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Streptococcus pneumoniae G54 (spne4)
Gene : ply
DDBJ      :ply          pneumolysin
Swiss-Prot:TACY_STRPN   RecName: Full=Pneumolysin;AltName: Full=Thiol-activated cytolysin;

Homologs  Archaea  0/68 : Bacteria  62/915 : Eukaryota  0/199 : Viruses  0/175   --->[See Alignment]
f.9.1
:471 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   2->468 1s3rA PDBj e-155 53.5 %
:RPS:PDB   6->466 3cqfA PDBj 0.0 42.4 %
:RPS:SCOP  4->469 1m3iA  f.9.1.1 * 0.0 46.2 %
:HMM:SCOP  2->469 1pfoA_ f.9.1.1 * 9.5e-208 58.5 %
:RPS:PFM   53->410 PF01289 * Thiol_cytolysin e-125 59.4 %
:HMM:PFM   3->468 PF01289 * Thiol_cytolysin 1.7e-245 60.3 466/467  
:BLT:SWISS 1->471 TACY_STRPN 0.0 100.0 %
:PROS 426->437|PS00481|THIOL_CYTOLYSINS

SeqInfo AminoSeq See neighboring genes
Links DAD Abbreviations Back to title page
GT:ID ACF56060.1 GT:GENE ply GT:PRODUCT pneumolysin GT:DATABASE GIB00761CH01 GT:ORG spne4 GB:ACCESSION GIB00761CH01 GB:LOCATION complement(1749821..1751236) GB:FROM 1749821 GB:TO 1751236 GB:DIRECTION - GB:GENE ply GB:PRODUCT pneumolysin GB:NOTE identified by match to protein family HMM PF01289 GB:PROTEIN_ID ACF56060.1 GB:DB_XREF GI:194357612 GB:GENE:GENE ply LENGTH 471 SQ:AASEQ MANKAVNDFILAMNYDKKKLLTHQGESIENRFIKEGNQLPDEFVVIERKKRSLSTNTSDISVTATNDSRLYPGALLVVDETLLENNPTLLAVDRAPMTYSIDLPGLASSDSFLQVEDPSNSSVRGAVNDLLAKWHQDYGQVNNVPARMQYEKITAHSMEQLKVKFGSDFEKTGNSLDIDFNSVHSGEKQIQIVNFKQIYYTVSVDAVKNPGDVFQDTVTVEDLKQRGISAERPLVYISSVAYGRQVYLKLETTSKSDEVEAAFEALIKGVKVAPQTEWKQILDNTEVKAVILGGDPSSGARVVTGKVDMVEDLIQEGSRFTADHPGLPISYTTSFLRDNVVATFQNSTDYVETKVTAYRNGDLLLDHSGAYVAQYYITWNELSYDHQGKEVLTPKAWDRNGQDLTAHFTTSIPLKGNVRNLSVKIRECTGLAWEWWRTVYEKTDLPLVRKRTISIWGTTLYPQVEDKVEND GT:EXON 1|1-471:0| SW:ID TACY_STRPN SW:DE RecName: Full=Pneumolysin;AltName: Full=Thiol-activated cytolysin; SW:GN Name=ply; OrderedLocusNames=SP_1923; SW:KW Complete proteome; Cytolysis; Hemolysis; Lipid-binding; Toxin. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->471|TACY_STRPN|0.0|100.0|471/471| GO:SWS:NREP 4 GO:SWS GO:0019835|"GO:cytolysis"|Cytolysis| GO:SWS GO:0044179|"GO:hemolysis of cells in other organism"|Hemolysis| GO:SWS GO:0008289|"GO:lipid binding"|Lipid-binding| GO:SWS GO:0009405|"GO:pathogenesis"|Toxin| PROS 426->437|PS00481|THIOL_CYTOLYSINS|PDOC00436| BL:PDB:NREP 1 BL:PDB:REP 2->468|1s3rA|e-155|53.5|467/473| RP:PDB:NREP 1 RP:PDB:REP 6->466|3cqfA|0.0|42.4|455/462| RP:PFM:NREP 1 RP:PFM:REP 53->410|PF01289|e-125|59.4|357/361|Thiol_cytolysin| HM:PFM:NREP 1 HM:PFM:REP 3->468|PF01289|1.7e-245|60.3|466/467|Thiol_cytolysin| GO:PFM:NREP 2 GO:PFM GO:0009405|"GO:pathogenesis"|PF01289|IPR001869| GO:PFM GO:0015485|"GO:cholesterol binding"|PF01289|IPR001869| RP:SCP:NREP 1 RP:SCP:REP 4->469|1m3iA|0.0|46.2|465/465|f.9.1.1| HM:SCP:REP 2->469|1pfoA_|9.5e-208|58.5|467/471|f.9.1.1|1/1|Perfringolysin| OP:NHOMO 76 OP:NHOMOORG 62 OP:PATTERN -------------------------------------------------------------------- ----------------------------------------------------------------------------------------2--2-2----------------------------------------------------------------------------------------------------11111111-111111------111---1----1111-1--------------------------------------------------1------222222212221111111111111-11---111-------------1-1----211--1--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 467 STR:RPRED 99.2 SQ:SECSTR #HHHHHHHHHHTccccHHHHTccccccccccccEEccEETTEEccEEEEEEEcccccccccccGGGcTTccTTcEEEccTTTTTTccEEcccccccEEEEccccccccccEEEEEccccHHHHHHHHHHHHHHHHHHTTTTcccccEEEEEEEEcccHHHHHHHHTccHHHHHHHHcccHHHHHTTccEEEEEEEEEEEEEEEccccccGGGGccccccHHHHHHHTccTTccEEEEEEEEEEEEEEEEEEEccccTTHHHHHHHHHHccTTTTTcTTTTTTTcEEEEEEcccccccTTTcEEEccHHHHHHHHHHTccccccccccEEEEEEEETTTccccccccccEEEEEcccccccEEEEEEEcccccEEEEEEEEEEEEcTTccEEEEEEEcTTTTcEEcccEEEEEEEcTTEEcccEEEEEEcccTTccEEEEEEEcccccccEEEEEEEEccccEEEEEEE### DISOP:02AL 1-4,467-472| PSIPRED ccHHHHHHHHHccccccccEEEEEccEEEcccccHHcccccEEEEEEEEcccccccccEEEEEEEcccccccHHHHHccHHHHcccccEEEEEcccEEEEEEcccEEccccEEEEEcccHHHHHHHHHHHHHHHHHHccccccEEEEEEEEEEEEEcHHHHHHHHcccHHHccccccccHHHHcccccEEEEEEEEEEEEEEEcccccccHHHHcccccHHHHHHcccccccccEEEEEEEcccEEEEEEEccccHHHHHHHHHHHHcccccccccHHHHHHHcEEEEEEEEcccccccEEEEEccHHHHHHHHHcccEEccccccccEEEEEEEEccccEEEEEEcccEEEEEEEEEcccEEEEEccccEEEEEEEEEccccccccccEEEEEEcccccccccccccEEEEEcccccEEEEEEEEEEEcccccHHHHHHcccccccccccEEEEEEcEEccccccccccc //