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Streptococcus pneumoniae G54 (spne4)
Gene : metM
DDBJ      :metM         homoserine dehydrogenase
Swiss-Prot:             

Homologs  Archaea  60/68 : Bacteria  763/915 : Eukaryota  113/199 : Viruses  0/175   --->[See Alignment]
c.2.1d.58.18d.58.3d.81.1
:428 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   3->318 3do5A PDBj 4e-41 40.6 %
:RPS:PDB   65->414 3c1nD PDBj 8e-34 14.3 %
:RPS:SCOP  57->185 1t1eA2  d.58.3.2 * 2e-21 9.5 %
:HMM:SCOP  2->159 1ebfA1 c.2.1.3 * 4.1e-34 40.0 %
:HMM:SCOP  138->303 1ebfA2 d.81.1.2 * 2.1e-53 48.2 %
:HMM:SCOP  348->416 2pc6A2 d.58.18.6 * 1.9e-06 18.8 %
:RPS:PFM   9->130 PF03447 * NAD_binding_3 2e-14 45.3 %
:RPS:PFM   138->316 PF00742 * Homoserine_dh 2e-51 52.0 %
:HMM:PFM   138->316 PF00742 * Homoserine_dh 4.1e-66 46.4 179/179  
:HMM:PFM   9->130 PF03447 * NAD_binding_3 3.2e-23 33.9 115/117  
:HMM:PFM   350->414 PF01842 * ACT 3.3e-08 21.9 64/66  
:BLT:SWISS 1->428 DHOM_LACLC e-160 64.0 %
:PROS 184->206|PS01042|HOMOSER_DHGENASE

SeqInfo AminoSeq See neighboring genes
Links DAD Abbreviations Back to title page
GT:ID ACF55841.1 GT:GENE metM GT:PRODUCT homoserine dehydrogenase GT:DATABASE GIB00761CH01 GT:ORG spne4 GB:ACCESSION GIB00761CH01 GB:LOCATION complement(1267358..1268644) GB:FROM 1267358 GB:TO 1268644 GB:DIRECTION - GB:GENE metM GB:PRODUCT homoserine dehydrogenase GB:NOTE thrA; identified by match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447 GB:PROTEIN_ID ACF55841.1 GB:DB_XREF GI:194357393 GB:GENE:GENE metM LENGTH 428 SQ:AASEQ MTVKIALLGFGTVASGVPFLLKENGGKINQSAHSDIKVAKVLVKDEDEKNRLLAAGNDFNFVTNVDDILSDQDITIVVELMGRIEPAKTFITRALEAGKHVVTANKDLLAVHGAELLEIAQANKVALYYEAAVAGGIPILRTLANSLASDKITRVLGVVNGTSNFMVTKMVEEGWSYDDALAEAQRLGFAESDPTNDVDGIDAAYKMVILSQFAFGMKIAFDDVAHKGIRNITPEDVAVAQEFGYVVKLVGSIEETSSGIAAEVTPTFLPKAHPLASVNGVMNAVFVESIGIGESMYYGPGAGQKPTATSVVADIVRIVRRLNDGTIGKDFNEYSRDLVLANPEDVKANYYFSILAPDSKGQVLKLAEIFNAQDISFKQILQDGKEGDKARVVIITHKINKAQLENVSAELKKVSEFDLLNTFKVLGE GT:EXON 1|1-428:0| BL:SWS:NREP 1 BL:SWS:REP 1->428|DHOM_LACLC|e-160|64.0|428/428| PROS 184->206|PS01042|HOMOSER_DHGENASE|PDOC00800| BL:PDB:NREP 1 BL:PDB:REP 3->318|3do5A|4e-41|40.6|293/311| RP:PDB:NREP 1 RP:PDB:REP 65->414|3c1nD|8e-34|14.3|343/452| RP:PFM:NREP 2 RP:PFM:REP 9->130|PF03447|2e-14|45.3|117/122|NAD_binding_3| RP:PFM:REP 138->316|PF00742|2e-51|52.0|179/179|Homoserine_dh| HM:PFM:NREP 3 HM:PFM:REP 138->316|PF00742|4.1e-66|46.4|179/179|Homoserine_dh| HM:PFM:REP 9->130|PF03447|3.2e-23|33.9|115/117|NAD_binding_3| HM:PFM:REP 350->414|PF01842|3.3e-08|21.9|64/66|ACT| GO:PFM:NREP 3 GO:PFM GO:0016491|"GO:oxidoreductase activity"|PF03447|IPR005106| GO:PFM GO:0050661|"GO:NADP