccccccccEEEEEccccccHHHHHHHHHHHHHHHHHcccEEEEEEEEEEEccEEEEEEEEcccccHHHHHHHHHccHHHHHHHHHHcccccccccccccccccccEEEEEccccccccccccccccccccccccccccccccHHHHHHHHcccccccccccEEEEEEEccccHHHHHHHHHHHHHcccEEEEEHHHHHHHHHcccEEEEEEccccccHHHHHHHHcccEEEEEEccccccccccccHHHHHHHHHccccEEEcHHHHHHHHHHHHHcccccccc //