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Streptococcus pneumoniae G54 (spne4)
Gene : spxB
DDBJ      :spxB         pyruvate oxidase
Swiss-Prot:POXB_STRPN   RecName: Full=Pyruvate oxidase;         EC=1.2.3.3;AltName: Full=Pyruvic oxidase;         Short=POX;

Homologs  Archaea  53/68 : Bacteria  759/915 : Eukaryota  165/199 : Viruses  0/175   --->[See Alignment]
c.31.1c.36.1c.92.2
:591 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   5->591 1v5fA PDBj 0.0 68.8 %
:RPS:PDB   7->537 1bfdA PDBj 4e-82 20.9 %
:RPS:SCOP  1->515 1fp4B  c.92.2.3 * 1e-46 9.9 %
:HMM:SCOP  5->172 1zpdA2 c.36.1.5 * 4.5e-42 34.1 %
:HMM:SCOP  186->362 2djiA1 c.31.1.3 * 5.9e-41 31.6 %
:HMM:SCOP  363->591 2djiA3 c.36.1.9 * 1.3e-54 32.8 %
:RPS:PFM   6->171 PF02776 * TPP_enzyme_N 1e-22 31.3 %
:RPS:PFM   196->323 PF00205 * TPP_enzyme_M 4e-15 39.1 %
:RPS:PFM   407->523 PF02775 * TPP_enzyme_C 2e-17 38.5 %
:HMM:PFM   7->174 PF02776 * TPP_enzyme_N 4.6e-43 35.1 168/172  
:HMM:PFM   387->535 PF02775 * TPP_enzyme_C 1.7e-35 34.5 145/150  
:HMM:PFM   196->326 PF00205 * TPP_enzyme_M 6e-26 35.1 131/137  
:BLT:SWISS 1->591 POXB_STRPN 0.0 99.8 %
:PROS 424->443|PS00187|TPP_ENZYMES
:SEG

SeqInfo AminoSeq See neighboring genes
Links DAD Abbreviations Back to title page
GT:ID ACF55639.1 GT:GENE spxB GT:PRODUCT pyruvate oxidase GT:DATABASE GIB00761CH01 GT:ORG spne4 GB:ACCESSION GIB00761CH01 GB:LOCATION 649535..651310 GB:FROM 649535 GB:TO 651310 GB:DIRECTION + GB:GENE spxB GB:PRODUCT pyruvate oxidase GB:NOTE identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; match to protein family HMM TIGR02720 GB:PROTEIN_ID ACF55639.1 GB:DB_XREF GI:194357191 GB:GENE:GENE spxB LENGTH 591 SQ:AASEQ MTQGKITASAAMLNVLKTWGVDTIYGIPSGTLSSLMDALAEDKDIRFLQVRHEETGALAAVMQAKFGGSIGVAVGSGGPGATHLINGVYDAAMDNTPFLAILGSRPVNELNMDAFQELNQNPMYNGIAVYNKRVAYAEQLPKVIDEACRAAISKKGPAVVEIPVNFGFQEIDENSYYGSGSYERSFIAPALNEVEIDKAVEILNNAERPVIYAGFGGVKAGEVITELSRKIKAPIITTGKNFEAFEWNYEGLTGSAYRVGWKPANEVVFEADTVLFLGSNFPFAEVYEAFKNTEKFIQVDIDPYKLGKRHALDASILGDAGQAAKAILDKVNPVESTPWWRANVKNNQNWRDYMNKLEGKTEGELQLYQVYNAINKHADQDAIYSIDVGNTTQTSTRHLHMTPKNMWRTSPLFATMGIALPGGIAAKKDNPDRQVWNIMGDGAFNMCYPDVITNVQYDLPVINLVFSNAEYGFIKNKYEDTNKHLFGVDFTNADYAKIAEAQGAVGFTVDRIEDIDAVVAEAVKLNKEGKTVVIDARITQHRPLPVEVLELDPKLHSEEAIKAFKEKYEAEELVPFRLFLEEEGLQSRAIK GT:EXON 1|1-591:0| SW:ID POXB_STRPN SW:DE RecName: Full=Pyruvate oxidase; EC=1.2.3.3;AltName: Full=Pyruvic oxidase; Short=POX; SW:GN Name=spxB; OrderedLocusNames=SP_0730; SW:KW Complete proteome; FAD; Flavoprotein; Magnesium; Metal-binding;Oxidoreductase; Thiamine pyrophosphate. SW:EXACT F SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->591|POXB_STRPN|0.0|99.8|591/591| GO:SWS:NREP 3 GO:SWS GO:0046872|"GO:metal ion binding"|Metal-binding| GO:SWS GO:0016491|"GO:oxidoreductase activity"|Oxidoreductase| GO:SWS GO:0055114|"GO:oxidation reduction"|Oxidoreductase| PROS 424->443|PS00187|TPP_ENZYMES|PDOC00166| SEG 67->81|ggsigvavgsggpga| BL:PDB:NREP 1 BL:PDB:REP 5->591|1v5fA|0.0|68.8|587/589| RP:PDB:NREP 1 RP:PDB:REP 7->537|1bfdA|4e-82|20.9|508/523| RP:PFM:NREP 3 RP:PFM:REP 6->171|PF02776|1e-22|31.3|166/170|TPP_enzyme_N| RP:PFM:REP 196->323|PF00205|4e-15|39.1|128/138|TPP_enzyme_M| RP:PFM:REP 407->523|PF02775|2e-17|38.5|117/139|TPP_enzyme_C| HM:PFM:NREP 3 HM:PFM:REP 7->174|PF02776|4.6e-43|35.1|168/172|TPP_enzyme_N| HM:PFM:REP 387->535|PF02775|1.7e-35|34.5|145/150|TPP_enzyme_C| HM:PFM:REP 