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Streptococcus pneumoniae G54 (spne4)
Gene : ddlA
DDBJ      :ddlA         D-alanine--D-alanine ligase
Swiss-Prot:DDL_STRP4    RecName: Full=D-alanine--D-alanine ligase;         EC=6.3.2.4;AltName: Full=D-alanylalanine synthetase;AltName: Full=D-Ala-D-Ala ligase;

Homologs  Archaea  3/68 : Bacteria  869/915 : Eukaryota  22/199 : Viruses  0/175   --->[See Alignment]
c.30.1d.142.1
:347 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   2->343 2i80B PDBj 6e-83 45.6 %
:RPS:PDB   2->343 3e5nA PDBj 2e-46 37.1 %
:RPS:SCOP  2->124 1ehiA1  c.30.1.2 * 4e-34 30.1 %
:RPS:SCOP  126->337 1e4eA2  d.142.1.1 * 3e-60 36.8 %
:HMM:SCOP  1->125 1e4eA1 c.30.1.2 * 5.1e-33 37.6 %
:HMM:SCOP  126->346 1ehiA2 d.142.1.1 * 2.2e-56 38.5 %
:RPS:PFM   5->115 PF01820 * Dala_Dala_lig_N 3e-18 49.0 %
:RPS:PFM   133->333 PF07478 * Dala_Dala_lig_C 1e-55 53.3 %
:HMM:PFM   133->332 PF07478 * Dala_Dala_lig_C 1.1e-73 45.5 200/203  
:HMM:PFM   4->116 PF01820 * Dala_Dala_lig_N 4e-31 36.3 113/117  
:BLT:SWISS 1->347 DDL_STRP4 0.0 100.0 %
:PROS 93->104|PS00843|DALA_DALA_LIGASE_1
:PROS 278->306|PS00844|DALA_DALA_LIGASE_2

SeqInfo AminoSeq See neighboring genes
Links DAD Abbreviations Back to title page
GT:ID ACF55674.1 GT:GENE ddlA GT:PRODUCT D-alanine--D-alanine ligase GT:DATABASE GIB00761CH01 GT:ORG spne4 GB:ACCESSION GIB00761CH01 GB:LOCATION complement(1521376..1522419) GB:FROM 1521376 GB:TO 1522419 GB:DIRECTION - GB:GENE ddlA GB:PRODUCT D-alanine--D-alanine ligase GB:NOTE identified by match to protein family HMM PF01820; match to protein family HMM PF02222; match to protein family HMM PF07478; match to protein family HMM TIGR01205 GB:PROTEIN_ID ACF55674.1 GB:DB_XREF GI:194357226 GB:GENE:GENE ddlA LENGTH 347 SQ:AASEQ MKQTIILLYGGRSAEREVSVLSAESVMRAVNYDRFTVKTFFISQSGDFIKTQEFSHAPGQEDRLMTNETIDWDKKVAPSAIYEEGAVVFPVLHGPMGEDGSVQGFLEVLKMPYVGCNILSSSLAMDKITTKRVLESAGIAQVPYVAIVEGDDVTAKIAEVEEKLAYPVFTKPSNMGSSVGISKSENQEELRQALKLAFRYDSRVLVEQGVNAREIEVGLLGNYDVKSTLPGEVVKDVAFYDYDAKYIDNKITMDIPAKISDDVVAVMRQNAETAFRAIGGLGLSRCDFFYTDKGEIFLNELNTMPGFTQWSMYPLLWDNMGISYPELIERLVDLAKESFDKREAHLI GT:EXON 1|1-347:0| SW:ID DDL_STRP4 SW:DE RecName: Full=D-alanine--D-alanine ligase; EC=6.3.2.4;AltName: Full=D-alanylalanine synthetase;AltName: Full=D-Ala-D-Ala ligase; SW:GN Name=ddl; OrderedLocusNames=SPG_1580; SW:KW ATP-binding; Cell shape; Cell wall biogenesis/degradation;Complete proteome; Cytoplasm; Ligase; Magnesium; Manganese;Metal-binding; Nucleotide-binding; Peptidoglycan synthesis. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->347|DDL_STRP4|0.0|100.0|347/347| GO:SWS:NREP 8 GO:SWS GO:0005524|"GO:ATP binding"|ATP-binding| GO:SWS GO:0008360|"GO:regulation of cell shape"|Cell shape| GO:SWS GO:0007047|"GO:cellular cell wall organization"|Cell wall biogenesis/degradation| GO:SWS GO:0005737|"GO:cytoplasm"|Cytoplasm| GO:SWS GO:0016874|"GO:ligase activity"|Ligase| GO:SWS GO:0046872|"GO:metal ion binding"|Metal-binding| GO:SWS GO:0000166|"GO:nucleotide binding"|Nucleotide-binding| GO:SWS GO:0009252|"GO:peptidoglycan biosynthetic process"|Peptidoglycan synthesis| PROS 93->104|PS00843|DALA_DALA_LIGASE_1|PDOC00659| PROS 