or NADPH binding"|PF03447|IPR005106| GO:PFM GO:0006520|"GO:cellular amino acid metabolic process"|PF00742|IPR001342| RP:SCP:NREP 1 RP:SCP:REP 57->185|1t1eA2|2e-21|9.5|126/179|d.58.3.2| HM:SCP:REP 2->159|1ebfA1|4.1e-34|40.0|155/169|c.2.1.3|1/1|NAD(P)-binding Rossmann-fold domains| HM:SCP:REP 138->303|1ebfA2|2.1e-53|48.2|164/190|d.81.1.2|1/1|Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain| HM:SCP:REP 348->416|2pc6A2|1.9e-06|18.8|69/0|d.58.18.6|1/1|ACT-like| OP:NHOMO 1139 OP:NHOMOORG 936 OP:PATTERN ------1111111111-111111111111111112111111111111111111111111111111-11 1221111111111111111-11111111111111111111111111111111112111111111112121111111111111111111--1-11----1-1212221122---------------11111111111222221111111111111111111111111111111111111111111111111221133333333233333333111133311211--111111411111111111111111111111-111121--22--11-1-111111111111111111111111-11-------------111111111111111222222212112221---122-11211122111111112221--12111111-11-1111111111111111111111111-1111111111111111112212111111211111111111111111111111111-----------------------------11111111111211122211111111111111111111111111112221121211111211111111111111111-1111111111111-111111111211221111111111111111111111111111112221111-1211111111211111121221-1-111111111111111111111111111-1111111111111111111111111211111111111111111111111111-111111111111111----------111111-11-1-111-1111222222111111111112122212111111--1-11--122222222222222122212211111111111111111--------------------------------------1--1-111111 ------1-21--111-11-11111121111111111111111111111111131111111111-1111111-11-111111---1111--11111-1111-11112-13------------------------------------------------------1---------1-1122Q2221234521432412112 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 415 STR:RPRED 97.0 SQ:SECSTR #cEEEEEEcccHHHHHHHHHHHHTGGGGGGGTEEEEEEEEEcccTTccccccGGTTTcccHHHHHHHHHHHHHHHHHHHHHHccccHHHHHHHHHHHHHHHHHHHHHHHHHTTccEEEccTTTEEcccTTcccEEEEcHHHHHHHHHTTTcEEEEETTEEEcTTccEEEccTTHHHHHHHHHHHHHHTcccEEEEEcccccccccTTTccccccEEEHHHHHTTccTTcccccHHHHHHHHHHTccEEEEEcccTTcccEEccccccEEEEEEEEEEEEEEcccccTTccHHHHHHHHHHGGGccccEEEccTTccEEEEEEETTcHHccccccccccEEEEEEEEEEEEEEcGGGTTcTTHHHHHHHHHHHTTccEEEEEEcccTTccTTccEEEEEEEHHHHHHHHHHHHHHHT############ DISOP:02AL 384-385| PSIPRED ccEEEEEEcccHHHHHHHHHHHHHHHHHHHHHcccEEEEEEEEccHHHHHHHHcccccccEEccHHHHHccccccEEEEcccccHHHHHHHHHHHHccccEEEcccHHHHHHHHHHHHHHHHHccEEEEEccHHHccHHHHHHHHHcccccEEEEEEEEccHHHHHHHHHHHccccHHHHHHHHHHccccccccccccccHHHHHHHHHHHHHHccccccHHHEEEcccccccHHHHHHHHHcccEEEEEEEEEEcccEEEEEEEEEEEcccccccccccccEEEEEEEcccccEEEEccccccHHHHHHHHHHHHHHHHHcccccccccccccccccccccHHHccccEEEEEEEcccccHHHHHHHHHHHccccHHHHHcccccccccEEEEEEEEccHHHHHHHHHHHHcccccccccEEEEccc //