196->326|PF00205|6e-26|35.1|131/137|TPP_enzyme_M| GO:PFM:NREP 5 GO:PFM GO:0030976|"GO:thiamin pyrophosphate binding"|PF02776|IPR012001| GO:PFM GO:0000287|"GO:magnesium ion binding"|PF00205|IPR012000| GO:PFM GO:0030976|"GO:thiamin pyrophosphate binding"|PF00205|IPR012000| GO:PFM GO:0003824|"GO:catalytic activity"|PF02775|IPR011766| GO:PFM GO:0030976|"GO:thiamin pyrophosphate binding"|PF02775|IPR011766| RP:SCP:NREP 1 RP:SCP:REP 1->515|1fp4B|1e-46|9.9|493/522|c.92.2.3| HM:SCP:REP 5->172|1zpdA2|4.5e-42|34.1|167/186|c.36.1.5|1/2|Thiamin diphosphate-binding fold (THDP-binding)| HM:SCP:REP 186->362|2djiA1|5.9e-41|31.6|177/0|c.31.1.3|1/1|DHS-like NAD/FAD-binding domain| HM:SCP:REP 363->591|2djiA3|1.3e-54|32.8|229/0|c.36.1.9|2/2|Thiamin diphosphate-binding fold (THDP-binding)| OP:NHOMO 2641 OP:NHOMOORG 977 OP:PATTERN ---1--4565565662-31221143--21111243121222221312213343111-----22-1-11 3261632222223243422-221157222223244444C91223223-232164453211324235657421222111-211511111223112---11-1111132211---------------21111111111222321111632423322211112111222223611111111211111211111-124444443461454435234434444225242-4444432423333333333333323333122145111-17622553331343231113---22222222222222-------------211222111122125-------5-42133111-112--2122165222121221112--1-111112-11-1236762144225333233332216-55644826362-2442356665676413156722124354444444421112212-----------------------------2322226A8676777767444477AC66664566C566722443233226243972323111311111111112322-922212222233412212112332222332421111111111-1-------1111211322231312222332422322222322233---2111-1111155543545666576766-6646767656666665664667543346455545556556553665666651-65555554455511---1---111122532222212-111-3222222221212241777735444476532221----1---313253333322222332222222211111111331122------------------------1-1----------11--1-111122 ----22--------153212123343511111111211111221122212112111211111211212-1221112212221111112-11132111111111222-24-4232112--1-11-22--13B2-2221---1-11111-111-1--11121131531111-2124-11118111225113122213111- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 590 STR:RPRED 99.8 SQ:SECSTR ccE#cEcHHHHHHHHHHHTTccEEEEcccGGGHHHHTTccHHTTcEEEEcccHHHHHHHHHHHHHHHTccEEEEEEHHHHHHHTHHHHHHHHHHTccEEEEEEEccHHHHTTTcTccTTGGGTTTTcccEEEccccGGGHHHHHHHHHHHHHcccccEEEEEEGGGTTccccGGGGGGTTccccccccccccHHHHHHHHHHHHHccccEEEEcHHHHTcHHHHHHHHHHHTccEEEccccccTTcTTEEEEcccGGGGcHHHHHHHHTTccEEEEEcccTTcccccccccTTcEEEEEEccHHHHHHccccEEEEEccHHHHHHHHHHHHHTTccHHHcccccccccccccccccccccccccccHHHHHHHHHHHccTTcEEEEEcGGGHHHHHHHcccccTTcEEEcTTccccccHHHHHHHHHHHcTTccEEEEEEHHHHTTTGGGHHHHHHHTcccEEEEEEccccHHHHHHHHHTcccccccccccccHHHHHHHTTcEEEEEccHHHHHHHHHHHHHHHHccccEEEEEEcccccccTTTTcccTTccGGGccccHHHHcTTccHHHHHHHHHHHTTccccccc DISOP:02AL 1-5,588-589,591-592| PSIPRED cccccccHHHHHHHHHHHccccEEEEcccccHHHHHHHHHHccccEEEEcccHHHHHHHHHHHHHHcccEEEEEEcccHHHHHHHHHHHHHHHHcccEEEEEccccHHHccccccccccHHHHHHcccEEEEEcccHHHHHHHHHHHHHHHHccccEEEEEEccHHHcccccccccccccccccccccccccHHHHHHHHHHHHHccccEEEEcHHHccHHHHHHHHHHHHcccEEEcccccccccccccccccccccccHHHHHHHHHHccEEEEEcccccccccccccccccEEEEEEccHHHccccccccEEEEccHHHHHHHHHHHHHcccccHHHHHHHHHHHHHHHHHHHHcccccccccHHHHHHHHHHHcccccEEEEccccHHHHHHHccccccccEEEEcccHHHHHHHHHHHHHHHHHccccEEEEEEccHHHHccHHHHHHHHHccccEEEEEEEccccHHHHHHcccccccccccccccccHHHHHHHccccEEEEccHHHHHHHHHHHHHHHcccccEEEEEEEccccccccccccccHHHccHHHHHHHHHcccHHHcccHHHHHHHcccHHHccc //