278->306|PS00844|DALA_DALA_LIGASE_2|PDOC00659| BL:PDB:NREP 1 BL:PDB:REP 2->343|2i80B|6e-83|45.6|331/347| RP:PDB:NREP 1 RP:PDB:REP 2->343|3e5nA|2e-46|37.1|326/340| RP:PFM:NREP 2 RP:PFM:REP 5->115|PF01820|3e-18|49.0|102/108|Dala_Dala_lig_N| RP:PFM:REP 133->333|PF07478|1e-55|53.3|199/199|Dala_Dala_lig_C| HM:PFM:NREP 2 HM:PFM:REP 133->332|PF07478|1.1e-73|45.5|200/203|Dala_Dala_lig_C| HM:PFM:REP 4->116|PF01820|4e-31|36.3|113/117|Dala_Dala_lig_N| GO:PFM:NREP 5 GO:PFM GO:0005618|"GO:cell wall"|PF01820|IPR011127| GO:PFM GO:0008716|"GO:D-alanine-D-alanine ligase activity"|PF01820|IPR011127| GO:PFM GO:0009252|"GO:peptidoglycan biosynthetic process"|PF01820|IPR011127| GO:PFM GO:0008716|"GO:D-alanine-D-alanine ligase activity"|PF07478|IPR011095| GO:PFM GO:0009252|"GO:peptidoglycan biosynthetic process"|PF07478|IPR011095| RP:SCP:NREP 2 RP:SCP:REP 2->124|1ehiA1|4e-34|30.1|123/132|c.30.1.2| RP:SCP:REP 126->337|1e4eA2|3e-60|36.8|204/211|d.142.1.1| HM:SCP:REP 1->125|1e4eA1|5.1e-33|37.6|125/0|c.30.1.2|1/1|PreATP-grasp domain| HM:SCP:REP 126->346|1ehiA2|2.2e-56|38.5|221/228|d.142.1.1|1/1|Glutathione synthetase ATP-binding domain-like| OP:NHOMO 1127 OP:NHOMOORG 894 OP:PATTERN ----------------------------------------------1-----1--------------1 121-311111131111111-11111111111111111111221312112331111111112232222121211111112221211211111111112--1111111111111111111111111111111111121111111111112111111111111111111111111111111111111111111111111323222122222211111122211121111111113311111111111111111111211111111111111111111111111111111111111111211111111111111111112111111114211111111111112111221321111121122111111112221111111211111111115221111111133333333332-111112111211222122222311112111131111111111111111111111111--------111111111111111111111111111111111111111111112111111211111111111111111111111111111211111111111111111211121111111111111111222233221111111111111111111111111111111111111212111111111111111111-1111111----22112212222222222-2222222222222122222222111112221222222222212222222221121111111111111111111111111121111111111111111111111111111122221212121331222111-111111111211111111112212222222111111112211111111111111--------------------------1212213112121 ----1-------11---------1-1--------------------------------1111---------------------------------1-------------------------------------------------------------------111-------1----1------3122-31------1 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 343 STR:RPRED 98.8 SQ:SECSTR ccEEEEEEEEcccTTHHHHHHHHHHHHHHccTTTEEEEEEEEcTTccEEEEcGGGcEEcTTcTTTcEEccccccEEEcTTcccccEEEEEEEccHHHHccHHHHHHHHTTcccccccHHHHHHHHcHHHHHHHHHHTTcccccEEEEEHHHHTTccHHHHHHHHcccEEEEEccccccTTcEEEccGGGHHHHHHHHTTTccEEEEEEccccEEEEEEEEcccccEEEEEEEEEcTTccccHHHHTEcccEEEEccccccHHHHHHHHHHHHHHHHHHTcccEEEEEEEEcTTccEEEEEEEccccccTTcHHHHHHHTTTccHHHHHHHHHHHHHHHHHHHH#### DISOP:02AL 1-1| PSIPRED ccEEEEEEEccccHHHHHHHHHHHHHHHHHHHcccEEEEEEEccccHHHHHHHHccccccccccccHHHHHHHHHHHHHHHcccccEEEEcccccccccHHHHHHHHHccccEEcccHHHHHHHccHHHHHHHHHHcccccccccEEccccccHHHHHHHHHHccccEEEEEccccccEEEEEEccHHHHHHHHHHHHHHccEEEEEEccccEEEEEEEEEcccccEEEEEEEcccccccccccEEEcccEEEEEcccccHHHHHHHHHHHHHHHHHHccEEEEEEEEEEcccccEEEEEEccccccccccHHHHHHHHHcccHHHHHHHHHHHHHHHHHHHHHHcc //