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Streptococcus pneumoniae G54 (spne4)
Gene : fhs
DDBJ      :fhs          formate--tetrahydrofolate ligase
Swiss-Prot:FTHS_STRP4   RecName: Full=Formate--tetrahydrofolate ligase;         EC=6.3.4.3;AltName: Full=Formyltetrahydrofolate synthetase;         Short=FHS;         Short=FTHFS;

Homologs  Archaea  7/68 : Bacteria  350/915 : Eukaryota  187/199 : Viruses  0/175   --->[See Alignment]
c.37.1
:556 amino acids
:SECSTR
:PSIPRED
:BLT:PDB   4->554 1fp7A PDBj 0.0 61.9 %
:RPS:PDB   4->554 1eg7A PDBj 2e-82 59.1 %
:RPS:SCOP  4->554 1eg7A  c.37.1.10 * 3e-77 59.1 %
:HMM:SCOP  4->554 1eg7A_ c.37.1.10 * 7.3e-251 64.8 %
:RPS:PFM   3->556 PF01268 * FTHFS 0.0 65.1 %
:HMM:PFM   1->556 PF01268 * FTHFS 2.9e-269 61.1 555/555  
:BLT:SWISS 1->556 FTHS_STRP4 0.0 100.0 %
:PROS 103->113|PS00721|FTHFS_1
:PROS 328->339|PS00722|FTHFS_2
:SEG

SeqInfo AminoSeq See neighboring genes
Links DAD Abbreviations Back to title page
GT:ID ACF55434.1 GT:GENE fhs GT:PRODUCT formate--tetrahydrofolate ligase GT:DATABASE GIB00761CH01 GT:ORG spne4 GB:ACCESSION GIB00761CH01 GB:LOCATION complement(1097966..1099636) GB:FROM 1097966 GB:TO 1099636 GB:DIRECTION - GB:GENE fhs GB:PRODUCT formate--tetrahydrofolate ligase GB:NOTE identified by match to protein family HMM PF01268 GB:PROTEIN_ID ACF55434.1 GB:DB_XREF GI:194356986 GB:GENE:GENE fhs LENGTH 556 SQ:AASEQ MKTDIEIAQSIELKPIVDVVEKLGISYDDLELYGKYKAKLSFDKIRAVESNPVGKLILVTAINPTPAGEGKSTLTIGLADALNKIGKKTMIAIREPSLGPVMGIKGGAAGGGYAQVLPMEDINLHFTGDMHAITTANNALSALIDNHLHQGNELGIDQRRILWKRVVDLNDRALRHVTVGLGGPLNGIPREDGFDITVASEIMAILCLATDIEDLKRRLANIVIGYRYDRTPVSVGDLQVEGALALILKDAIKPNLVQTIYGTPAFVHGGPFANIAHGCNSVLATTTALHLADYTVTEAGFGADLGAEKFLDIKTPNLPTSPDAVVIVATLRALKMNGGVAKDALTEENVEAVRAGFANLKRHVENIRKFGIPAVVAINEFVSDTEAEIAALKELCALIDVPVELASVWADGVEGGVELAETVVKTIAENPANYKRLYDNDLSVQEKIEKIVTEIYRGSKVNFEKKAQTQIAQVVQNGWDKLPICMAKTQYSFSDNPNALGAPENFEITIRELVPKLGAGFIVALTGDVMTMPGLPKRPAALNMDVESDGTVLGLF GT:EXON 1|1-556:0| SW:ID FTHS_STRP4 SW:DE RecName: Full=Formate--tetrahydrofolate ligase; EC=6.3.4.3;AltName: Full=Formyltetrahydrofolate synthetase; Short=FHS; Short=FTHFS; SW:GN Name=fhs; OrderedLocusNames=SPG_1120; SW:KW ATP-binding; Complete proteome; Ligase; Nucleotide-binding;One-carbon metabolism. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->556|FTHS_STRP4|0.0|100.0|556/556| GO:SWS:NREP 4 GO:SWS GO:0005524|"GO:ATP binding"|ATP-binding| GO:SWS GO:0016874|"GO:ligase activity"|Ligase| GO:SWS GO:0000166|"GO:nucleotide binding"|Nucleotide-binding| GO:SWS GO:0006730|"GO:one-carbon metabolic process"|One-carbon metabolism| PROS 103->113|PS00721|FTHFS_1|PDOC00595| PROS 328->339|PS00722|FTHFS_2|PDOC00595| SEG 106->112|ggaaggg| BL:PDB:NREP 1 BL:PDB:REP 4->554|1fp7A|0.0|61.9|549/549| RP:PDB:NREP 1 RP:PDB:REP 4->554|1eg7A|2e-82|59.1|548/549| RP:PFM:NREP 1 RP:PFM:REP 3->556|PF01268|0.0|65.1|553/553|FTHFS| HM:PFM:NREP 1 HM:PFM:REP 