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Streptococcus pneumoniae G54 (spne4)
Gene : sulA
DDBJ      :sulA         dihydropteroate synthase
Swiss-Prot:DHPS_STRR6   RecName: Full=Dihydropteroate synthase;         Short=DHPS;         EC=2.5.1.15;AltName: Full=Dihydropteroate pyrophosphorylase;

Homologs  Archaea  29/68 : Bacteria  792/915 : Eukaryota  118/199 : Viruses  0/175   --->[See Alignment]
c.1.21
:324 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   17->313 2vefA PDBj e-120 99.6 %
:RPS:PDB   18->314 2bmbA PDBj 1e-35 29.5 %
:RPS:SCOP  19->310 1ad1A  c.1.21.1 * 3e-53 35.3 %
:HMM:SCOP  19->313 1eyeA_ c.1.21.1 * 2.1e-79 47.9 %
:RPS:PFM   25->250 PF00809 * Pterin_bind 4e-36 44.9 %
:HMM:PFM   25->250 PF00809 * Pterin_bind 2e-82 57.0 207/210  
:BLT:SWISS 11->324 DHPS_STRR6 e-140 95.9 %
:PROS 22->37|PS00792|DHPS_1
:PROS 56->69|PS00793|DHPS_2
:SEG

SeqInfo AminoSeq See neighboring genes
Links DAD Abbreviations Back to title page
GT:ID ACF56622.1 GT:GENE sulA GT:PRODUCT dihydropteroate synthase GT:DATABASE GIB00761CH01 GT:ORG spne4 GB:ACCESSION GIB00761CH01 GB:LOCATION 265179..266153 GB:FROM 265179 GB:TO 266153 GB:DIRECTION + GB:GENE sulA GB:PRODUCT dihydropteroate synthase GB:NOTE identified by match to protein family HMM PF00809; match to protein family HMM TIGR01496 GB:PROTEIN_ID ACF56622.1 GB:DB_XREF GI:194358174 GB:GENE:GENE sulA LENGTH 324 SQ:AASEQ MMKILEGVTDMSSKANHAKTVICGIINVTPDSFSDGGKFFALEQALQQARKLIAEGASMLDIGGESTRPGSSYVEIEEEIQRVVPVIKAIRKESDVLISIDTWKSQVAEAALAAGADLVNDITGLMGDEKMAHVVAEARAQVVIMFNPVMARPQHPSSLIFPHFGFGQAFTEEELADFETLPIEELMEAFFERALARAAEAGIAPENILLDPGIGFGLTKKENLLLLRDLDKLHQKGYPIFLGVSRKRFVINILEENGFEVNPETELGFRNRDTASAHVTSIAARQGVEVVRVHDVASHRMAVEIASAIRLADEAENLDLKQYK GT:EXON 1|1-324:0| SW:ID DHPS_STRR6 SW:DE RecName: Full=Dihydropteroate synthase; Short=DHPS; EC=2.5.1.15;AltName: Full=Dihydropteroate pyrophosphorylase; SW:GN Name=sulA; OrderedLocusNames=spr0266; SW:KW 3D-structure; Antibiotic resistance; Complete proteome;Folate biosynthesis; Transferase. SW:EXACT F SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 11->324|DHPS_STRR6|e-140|95.9|314/314| GO:SWS:NREP 3 GO:SWS GO:0046677|"GO:response to antibiotic"|Antibiotic resistance| GO:SWS GO:0046656|"GO:folic acid biosynthetic process"|Folate biosynthesis| GO:SWS GO:0016740|"GO:transferase activity"|Transferase| PROS 22->37|PS00792|DHPS_1|PDOC00630| PROS 56->69|PS00793|DHPS_2|PDOC00630| SEG 108->116|aeaalaaga| SEG 188->201|eafferalaraaea| SEG 218->236|ltkkenllllrdldklhqk| BL:PDB:NREP 1 BL:PDB:REP 17->313|2vefA|e-120|99.6|279/279| RP:PDB:NREP 1 RP:PDB:REP 18->314|2bmbA|1e-35|29.5|285/513| RP:PFM:NREP 1 RP:PFM:REP 25->250|PF00809|4e-36|44.9|207/208|Pterin_bind| HM:PFM:NREP 1 HM:PFM:REP 25->250|PF00809|2e-82|57.0|207/210|Pterin_bind| GO:PFM:NREP 1 GO:PFM GO:0042558|"GO:pteridine and derivative metabolic process"|PF00809|IPR000489| RP:SCP:NREP 1 RP:SCP:REP 19->310|1ad1A|3e-53|35.3|255/264|c.1.21.1| HM:SCP:REP 19->313|1eyeA_|2.1e-79|47.9|267/0|c.1.21.1|1/1|Dihydropteroate synthetase-like| OP:NHOMO 1019 OP:NHOMOORG 939 OP:PATTERN -----------------11-1-1-211-1111------------111111111--1--1111111--1 1112222222212122222-2222222222222222223322111121111211111111223113222221---111111111111111111111---1111111111111----11111111111111111111-----1111111111111111111111111111131111111-111111111111111111111111111111111111111111111111111111111111111111111111111--1--11-1-1111--1--1--111111111111111111111111111111111111111111-111111-111111111-1-11111111--1-11--11111111--111111111-111111-----111111111111111111111111-11111111111-1111111111111-111111111111111111111111111111111122211----11--1--------1-111-11111111111111111111111111111111111-1111111111111111111111111111111111111-11111111111111111111111111111111-111-----11111111111111111111-111111111111111111111111111-11111------11111111111111121-11112211111111111112111111111111311111211111111121211111111111111111111111111111111211111112111111111211-1111111111111111111111-1--1-11111111111211111111111111111111111-111111-----------1-1----------------------11-1111111111 1---11------11111111111111111111111111111111111-11111111111111111111111111111-1111111111-12111121111111111-13------------------------------------------------------------------111--1111121211211121111 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 319 STR:RPRED 98.5 SQ:SECSTR #HHHHHTTcccccEEEEcccEEEEEEEcccccTTTTTTTTTHHHHHHHHHHHTTcccEEEEEEcccccTTcccccHHHHHHHHHHHHHHHHHccGEEEEEEcccHHHHHHHHHTTccEEEETTTTcccTTHHHHHHTTTcEEEEEccccTccTTTGGGcccccccTTTTTEEEEETHHHHcHHHHHHHHHHHHHHHHHHHTTccGGGEEEEccTTccccHHHHHHHHHTHHHHTTEEEEcEEccTTcHHHHHHHccccTcccGHTcccGGGGHHHHHHHHHHHHHTTccEEEEccHHHHHHHHHHHHHHHHcccTccccc#### DISOP:02AL 1-1,323-325| PSIPRED ccccccccccccccccccccEEEEEEEccccccccccccccHHHHHHHHHHHHHccccEEEEcccccccccccccHHHHHHHHHHHHHHHHHccccEEEEEcccHHHHHHHHHccccEEEEcccccccHHHHHHHHHccccEEEEcccccccccccccccccccccccccccccccccccHHHHHHHHHHHHHHHHHHHHccccHHHEEEEccccccccHHHHHHHHHHHHHHHHccccEEEEcccHHHHHHHHccccccccccccccHHHHHHHHHHHHHHHHHccccEEEEccHHHHHHHHHHHHHHHHHcccccccHHHcc //