1->556|PF01268|2.9e-269|61.1|555/555|FTHFS| GO:PFM:NREP 3 GO:PFM GO:0004329|"GO:formate-tetrahydrofolate ligase activity"|PF01268|IPR000559| GO:PFM GO:0005524|"GO:ATP binding"|PF01268|IPR000559| GO:PFM GO:0009396|"GO:folic acid and derivative biosynthetic process"|PF01268|IPR000559| RP:SCP:NREP 1 RP:SCP:REP 4->554|1eg7A|3e-77|59.1|548/549|c.37.1.10| HM:SCP:REP 4->554|1eg7A_|7.3e-251|64.8|549/0|c.37.1.10|1/1|P-loop containing nucleoside triphosphate hydrolases| OP:NHOMO 757 OP:NHOMOORG 544 OP:PATTERN ------------------------1---1-1--------------1---------------111---- 1----11----111--------------------------------11----111--1----11--1----111111111123-----1111-111----1-----------------------------------1111111211----------------------------------------1-111-1-111111111111111--111-111---2-111111111-1111111111111111111212111111121111111111111111111211121111111111111222222222222221111111111211111111111111111111111111111122211111111111111111------1--111-----------------------1111111111--1--11111111111-111121111112--------1---1--------------------------------1----1---------------------------------------1-------------1-1-11111111-------1111-1-1-----1-------------1-11-11------------------------11---------11111--111111111111-----------------1---------------------------------------1--------------------------1------------------------1----111---1-----------------1-----------------------------11111111111121-----------------1--------------1-1------------------1---1111111111111111 ----111-21--1111111111111111111111111111-111111111111111111111222222122121222-3222222122-12111111111111212-12223334332222222542836R6-5232222322322222222242223313311143411332111111H1111111521211112113 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 553 STR:RPRED 99.5 SQ:SECSTR ##EcccTTcccccccHHHHHHTTTccGGGEEEcccccEEEcTHHHHHHTTccccEEEEEEEccccTTcccHHHHHHHHHHHHHHTTccEEEEEcccccTHHHHTTccccEETTEEEEcHHHHHTTTTcHHHHHHHHHHHHHHHHHHHHHTTcTTcccGGGccccEEEccccGGGccEEEccccTTccccEEEcEEEGGGcHHHHHHHHcccHHHHHHHHHTcEEEEcTTccEEETGGGTcHHHHHHHTTTTTccEEEEETTccEEEEccccccccccccccHHHHHHHHHHccEEEEEccccTTTHHHHHHHTHHHHHTccccEEEEEEcHHHHHHTTTccGGGTTcccHHHHHHHHHHHHHHHHHHHTTTccEEEEEEccTTccHHHHHHHHHHTTTcEEEEccTTTGGGGGHGcHHHHHHHHHHHHHccccccccccTTccHHHHHHHHHHHTTcccEEEEcHHHHHHHHHHHHTTcTTccEEEEccTTcccccTTccccccccEEEEcccEEETTTEEEEEcccTTccccccccccGGGTcEEccccEEccc# PSIPRED cccHHHHHHHcccccHHHHHHHccccHHHcccccccEEEEcHHHHHHHccccccEEEEEEEccccccccccHHHHHHHHHHHHHcccEEEEEEEcccccccccccccccccccEEEEcHHHccccccccHHHHHHHHHHHHHHHHHHHHccccccccccEEEEEEEcccccHHHcccccccccccccEEEcccEEEEHHHHHHHHHHHHccHHHHHHHHHcEEEEEEcccccEEEEEcccHHHHHHHHHHHccccEEEEEcccEEEEEccccHHHHccccHHHHHHHHHHHccEEEEcccccccccccEEEEEEcccccccccEEEEEEccHHHHHcccccHHHHccccHHHHHHHHHHHHHHHHHHHHccccEEEEEEccccccHHHHHHHHHHHHHccccEEEEEHHHHcccHHHHHHHHHHHHHHccccccEEcccccccHHHHHHHHHHHHcccccEEEcHHHHHHHHHHHHcccccccEEEEEccccccccHHHHccccccEEEEEEEEEEccccEEEEEEccccccccccccccHHccEEccccEEEEcc //